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Original

Regulatory T cells in peripheral blood of patients with mixed connective tissue disease

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Pages 300-304 | Received 20 May 2005, Accepted 10 Feb 2006, Published online: 12 Jul 2009

References

  • Lan R. Y., Ansari A. A., Lian Z. X., Gershwin M. E. Regulatory T cells: development, function and role in autoimmunity. Autoimmun Rev 2005; 4: 351–63
  • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self‐tolerance maintained by achieved T cells expressing IL‐2 receptor alpha‐chains (CD25). Breakdown of single mechanism of self‐tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151–64
  • Vieira P. L., Christensen J. R., Minaee S., O'Neill E. J., Barrat F. J., Boonstra A., et al. IL‐10‐secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol 2004; 172: 5986–93
  • Sharp G. C., Irvin W. S., Tan E. M., Gould R. G., Holman H. R. Mixed connective tissue disease – an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972; 52: 148–59
  • Bodolay E., Szekanecz Z., Devenyi K., Galuska L., Csipo I., Vegh J., et al. Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD). Rheumatology (Oxford) 2005; 44: 656–61
  • Greidinger E. L., Hoffman R. W. The appearance of U1‐RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1‐70 kD and B′/B proteins as predominant U1‐RNP immunogens. Arthritis Rheum 2001; 44: 368–75
  • Hassan A. B., Gunnarsson I., Karlsson G., Klareskog L., Forslid J., Lundberg I. E. Longitudinal study of interleukin‐10, tumor necrosis factor‐α, anti‐U1‐snRNP antibody levels and disease activity in patients with mixed connective tissue disease. Scand J Rheumatol 2001; 30: 282–9
  • Hassan A. B., Ronnelid J., Gunnarson I., Karlsson G., Berg L., Lundberg I. Increased serum levels of immunoglobulins, C‐reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease. J Autoimmun 1998; 11: 503–8
  • Bodolay E., Aleksza M., Antal‐Szalmás P., Vegh J., Szodoray P., Soltesz P., et al. Serum cytokine levels, type 1 and intracellular T cell cytokine profiles in mixed connective tissue disease. J Rheumatol 2002; 29: 2136–42
  • Alarcon‐Segovia D. A., Villarel M. Classification and diagnostic criteria for mixed connective tissue disease. Mixed connective tissue disease and anti‐nuclear antibodies, R Kasukawa, G. C Sharp. Excerpta Medica, Amsterdam 1987; 33–40
  • Liang M. H., Socher S. A., Larson M. G., Schur P. H. Reliability and validity of six systems for the clinical assessment disease activity in systemic lupus erythematosus. Arthritis Rheum 1989; 32: 1107–18
  • Liu M. F., Wang C. R., Fung L. L., Wu C. R. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004; 59: 198–202
  • Monk C. R., Spachidou M., Rovis F., Leung E., Botto M., Lechler R. I., et al. MRL/Mp CD4+,CD25– T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum 2005; 52: 1180–4
  • Fattorosi A., Battaglia A., Buzzonetti A., Ciaraffa F., Scambia G., Evoli A. Circulating and thymic CD4+CD25+ T regulatory cells in myasthenia gravis: effect of immnosuppressive treatment. Immunology 2005; 116: 134–41
  • Mottonen M., Heikkinen J., Mustonen L., Isomaki P., Luukkainen R., Lassila O. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005; 140: 360–7
  • Pop S. M., Wong C. P., Culton D. A., Clarke S. H., Tisch R. Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 2005; 201: 1333–46
  • Putnam A. L., Vendrame F., Dotta F., Gotlieb P. A. CD4+CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun 2005; 24: 55–62
  • Appel H., Neure L., Kuhne M., Braun J., Rudwaleit M., Sieper J. An elevated level of IL‐10‐ and TGFbeta‐secreting T cells, B cells and macrophages in the synovial membrane of patients with reactive arthritis compared to rheumatoid arthritis. Clin Rheumatol 2004; 23: 435–40
  • Sundstedt A., O'Neil E. J., Nicolson K. S., Wraith D. C. Role for IL‐10 in suppression mediated by peptide‐induced regulatory T cells in vivo. J Immunol 2003; 170: 1240–8
  • Barrat F. J., Cua D. J., Boonstra A., Richards D. F., Crain C., Savelkoul H. F., et al. In vitro generation of interleukin 10‐producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)‐ and Th2‐inducing cytokines. J Exp Med 2002; 195: 603–16
  • Boussiotis V. A., Tsai E. Y., Yunis E. J., Thim S., Delgado J. C., Dascher C. C., et al. IL‐10‐producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest 2000; 105: 1317–25
  • O'Garra A., Vieira P. L., Vieira P. Goldfeld AE. IL‐10‐producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest 2004; 114: 1372–8
  • Doganci A., Eigenbrod T., Krug N., De Sanctis G. T., Hausding M., Erpenbeck V. J., et al. The IL‐6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest 2005; 115: 313–25
  • Nishimaki T., Aotsuka S., Kondo H., Yamamoto K., Takasaki Y., Sumiya M., et al. Immunological analysis of pulmonary hypertension in connective tissue diseases. J Rheumatol 1999; 26: 2357–62

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