Heparin-Binding Protein Pleiotrophin: An Important player in the Angiogenic Process

REFERENCES

• Kretchmer P.J., Fairhust J.L., Hulmes J.D., Popjes M.L., Bohlen P., Kovesdi I. Genomic organisation of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant. Biochem. Biophys. Res. Commun. 1993; 192: 420–429
   PubMed Web of Science ®Google Scholar
• Papadimitriou E., Polykratis A., Hatziapostolou M., Polytarchou C., Mikelis C. Heparin affin regulatory peptide: a new target for tumour therapy?. Curr. Cancer Drug Targets 2004; 4: 471–482
   PubMed Web of Science ®Google Scholar
• Mikelis C., Koutsioumpa M., Papadimitriou E. Pleiotrophin as a possible new target for angiogenesis-related diseases and cancer. Recent Patents Antican. Drug Discov. 2007; 2: 175–186
   PubMed Web of Science ®Google Scholar
• Kinnunen T., Raulo E., Nolo R., Maccarana M., Lindahl U., Rauvala H. Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. J. Biol. Chem. 1996; 271: 2243–2248
   PubMed Web of Science ®Google Scholar
• Raulo E., Chernousov M.A., Carey D.J., Nolo R., Rauvala H. Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). J. Biol. Chem. 1994; 269: 12999–13004
   PubMed Web of Science ®Google Scholar
• Stoica G.E., Kuo A., Aigner A., Sunitha I., Souttou B., Malerczyk C., Caughey D.J., Wen D., Karavanov A., Riegel A.T., Wellstein A. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. J. Biol. Chem. 2001; 276: 16772–16779
   PubMed Web of Science ®Google Scholar
• Mathivet T., Mazot P., Vigny M. In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?. Cell Signal. 2007; 12: 2434–2443
   Google Scholar
• Perez-Pinera P., Zhang W., Chang Y., Vega J.A., Deuel T.F. Anaplastic lymphoma kinase is activated through the pleiotrophin receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. J. Biol. Chem. 2007; 282: 28683–28690
   PubMed Web of Science ®Google Scholar
• Levy J.B., Canoll P.D., Silvennoinen O., Barnea G., Morse B., Honegger A.M., Huang J.-T., Cannizzaro L.A., Park S.H., Druck T., Huebner K., Sap J., Ehrlich M., Musacchio J.M., Schlessinger J. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. J. Biol. Chem. 1993; 268: 10573–10581
   PubMed Web of Science ®Google Scholar
• Garwood J., Heck N., Reichardt F., Faissner A. Phosphacan short isoform, a novel non proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J. Biol. Chem. 2003; 278: 24164–24173
   PubMed Web of Science ®Google Scholar
• Polykratis A., Katsoris P., Courty J., Papadimitriou E. Characterization of heparin affin regulatory peptide signaling in human endothelial cells. J. Biol. Chem. 2005; 280: 22454–22461
   PubMed Web of Science ®Google Scholar
• Li Y.S., Hoffman R.M., Le Beau M. M., Espinosa R., Jenkins N.A., Gilbert D.J., Copeland N.J., Deuel T.F. Characterization of the human pleiotrophin gene. J. Biol. Chem. 1992; 267: 26011–26016
   PubMed Web of Science ®Google Scholar
• Antoine M., Tag C.G., Wirz W., Borkham-Kamphorst E., Sawitza I., Gressner A.M., Kiefer P. Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesis. Biochem. Biophys. Res. Commun. 2005; 337: 1153–1164
   PubMed Web of Science ®Google Scholar
• Li J., Wei H., Chesley A., Moon C., Krawczyk M., Ziman B., Margulies K.B., Talan M., Crow M.T., Boheler K.R. The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. J. Biol. Chem. 2007; 282: 34984–34993
   PubMed Web of Science ®Google Scholar
• Mourlevat S., Debeir T., Ferrario J.E., Delbe J., Caruelle D., Lejeune O., Depienne C., Courty J., Raisman-Vozari R., Ruberg M. Pleiotrophin mediates the neurotrophic effect of cyclic AMP on dopaminergic neurons: analysis of suppression-subtracted cDNA libraries and confirmation in vitro. Exp. Neurol. 2005; 194: 243–254
   PubMed Web of Science ®Google Scholar
• Chen H., Rubin E., Zhang H., Chung S., Jie C.C., Garrett E., Biswal S., Sukumar S. Identification of transcriptional targets of HOXA5. J. Biol. Chem. 2005; 280: 19373–19380
   PubMed Web of Science ®Google Scholar
• Polytarchou C., Hatziapostolou M., Papadimitriou E. Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J. Biol. Chem. 2005; 280: 40428–40435
   PubMed Web of Science ®Google Scholar
• Hatziapostolou M., Polytarchou C., Katsoris P., Courty J., Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. J. Biol. Chem. 2006; 281: 32217–32226
   PubMed Web of Science ®Google Scholar
• Soh B.S., Song C.M., Vallier L., Li P., Choong C., Yeo B.H., Lim E.H., Pedersen R.A., Yang H.H., Rao M., Lim B. Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells. Stem Cells 2007; 25: 3029–3037
   PubMed Web of Science ®Google Scholar
• Milner P.G., Li Y.-S., Hoffman R.M., Kodner C.M., Siegel N.R., Deuel T.F. A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochem. Biophys. Res. Commun. 1989; 3: 1096–1103
   Google Scholar
• Vanderwinden J.M., Mailleux P., Schiffman S.N., Vanderhaegen J.J. Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat. Embryol. 1992; 186: 387–406
   PubMedGoogle Scholar
• Heiss C., Wong M.L., Block V.I., Lao D., Real W.M., Yeghiazarians Y., Lee R.J., Springer M.L. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J. Cell Physiol. 2008; 215: 366–373
   PubMed Web of Science ®Google Scholar
• Sharifi B.G., Zeng Z., Wang L., Song L., Chen H., Qin M., Sierra-Honigmann M.R., Wacshmann-Hogiu S., Shah P.K. Pleiotrophin induces transdifferentiation of monocytes into functional endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2006; 26: 1273–1280
   PubMed Web of Science ®Google Scholar
• Papadimitriou E., Polykratis A., Courty J., Koolwijk P., Heroult M., Katsoris P. HARP induces angiogenesis in vivo and in vitro: implication of N or C terminal peptides. Biochem. Biophys. Res. Commun. 2001; 282: 306–313
   PubMed Web of Science ®Google Scholar
• Polytarchou C., Gligoris T., Kardamakis D., Kotsaki E., Papadimitriou E. X-rays affect the expression of genes involved in angiogenesis. Anticancer Res. 2004; 24: 2941–2945
   PubMed Web of Science ®Google Scholar
• Magnusson P.U., Dimberg A., Mellberg S., Lukinius A., Claesson-Welsh L. FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin. Blood 2007; 110: 4214–4222
   PubMed Web of Science ®Google Scholar
• Chang Y., Zuka M., Perez-Pinera P., Astudillo A., Mortimer J., Berenson J.R., Deuel T.F. Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment. Proc. Natl. Acad. Sci. 2007; 104: 10888–10893
   PubMed Web of Science ®Google Scholar
• Hatziapostolou M., Delbe J., Katsoris P., Polytarchou C., Courty J., Papadimitriou E. Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicity. Prostate 2005; 65: 151–158
   PubMed Web of Science ®Google Scholar
• Heroult M., Bernard-Pierrot I., Delbe J., Hamma-Kourbali Y., Katsoris P., Barritault D., Papadimitriou E., Plouet J., Courty J. Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. Oncogene 2004; 23: 1745–1753
   PubMed Web of Science ®Google Scholar
• Calvet L., Geoerger B., Regairaz M., Opolon P., Machet L., Morizet J., Joseph J-M., Elie N., Vassal G. Pleiotrophin, a candidate gene for poor tumor vasculature and in vivo neuroblastoma sensitivity to irinotecan. Oncogene 2006; 25: 3150–3159
   PubMed Web of Science ®Google Scholar
• Parthymou A., Lampropoulou E., Mikelis C., Drosou G., Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells. Eur. J. Cell Biol. 2008; 87: 17–29
   PubMed Web of Science ®Google Scholar