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Original Articles

Highly virulent Marek’s disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens

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Pages 564-572 | Received 15 Mar 2019, Accepted 05 Jul 2019, Published online: 07 Aug 2019

References

  • Berthault, C., Larcher, T., Härtle, S., Vautherot, J.F., Trapp-Fragnet, L. & Denesvre, C. (2018). Atrophy of primary lymphoid organs induced by Marek’s disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia. Veterinary Research, 49, 31–48. doi: 10.1186/s13567-018-0526-x
  • Calnek, B.W., Harris, R.W., Buscaglia, C., Schat, K.A. & Lucio, B. (1998). Relationship between the immunosuppressive potential and the pathotype of Marek’s disease virus isolates. Avian Diseases, 42, 124–132. doi: 10.2307/1592584
  • Churchill, A.E., Payne, L.N. & Chubb, R.C. (1969). Immunization against Marek’s disease using a live attenuated virus. Nature, 221, 744–747. doi: 10.1038/221744a0
  • Dunn, J. & Gimeno, I.M. (2013). Current status of Marek’s disease in the United States and worldwide based on a questionnaire survey. Avian Diseases, 57, 483–490. doi: 10.1637/10373-091412-ResNote.1
  • Dunn, J.R., Auten, K., Heidari, M. & Buscaglia, C. (2014). Correlation between Marek’s disease virus pathotype and replication. Avian Diseases, 58, 287–292. doi: 10.1637/10678-092513-Reg.1
  • Dwyer, J.M. & Johnson, C. (1981). The use of concanavalin A to study the immunoregulation of human T cells. Clinical and Experimental Immunology, 46, 237–249.
  • Eidson, C.S. & Schmittle, S.C. (1968). Studies on acute Marek’s disease. I. Characteristics of isolate GA in chickens. Avian Diseases, 12, 467–476. doi: 10.2307/1588162
  • Fahey, K.J. & York, J.J. (1990). The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens. Journal of General Virology, 71, 2401–2405. doi: 10.1099/0022-1317-71-10-2401
  • Faiz, N.M., Cortes, A.L., Guy, J.S., Fletcher, O.J., West, M., Montiel, E. & Gimeno, I.M. (2016a). Early infection with Marek’s disease virus can jeopardize protection conferred by laryngotracheitis vaccines: a method to study MDV-induced immunosuppression. Avian Pathology, 45, 606–615. doi: 10.1080/03079457.2016.1191618
  • Faiz, N.M., Cortes, A.L., Guy, J.S., Fletcher, O.J., Cimino, T. & Gimeno, I.M. (2017). Evaluation of factors that affect the development of late Marek’s disease virus-induced immunosuppression: virus pathotype and host sex. Avian Pathology, 46, 376–385. doi: 10.1080/03079457.2017.1290214
  • Faiz, N.M., Cortes, A.L., Guy, J.S., Fogle, J.E. & Gimeno, I.M. (2016b). Efficacy of various Marek’s disease vaccines protocols against Marek’s disease virus-induced immunosuppression. Vaccine, 34, 4180–4187. doi: 10.1016/j.vaccine.2016.06.061
  • Faiz, N.M., Cortes, A.L., Guy, J.S., Reddy, S.M. & Gimeno, I.M. (2018). Differential attenuation of Marek’s disease virus-induced tumours and late-Marek’s disease virus-induced immunosuppression. Journal of General Virology, 99, 927–936. doi: 10.1099/jgv.0.001076
  • Gimeno, I.M. & Cortes, A.L. (2011). Chronological study of cytokine transcription in the spleen and lung of chickens after vaccination with serotype 1 Marek’s disease vaccines. Vaccine, 29, 1583–1594. doi: 10.1016/j.vaccine.2010.12.079
  • Gimeno, I.M., Witter, R.L., Hunt, H.D., Lee, L.F., Reddy, S.M. & Neumann, U. (2001a). Marek’s disease virus infection in the brain: virus replication, cellular infiltration and major histocompatibility complex antigen expression. Veterinary Pathology, 38, 491–503. doi: 10.1354/vp.38-5-491
  • Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M. & Neumann, U. (2001b). Differential attenuation of the induction by Marek’s disease virus of transient paralysis and persistent neurological disease: a model for pathogenesis studies. Avian Pathology, 30, 397–409. doi: 10.1080/03079450120066403
  • Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M. & Reed, W.M. (2004). Biocharacteristics shared by highly protective vaccines against Marek’s disease. Avian Pathology, 33, 57–66. doi: 10.1080/0307945031000163264
  • Hunt, H.D., Lupiani, B., Miller, M.M., Gimeno, I.M., Lee, L.F. & Parcells, M.S. (2001). Marek’s disease virus down regulates surface expression of MHC (B complex) class I (BF) glycoproteins during active but not latent infection of chicken cells. Virology, 282, 198–205. doi: 10.1006/viro.2000.0797
  • Islam, A.F., Wong, C.W., Walkden-Brown, S.W., Colditz, I.G., Arzey, K.E. & Groves, P.J. (2002). Immunosuppressive effects of Marek’s disease virus (MDV) and herpesvirus of turkeys (HVT) in broiler chickens and the protective effect of HVT vaccination against MDV challenge. Avian Pathology, 31, 449–461. doi: 10.1080/0307945021000005824
  • Jarosinski, K.W., Hunt, H.D. & Osterrieder, N. (2010). Down-regulation of MHC class I by the Marek’s disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion. Virology, 405, 457–463. doi: 10.1016/j.virol.2010.06.041
  • Kaspers, B., Lillehoj, H.S. & Lillehoj, E.P. (1993). Chicken macrophages and thrombocytes share a common cell surface antigen defined by a monoclonal antibody. Veterinary Immunology and Immunopathology, 36, 333–346. doi: 10.1016/0165-2427(93)90029-4
  • Kim, T., Hunt, H.D., Parcells, M.S., van Santen, V. & Ewald, S.J. (2018). Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs. Immunogenetics, 70, 599–611. doi: 10.1007/s00251-018-1066-2
  • Lee, L.F., Sharma, J.M., Nazerian, K. & Witter, R.L. (1978a). Suppression and enhancement of mitogen response in chickens infected with Marek’s disease virus and the herpesvirus of turkeys. Infection and Immunity, 21, 474–479.
  • Lee, L.F., Sharma, J.M., Nazerian, K. & Witter, R.L. (1978b). Suppression of mitogen-induced proliferation of normal spleen cells by macrophages from chickens inoculated with Marek’s disease virus. The Journal of Immunology, 120, 1554–1559.
  • Levy, A.M., Davidson, I., Burgess, S.C. & Heller, E.D. (2003). Major histocompatibility complex class I is downregulated in Marek’s disease virus infected chicken embryo fibroblasts and corrected by chicken interferon. Comparative Immunology, Microbiology and Infectious Diseases, 26, 189–198. doi: 10.1016/S0147-9571(02)00055-3
  • Lu, Y.S. (1974). Spleen cell mitogenic response in Marek’s disease. Dissertation Abstracts International B, 35, 590–590.
  • Morimura, T., Ohashi, K., Kon, Y., Hattori, M., Sugimoto, C. & Onuma, M. (1996). Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek’s disease virus - brief report. Archives of Virology, 141, 2243–2249. doi: 10.1007/BF01718230
  • Morimura, T., Ohashi, K., Kon, Y., Hattori, M., Sugimoto, C. & Onuma, M. (1997). Apoptosis in peripheral CD4 + T cells and thymocytes by Marek’s disease virus-infection. Leukemia, 11, 206–211. doi: 10.1038/sj.leu.2400558
  • Paramithiotis, E., Tkalec, L. & Ratcliffe, M.J.H. (1991). High levels of CD45 are coordinately expressed with CD4 and CD8 on avian thymocytes. The Journal of Immunology, 147, 3710–3717.
  • Peters, M.A., Browning, G.F., Washington, E.A., Crabb, B.S. & Kaiser, P. (2003). Embryonic age influences the capacity for cytokine induction in chicken thymocytes. Immunology, 110, 358–367. doi: 10.1046/j.1365-2567.2003.01744.x
  • Read, A.F., Baigent, S.J., Powers, C., Kgosana, L.B., Blackwell, L., Smith, L.P., Kennedy, D.A., Walkden-Brown, S.W., Nair, V.K. & Fraser, C. (2015). Imperfect vaccination can enhance the transmission of highly virulent pathogens. PLoS Biology, 13, e1002198. doi: 10.1371/journal.pbio.1002198
  • Reddy, S.M., Sun, A., Khan, O.A., Lee, L.F. & Lupiani, B. (2013). Cloning of a very virulent plus, 686 strain of Marek’s disease virus as a bacterial artificial chromosome. Avian Diseases, 57, 469–473. doi: 10.1637/10444-110412-ResNote.1
  • Rispens, B.H., Van Vloten, J., Mastenbroek, N., Maas, H.J.L. & Schat, K.A. (1972). Control of Marek’s disease in the Netherlands. I. Isolation of an avirulent Marek’s disease virus (strain CVI 988) and its use in laboratory vaccination trials. Avian Diseases, 16, 108–125. doi: 10.2307/1588905
  • Salomonsen, J., Skjodt, K., Crone, M. & Simonsen, M. (1987). The chicken erythrocyte-specific MHC antigen. Characterization and purification of the B-G antigen by monoclonal antibodies. Immunogenetics, 25, 373–382. doi: 10.1007/BF00396103
  • Schat, K.A. & Nair, V.K. (2008). Marek’s disease. In Y.M. Saif, A.M. Fadly, J.R. Glisson, L.R. McDougald, L.K. Nolan & D.E. Swayne (Eds.), Diseases of Poultry (12th ed., pp. 449–514). Ames, IA: Blackwell Publishing Professionals.
  • Schuren, A.B., Costa, A.I. & Wiertz, E.J. (2016). Recent advances in viral evasion of the MHC class I processing pathway. Current Opinion in Immunology, 40, 43–50. doi: 10.1016/j.coi.2016.02.007
  • Silva, R.F., Dunn, J.R., Cheng, H.H. & Niikura, M. (2010). A MEQ-deleted Marek’s disease virus cloned as a bacterial artificial chromosome is a highly efficacious vaccine. Avian Diseases, 54, 862–869. doi: 10.1637/9048-090409-Reg.1
  • Swaggerty, C.L., Pevzner, I.Y., Kaiser, P. & Kogut, M.H. (2008). Profiling pro-inflammatory cytokine and chemokine mRNA expression levels as a novel method for selection of increased innate immune responsiveness. Veterinary Immunology and Immunopathology, 126, 35–42. doi: 10.1016/j.vetimm.2008.06.005
  • Theis, G.A., McBride, R.A. & Schierman, L.W. (1975). Differences in responsiveness to phytohemagglutinin of spleen cells cultured from chickens with acute Marek’s disease. Federation Proceedings, 34, 951–951.
  • Walkden-Brown, S.W., Islam, A., Islam, A.F., Burgess, S.K., Groves, P.J. & Cooke, J. (2013). Pathotyping of Australian isolates of Marek’s disease virus in commercial broiler chickens vaccinated with herpesvirus of turkeys (HVT) or bivalent (HVT/SB1) vaccine and association with viral load in the spleen and feather dander. Australian Veterinary Journal, 91, 341–350. doi: 10.1111/avj.12084
  • Witter, R.L. (1997). Increased virulence of Marek’s disease virus field isolates. Avian Diseases, 41, 149–163. doi: 10.2307/1592455
  • Witter, R.L., Calnek, B.W., Buscaglia, C., Gimeno, I.M. & Schat, K.A. (2005). Classification of Marek’s disease viruses according to pathotype: philosophy and methodology. Avian Pathology, 34, 75–90. doi: 10.1080/03079450500059255
  • Witter, R.L. & Kreager, K.S. (2004). Serotype 1 viruses modified by backpassage or insertional mutagenesis: approaching the threshold of vaccine efficacy in Marek’s disease. Avian Diseases, 48, 768–782. doi: 10.1637/7203-050304R
  • Witter, R.L., Nazerian, K., Purchase, H.G. & Burgoyne, G.H. (1970). Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek’s disease virus. American Journal of Veterinary Research, 31, 525–538.
  • Witter, R.L., Sharma, J.M. & Fadly, A.M. (1980). Pathogenicity of variant Marek’s disease virus isolants in vaccinated and unvaccinated chickens. Avian Diseases, 24, 210–232. doi: 10.2307/1589781
  • York, J.J. & Fahey, K.J. (1990). Humoral and cell-mediated immune responses to the glycoproteins of infectious laryngotracheitis herpesvirus. Archives of Virology, 115, 289–297. doi: 10.1007/BF01310537
  • Yu, C., Liu, Q., Qin, A., Hu, X., Xu, W., Qian, K., Shao, H. & Jin, W. (2013). Expression kinetics of chicken beta2-microglobulin and class I MHC in vitro and in vivo during Marek’s disease viral infections. Veterinary Research Communications, 37, 277–283. doi: 10.1007/s11259-013-9572-z
  • Yunis, R., Jarosinski, K.W. & Schat, K.A. (2004). Association between rate of viral genome replication and virulence of Marek’s disease herpesvirus strains. Virology, 328, 142–150. doi: 10.1016/j.virol.2004.07.017

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