290
Views
13
CrossRef citations to date
0
Altmetric
Articles

Modulatory effects of inflammation and therapy on GDF‐5 expression in rheumatoid arthritis synovium

, , , , , , , , , , & show all
Pages 401-409 | Accepted 10 Apr 2008, Published online: 12 Jul 2009

References

  • BramLage C. P., Haupl T., Kaps C., Ungethum U., Krenn V., Pruss A., et al. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther 2006; 8: R58
  • Kaps C., BramLage C., Smolian H., Haisch A., Ungethum U., Burmester G. R., et al. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 2002; 46: 149–62
  • BramLage C. P., Haupl T., Kaps C., BramLage P., Muller G. A., Strutz F. Bone morphogenetic proteins in the skeletal system [in German]. Z Rheumatol 2005; 64: 416–22
  • Allen J. B., Manthey C. L., Hand A. R., Ohura K., Ellingsworth L., Wahl S. M. Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med 1990; 171: 231–47
  • Wolfman N. M., Hattersley G., Cox K., Celeste A. J., Nelson R., Yamaji N., et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF‐beta gene family. J Clin Invest 1997; 100: 321–30
  • van Beuningen H. M., Glansbeek H. L., van der Kraan P. M., van den Berg W. B. Differential effects of local application of BMP‐2 or TGF‐beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage 1998; 6: 306–17
  • Merino R., Macias D., Ganan Y., Economides A. N., Wang X., Wu Q., et al. Expression and function of Gdf‐5 during digit skeletogenesis in the embryonic chick leg bud. Dev Biol 1999; 206: 33–45
  • Storm E. E., Kingsley D. M. GDF5 coordinates bone and joint formation during digit development. Dev Biol 1999; 209: 11–27
  • Kingsley D. M., Bland A. E., Grubber J. M., Marker P. C., Russell L. B., Copeland N. G., et al. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 1992; 71: 399–410
  • Buxton P., Edwards C., Archer C. W., Francis‐West P. Growth/differentiation factor‐5 (GDF‐5) and skeletal development. J Bone Joint Surg Am 2001; 83‐A Suppl 1((Pt 1))S23–30
  • Edwards C. J., Francis‐West P. H. Bone morphogenetic proteins in the development and healing of synovial joints. Semin Arthritis Rheum 2001; 31: 33–42
  • Coleman C. M., Tuan R. S. Functional role of growth/differentiation factor 5 in chondrogenesis of limb mesenchymal cells. Mech Dev 2003; 120: 823–36
  • Katayama R., Wakitani S., Tsumaki N., Morita Y., Matsushita I., Gejo R., et al. Repair of articular cartilage defects in rabbits using CDMP1 gene‐transfected autologous mesenchymal cells derived from bone marrow. Rheumatology (Oxford) 2004; 43: 980–5
  • Simank H. G., Sergi C., Jung M., Adolf S., Eckhardt C., Ehemann V., et al. Effects of local application of growth and differentiation factor‐5 (GDF‐5) in a full‐thickness cartilage defect model. Growth Factors 2004; 22: 35–43
  • Miyamoto Y., Mabuchi A., Shi D., Kubo T., Takatori Y., Saito S., et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet 2007; 39: 529–33
  • Cuchacovich M., Soto L., Edwardes M., Gutierrez M., Llanos C., Pacheco D., et al. Tumour necrosis factor (TNF)alpha –308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scand J Rheumatol 2006; 35: 435–40
  • Kim H. R., Kim H. S., Park M. K., Cho M. L., Lee S. H., Kim H. Y. The clinical role of IL‐23p19 in patients with rheumatoid arthritis. Scand J Rheumatol 2007; 36: 259–64
  • Morita Y., Fukazawa T., Hirashima M., Kaga K., Kusaoi M., Morita T., et al. The effect of methotrexate (MTX) on expression of signalling lymphocytic activation molecule (SLAM) in patients with rheumatoid arthritis (RA) and its role in the regulation of cytokine production. Scand J Rheumatol 2006; 35: 268–72
  • Vergunst C. E., van de Sande M. G., Lebre M. C., Tak P. P. The role of chemokines in rheumatoid arthritis and osteoarthritis. Scand J Rheumatol 2005; 34: 415–25
  • Lories R. J., Derese I., Ceuppens J. L., Luyten F. P. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast‐like synoviocyte apoptosis. Arthritis Rheum 2003; 48: 2807–18
  • Cinelli M., Guiducci S., Del Rosso A., Pignone A., Del Rosso M., Fibbi G., et al. Piascledine modulates the production of VEGF and TIMP‐1 and reduces the invasiveness of rheumatoid arthritis synoviocytes. Scand J Rheumatol 2006; 35: 346–50
  • Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–24
  • Krenn V., Morawietz L., Burmester G. R., Haupl T. Synovialitis score: histopathological grading system for chronic rheumatic and non‐rheumatic synovialitis [in German]. Z Rheumatol 2005; 64: 334–42
  • Strutz F., Zeisberg M., Ziyadeh F. N., Yang C. Q., Kalluri R., Muller G. A., et al. Role of basic fibroblast growth factor‐2 in epithelial‐mesenchymal transformation. Kidney Int 2002; 61: 1714–28
  • Kaps C., Frauenschuh S., Endres M., Ringe J., Haisch A., Lauber J., et al. Gene expression profiling of human articular cartilage grafts generated by tissue engineering. Biomaterials 2006; 27: 3617–30
  • Nagai H., Miyamoto Y., Nakata A., Hatakeyama S., Iwanami Y., Fukuda M. Isolation and characterization of synovial cells from the human temporomandibular joint. J Oral Pathol Med 2006; 35: 104–10
  • Bobacz K., Gruber R., Soleiman A., Graninger W. B., Luyten F. P., Erlacher L. Cartilage‐derived morphogenetic protein‐1 and ‐2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage 2002; 10: 394–401
  • Rountree R. B., Schoor M., Chen H., Marks M. E., Harley V., Mishina Y., et al. BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol 2004; 2: e355
  • Nishitoh H., Ichijo H., Kimura M., Matsumoto T., Makishima F., Yamaguchi A., et al. Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor‐5. J Biol Chem 1996; 271: 21345–52
  • Simank H. G., Manggold J., Sebald W., Ries R., Richter W., Ewerbeck V., et al. Bone morphogenetic protein‐2 and growth and differentiation factor‐5 enhance the healing of necrotic bone in a sheep model. Growth Factors 2001; 19: 247–57
  • Gould S. E., Day M., Jones S. S., Dorai H. BMP‐7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. Kidney Int 2002; 61: 51–60
  • Leclerc N., Luppen C. A., Ho V. V., Nagpal S., Hacia J. G., Smith E., et al. Gene expression profiling of glucocorticoid‐inhibited osteoblasts. J Mol Endocrinol 2004; 33: 175–93
  • Ferraccioli G., Casatta L., Bartoli E. Increase of bone mineral density and anabolic variables in patients with rheumatoid arthritis resistant to methotrexate after cyclosporin A therapy. J Rheumatol 1996; 23: 1539–42

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.