Transgenic Models of Metabolic Bone Disease: Impact of Estrogen Receptor Deficiency on Skeletal Metabolism

References

• Riggs, B.L., Khosla, S., and Melton, J. (1998). A unitary model for in- volutional osteoporosis: Estrogen deficiency causes both type I and typeII osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. 13:763–773.
   PubMed Web of Science ®Google Scholar
• Cutler, G.B. (1997). The role of estrogen in bone growth and maturation during childhood and adolescence. J. Steroid Biochem. Mol. Biol. 61:141–144.
   PubMed Web of Science ®Google Scholar
• Takagi, M., Miyashita, Y., Koga, M., Ebara, S., Arita, N., and Kasayama,S. (2000). Estrogen deficiency is a potential cause for osteopenia in adult male patients with Noonan’s syndrome. Calci. Tiss. Inter. 66:200–203.
   PubMed Web of Science ®Google Scholar
• Compston, J.E. (2001). Sex steroids and bone. Physiol. Rev. 81: 419–447.
   PubMed Web of Science ®Google Scholar
• Nilsson, S., Ma¨kela¨, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., and Gustafsson, J. (2001).Mechanisms of estrogen action. Physiol. Rev. 81:1535–1565.
   PubMed Web of Science ®Google Scholar
• Murphy, L.C., Dotzlaw, H., Leygue, E., Douglas, D., Coutts, A., and Watson, P.H. (1997). Estrogen receptor variants and mutations. Mol. Biol. 62:363–372.
   Web of Science ®Google Scholar
• Resche-Rigon, M., and Gronemeyer, H. (1998). Therapeutic potential of selective modulators of nuclear receptor action. Curr. Opin. Chemi. Biol. 2:501–507.
   PubMed Web of Science ®Google Scholar
• Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J.M., Argos, P., and Chambon, P. (1986). Human estrogen receptor cDNA: Sequence, expres- sion and homology to v-erb-A. Nature 320:134–139.
   PubMed Web of Science ®Google Scholar
• Kuiper, G.G.J.M., Enmark, E., Pelto-Huikko, M., Nilsson, S., and Gustafsson, J.A. (1996). Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Biochemistry 93:5925–5930.
   Google Scholar
• Kuiper, G.G.J.M., and Gustafsson, J.A. (1997). The novel estrogen receptor-ß subtype: Potential role in the cell- and promotor-specific ac- tions of estrogens and anti-estrogens. FEBS Lett. 410:87–90.
   PubMed Web of Science ®Google Scholar
• Nilsson, S., Kuiper, G.G.J.M., and Gustafsson, J.A. (1998). ERß: A novel estrogen receptor offers the potential for new drug development. TEM 9:387–395.
   PubMed Web of Science ®Google Scholar
• Bodenner, D.L., Kozlowski, M., and Manolagas, S.C. (1998). Switch from transcriptional inhibition to stimulation of the IL-6 gene depending upon the estrogen receptor form (α vs. β) and type of ligand (estradiol vs. hydroxytamoxifen). J. Bone. Miner. Res. 23:S186
   Google Scholar
• Coleman, K.M., Gustafsson, J.A., and Smith, C.L. (1999). Activation of estrogen receptor-alpha and estrogen receptor-beta by ligand-dependent and ligand-independent pathways. Abstracts Endocr. Soc. P1:234(abstr.)
   Google Scholar
• Paige, L.A., Christensen, D.J., Grøn, H., Norris, J.D., Gottlin, E., Padilla, K.M., Chang, C.-Y., Ballas, L.M., Hamilton, P.T., McDonnell, D.P., and Fowlkes, D.M. (1999). Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β. Med. Sci. 96:3999–4004.
   Google Scholar
• Zou, A., Marschke, K.B., Arnold, K.E., Berger, E.M., Fitzgerald, P., Mais, D.E., and Allegretto, E. (1999). Estrogen receptor ß activates the hu- man retinoic acid receptor α-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen. Mol. Endocrinol. 13:418–430.
   Google Scholar
• Webb, P., Nguyen, P., Valentine, C., Lopez, G., Kwok, G., McInerney, E., Katzenellenbogen, B., Enmark, E., Gustafsson, J., Nilsson, S., and Kushner, P. (1999). The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactiva- tion functions. Mol. Endocrinol. 13:1672–1685.
   PubMed Web of Science ®Google Scholar
• Bland, R. (2000). Steroid hormone receptor expression and action in bone. Clin. Sci. 98:217–240.
   PubMed Web of Science ®Google Scholar
• Paech, K., Webb, P., Kuiper, G.G.J.M., Nilsson, S., Gustafsson, J.A., Kushner, P.J., and Scanlan, T.S. (1997). Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508–1510.
   Google Scholar
• Oursler, M.J. (1998). Estrogen regulation of gene expression in osteoblasts and osteoclasts. Crit. Rev. Eukaryotic Gene Expres. 8:125–140.
   PubMed Web of Science ®Google Scholar
• Pacifici, R. (1998). Estrogen and bone loss. Adv. Organ Biol. 5C:641– 659.
   Google Scholar
• Dupont, S., Kru¨st, A., Gansmuller, A., Dierich, A., Chambon, P., and Mark, M. (2000). Effect of single and compound knockouts of estrogen receptors alpha (ERα) and beta (ERβ) on mouse reproductive phenotypes. Development 127:4277–4291.
   Google Scholar
• Parfitt, A.M., Drezner, M.K., Glorieux, F.H., Kanis, J.A., Malluche, H., Meunier, P.J., Ott, S.M., and Recker, R.R. (1989). Bone histomorphometry: Standardization of nomenclature, symbols, and units. J. Bone. Miner. Res. 2:595–610.
   Web of Science ®Google Scholar
• Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L., Brown, M.B., and Feldkamp, L.A. (1994). The relationship between the structural and orthogonal compressive properties of trabecular bone. J. Biomech. 27:375–389.
   PubMed Web of Science ®Google Scholar
• Kuhn, J.L., Goldstein, S.A., Feldkamp, L.A., Goulet, R.W., and Jesion,G. (1990). Evaluation of a microcomputed tomography system to study trabecular bone structure. J. Orthop. Res. 8:833–842.
   PubMed Web of Science ®Google Scholar
• Xu, T., Bianco, P., Fisher, L.W., Longenecker, G., Smith, E., Goldstein, S., Bonadio, J., Boskey, A., Heegaard, A.M., Sommer, B., Satomura, K., Dominguez, P., Zhao, C., Kulkarni, A.B., Robey, P.G., and Young, M.F. (1998). Targeted disruption of the biglycan gene leads to an osteoporosis- like phenotype in mice. Nat. Gen. 20:78–82.
   PubMed Web of Science ®Google Scholar
• Koh, A.J., Beecher, C.A., Rosol, T.J., and McCauley, L.K. (1999). 3¹,5¹-Cyclic adenosine monophosphate activation in osteoblastic cells: Effects of parathyroid hormone-1 receptors and osteoblastic differenti- ation, in vitro. Endocrinology 140:3154–3162.
   PubMed Web of Science ®Google Scholar
• McCauley, L.K., Koh, A.J., Beecher, C.A., Cui, Y., Decker, J.D., and Francheschi, R.T. (1995). Effects of differentiation and transforming growth factor beta on PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells. J. Bone Miner. Res. 10:1243–1255.
   PubMed Web of Science ®Google Scholar
• Kimble, R.B., Bain, S., and Pacifici, R. (1997). The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J. Bone Miner. Res. 12:935–941.
   PubMed Web of Science ®Google Scholar
• Kimmel, D.B., Bozzato, R.P., Kronis, K.A. Coble, T., Sindrey, D., Kwong, P., and Recker, R.R. (1993). The effect of recombinant humen (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats. Endocrinology 132:1577–1584.
   PubMed Web of Science ®Google Scholar
• Lane, N.E., Haupt, D., Kimmel, D.B., Modin, G., and Kinney, J.H. (1999). Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. J. Bone Miner. Res. 14:206–214.
   PubMed Web of Science ®Google Scholar
• Shen, V., Birchman, R., Xu, R., Otter, M., Wu, D., Lindsay, R., and Dempster, D. (1995). Effects of reciprocal treatment with estrogen and es- trogen plus parathyroid hormone on bone structure and strength in ovariec- tomized rats. J. Clin. Invest. 96:2331–2338.
   PubMed Web of Science ®Google Scholar
• Vidal, O., Lindberg, M.K., Hollberg, K., Baylink, D.J., Andersson, G., Lubahn, D.B., Mohan, S., Gustafsson, J.A., and Ohlsson, C. (2000). Estro- gen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc. Natl. Acad. Sci. USA 97:5474–5479.
   PubMed Web of Science ®Google Scholar
• Couse, J.F., and Korach, K.S. (1999). Estrogen receptor null mice: What have we learned and where will they lead us? Endocr. Rev. 20:358–417.
   PubMed Web of Science ®Google Scholar
• Couse, J.F., Curtis, S.W., Washburn, T.F., Lindzey, J., Golding, T.S., Lubahn, D.B., Smithies, O., and Korach, K.S. (1995). Analysis of transcription and estrogen insensitivity in the female mouse after tar- geted disruption of the estrogen receptor gene. Mol. Endocrinol. 9:1441–1454.
   PubMed Web of Science ®Google Scholar
• Curtis, S.W., Clark, J., Myers, P., and Korach, K.S. (1999). Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor α knockout mouse uterus. Biochemistry 96:3646–3651.
   Google Scholar
• Schomberg, D.W., Couse, J.F., Mukherykee, A., Lubahn, D.B., Sar, M., Mayo, K.E., and Korach, K.S. (1999). Targeted disruption of the estro- gen receptor α (ERα) gene in female mice: Characterization of ovarian responses and phenotype in the adult. Endocrinology 140:2733–2744.
   Google Scholar
• Komm, B.S., Terpening, C.M., Benz, D.J., Graeme, K.A., Gallegos, A.,Korc, M., Greene, G.L., O’Malley, B.W., and Haussler, M.R. (1988). Estrogen binding, receptor mRNA and biologic response in osteoblast- like osteosarcoma cells. Science 241:81–84.
   PubMed Web of Science ®Google Scholar
• Eriksen, E.F., Colvard, D.S., Berg, N.J., Graham, M.L., Mann, K.G., Spelsberg, T.C., and Riggs, B.L. (1988). Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84–86.
   PubMed Web of Science ®Google Scholar
• Arts, J., Kuiper, G.G.J.M., Janssen, J.M.M.F., Gustafsson, J.A., Lowik, C.W., Pols, H.A.P., and van Leeuwen, J.P. (1997). Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067–5070.
   Google Scholar
• Bodine, P.V., Henderson, R.A., Green, J., Aronow, M., Owen, T., Stein, G.S., Lian, J.B., and Komm, B.S. (1998). Estrogen receptor-alpha is de- velopmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Endocrinology 139:2048–2057.
   PubMed Web of Science ®Google Scholar
• Oursler, M.J., Landers, J.P., Riggs, B.L., and Spelsberg, T.C. (1993). Oestrogen effects on osteoblasts and osteoclasts. Ann. Med. 25:361–371.
   PubMed Web of Science ®Google Scholar
• Vandenput, L., Ederveen, A.G.H., Erben, R., Stahr, K., Swinnen, J.V., Van Herck, E., Verstuyf, A., Boonen, S., Bouillon, R., and Vanderschueren, D. (2001). Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-α knockout mice. Biochem. Biophys. Res. Comm. 285:70–76.
   Google Scholar
• Srivastava, S., Weitzmann, M., Cenci, S., Ross, F. P., Adler, S., and Pacifici,R. (1999). Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J. Clin. Invest. 104:503–513.
   PubMed Web of Science ®Google Scholar
• Oursler, M.J., Cortese, C., Keeting, P., Anderson, M.A., Bonde, S.K., Riggs, B.L., and Spelsberg, T.C. (1991). Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone. Endocrinology 129:3313–3320.
   PubMed Web of Science ®Google Scholar
• Ng, K.W., and Martin, T.J. (1998). Hormonal regulation of bone remod- eling. Adv. Organ Biol. 5A:65–100.
   Google Scholar
• Kousteni, S., Bellido, T., Plotkin, L.I., O’Brien, C.A., Bodenner, D.L., Han, L., Han, K., DiGregorio, G.B., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L. and Manolagas, S.C. (2001). Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 104:719–730.
   PubMed Web of Science ®Google Scholar
• Watson, C.S., and Gametchu, B. (1999). Membrane-initiated steroid ac- tions and the proteins that mediate them. Proc. Soc. Exp. Biol. Med. 220: 9–19.
   PubMed Web of Science ®Google Scholar