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Original Articles

Wnt/β-catenin signaling is required for distraction osteogenesis in rats

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Pages 45-54 | Received 16 Nov 2016, Accepted 20 Feb 2017, Published online: 27 Mar 2017

References

  • Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: part I. The influence of stability of fixation and soft-tissue preservation. Clin Orthop Relat Res 1989;238:249–281.
  • Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res 1989;239:263–285.
  • Aronson J, Shen XC, Gao GG, Miller F, Quattlebaum T, Skinner RA, Badger TM, Lumpkin CK. Sustained proliferation accompanies distraction osteogenesis in the rat. J Orthop Res 1997;15:563–569.
  • Bouletreau PJ, Warren SM, Longaker MT. The molecular biology of distraction osteogenesis. J Cranio-Maxillofac Surg 2002;30:1–11.
  • Amir LR, Everts V, Bronckers A. Bone regeneration during distraction osteogenesis. Odontology 2009;97:63–75.
  • Behrens J, Von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996;382:638–642.
  • Moon RT, Bowerman B, Boutros M, Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science 2002;296:1644–1646.
  • Kim JB, Leucht P, Lam K, Luppen C, Ten Berge D, Nusse R, Helms JA. Bone regeneration is regulated by Wnt signaling. J Bone Mine Res 2007;22:1913–1923.
  • Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Mine Metab 2009;27:265–271.
  • Macsai CE, Foster BK, Xian CJ. Poles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair. J Cell Physiol 2008;215:578–587.
  • Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Hill AA, Akhter MP, Johnson ML, Recker RR, Komm BS, Bex FJ. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006;281:31720–31728.
  • Jansen JH, Eijken M, Jahr H, Chiba H, Verhaar JA, van Leeuwen JP, Weinans H. Stretch-induced inhibition of Wnt/β-catenin signaling in mineralizing osteoblasts. J Orthop Res 2010;28:390–396.
  • Bonewald, LF, Johnson, ML. Osteocytes, mechanosensing and Wnt signaling. Bone 2008;42:606–615.
  • Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998;14:59–88.
  • Silkstone D, Hong H, Alman BA. Beta-Catenin in the race to fracture repair: in it to Wnt. Nat Clin Pract Rheumatol 2008;4:413–419.
  • Chung R, Wong D, Macsai C, Piergentili A, Del Bello F, Quaglia W, Xian CJ. Roles of Wnt/beta-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats. Bone 2013;52:651–658.
  • Komatsu DE, Mary MN, Schroeder RJ, Robling AG, Turner CH, Warden SJ. Modulation of Wnt signaling influences fracture repair. J Orthop Res 2010;28:928–936.
  • Kasaai B, Moffatt P, Al-Salmi L, Lauzier D, Lessard L, Hamdy RC. Spatial and temporal localization of WNT signaling proteins in a mouse model of distraction osteogenesis. J Histochem Cytochem 2012;60:219–228.
  • Wang X, Zhu S, Jiang X, Li Y, Song D, Hu J. Systemic administration of lithium improves distracted bone regeneration in rats. Calcif Tissue Int 2015;96:534–540.
  • Hahn M, Vogel M, Delling G. Undecalcified preparation of bone tissue – report of technical experience and development of new methods. Virchows Arch A Pathol Anat Histopathol 1991;418:1–7.
  • Weaver AS, Su YP, Begun DL, Miller JD, Alford AI, Goldstein SA. The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application. Bone 2010;47:41–48.
  • Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 2008;87:107–118.
  • Rawadi G, Vayssière B, Dunn F, Baron R, Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003;18:1842–1853.
  • Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005;8:751–764.
  • Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem 2005;39:</b>33132–33140.
  • Song L, Liu M, Ono N, Bringhurst FR, Kronenberg HM, Guo J. Loss of Wnt/beta-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes. J Bone Miner Res 2012;27:2344–2258.
  • Hadjiargyrou M, Lombardo F, Zhao S, Ahrens W, Joo J, Ahn H, Jurman M, White DW, Rubin CT. Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem 2002;277:30177–30182.
  • Zhong N, Gersch RP, Hadjiargyrou M. Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone 2006;39:5–16.
  • van der Horst G, van der Werf SM, Farih-Sips H, van Bezooijen RL, Löwik CW, Karperien M. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J Bone Miner Res 2005;20:1867–1877.
  • Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab 2010;11:161–171.
  • Agholme F, Isaksson H, Kuhstoss S, Aspenberg P. The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions. Bone 2011;48:988–996.
  • Jin H, Wang B, Li J, Xie W, Mao Q, Li S, Dong F, Sun Y, Ke HZ, Babij P, Tong P, Chen D. Anti-Dkk1 antibody promotes bone fracture healing through activation of beta-catenin signaling. Bone 2015;71:63–75.

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