The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency

References

• Wang XD, Zhang JN, Gan YH, Zhou YH. Current understanding of pathogenesis and treatment of TMJ osteoarthritis. J Dent Res. 2015;94(5):666–673. DOI:10.1177/0022034515574770.
   PubMed Web of Science ®Google Scholar
• Zhang J, Jiao K, Zhang M, Zhou T, Liu XD, Yu SB, Lu L, Jing L, Yang T, Zhang Y, Chen D, Wang M-Q. Occlusal effects on longitudinal bone alterations of the temporomandibular joint. J Dent Res. 2013;92(3):253–259. DOI:10.1177/0022034512473482.
   PubMed Web of Science ®Google Scholar
• Milam SB. Pathogenesis of degenerative temporomandibular joint arthritides. Odontology. 2005;93(1):7–15. DOI:10.1007/s10266-005-0056-7.
   PubMedGoogle Scholar
• Zarb GA, Carlsson GE. Temporomandibular disorders: osteoarthritis. J Orofac Pain. 1999;13(4):295–306.
   PubMed Web of Science ®Google Scholar
• Robinson J, O’-Brien A, Chen J, Wadhwa S. Progenitor cells of the mandibular condylar cartilage. Curr Mol Biol Rep. 2015;1(3):110–114. DOI:10.1007/s40610-015-0019-x.
   PubMedGoogle Scholar
• Mizoguchi I, Toriya N, Nakao Y. Growth of the mandible and biological characteristics of the mandibular condylar cartilage. Jpn Dent Sci Rev. 2013;49(4):139–150. DOI:10.1016/j.jdsr.2013.07.004.
   Google Scholar
• Shibukawa Y, Young B, Wu C, Yamada S, Long F, Pacifici M, Koyama E. Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn. 2007;236(2):426–434. DOI:10.1002/dvdy.21036.
   PubMed Web of Science ®Google Scholar
• Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest. 2007;117(6):1627–1636. DOI:10.1172/JCI30765.
   PubMed Web of Science ®Google Scholar
• Wang K, Xu J, Hunter DJ, and Ding C. Investigational drugs for the treatment of osteoarthritis. Expert Opin Investig Drugs. 2015;24(12):1–18.
   PubMed Web of Science ®Google Scholar
• Dancevic CM, McCulloch DR. Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis. Arthritis Res Ther. 2014;16(5):429. DOI:10.1186/s13075-014-0429-9.
   PubMed Web of Science ®Google Scholar
• Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: structure, composition, and function. Sports Health. 2009;1(6):461–468. DOI:10.1177/1941738109350438.
   PubMedGoogle Scholar
• Kiani C, Chen L, Wu YJ, Yee AJ, Yang BB. Structure and function of aggrecan. Cell Res. 2002;12(1):19–32. DOI:10.1038/sj.cr.7290106.
   PubMed Web of Science ®Google Scholar
• Wang M, Li S, Xie W, Shen J, Im HJ, Holz JD, Wang M, Diekwisch T, Chen D. Activation of β-catenin signalling leads to temporomandibular joint defects. Eur Cell Mater. 2014;28:223–235.
   PubMed Web of Science ®Google Scholar
• Kintakas C, McCulloch DR. Emerging roles for ADAMTS5 during development and disease. Matrix Biol. 2011;30(5–6):311–317. DOI:10.1016/j.matbio.2011.05.004.
   PubMed Web of Science ®Google Scholar
• Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005;434(7033):648–652. DOI:10.1038/nature03417.
   PubMed Web of Science ®Google Scholar
• Rogers AW, Cisewski SE, Kern CB. The zonal architecture of the mandibular condyle requires ADAMTS5. J Dent Res. 2018;97(12):1383–1390. DOI:10.1177/0022034518777751.
   PubMed Web of Science ®Google Scholar
• Rogers-DeCotes AW, Porto SC, Dupuis LE, Kern CB. ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle. Osteoarthritis Cartilage. 2021;29(4):547–557. DOI:10.1016/j.joca.2021.01.005.
   PubMed Web of Science ®Google Scholar
• Jungers KA, Le Goff C, Somerville RP, Apte SS. Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns. 2005;5(5):609–617. DOI:10.1016/j.modgep.2005.03.004.
   PubMed Web of Science ®Google Scholar
• McCulloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, Sasaki T, Cooley MA, Argraves WS, Apte SS. ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell. 2009;17(5):687–698. DOI:10.1016/j.devcel.2009.09.008.
   PubMed Web of Science ®Google Scholar
• Sobue T, Yeh WC, Chhibber A, Utreja A, Diaz-Doran V, Adams D, Kalajzic Z, Chen J, Wadhwa S. Murine TMJ loading causes increased proliferation and chondrocyte maturation. J Dent Res. 2011;90(4):512–516. DOI:10.1177/0022034510390810.
   PubMed Web of Science ®Google Scholar
• Fujisawa T, Kuboki T, Kasai T, Sonoyama W, Kojima S, Uehara J, Komori C, Yatani H, Hattori T, Takigawa M. A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint. J Dent Res. 2003;82(9):731–735. DOI:10.1177/154405910308200914.
   PubMed Web of Science ®Google Scholar
• Utreja A, Dyment NA, Yadav S, Villa MM, Li Y, Jiang X, Nanda R, Rowe DW. Cell and matrix response of temporomandibular cartilage to mechanical loading. Osteoarthritis Cartilage. 2016;24(2):335–344. DOI:10.1016/j.joca.2015.08.010.
   PubMed Web of Science ®Google Scholar
• Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Methodology Series B. 1995;57:11.
   Web of Science ®Google Scholar
• Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B. Interactions between Sox9 and β-catenin control chondrocyte differentiation. Genes Dev. 2004;18(9):1072–1087. DOI:10.1101/gad.1171104.
   PubMed Web of Science ®Google Scholar
• Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E, Bell DM, Tam PPL, Cheah KSE, Koopman P. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol. 1997;183(1):108–121. DOI:10.1006/dbio.1996.8487.
   PubMed Web of Science ®Google Scholar
• Zhou G, Lefebvre V, Zhang Z, Eberspaecher H, de Crombrugghe B. Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo. J Biol Chem. 1998;273(24):14989–14997. DOI:10.1074/jbc.273.24.14989.
   PubMed Web of Science ®Google Scholar
• Hinton RJ, Jing Y, Jing J, Feng JQ. Roles of chondrocytes in endochondral bone formation and fracture repair. J Dent Res. 2017;96(1):23–30. DOI:10.1177/0022034516668321.
   PubMed Web of Science ®Google Scholar
• Jing Y, Zhou X, Han X, Jing J, von der Mark K, Wang J, de Crombrugghe B, Hinton RJ, Feng JQ. Chondrocytes directly transform into bone cells in mandibular condyle growth. J Dent Res. 2015;94(12):1668–1675. DOI:10.1177/0022034515598135.
   PubMed Web of Science ®Google Scholar
• Zhou X, von der Mark K, Henry S, Norton W, Adams H, de Crombrugghe B, Warman ML. Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice. PLoS Genet. 2014;10(12):e1004820. DOI:10.1371/journal.pgen.1004820.
   PubMed Web of Science ®Google Scholar
• Yang G, Zhu L, Hou N, Lan Y, Wu XM, Zhou B, Teng Y, Yang X. Osteogenic fate of hypertrophic chondrocytes. Cell Res. 2014;24(10):1266–1269. DOI:10.1038/cr.2014.111.
   PubMed Web of Science ®Google Scholar
• Yang L, Tsang KY, Tang HC, Chan D, Cheah KS. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci USA. 2014;111(33):12097–12102. DOI:10.1073/pnas.1302703111.
   PubMed Web of Science ®Google Scholar
• Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423(6937):332–336. DOI:10.1038/nature01657.
   PubMed Web of Science ®Google Scholar
• Marshall WF. Basal bodies platforms for building cilia. Curr Top Dev Biol. 2008;85:1–22.
   PubMed Web of Science ®Google Scholar
• Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK. Intraflagellar transport is essential for endochondral bone formation. Development. 2007;134(2):307–316. DOI:10.1242/dev.02732.
   PubMed Web of Science ®Google Scholar
• Cortes M, Baria AT, Schwartz NB. Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development. 2009;136(10):1697–1706. DOI:10.1242/dev.030742.
   PubMed Web of Science ®Google Scholar
• Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M. Developmental regulation of Wnt/β-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005;280(19):19185–19195. DOI:10.1074/jbc.M414275200.
   PubMed Web of Science ®Google Scholar
• Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, Little CB. Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum. 2013;65(6):1547–1560. DOI:10.1002/art.37900.
   PubMedGoogle Scholar
• Zhou Y, Shu B, Xie R, Huang J, Zheng L, Zhou X, Xiao G, Zhao L, Chen D. Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling. J Cell Physiol. 2019;234(2):1720–1729. DOI:10.1002/jcp.27043.
   PubMed Web of Science ®Google Scholar
• Hui T, Zhou Y, Wang T, Li J, Zhang S, Liao L, Gu J, Ye L, Zhao L, Chen D. Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects. Int J Oral Sci. 2018;10(2):13. DOI:10.1038/s41368-018-0016-z.
   PubMedGoogle Scholar
• Jiao K, Niu LN, Wang MQ, Dai J, Yu SB, Liu XD, Wang J. Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats. Bone. 2011;48:362–371.
   PubMed Web of Science ®Google Scholar
• Wang YL, Zhang J, Zhang M, Lu L, Wang X, Guo M, Zhang X, Wang M-Q. Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis. Oral Dis. 2014;20(3):301–306. DOI:10.1111/odi.12112.
   PubMed Web of Science ®Google Scholar
• Wang D, Yang H, Zhang M, Zhang H, Lu L, Zhang J, Wan X, Wang M. Insulin-Like growth factor-1 engaged in the mandibular condylar cartilage degeneration induced by experimental unilateral anterior crossbite. Arch Oral Biol. 2019;98:17–25.
   PubMed Web of Science ®Google Scholar
• Shibata S, Suzuki S, Tengan T, Yamashita Y. A histochemical study of apoptosis in the reduced ameloblasts of erupting mouse molars. Arch Oral Biol. 1995;40(7):677–680. DOI:10.1016/0003-9969(95)00021-G.
   PubMed Web of Science ®Google Scholar
• Chen J, Sobue T, Utreja A, Kalajzic Z, Xu M, Kilts T, Young M, Wadhwa S. Sex differences in chondrocyte maturation in the mandibular condyle from a decreased occlusal loading model. Calcif Tissue Int. 2011;89(2):123–129. DOI:10.1007/s00223-011-9498-9.
   PubMed Web of Science ®Google Scholar