253
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis

, , , , &
Pages 625-633 | Received 23 Aug 2021, Accepted 15 Mar 2022, Published online: 21 Mar 2022

References

  • Testa DCS, Petrelli F, Giannini D, Bilia S, Alunno A, Puxeddu I. One year in review 2021: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 2021;39(3):445–452.
  • Mousavi MJ, Karami J, Aslani S, Tahmasebi MN, Vaziri AS, Jamshidi A, Farhadi E, Mahmoudi M. Transformation of fibroblast-like synoviocytes in rheumatoid arthritis; from a friend to foe. Auto Immun Highlights. 2021;12(1):3. doi:10.1186/s13317-020-00145-x.
  • Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013;9(1):24–33. doi:10.1038/nrrheum.2012.190.
  • Magna M, Pisetsky DS. The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases. Mol Med. 2014;20(1):138–146. doi:10.2119/molmed.2013.00164.
  • Taniguchi NKK, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I. High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum. 2003;48(4):971–981. doi:10.1002/art.10859.
  • Steenvoorden MMTR, Ronday HK, Huizinga TW, Degroot J. RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro. Clin Exp Rheumatol. 2007;25(5):740–742.
  • Zhang BWH, Wang Y, Yang M, Gu J, Yao M. High mobility group box protein 1 downregulates acid β-glucosidase 1 in synovial fibroblasts from patients with rheumatoid arthritis. Int J Clin Exp Pathol. 2018;11(7):3575–3582.
  • Kinghorn KJ, Gronke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. A drosophila model of Neuronopathic gaucher disease demonstrates lysosomal-autophagic defects and altered mTOR signalling and is functionally rescued by rapamycin. J Neurosci. 2016;36(46):11654–11670. doi:10.1523/JNEUROSCI.4527-15.2016.
  • Kim S, Wong YC, Gao F, Krainc D. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease. Nat Commun. 2021;12(1):1807. doi:10.1038/s41467-021-22113-3.
  • Aureli M, Bassi R, Loberto N, Regis S, Prinetti A, Chigorno V, Aerts JM, Boot RG, Filocamo M, Sonnino S. Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts. J Inherit Metab Dis. 2012;35(6):1081–1091. doi:10.1007/s10545-012-9478-x.
  • Skacel J, Slusher BS, Tsukamoto T. Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid network. J Med Chem. 2021;64(1):279–297. doi:10.1021/acs.jmedchem.0c01664.
  • Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009;284(19):12979–12988. doi:10.1074/jbc.M809500200.
  • Sabatini M, Rolland G, Leonce S, Thomas M, Lesur C, Perez V, de Nanteuil G, Bonnet J. Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. Biochem Biophys Res Commun. 2000;267(1):438–444. doi:10.1006/bbrc.1999.1983.
  • Okazaki T, Kondo T, Kitano T, Tashima M. Diversity and complexity of ceramide signalling in apoptosis. Cell Signal. 1998;10(10):685–692. doi:10.1016/s0898-6568(98)00035-7.
  • Wilhelm R, Eckes T, Imre G, Kippenberger S, Meer M, Thomas D, Trautmann S, Merlio JP, Chevret E, Kaufmann R, Pfeilschifter J, Koch A, Jager M. C6 Ceramide (d18:1/6:0) as a novel treatment of cutaneous T cell Lymphoma. Cancer (Basel). 2021;13(2):270. doi:10.3390/cancers13020270.
  • Liu L, Ye Q, Liu L, Bihl JC, Chen Y, Liu J, Cheng Q. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020;18(1):298. doi:10.1186/s12967-020-02468-9.
  • Li G, Liu D, Kimchi ET, Kaifi JT, Qi X, Manjunath Y, Liu X, Deering T, Avella DM, Fox T, Rockey DC, Schell TD, Kester M, Staveley-O’Carroll KF. Nanoliposome C6-ceramide increases the anti-tumor immune response and slows growth of liver tumors in mice. Gastroenterology. 2018;154(4):1024–1036 e1029. doi:10.1053/j.gastro.2017.10.050.
  • Zanieri F, Levi A, Montefusco D, Longato L, De Chiara F, Frenguelli L, Omenetti S, Andreola F, Luong TV, Massey V, Caballeria J, Fondevila C, Shanmugavelandy SS, Fox T, Mazza G, Argemi J, Bataller R, Cowart LA, Kester M, Pinzani M, Rombouts K. Exogenous liposomal ceramide-C6 ameliorates lipidomic profile, energy homeostasis, and anti-oxidant systems in NASH. Cells. 2020;9(5):1237. doi:10.3390/cells9051237.
  • Wang J, Zhao Y, Xin M, Pan L, Wang L, Yang K. Effectiveness of lentivirus-mediated RNA interference targeting mouse tumor necrosis factor alpha in vitro and in vivo. Exp Ther Med. 2018;15(2):2134–2139. doi:10.3892/etm.2017.5609.
  • Hayer S, Vervoordeldonk MJ, Denis MC, Armaka M, Hoffmann M, Backlund J, Nandakumar KS, Niederreiter B, Geka C, Fischer A, Woodworth N, Bluml S, Kollias G, Holmdahl R, Apparailly F, Koenders MI. ‘SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models. Ann Rheum Dis. 2021. doi:10.1136/annrheumdis-2020-219247.
  • Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M. Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A. 2010;107(45):19473–19478. doi:10.1073/pnas.1003308107.
  • Dasari SK, Bialik S, Levin-Zaidman S, Levin-Salomon V, Merrill AH Jr., Futerman AH, Kimchi A. Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death. Cell Death Differ. 2017;24(7):1288–1302. doi:10.1038/cdd.2017.80.
  • Zhao M, Yang M, Li X, Hou L, Liu X, Xiao W. Acid Sphingomyelinase and Acid beta-Glucosidase 1 Exert Opposite Effects on Interleukin-1beta-Induced Interleukin 6 Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Inflammation. 2021. doi:10.1007/s10753-021-01444-9.
  • Gilbert SJ, Duance VC, Mason DJ. Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism. Arthritis Res Ther. 2004;6(1):R46–R55. doi:10.1186/ar1024.
  • Ichinose Y, Eguchi K, Migita K, Kawabe Y, Tsukada T, Koji T, Abe K, Aoyagi T, Nakamura H, Nagataki S. Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. J Lab Clin Med. 1998;131(5):410–416. doi:10.1016/s0022-2143(98)90141-x.
  • Mizushima NKH, Miyasaka N. Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. Ann Rheum Dis. 1998;57(8):495–499. doi:10.1136/ard.57.8.495.
  • Migita K, Honda S, Yamasaki S, Hirai Y, Fukuda T, Aoyagi T, Kita M, Ida H, Tsukada T, Kawakami A, Kawabe Y, Eguchi K. Regulation of rheumatoid synovial cell growth by ceramide. Biochem Biophys Res Commun. 2000;269(1):70–75. doi:10.1006/bbrc.2000.2239.
  • Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid LM, Yaegashi N, Grabowski GA, Hannun YA. Activation of p38 mitogen-activated protein Kinase in Gaucher’s Disease. PLoS One. 2015;10(8):e0136633. doi:10.1371/journal.pone.0136633.
  • Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR. Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995;182(2):599–604. doi:10.1084/jem.182.2.599.
  • Gerritsen MESC, Perry CA. Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha. Am J Pathol. 1998;152(2):505–512.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.