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Original Articles

CRYSTAL AND MOLECULAR STRUCTURE OF 2-OXO-BIS(2-β-CHLOROETHYLAMINO)-4,6-DIMETHYL-1,3,2-OXAZAPHOSPHORINANE: AN ANALOGUE OF CYCLOPHOSPHAMIDE

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Pages 287-293 | Received 29 May 1981, Accepted 25 Oct 1981, Published online: 03 Jan 2007

References

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  • Bartczak , T. J. , Christensen , A. , Kinas , R. and Stec , W. J. 1975 . Cryst. Struct. Comm. , 4 : 701 This geometry is also closely realized in the related systems 10, and 11 (A. Grand, J. B. Robert and A. Filhol, Acta Crystallogr., B33, 1526 (1977)).
  • Cameron , T. S. and Karolak‐Wojciechowska , J. 1977 . Acta Crystallogr. , B33 : 2342 It should be noted that a CNH moiety has a considerable tendency to be axial despite the absence of an equatorial group on the ring. Thus not only the S(—) enantiomer of 2 is consistent with this no‐tion but the same is true for compounds 12, and 13 (T. S. Cameron, Z. Galdecki and J. Karolak‐Wojciechowska, Acta Crystallogr., B32, 492 (1976). In all three cases, however, the plane defined by the nitrogen and its pendant atoms is twisted away from coplanarity with the O=P—N plane suggesting the presence of prohibitively large syn‐1,3‐diaxal interactions even with the N—H hydrogen
  • Johnson , C. A. 1971 . ORTEP‐II, A Fortran Thermal‐Ellipsoid Plot Program for Crystal Structure Illustrations , Oak Ridge, Tenn. : Oak Ridge National Laboratory . U.S. Atomic Energy Commission Report ORNYL‐3794, Second Revision with Supplemental Instructions

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