53
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Effects of metabolic stress and ischaemia on the bladder, and the relationship with bladder overactivity

, , &
Pages 84-92 | Published online: 09 Jul 2009

References

  • Brading AF, Greenland JE, Mills IW, McMurray G, Symes S. Blood supply to the bladder during filling. Scand J Urol Nephrol 1999; 33 (Suppl 201): 25�31.
  • Greenland JE, Brading AF. Urinary bladder blood flow changes during the micturition cycle in a conscious pig model. J Urol 1996; 156: 1858�61.
  • Greenland JE, Brading AF. The effect of bladder outflow obstruction on detrusor blood flow changes during the voiding cycle in conscious pigs. J Urol 2001; 165: 245�8.
  • Levin RM, Brading AF, Longhurst PA, Mills IW. Experimental models of bladder outlet obstruction. In: Lepor H, editor. Prostatic diseases. Philadelphia, PA: WB Saunders; 2000.
  • Wellner MC, Isenberg G. Stretch effects on whole-cell currents of guinea-pig urinary bladder myocytes. J Physiol (Lond) 1994; 480: 439�48.
  • Wendt IR, Gibbs CL. Energy expenditure of longitudinal smooth muscle of rabbit urinary bladder. Am J Physiol 1987; 252: C88�96.
  • Wendt IR. Effects of substrate and hypoxia on smooth muscle metabolism and contraction. Am J Physiol 1989; 256: C719�27.
  • Paul RJ. Functional compartmentalisation of oxidative and glycolytic metabolism in vascular smooth muscle. Am J Physiol 1983; 244: C399�409. 9. Takai A, Tomita T. Glycolysis and oxidative phos-phorylation during activation of the sodium pump in the taenia from guinea-pig caecum. J Physiol 1986; 381: 65�75.
  • Greenland JE, Hvistendahl JJ, Andersen H, Jorgensen TM, McMurray G, Cortina-Borja M, et al. The effect of bladder outlet obstruction on tissue oxygen tension and blood flow in the pig bladder. BJU Int 2000; 85: 1109� 14.
  • Kato K, Lin AT, Haugaard N, Longhurst PA, Wein AJ, Levin RM. Effects of outlet obstruction on glucose metabolism of the rabbit urinary bladder. J Urol 1990; 143: 844�7.
  • Mills IW. The pathophysiology of detrusor instability and the role of bladder ischaemia in its aetiology. Oxford: Pharmacology Department; 1999.
  • Mills IW, Noble JG, Brading AF. The effects of in vitro ischemia on detrusor smooth muscle responses. J Urol 2000; 163: 45.
  • Levin RM, High J, Wein AJ. Metabolic and contractile effects of anoxia on the rabbit urinary bladder. J Urol 1982; 128: 194�6.
  • Pessina F, McMurray G, Wiggin A, Brading AF. The effect of anoxia and glucose-free solutions on the contractile response of guinea-pig detrusor strips to intrinsic nerve stimulation and the application of excitatory agonists. J Urol 1997; 157: 2375�80.
  • Lorenzi B, McMurray G, Jarvis G, Brading AF. Preconditioning protects the guinea-pig urinary bladder against ischaemic conditions in vitro. Neurourol Urodyn 2003; 22: 687�92.
  • Levin RM, Wein AJ. Response of the in vitro whole bladder (rabbit) preparation to autonomic agonists. J Urol 1982; 128: 1087�90.
  • Levin RM, Leggett R, Whitbeck C, Horan P. Effect of calcium and calcium chelator on the response of the bladder to in vitro ischaemia. Br J Urol 1998; 82: 882�7.
  • Bramich NJ, Brading AF. Electrical properties of smooth muscle in the guinea-pig urinary bladder. J Physiol 1996; 492: 185�98.
  • Saito M, Wada K, Kamisaki Y, Miyagawa I. Effect of ischemia�reperfusion on contractile function of rat urinary bladder: possible role of nitric oxide. Life Sci 1998; 62: PL149�56.
  • Bratslavsky G, Whitbeck C, Horan P, Levin RM. Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl. Pharmacology 1999; 59: 221�6.
  • Speakman MJ, Brading AF, Gilpin CJ, Dixon JS, Gilpin SA, Gosling JA. Bladder outflow obstruction�a cause of denervation supersensitivity. J Urol 1987; 138: 1461�6.
  • Sibley GNA. The physiological response of the detrusor muscle to experimental bladder outflow obstruction in the pig. Br J Urol 1987; 60: 332�6.
  • Harrison SC, Hunnam GR, Farman P, Ferguson DR, Doyle PT. Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol 1987; 60: 519�22.
  • Yokoyama O, Nagano K, Kawaguchi K, Hisazumi H. The response of the detrusor muscle to acetylcholine in patients with infravesical obstruction. Urol Res 1991; 19: 117�21.
  • German K, Bedwani J, Davies J, Brading AF, Stephenson TP. Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patients. J Urol 1995; 153: 1678�83.
  • Turner WH, Brading AF. Smooth muscle of the bladder in the normal and the diseased state: pathophysiology, diagnosis and treatment. Pharmacol Ther 1997; 75: 77� 110.
  • Mills IW, Greenland JE, McMurray G, McCoy R, Ho KM, Noble JG, Brading AF. Studies of the pathophysi-ology of idiopathic detrusor instability: the physiological properties of the detrusor smooth muscle and its pattern of innervation. J Urol 2000; 163: 646�51.
  • Drake MJ, Hedlund P, Mills IW, McCoy R, McMurray G, Gardner BP, et al. Structural and functional dener-vation of human detrusor after spinal cord injury. Lab Invest 2000; 80: 1491�9.
  • Drake MJ, Gardner BP, Brading AF. Innervation of the detrusor muscle bundle in neurogenic detrusor over-activity. BJU Int 2003; 91: 702�10.
  • Brading AF, Turner WH. The unstable bladder: towards a common mechanism. Br J Urol 1994; 73: 3�8.
  • Brading AF. A myogenic basis for the overactive bladder. Urology 1997; 50: 57�67; Discussion 68�73.
  • Sethia KK, Brading AF, Smith JC. An animal model of non-obstructive bladder instability. J Urol 1990; 143: 1243�6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.