Total iron binding capacity: an independent predictor of prognosis for pulmonary arterial hypertension in systemic lupus erythematosus

References

• Dodson MW, Brown LM, Elliott CG. Pulmonary arterial hypertension. Heart Fail Clin 2018;14:255–69.
   PubMed Web of Science ®Google Scholar
• Xiong J, Yu S, Liu R, Fang X, Wu R. The role of conjunctival microvasculation combined with echocardiography in evaluating pulmonary arterial hypertension in systemic lupus erythematosus. Dis Markers 2021;2021:2135942.
   PubMed Web of Science ®Google Scholar
• Ramakrishnan L, Pedersen SL, Toe QK, Quinlan GJ, Wort SJ. Pulmonary arterial hypertension: iron matters. Front Physiol 2018;9:641.
   PubMed Web of Science ®Google Scholar
• Quatredeniers M, Mendes-Ferreira P, Santos-Ribeiro D, Nakhleh MK, Ghigna MR, Cohen-Kaminsky S, et al. Iron deficiency in pulmonary arterial hypertension: a deep dive into the mechanisms. Cells 2021;10:477.
   PubMed Web of Science ®Google Scholar
• Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, et al. Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice. Proc Natl Acad Sci U S A 2019;116:13122–30.
   PubMed Web of Science ®Google Scholar
• Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, et al. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. Jama 2009;302:1444–50.
   PubMed Web of Science ®Google Scholar
• Soon E, Treacy CM, Toshner MR, MacKenzie-Ross R, Manglam V, Busbridge M, et al. Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension. Thorax 2011;66:326–32.
   PubMed Web of Science ®Google Scholar
• Ruiter G, Manders E, Happé CM, Schalij I, Groepenhoff H, Howard LS, et al. Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency. Pulm Circ 2015;5:466–72.
   PubMed Web of Science ®Google Scholar
• Howard L, He J, Watson GMJ, Huang L, Wharton J, Luo Q, et al. Supplementation with iron in pulmonary arterial hypertension. two randomized crossover trials. Ann Am Thorac Soc 2021;18:981–8.
   PubMed Web of Science ®Google Scholar
• Shin JI, Lee KH, Park S, Yang JW, Kim HJ, Song K, et al. Systemic lupus erythematosus and lung involvement: a comprehensive review. J Clin Med 2022;11:6714.
   PubMed Web of Science ®Google Scholar
• Hassoun PM. Pulmonary arterial hypertension complicating connective tissue diseases. Semin Respir Crit Care Med 2009;30:429–39.
   PubMed Web of Science ®Google Scholar
• Rhee RL, Gabler NB, Sangani S, Praestgaard A, Merkel PA, Kawut SM. Comparison of treatment response in idiopathic and connective tissue disease-associated pulmonary arterial hypertension. Am J Respir Crit Care Med 2015;192:1111–17.
   PubMed Web of Science ®Google Scholar
• Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. European league against Rheumatism/American college of rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis 2019;78:1151–9.
   PubMed Web of Science ®Google Scholar
• Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 2022;43:3618–731.
   PubMed Web of Science ®Google Scholar
• Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Rev Esp Cardiol (Engl Ed) 2016;69:177.
   PubMed Web of Science ®Google Scholar
• Schreiber BE, Connolly MJ, Coghlan JG. Pulmonary hypertension in systemic lupus erythematosus. Best Pract Res Clin Rheumatol 2013;27:425–34.
   PubMed Web of Science ®Google Scholar
• Chow SL, Chandran V, Fazelzad R, Johnson SR. Prognostic factors for survival in systemic lupus erythematosus associated pulmonary hypertension. Lupus 2012;21:353–64.
   PubMed Web of Science ®Google Scholar
• van Empel Vp, Lee J, Williams TJ, Kaye DM. Iron deficiency in patients with idiopathic pulmonary arterial hypertension. Heart Lung Circ 2014;23:287–92.
   PubMed Web of Science ®Google Scholar
• Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev 2009;23:95–104.
   PubMed Web of Science ®Google Scholar
• Wlaschek M, Singh K, Sindrilaru A, Crisan D, Scharffetter-Kochanek K. Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds. Free Radic Biol Med 2019;133:262–75.
   PubMed Web of Science ®Google Scholar
• Koskenkorva-Frank TS, Weiss G, Koppenol WH, Burckhardt S. The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress. Free Radic Biol Med 2013;65:1174–94.
   PubMed Web of Science ®Google Scholar
• Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, et al. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol 2006;290:L1069–77.
   PubMed Web of Science ®Google Scholar
• Wunderlich C, Schmeisser A, Heerwagen C, Ebner B, Schober K, Braun-Dullaeus RC, et al. Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice. Pulm Pharmacol Ther 2008;21:507–15.
   PubMed Web of Science ®Google Scholar
• Wong CM, Preston IR, Hill NS, Suzuki YJ. Iron chelation inhibits the development of pulmonary vascular remodeling. Free Radic Biol Med 2012;53:1738–47.
   PubMed Web of Science ®Google Scholar
• Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res 2015;116:1680–90.
   PubMed Web of Science ®Google Scholar
• Naito Y, Hosokawa M, Hao H, Sawada H, Hirotani S, Iwasaku T, et al. Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats. Biochem Biophys Res Commun 2013;436:145–51.
   PubMed Web of Science ®Google Scholar
• Viethen T, Gerhardt F, Dumitrescu D, Knoop-Busch S, ten Freyhaus H, Rudolph TK, et al. Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: a pilot study. Int J Cardiol 2014;175:233–9.
   PubMed Web of Science ®Google Scholar
• Saluja P, Gautam N, Amisha F, Salah HM, Smith J, Biyani S, et al. Influence of iron deficiency on clinical and haemodynamic parameters in pulmonary arterial hypertension cohorts. Heart Lung Circ 2022;31:1594–603.
   PubMed Web of Science ®Google Scholar
• Ruiter G, Lankhorst S, Boonstra A, Postmus PE, Zweegman S, Westerhof N, et al. Iron deficiency is common in idiopathic pulmonary arterial hypertension. Eur Respir J 2011;37:1386–91.
   PubMed Web of Science ®Google Scholar
• Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JS, et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights. J Am Coll Cardiol 2011;58:300–9.
   PubMed Web of Science ®Google Scholar
• Ruiter G, Lanser IJ, de Man FS, van der Laarse WJ, Wharton J, Wilkins MR, et al. Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension. Rheumatology (Oxford) 2014;53:285–92.
   PubMed Web of Science ®Google Scholar
• Frise MC, Cheng HY, Nickol AH, Curtis MK, Pollard KA, Roberts DJ, et al. Clinical iron deficiency disturbs normal human responses to hypoxia. J Clin Invest 2016;126:2139–50.
   PubMed Web of Science ®Google Scholar
• Nguyen LT, Buse JD, Baskin L, Sadrzadeh SMH, Naugler C. Influence of diurnal variation and fasting on serum iron concentrations in a community-based population. Clin Biochem 2017;50:1237–42.
   PubMed Web of Science ®Google Scholar