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Original Articles

DIASTEREOSELECTIVITY IN THE ALKYLATION OF CHIRAL 2-AMINOMETHYL-1,3,2-DIOXAPHOSPHORINANE 2-OXIDES

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Pages 1-14 | Received 15 Sep 1986, Accepted 27 Dec 1986, Published online: 19 Dec 2006

References

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  • These results provide further evidence that the lower homolog 1D-d undergoes alkylation from the C-equatorial conformation (1Deq). Consistent with this interpretation is the observation that alkylation of the trimethyl derivative 5T-e, in which the carbanion is fixed in the equatorial position, shows a slight selectivity (9% de) for the diastereomer corresponding to (4R,6R)-4D-d i.e., asymmetric induction of the same relative sense.
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