99
Views
56
CrossRef citations to date
0
Altmetric
Research Article

The Role of RANKL (TRANCE/TNFSF11), a Tumor Necrosis Factor Family Member, in Skeletal Development: Effects of Gene Knockout and Transgenic Rescue

, , , , &
Pages 264-271 | Published online: 06 Aug 2009

References

  • Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D., and Galibert, L. (1997). A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175–179.
  • ASBMR President’s Committee on Nomenclature. (2000). Proposed stan- dard nomenclature for new tumor necrosis factor family members in- volved in the regulation of bone resorption. J. Bone Min. Res. 15:2293–2296.
  • Collin-Osdoby, P., Rothe, L., Anderson, F., Nelson, M., Maloney, W., and Osdoby, P. (2001). Receptor activator of NF-kappa B and osteopro- tegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J. Biol. Chem. 276:20659–20672.
  • Eggli, P.S., Herrmann, W., Hunziker, E.B., and Schenk, R.K. (1985). Ma- trix compartments in the growth plate of the proximal tibia of rats. Anat. Rec. 211:246–257.
  • Ek-Rylander, B., Marks, S.C., Jr., Hammarstrom, L.E., and Andersson, G.N. (1989). Osteoclastic acid ATPase: Biochemical and histochemical studies of the osteopetrotic mutations in the rat. Bone Miner. 5:309–321.
  • Hofbauer, L.C., Khosla, S., Dunstan, C.R., Lacey, D.L., Boyle, W.J., and Riggs, B.L. (2000). The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 15:2–12.
  • Hunziker, E.B., Herrmann, W., and Schenk, R.K. (1982). Improved carti- lage fixation by ruthenium hexammine trichloride (RHT). A prerequisite for morphometry in growth cartilage. J. Ultrastruct. Res. 81:1–12.
  • Idriss, H.T., and Naismith, J.H. (2000). TNF alpha and the TNF recep- tor superfamily: Structure-function relationship(s). Microsc. Res. Tech. 50:184–195.
  • Kim, D., Mebius, R.E., MacMicking, J.D., Jung, S., Cupedo, T.,Castellanos, Y., Rho, J., Wong, B.R., Josien, R., Kim, N., Rennert, P.D., and Choi, Y. (2000a). Regulation of peripheral lymph node genesis by thetumor necrosis factor family member TRANCE. J. Exp. Med. 192:1467–1478.
  • Kim, N., Odgren, P.R., Kim, D.K., Marks, S.C., Jr., and Choi, Y. (2000b). Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc. Natl. Acad. Sci. USA 97:10905–10910.
  • Kong, Y.Y., Boyle, W.J., and Penninger, J.M. (1999a). Osteoprote- gerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol. Cell Biol. 77:188–193.
  • Kong, Y.Y., Yoshida, H., Sarosi, I., Tan, H.L., Timms, E., Capparelli,C., Morony, S., Oliveira-dos-Santos, A.J., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, C.R., Lacey, D.L., Mak, T.W., Boyle, W. J., and Penninger, J.M. (1999b). OPGL is a key regulator of osteoclastoge- nesis, lymphocyte development and lymph-node organogenesis. Nature 397:315–323.
  • Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., and Boyle,W.J. (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165–176.
  • Lee, E.R., Lamplugh, L., Shepard, N.L., and Mort, J.S. (1995). The sep- toclast, a cathepsin B-rich cell involved in the resorption of growth plate cartilage. J. Histochem. Cytochem. 43:525–536.
  • Locksley, R.M., Killeen, N., and Lenardo, M.J. (2001). The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 104:487–501.
  • Marks, S.C., Jr., Cielinski, M.J., Sundquist, K., Wise, G.E., and Gorski, J.P. (1994). The role of bone resorption in tooth eruption. In Proceedings of the International Conference on Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants, Z. Davidovitch (ed.), pp. 483– (Birmingham, AL: EBSCO Press).
  • Min, H., Morony, S., Sarosi, I., Dunstan, C.R., Capparelli, C., Scully, S., Van, G., Kaufman, S., Kostenuik, P.J., Lacey, D.L., Boyle, W.J., and Simonet, W.S. (2000). Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J. Exp. Med. 192:463–474.
  • Odgren, P.R., Kim, N., Van Wesenbeeck, L., MacKay, C.A., Mason-Savas, A., Safadi, F.F., Popoff, S. N., Lengner, C., Van Hul, W., Choi, Y., and Marks, S.C.J. (2001). Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene. Int. J. Dev. Biol. 45:853–859.
  • Odgren, P.R., Popoff, S.N., Safadi, F.F., MacKay, C.A., Mason-Savas, A., Seifert, M.F., and Marks, S.C., Jr. (1999). The toothless osteopetrotic rat has a normal vitamin D-binding protein-macrophage activating factor (DBP-MAF) cascade and chondrodysplasia resistant to treatments with colony stimulating factor-1 (CSF-1) and/or DBP-MAF. Bone 25:175–181.
  • Seifert, M.F. (1996). Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless rat. Bone. 19:329–338.
  • Simonet, W.S., Lacey, D.L., Dunstan, C.R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., Shimamoto, G., DeRose, M., Elliott, R., Colombero, A., Tan, H.-L., Trail, G., Sullivan, J., Davy, E., Bucay, N., Renshaw-Gegg, L., Hughes, T.M., Hill, D., Pattison, W., Campbell, P., Sander, S., Van, G., Tarpley, J., Derby, P., Lee, R., and Boyle, W.J. (1997). Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309–319.
  • Sundquist, K.T., and Marks, S.C., Jr. (1994). Bafilomycin A1 inhibits bone resorption and tooth eruption in vivo. J. Bone. Miner. Res. 9:1575–1582.
  • Takahashi, N., Udagawa, N., and Suda, T. (1999). A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem. Biophys. Res. Comm. 256:449–455.
  • Wong, B.R., Josien, R., Lee, S.Y., Sauter, B., Li, H. L., Steinman, R.M., and Choi, Y. (1997a). TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186:2075–2080.
  • Wong, B.R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F.S., 3rd, Frankel, W.N., Lee, S.Y., and Choi, Y. (1997b). TRANCE is a novel ligand of the tumor necrosisfactor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272:25190–25194.
  • Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N., and Suda, T. (1998). Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95:3597–3602.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.