NHE-1: A Molecular Target for Signalling and Cell Matrix Interactions

REFERENCES

• Putney L., Denker S., Barber D. The changing face of the Na+/H +exchanger, NHE1: structure, regulation, and cellular actions. Ann. Rev. Pharmacol. Toxicol. 2002; 42: 527–552
   PubMed Web of Science ®Google Scholar
• Orlowski J., Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflug. Archiv. 2004; 447(5)549–565
   PubMed Web of Science ®Google Scholar
• Fliegel L. The Na+/H+ exchanger isoform 1. Inter. J. Biochem. Cell Biol. 2005; 37: 33–37
   PubMed Web of Science ®Google Scholar
• Wakabayashi S., Pang T., Su X., Shigekawa M. A novel topology model o the human Na+/H +exchanger isoform 1. J. Biol. Chem. 2000; 275: 7942–7949
   PubMed Web of Science ®Google Scholar
• Khaled A., Moor A., Li A., Kim K., Ferris D., Muegge K., et al. Trophic factor withdrawal: p-38 mitogen-activator protein kinase activates NHE1, which induces intracellular alklinization. Mol. Cell. Biol. 2001; 21: 7545–7557
   PubMed Web of Science ®Google Scholar
• Moor A., Gan X., Karmazyn M., Fliegel L. Protein kinase mediated regulation of the Na+/H+ exchanger isoform 1 (NHE1) in ischemic and ischemic/reperfused rat heart. J. Biol. Chem. 2001; 27: 16113–16122
   Web of Science ®Google Scholar
• Tominanga T., Barber D. NHE1 acts downstream of RhoA to regulate integrin induced cell adhesion and spreading. Mol. Biol. Cell. 1998; 9: 2287–2303
   PubMed Web of Science ®Google Scholar
• Avkiran M., Haworth R. Regulatory effects of G protein-coupled receptors on cardiac sorcolemmal Na+/H+ exchanger activity: signalling and significance. Cardvasc. Res. 2003; 57: 942–952
   PubMed Web of Science ®Google Scholar
• Shrode L., Tapper H., Grinstein S. Role of intracellular pH in proliferation, transformation, and apoptosis. J. Bioenerg. Biomembranes. 1997; 29: 393–399
   PubMed Web of Science ®Google Scholar
• Delvaux M., Bastie M., Chentoufi J., Cragoe E., Vaysse N., Ribet A. Amiloride and analogues inhibit Na+/H+ exchange and cell proliferation in AR42J pancreatic cell line. Am. J. Physiol. 1990; 259: G842–G849
   PubMedGoogle Scholar
• Kapus A., Gristein S., Wasan S., Kandasamy R., Orlowski J. Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role of cell proliferation. J. Biol. Chem. 1994; 269: 23544–23552
   PubMed Web of Science ®Google Scholar
• Madshus I. Regulation of intracellular pH in eukaryotic cells. Biochem. J. 1988; 250: 1–8
   PubMed Web of Science ®Google Scholar
• O’Neill W. Physiological significance of volume-regulatory transporters. Am. J. Physiol. 1999; 276: C995–C1011
   PubMed Web of Science ®Google Scholar
• Rouzaire-Dubois B., O’Regan S., Dubois J. Cell size-dependent and independent proliferation of rodent neuroblastoma x glioma cells. J. Cell. Physiol. 2005; 203: 243–250
   PubMed Web of Science ®Google Scholar
• Dmitrieva N., Michea L., Rocha G., Burg M. Cell cycle delay and apoptosis in response to osmotic stress. Comb. Biochem. Physiol. A Mol. Integr. Physiol. 2001; 130: 411–420
   PubMed Web of Science ®Google Scholar
• Wang D., Balkovetz D., Wornock D. Mutational analysis of transmembrane histidines in the amiloride sensitive Na+/H+ exchanger. Am. J Physiol. 1995; 269: C392–C402
   PubMedGoogle Scholar
• Bell S., Schreiner C., Schultheis P., Miller M., Evans R., et al. Targeted disruption of the murine NHE1 locus induces ataxia, growth retardation and seizures. Am. J. Physiol. 1999; 276: C788–C795
   PubMed Web of Science ®Google Scholar
• Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol. 2001; 2: 589–598
   PubMed Web of Science ®Google Scholar
• Lang F., Madlung J., Bock J., Lukewille U., Kaltenbach S., Lang K., et al. Inhibition of Jurkat-T-lymphocyte Na+/H+ exchanger by CD95 (Fas/Apo-1)-receptor stimulation. Pflugers. Arch. 2000; 440: 902–907
   PubMed Web of Science ®Google Scholar
• Wu K., Khan S., Lajhe-Reddy S., Wang L., Jarad J., Miller R., et al. Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE-2 Na+/H +exchanger. Am. J. Physiol. Renal. Physiol. 2003; 284: F829–F839
   PubMed Web of Science ®Google Scholar
• Cho Y., Lee K., Lee S., Namkoong S., Kim Y., Lee H., et al. Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. Biochem. Biophys. Res. Commun. 2005; 326: 752–758
   PubMed Web of Science ®Google Scholar
• Nylandsted J., Jaattela M., Hoffmann E., Pedersen S. Hsp70 protects fibrosarcoma cells against shrinkage-induced programmed cell death via mechanism independent of effects on cell volume-regulatory membrane transport proteins. Pflugers. Arch. 2004; 449: 175–185
   PubMed Web of Science ®Google Scholar
• Rich I., Worthington-White D., Garden O., Musk P. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+ exchanger. Blood 2000; 95: 1427–1434
   PubMed Web of Science ®Google Scholar
• Thangarayu M., Sharma K., Liu D., Shen S., Srikant C. Interdependent regulation of intracellular acidification and SHP-1 in apoptosis. Cancer. Res. 1999; 59: 1649–1654
   PubMed Web of Science ®Google Scholar
• Matsuyama S., Llopis J., Deveraux Q., Tsien R., Reed J. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat. Cell. Biol. 2000; 2: 318–325
   PubMed Web of Science ®Google Scholar
• Bortner C., Cidlowski J. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am. J. Physiol. 1996; 271: C950–C961
   PubMed Web of Science ®Google Scholar
• Friis M., Friborg C., Schneider L., Nielsen M., Lambert I., Christensen S., et al. Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. J. Physiol. 2005; 567: 427–443
   PubMed Web of Science ®Google Scholar
• Pedersen S., O’Donnell M., Anderson S., Cala P. Electroneutral Na +transport in health and disease: role Na+/H+ exchange and a Na+, K+, 2Cl- cotransport. Am. J. Physiol. Regul. Integr. Comb. Physiol. 2006; 291: R1–25
   PubMed Web of Science ®Google Scholar
• Askenasy N., Vivi A., Tassini M., Navon G. The relation between cellular sodium, pH and volumes and the activity of Na+/H+ antiport during hypothermic ischemia: multinuclear NMR studies of rat hearts. J. Mol. Cell. Cardiol. 1996; 28: 589–601
   PubMed Web of Science ®Google Scholar
• Kintner D., Su G., Lenart B., Ballard A., Meyer J., Ng L., et al. Increased tolerance to oxygen and glucose deprivation in astrocytes from Na+/H +exchanger isoform 1 null mice. Am. J. Physiol. Cell. Physiol. 2004; 287: C12–C21
   PubMed Web of Science ®Google Scholar
• Otani H., Uchiyama T., Yamamura T., Nakao Y., Hattori R., Ninomiya H., et al. Effects of Na+/H +exchange inhibitor cariporide (HOE 642) on cardiac function and cardiomyocyte cell death in rat ischemic-reperfused heart. Clin. Exp. Pharmacol. Physiol. 2000; 27: 387–393
   PubMed Web of Science ®Google Scholar
• Chakrabarti S., Hoque A., Karmazyn M. A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J. Mol. Cell. Cardiol. 1997; 29: 3169–3174
   PubMed Web of Science ®Google Scholar
• Teshima Y., Akao M., Jones S., Marban E. Cariporide, a selective Na+/H +exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 2003; 27: 729–742
   Google Scholar
• Stock C., Schwab A. Role of the Na+/H+ exchanger NHE1 in cell migration. Acta. Physiol. 2006; 187: 149–157
   PubMed Web of Science ®Google Scholar
• Mitchison T., Cramer L. Actin-based cell motility and cell locomotion. Cell 1996; 84: 371–379
   PubMed Web of Science ®Google Scholar
• Diez S., Gerisch G., Anderson K., Miller-Taubenberger A., Bretschneider T. Subsecond reorganization of the actin network in cell motility and chemotaxis. Proc. Natl. Acad. Sci. 2005; 102: 7601–7606
   PubMed Web of Science ®Google Scholar
• Bretscher M., Aguado-Velasco C. Membrane traffic during cell locomotion. Curr. Opin. Cell. Biol. 1998; 10: 537–541
   PubMed Web of Science ®Google Scholar
• Beningo K., Dembo M., Kaverina I., Small J., Wang Y. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell. Biol. 2001; 153: 881–887
   PubMed Web of Science ®Google Scholar
• Jalali S., Del Pozo M., Chen K., Miao H., Li Y., Schwartz M., et al. Integrin-mediated mechanotranduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc. Natl. Acad. Sci. 2001; 98: 1042–1046
   PubMed Web of Science ®Google Scholar
• Webb D., Parsons J., Horwitz A. Adhesion assembly, disassembly and turnover in migrating cell-over and over and over again. Nat. Cell. Biol. 2002; 4: E97–E100
   PubMed Web of Science ®Google Scholar
• Kostidou E., Koliakos G., Alamdari D., Paletas K., Tsapas A., Kaloyianni M. Enhanced laminin carbonylation by monocytes in diabetes mellitus. Clin. Bioch. 2007; 40: 671–679
   PubMed Web of Science ®Google Scholar
• Koliakos G., Trachana V., Gaitatzi M., Dimitriadou A. Phosphorylation of laminin-1 by protein kinase C. Mol. Cells 2001; 11: 179–185
   PubMed Web of Science ®Google Scholar
• Verfaillie C., Benis A., Iida J., McGlave P., McCarthy J. Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha2beta1 and the CD44 adhesion receptor. Blood 1994; 84: 1802–1811
   PubMed Web of Science ®Google Scholar
• Stock C.G.B., Hauck C.R., Arnold H., Mally S., Eble J.A., Dieterich P., Schwab A. Migration of human melanoma cells depends on extracellular pH and Na+/H +exchange. J. Physiol. 2005; 567: 225–238
   PubMed Web of Science ®Google Scholar
• Reshkin S., Bellizzi A., Albarani V., Guerra L., Tommasino M., Paradiso A., et al. Phosphoinositide 3-kinase is involved in th tumor-specific activation of human breast cancer cell Na+/H+ exchange, motility, and invasion induced by serum deprivation. J. Biol. Chem. 2000; 275: 5361–5369
   PubMed Web of Science ®Google Scholar
• McHardy L., Sinotte R., Troussard A., Sheldon C., Church J., et al. The tumor invasion inhibitor dihydromotuporamine C activates Rho, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Res. 2004; 64: 1468–1474
   PubMed Web of Science ®Google Scholar
• Paradiso A., Cardone R., Bellizzi A., Bagorda A., et al. The Na+/H +exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res. 2004; 6: R616–R628
   PubMed Web of Science ®Google Scholar
• Bussolino F., Wang J., Turrini F., Alessi D., et al. Stimulation of Na+/H +exchanger in human endothelial cells activated by granulocyte-macrophage-colony-stimulating factor. Evidence for a role in proliferation and migration. J. Biol. Chem. 1989; 264: 18284–18287
   PubMed Web of Science ®Google Scholar
• Roesengren S., Henson P., Worthen G. Migration associated volume changes in neutrophils facilitate the migratory process in vitro. Am. J. Physiol. 1994; 267: C1623–C1632
   PubMedGoogle Scholar
• Denker S., Barber D. The changing face of Na/H exchanger. NHE1: structure, regulation and cellular actions. Annu. Rev. Pharmacol. Toxicol. 2002; 42: 527–552
   PubMed Web of Science ®Google Scholar
• Denker S., Barber D. Cell migration requires both ion translocation and cytoskeletal anchoring by them Na-H exchanger NHE1. J. Cell Biol. 2002; 159: 1087–1096
   PubMed Web of Science ®Google Scholar
• Yan W., Nehrke K., Choi J., Barber D. The Nck interactive kinase (NIK) phosphorylates NHE1 and regulates NHE1 activation by platelet-derived growth factor. J. Biol. Chem. 2001; 276: 31349–31356
   PubMed Web of Science ®Google Scholar
• Aharonovitz O., Zaum H., Balla T., York J., Orlowski J., Grinstein S. Intracellular pH regulation by NHE requires phosphatidylinositol 4,5 bisphospate. J. Cell. Biol. 2000; 150: 213–224
   PubMed Web of Science ®Google Scholar
• Pang T., Su X., Wakabayashi S., Shigekawa M. Calcineurin homologous protein as an essential cofactor for NHE. J. Biol. Chem. 2001; 276: 17367–17372
   PubMed Web of Science ®Google Scholar
• Rohatgi R., Nollau P., Ho H., Kirschner M., Mayer B. Nck and phospatidylinositol 3.4 bisphosphate synergistically activate actin polymerization through the N-WASP Arp2/3 pathway. J. Biol. Chem. 2001; 276: 26448–26452
   PubMed Web of Science ®Google Scholar
• Lehoux S., Abe J., Florian J., Berk B. 14–3-3 binding to NHE isoform 1 is associated with serum-dependent activation of NHE1. J. Biol. Chem. 2001; 276: 15794–15800
   PubMed Web of Science ®Google Scholar
• Silva N., Haworth R., Singh D., Fliegel L. The carbonyl-terminal region of NHHE1 interacts with mammalin heat shock protein. Biochemistry 1995; 34: 10412–10420
   PubMed Web of Science ®Google Scholar
• Li X., Alvarez B., Casey J., Reithmeier R., Fliegel L. Carbonic anhydrase II binds to and anhances the activity of NHE1. J. Biol. Chem. 2002; 277: 36085–36091
   PubMed Web of Science ®Google Scholar
• Coupaye-Gerard B., Bookstein C., Duncan P., Chen X., Smith P., Musch M., et al. Biosynthesis and cell surface delivery of NHE1 isoform in A6 cells. Am. J. Physiol Cell Physiol. 1996; 271: C2951–C2959
   Web of Science ®Google Scholar
• Grinstein S., Woodside M., Waddell T., Downey G., Orlowski J., Poyssegour J., et al. Focal localization of NHE1 isoform: effects on intracellular pH. EMBO J 1993; 12: 5209–5218
   PubMed Web of Science ®Google Scholar
• Baumgartner M., Patel H., Barber D. NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am. J. Physiol. Cell Physiol. 2004; 287: C844–C850
   PubMed Web of Science ®Google Scholar
• Cingolani H., Perez N., Aiello E., Camilion de Hurtado M. Intracellular signaling following myocardial stretch: an autocrine/paracrine loop. Reg. Pept. 2005; 128: 211–220
   PubMed Web of Science ®Google Scholar
• Allen D., Xiao X. Role of cardiac Na+/H+ exchanger during ischemia and reperfusion. Cardiovasc. Res. 2003; 57: 934–941
   PubMed Web of Science ®Google Scholar
• Stagg M., Terracciano C. Less Na+/H+ exchanger to treat heart failure: a simple solution for a complex problem. Cardiovasc. Res. 2005; 65: 10–12
   PubMed Web of Science ®Google Scholar