Advanced search
Publication Cover
Connective Tissue Research Volume 44, 2003 - Issue 1
Submit an article Journal homepage
41
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Activating (P253R, C278F) and Dominant Negative Mutations of FGFR2: Differential Effects on Calvarial Bone Cell Proliferation, Differentiation, and Mineralization

Chootima Ratisoontorn Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Departments of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Gao-Feng Fan Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Kerry McEntee Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
&
Hyun-Duck Nah Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pages 292-297 | Published online: 06 Aug 2009

References

  • Fantl, W.J., Johnson, D.E., and Williams, L.T. (1993). Signalling by re- ceptor tyrosine kinases. Ann. Rev. Biochem. 62:453–481.
  • Johnson, D.E., and Williams, L.T. (1993). Structural and functional diver- sity in the FGF receptor multigene family. Adv. Cancer Res. 60:1–41.
  • Rice, D.P., Aberg, T., Chan, Y., Tang, Z., Kettunen, P.J., Pakarinen, L., Maxson, R.E., and Thesleff, I. (2000). Integration of FGF and TWIST in calvarial bone and suture development. Development 127:1845–1855.
  • De Moerlooze, L., and Dickson, C. (1997). Skeletal disorders associated with fibroblast growth factor receptor mutations. Curr. Opin. Genet. Dev. 7:378–385.
  • Muenke, M., and Schell, U. (1995). Fibroblast-growth-factor receptor mu- tations in human skeletal disorders. Trends Genet. 11:308–313.
  • Celli, G., LaRochelle, W.J., Mackem, S., Sharp, R., and Merlino, G. (1998). Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J. 17:1642–1655.
  • Arman, E., Haffner-Krausz, R., Chen, Y., Heath, J.K., and Lonai, P. (1998). Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. USA 95:5082–5087.
  • Arman, E., Haffner-Krausz, R., Gorivodsky, M., and Lonai, P. (1999). Fgfr2 is required for limb outgrowth and lung-branching morphogenesis. Proc. Natl. Acad. Sci. USA 96:11895–11899.
  • Hughes, S.H., Greenhouse, J.J., Petropoulos, C.J., and Sutrave, P. (1987). Adaptor plasmids simplify the insertion of foreign DNA into helper- independent retroviral vectors. J. Virol. 61:3004–3012.
  • Fekete, D.M., and Cepko, C.L. (1993). Replication-competent retrovi- ral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo. Mol. Cell Biol. 13:2604–2613.
  • Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V. (1993). Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J. Cell Biol. 123:921–933.
  • Bikfalvi, A., Klein, S., Pintucci, G., and Rifkin, D.B. (1997). Biological roles of fibroblast growth factor-2. Endocr. Rev. 18:26–45.
  • Boudreaux, J.M., and Towler, D.A. (1996). Synergistic induction of os- teocalcin gene expression: Identification of a bipartite element conferring fibroblast growth factor 2 and cyclic AMP responsiveness in the rat osteo- calcin promoter. J. Biol. Chem. 271:7508–7515.
  • Anderson, J., Burns, H.D., Enriquez-Harris, P., Wilkie, A.M., and Heath, J.K. (1998). Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Hum. Mol. Genet. 7:1475–1483.
  • Siegel, P.M., and Muller, W.J. (1996). Mutations affecting conserved cys- teine residues within the extracellular domain of Neu promote recep- tor dimerization and activation. Proc. Natl. Acad. Sci. USA 93:8878–8883.
  • Neilson, K.M., and Friesel, R.E. (1995). Constitutive activation of fibrob- last growth factor receptor-2 by a point mutation associated with Crouzon syndrome. J. Biol. Chem. 270:26037–26040.
  • Yu, K., Herr, A.B., Waksman, G., and Ornitz, D.M. (2000). Loss of fibrob- last growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc. Natl. Acad. Sci. USA 97:14536–14541.
  • Fragala, A., Tartaglia, M., Bernardini, S., Di Stasi, A.M.M., Di Rocco, C., Velardi, F., Teti, A., Battaglia, P.A., and Migliaccio, S. (1999). Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders. Am. J. Pathol. 154:1465–1477.
  • Lomri, A., Lemonnier, J., Hott, A., de Parseval, N., Lajeunie, E., Munnich, A., Renier, D., and Marie, P.J. (1998). Increased calvarial cell differ- entiation and bone matrix formation induced by fibroblast growth fac- tor receptor 2 mutations in Apert syndrome. J. Clin. Invest. 101:1310–1317.
  • Mansukhani, A., Bellosta, P., Sahni, M., and Basilico, C. (2000). Sig- naling by fibroblast growth factors and fibroblast growth factor receptor 2 (FGFR2)-activating mutations block mineralization and induces apoptosis in osteoblasts. J. Cell Biol. 149:1297–1308.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.