Growth Factors in Intervertebral Disc Homeostasis

REFERENCES

• Urban J.P., Roberts S. Degeneration of the intervertebral disc. Arthritis Res. Ther. 2003; 5: 120–130
   PubMed Web of Science ®Google Scholar
• Johnson W.E., Eisenstein S.M., Roberts S. Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect. Tissue Res. 2001; 42: 197–207
   PubMed Web of Science ®Google Scholar
• Melrose J., Smith S., Little C.B., Kitson J., Hwa S.Y., Ghosh P. Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repair. Spine 2002; 27: 1756–1764
   PubMed Web of Science ®Google Scholar
• Nagano T., Yonenobu K., Miyamoto S., Tohyama M., Ono K. Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs. Spine 1995; 20: 1972–1978
   PubMed Web of Science ®Google Scholar
• Tolonen J., Gronblad M., Virri J., Seitsalo S., Rytomaa T., Karaharju E. Basic fibroblast growth factor immunoreactivity in blood vessels and cells of disc herniations. Spine 1995; 20: 271–276
   PubMed Web of Science ®Google Scholar
• Doita M., Kanatani T., Harada T., Mizuno K. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine. Spine 1996; 21: 235–241
   PubMed Web of Science ®Google Scholar
• Tolonen J., Gronblad M., Vanharanta H., Virri J., Guyer R.D., Rytomaa T., Karaharju E.O. Growth factor expression in degenerated intervertebral disc tissue. An immunohistochemical analysis of transforming growth factor beta, fibroblast growth factor and platelet-derived growth factor. Eur. Spine J. 2006; 15: 588–596
   PubMedGoogle Scholar
• Le Maitre C.L., Richardson S.M., Baird P., Freemont A.J., Hoyland J.A. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J. Pathol. 2005; 207: 445–452
   PubMed Web of Science ®Google Scholar
• Murakami H., Yoon S.T., Attallah-Wasif E.S., Tsai K.J., Fei Q., Hutton W.C. The expression of anabolic cytokines in intervertebral discs in age-related degeneration. Spine 2006; 31: 1770–1774
   PubMed Web of Science ®Google Scholar
• Osada R., Ohshima H., Ishihara H., Yudoh K., Sakai K., Matsui H., Tsuji H. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J. Orthop. Res. 1996; 14: 690–699
   PubMed Web of Science ®Google Scholar
• Specchia N., Pagnotta A., Toesca A., Greco F. Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur. Spine J. 2002; 11: 145–151
   PubMed Web of Science ®Google Scholar
• Tolonen J., Gronblad M., Virri J., Seitsalo S., Rytomaa T., Karaharju E.O. Platelet-derived growth factor and vascular endothelial growth factor expression in disc herniation tissue: and immunohistochemical study. Eur. Spine J. 1997; 6: 63–69
   PubMedGoogle Scholar
• Konttinen Y.T., Kemppinen P., Li T.F., Waris E., Pihlajamaki H., Sorsa T., Takagi M., Santavirta S., Schultz G.S., Humphreys-Beher M.G. Transforming and epidermal growth factors in degenerated intervertebral discs. J. Bone Joint Surg. Br. 1999; 81: 1058–1063
   PubMedGoogle Scholar
• Tolonen J., Gronblad M., Virri J., Seitsalo S., Rytomaa T., Karaharju E. Transforming growth factor beta receptor induction in herniated intervertebral disc tissue: an immunohistochemical study. Eur. Spine J. 2001; 10: 172–176
   PubMed Web of Science ®Google Scholar
• Nerlich A.G., Bachmeier B.E., Boos N. Expression of fibronectin and TGF-beta1 mRNA and protein suggest altered regulation of extracellular matrix in degenerated disc tissue. Eur. Spine J. 2005; 14: 17–26
   PubMed Web of Science ®Google Scholar
• Takae R., Matsunaga S., Origuchi N., Yamamoto T., Morimoto N., Suzuki S., Sakou T. Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc. Spine 1999; 24: 1397–1401
   PubMed Web of Science ®Google Scholar
• Nakase T., Ariga K., Miyamoto S., Okuda S., Tomita T., Iwasaki M., Yonenobu K., Yoshikawa H. Distribution of genes for bone morphogenetic protein-4, -6, growth differentiation factor-5, and bone morphogenetic protein receptors in the process of experimental spondylosis in mice. J. Neurosurg. 2001; 94: 68–75
   PubMed Web of Science ®Google Scholar
• Yoon S.T. Molecular therapy of the intervertebral disc. Spine J. 2005; 5: 280S–286S
   PubMedGoogle Scholar
• Masuda K., An H.S. Prevention of disc degeneration with growth factors. Eur. Spine J. 2006; 15(Suppl 15)422–432
   Google Scholar
• Walsh A.J., Bradford D.S., Lotz J.C. In vivo growth factor treatment of degenerated intervertebral discs. Spine 2004; 29: 156–163
   PubMed Web of Science ®Google Scholar
• Chujo T., An H.S., Akeda K., Miyamoto K., Muehleman C., Attawia M., Andersson G., Masuda K. Effects of growth differentiation factor-5 on the intervertebral disc—in vitro bovine study and in vivo rabbit disc degeneration model study. Spine 2006; 31: 2909–2917
   PubMed Web of Science ®Google Scholar
• Masuda K., An H.S. Growth factors and the intervertebral disc. Spine J. 2004; 4: 330S–340S
   PubMedGoogle Scholar
• Tim Yoon S., Su Kim K., Li J., Soo Park J., Akamaru T., Elmer W.A., Hutton W.C. The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine 2003; 28: 1773–1780
   PubMed Web of Science ®Google Scholar
• Li J., Yoon S.T., Hutton W.C. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J. Spinal Disord. Tech. 2004; 17: 423–428
   PubMed Web of Science ®Google Scholar
• Kim D.J., Moon S.H., Kim H., Kwon U.H., Park M.S., Han K.J., Hahn S.B., Lee H.M. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine 2003; 28: 2679–2684
   PubMed Web of Science ®Google Scholar
• Masuda K., Takegami K., An H., Kumano F., Chiba K., Andersson G.B., Schmid T., Thonar E. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J. Orthop. Res. 2003; 21: 922–930
   PubMed Web of Science ®Google Scholar
• Takegami K., An H.S., Kumano F., Chiba K., Thonar E.J., Singh K., Masuda K. Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J. 2005; 5: 231–238
   PubMedGoogle Scholar
• Takegami K., Thonar E.J., An H.S., Kamada H., Masuda K. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine 2002; 27: 1318–1325
   PubMed Web of Science ®Google Scholar
• Gruber H.E., Fisher E.C., Jr., Desai B., Stasky A.A., Hoelscher G., Hanley E.N., Jr. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp. Cell Res. 1997; 235: 13–21
   PubMed Web of Science ®Google Scholar
• Wang H., Kroeber M., Hanke M., Ries R., Schmid C., Poller W., Richter W. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J. Mol. Med. 2004; 82: 126–134
   PubMed Web of Science ®Google Scholar
• Risbud M.V., Izzo M.W., Adams C.S., Arnold W.W., Hillibrand A.S., Vresilovic E.J., Vaccaro A.R., Albert T.J., Shapiro I.M. An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells. Spine 2003; 28: 2652–2658, discussion 2658–2659
   PubMed Web of Science ®Google Scholar
• Risbud M.V., Di Martino A., Guttapalli A., Seghatoleslami R., Denaro V., Vaccaro A.R., Albert T.J., Shapiro I.M. Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine 2006; 31: 884–890
   PubMed Web of Science ®Google Scholar
• Pattison S.T., Melrose J., Ghosh P., Taylor T.K. Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by Transforming Growth Factor-beta(1)and insulin like growth factor-I. Cell Biol. Int. 2001; 25: 679–689
   PubMed Web of Science ®Google Scholar
• Thompson J.P., Oegema T.R. Jr., Bradford D.S. Stimulation of mature canine intervertebral disc by growth factors. Spine 1991; 16: 253–260
   PubMed Web of Science ®Google Scholar
• Gruber H.E., Norton H.J., Leslie K., Hanley E.N. Jr. Clinical and demographic prognostic indicators for human disc cell proliferation in vitro: pilot study. Spine 2001; 26: 2323–2327
   PubMed Web of Science ®Google Scholar
• Gruber H.E., Norton H.J., Hanley E.N. Jr. Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 2000; 25: 2153–2157
   PubMed Web of Science ®Google Scholar
• Pratsinis H., Kletsas D. PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur. Spine J. 2007, in press
   PubMed Web of Science ®Google Scholar
• Masuda K., Imai Y., Okuma M., Muehleman C., Nakagawa K., Akeda K., Thonar E., Andersson G., An HS. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine 2006; 31: 742–754
   PubMed Web of Science ®Google Scholar
• Okuda S., Myoui A., Ariga K., Nakase T., Yonenobu K., Yoshikawa H. Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine 2001; 26: 2421–2426
   PubMed Web of Science ®Google Scholar
• Nagano S., Matsunaga S., Takae R., Morimoto N., Suzuki S., Yoshida H. Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse. Int. J. Oncol. 2000; 17: 461–466
   PubMed Web of Science ®Google Scholar
• Matsunaga S., Nagano S., Onishi T., Morimoto N., Suzuki S., Komiya S. Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs. J. Neurosurg. 2003; 98: 63–67
   PubMed Web of Science ®Google Scholar
• Roberts S., Evans E.H., Kletsas D., Jaffray D.C., Eisenstein S.M. Senescence in human intervertebral discs. Eur. Spine J. 2006; 15(Suppl 15)312–316
   Google Scholar
• Gruber H.E., Ingram J.A., Norton H.J., Hanley E.N. Jr. Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine 2007; 32: 321–327
   PubMed Web of Science ®Google Scholar
• Le Maitre C.L., Freemont A.J., Hoyland J.A. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthr. Res. Ther. 2007; 9: R45
   PubMed Web of Science ®Google Scholar