The relationship between polypharmacy and physical performance in patients with early-stage Alzheimer’s disease

References

• Weller J, Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Res. 2018;7:1161. doi: 10.12688/f1000research.14506.1.
   Google Scholar
• Tiwari S, Atluri V, Kaushik A, et al. Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine. 2019;14:5541–5554. doi: 10.2147/IJN.S200490.
   PubMed Web of Science ®Google Scholar
• Perneczky R, Wagenpfeil S, Komossa K, et al. Mapping scores onto stages: mini-mental state examination and clinical dementia rating. Am J Geriatr Psychiatry. 2006;14(2):139–144. doi: 10.1097/01.JGP.0000192478.82189.a8.
   PubMed Web of Science ®Google Scholar
• Ambrose AF, Paul G, Hausdorff JM. Risk factors for falls among older adults: a review of the literature. Maturitas. 2013;75(1):51–61. doi: 10.1016/j.maturitas.2013.02.009.
   PubMed Web of Science ®Google Scholar
• Bjerrum L, Rosholm JU, Hallas J, et al. Methods for estimating the occurrence of polypharmacy by means of a prescription database. Eur J Clin Pharmacol. 1997;53(1):7–11. doi: 10.1007/s002280050329.
   PubMed Web of Science ®Google Scholar
• Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230. doi: 10.1186/s12877-017-0621-2.
   PubMed Web of Science ®Google Scholar
• Hughes C. Appropriate and inappropriate polypharmacy-choosing the right strategy. Br J Clin Pharmacol. 2021;87(1):84–86. doi: 10.1111/bcp.14589.
   PubMed Web of Science ®Google Scholar
• Ozkok S, Aydin CO, Sacar DE, et al. Associations between polypharmacy and physical performance measures in older adults. Arch Gerontol Geriatr. 2022;98:104553. doi: 10.1016/j.archger.2021.104553.
   PubMed Web of Science ®Google Scholar
• Fried TR, O'Leary J, Towle V, et al. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62(12):2261–2272. doi: 10.1111/jgs.13153.
   PubMed Web of Science ®Google Scholar
• Mueller C, Molokhia M, Perera G, et al. Polypharmacy in people with dementia: associations with adverse health outcomes. Exp Gerontol. 2018;106:240–245. doi: 10.1016/j.exger.2018.02.011.
   PubMed Web of Science ®Google Scholar
• Cherubini A, Ruggiero C, Dell’Aquila G, et al. Underrecognition and undertreatment of dementia in ıtalian nursing homes. J Am Med Dir Assoc. 2012;13(8):759.e7-13–759.13. doi: 10.1016/j.jamda.2012.05.015.
   PubMed Web of Science ®Google Scholar
• Soysal P, Perera G, Isik AT, et al. The relationship between polypharmacy and trajectories of cognitive decline in people with dementia: a large representative cohort study. Exp Gerontol. 2019;120:62–67. doi: 10.1016/j.exger.2019.02.019.
   PubMed Web of Science ®Google Scholar
• Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952–1960. doi: 10.1001/archinternmed.2009.357.
   PubMedGoogle Scholar
• McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the national ınstitute on aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–269. doi: 10.1016/j.jalz.2011.03.005.
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6.
   PubMed Web of Science ®Google Scholar
• Chippa V, Roy K. Geriatric cognitive decline and polypharmacy. 2023. In: StatPearls [ınternet]. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised european consensus on definition and diagnosis. Age Ageing. 2019;48(4):601–601. doi: 10.1093/ageing/afz046.
   PubMed Web of Science ®Google Scholar
• Podsiadlo D, Richardson S. The timed “Up & go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–148. doi: 10.1111/j.1532-5415.1991.tb01616.x.
   PubMed Web of Science ®Google Scholar
• Puente-González AS, Sánchez-González F, Hernández-Xumet JE, et al. Short and medium-term effects of a multicomponent physical exercise program with a mediterranean diet on bone mineral density, gait, balance, and fall risk for patients with Alzheimer disease: randomized controlled clinical trial study protocol. Medicine. 2020;99(38):e22385. doi: 10.1097/MD.0000000000022385.
   PubMed Web of Science ®Google Scholar
• Beeri MS, Leugrans SE, Delbono O, et al. Sarcopenia is associated with incident Alzheimer’s dementia, mild cognitive impairment, and cognitive decline. J Am Geriatr Soc. 2021;69(7):1826–1835. doi: 10.1111/jgs.17206.
   PubMed Web of Science ®Google Scholar
• Cámara-Calmaestra R, Martínez-Amat A, Aibar-Almazán A, et al. Effectiveness of physical exercise on Alzheimer’s disease. A systematic review. J Prev Alzheimers Dis. 2022;9(4):601–616.
   PubMed Web of Science ®Google Scholar
• Soysal P, Tan SG. The prevalence and co-incidence of geriatric syndromes in older patients with early-stage Alzheimer’s disease and dementia with lewy bodies. Aging Clin Exp Res. 2021;33(9):2599–2603. doi: 10.1007/s40520-020-01774-y.
   PubMed Web of Science ®Google Scholar
• Kimura A, Sugimoto T, Niida S, et al. Association between appetite and sarcopenia in patients With mild cognitive ımpairment and early-stage Alzheimer’s disease: a case-control study. Front Nutr. 2018;5:128. doi: 10.3389/fnut.2018.00128.
   PubMed Web of Science ®Google Scholar
• Lopez A, Cacoub P, Macdougall IC, et al. Iron deficiency anaemia. Lancet. 2016;387(10021):907–916. doi: 10.1016/S0140-6736(15)60865-0.
   PubMed Web of Science ®Google Scholar
• Lukaski HC. Vitamin and mineral status: effects on physical performance. Nutrition. 2004;20(7–8):632–644. doi: 10.1016/j.nut.2004.04.001.
   PubMed Web of Science ®Google Scholar
• George C, Verghese J. Polypharmacy and gait performance in community-dwelling older adults. J Am Geriatr Soc. 2017;65(9):2082–2087. doi: 10.1111/jgs.14957.
   PubMed Web of Science ®Google Scholar
• Umegaki H, Yanagawa M, Komiya H, et al. Polypharmacy and gait speed in individuals with mild cognitive impairment. Geriatr Gerontol Int. 2019;19(8):730–735. doi: 10.1111/ggi.13688.
   PubMed Web of Science ®Google Scholar
• Soysal P, Isik AT, Stubbs B, et al. Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016;87(12):1368–1374. doi: 10.1136/jnnp-2016-313660.
   PubMed Web of Science ®Google Scholar
• Whitney SL, Wrisley DM, Marchetti GF, et al. Clinical measurement of sit-to-stand performance in people with balance disorders: validity of data for the five-times-sit-to-stand test. Phys Ther. 2005;85(10):1034–1045.
   PubMed Web of Science ®Google Scholar