Cytotoxicity of gamma irradiated aflatoxin B₁ and ochratoxin A

References

• Reddy, K. R. N.; Salleh, B.; Saad, B.; Abbas, H. K.; Abel, C. A.; Shier, W. T. An overview of mycotoxin contamination in foods and its implications for human health. Toxin. Rev. 2010, 29, 3–26.
   Web of Science ®Google Scholar
• Streit, E.; Schatzmayr, G.; Tassis, P.; Tzika, E.; Marin, D.; Taranu, I.; Tabuc, K.; Nicolau, A.; Aprodu, I.; Puel, O.; Oswald, I. P. Current situation of mycotoxin contamination and co-occurrence in animal feed - focus on Europe. Toxins 2012, 4, 788–809. doi: 10.3390/toxins4100788
   PubMed Web of Science ®Google Scholar
• Pinotti, L.; Ottoboni, M.; Giromini, C.; Dell’Orto, V.; Cheli, F. Mycotoxin contamination in the EU feed supply chain: A focus on cereal byproducts. Toxins 2016, 8, 45. doi: 10.3390/toxins8020045
   PubMed Web of Science ®Google Scholar
• International Programme on Chemical Safety, IPCS. Safety evaluation of certain mycotoxins in food. WHO Food Add Ser. 2001, 47, 103–415.
   Google Scholar
• International Agency for Research on Cancer, IARC. Some traditional herbal medicines, some mycotoxins, naphthalene, and styrene. IARC Monographs. Vol. 82, IARC, Lyon, 2002.
   Google Scholar
• International Agency for Research on Cancer, IARC. Some naturally occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 56, IARC, Lyon, 1993.
   Google Scholar
• Commission Regulation (EU) 1881/2006.of 19 December 2006. setting maximum levels for certain contaminants in foodstuffs. Off. J. L 364:5–24.
   Google Scholar
• Commission Recommendation No. Off. J. L 2013, Vol. 91, 12–15. /165/EU of 27 March 2013 on the Presence of T-2 and HT-2 Toxin in Cereals and Cereal Products.
   Google Scholar
• Aziz, N. H.; Moussa, L. A. A. Influence of gamma-radiation on mycotoxin producing moulds and mycotoxins in fruits. Food Control 2002, 13, 281–288.
   Web of Science ®Google Scholar
• Jalili, M.; Jinap, S.; Noranizan, M. A. Aflatoxins and ochratoxin a reduction in black and white pepper by gamma radiation. Rad. Phys. Chem. 2012, 81, 1786–1788.
   Web of Science ®Google Scholar
• Kumar, S.; Kunwar, A.; Gautam, S.; Sharma, A. Inactivation of A. ochraceus spores and detoxification of ochratoxin a in coffee beans by gamma irradiation. J. Food Sci. 2012, 77, 44–51.
   PubMed Web of Science ®Google Scholar
• Iqbal, S. Z.; Bhatti, I. A.; Asi, M. R.; Zuber, M.; Shahid, M.; Parveen, I. Effect of γ irradiation on fungal load and aflatoxins reduction in red chillies. Rad. Phys. Chem. 2013, 82, 80–84.
   Web of Science ®Google Scholar
• Domijan, A.-M.; Pleadin, J.; Mihaljević, B.; Vahčić, N.; Frece, J.; Markov, K. Reduction of ochratoxin a in dry-cured meat products using gamma-irradiation. Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess 2015, 32, 1185–1191.
   PubMed Web of Science ®Google Scholar
• Markov, K.; Mihaljević, B.; Domijan, A.-M.; Pleadin, J.; Delaš, F.; Frece, J. Inactivation of aflatoxicogenic fungi and the reduction of aflatoxin B1 in vitro and in situ using gamma irradiation. Food Control 2015, 54, 79–85.
   Web of Science ®Google Scholar
• Ražem, D.; Anđelić, L. J.; Dvornik, I. Consistency of ethanol-chlorobenzene dosimetry. Proceedings of IAEA Symposium on High-Dose Dosimetry. IAEA: Vienna, 1984; 143–156.
   Google Scholar
• Chan, H. T.; Chan, C.; Ho, J. W. Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells. Toxicology 2003, 188, 211–217.
   PubMed Web of Science ®Google Scholar
• Lei, M. M.; Zhang, N.; Qi, D. In vitro investigation of individual and combined cytotoxic effects of aflatoxin B1 and other selected mycotoxins on the cell line porcine kidney 15. Exp. Toxicol. Pathol. 2013, 65, 1149–1157.
   PubMed Web of Science ®Google Scholar
• Nones, J.; Nones, J.; Trentin, A. G. Flavonoid hesperidin protects neural crest cells from death caused by aflatoxin B(1). Cell Biol. Int. 2013, 37, 181–186.
   PubMed Web of Science ®Google Scholar
• Sun, L. H.; Lei, M. Y.; Zhang, N. Y.; Gao, X.; Li, C.; Krumm, C. S.; Qi, D. S. Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. Toxicon 2015, 95, 6–12.
   PubMed Web of Science ®Google Scholar
• Cao, J.; Liu, Y.; Jia, L.; Jiang, L. P.; Geng, C. Y.; Yao, X. F.; Kong, Y.; Jiang, B. N.; Zhong, L. F. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J. Agric. Food Chem. 2008, 56, 12059–12063.
   PubMed Web of Science ®Google Scholar
• Ehrlich, V.; Darroudi, F.; Uhl, M.; Steinkellner, H.; Zsivkovits, M.; Knasmueller, S. Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells. Mutagenesis 2002, 17, 257–260.
   PubMed Web of Science ®Google Scholar
• Costa, S.; Utan, A.; Speroni, E.; Cervellati, R.; Piva, G.; Prandini, A.; Guerra, M. C. Carnosic acid from rosemary extracts: A potential chemoprotective agent against Aflatoxin B1. An in vitro study. J. Appl. Toxicol. 2007, 27, 152–159.
   PubMed Web of Science ®Google Scholar
• Ghaderi, M.; Allameh, A.; Soleimani, M.; Rastegar, H.; Ahmadi-Ashtiani, H. R. A comparison of DNA damage induced by aflatoxin B1 in hepatocyte-like cells, their progenitor mesenchymal stem cells and CD34+ cells isolated from umbilical cord blood. Mut. Res. Gen. Toxicol. Environ. Mutag. 2011, 719, 14–20.
   Web of Science ®Google Scholar
• Liu, Y.; Du, M.; Zhang, G. Proapoptotic activity of Aflatoxin B1 and sterigmatocystin in HepG2 Cells. Toxicol. Report 2014, 1, 1076–1086.
   PubMedGoogle Scholar
• Corcuera, L. A.; Arbillaga, L.; Vettorazzi, A.; Azqueta, A.; López de Cerain, A. Ochratoxin a reduces Aflatoxin B1 induced DNA damage detected by the comet assay in Hep G2 cells. Food Chem. Toxicol. 2011, 49, 2883–2889.
   PubMed Web of Science ®Google Scholar
• Zhang, X.; Boesch-Saadatmandi, C.; Lou, Y.; Wolffram, S.; Huebbe, P.; Rimbach, G. Ochratoxin a induces apoptosis in neuronal cells. Genes Nutr. 2009, 4, 41–48.
   PubMed Web of Science ®Google Scholar
• Hundhausen, C.; Bosch-Saadatmandi, C.; Augustin, K.; Blank, R.; Wolffram, S.; Rimbach, G. Effect of vitamin E and polyphenols on Ochratoxin A-induced cytotoxicity in liver (HepG2) cells. J. Plant Physiol. 2005, 162, 818–822.
   PubMed Web of Science ®Google Scholar
• Boesch-Saadatmandi, C.; Loboda, A.; Jozkowicz, A.; Huebbe, P.; Blank, R.; Wolffram, S.; Dulak, J.; Rimbach, G. Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells. Food Chem. Toxicol. 2008, 46, 2665–2671.
   PubMed Web of Science ®Google Scholar
• Boesch-Saadatmandi, C.; Wagner, A. E.; Graeser, A. C.; Hundhausen, C.; Wolffram, S.; Rimbach, G. Ochratoxin a impairs Nrf2-dependent gene expression in porcine kidney tubulus cells. J. Anim. Physiol. Anim. Nutr. 2009, 93, 547–554.
   PubMed Web of Science ®Google Scholar
• Gayathri, L.; Dhivya, R.; Dhanasekaran, D.; Periasamy, V. S.; Alshatwi, A. A.; Akbarsha, M. A. Hepatotoxic effect of Ochratoxin A and citrinin, alone and in combination, and protective effect of vitamin E: In vitro study in HepG2 cell. Food Chem. Toxicol. 2015, 83, 151–163.
   PubMed Web of Science ®Google Scholar
• Calado, T.; Fernández-Cruz, M. L.; Cabo Verde, S.; Venâncio, A.; Abrunhosa, L. Gamma irradiation effects on Ochratoxin A: Degradation, cytotoxicity and application in food. Food Chem. 2018, 240, 463–471.
   PubMed Web of Science ®Google Scholar
• Calado, T.; Venancio, A.; Abrunhosa, L. Irradiation for mould and mycotoxin control: A review. Comp Rev. Food Sci. Food Saf. 2014, 13, 1049–1061.
   Web of Science ®Google Scholar
• Wang, F.; Xie, F.; Xue, X.; Wang, Z.; Fan, B.; Ha, Y. Structure elucidation and toxicity analyses of the radiolytic products of Aflatoxin B1 in methanol-water solution. J. Hazard Mat. 2011, 192, 1192–1202.
   PubMed Web of Science ®Google Scholar
• Mutluer, B.; Erko, F. U. Effects of gamma irradiation on aflatoxins. Z Lebensm. Unters. Forch. 1987, 185, 398–401.
   PubMedGoogle Scholar
• Mishra, H. N.; Das, C. A review on biological control and metabolism of aflatoxin. Crit. Rev. Food Sci. Nutr. 2003, 43, 245–264.
   PubMed Web of Science ®Google Scholar
• Wogan, G. N.; Edwards, G. S.; Newberne, P. M. Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogues. Cancer Res. 1971, 31, 1936–1942.
   PubMed Web of Science ®Google Scholar
• Aziz, N. H.; Souzan, R. M.; Azza, A. Effect of gamma-irradiation on the occurrence of pathogenic microorganisms and nutritive value of four principal cereal grains. App. Rad. Isotopes 2006, 64, 1555–1562.
   PubMed Web of Science ®Google Scholar
• Taipina, M. S.; Garbelotti, M. L.; Lamardo, L. C. A.; Santos, J. S.; Rodas, M. A. B. The effect of gamma irradiation on the nutritional properties of sunflower whole grain cookies. Proc. Food Sci. 2011, 1, 1992–1996.
   Google Scholar
• Hamza, R. G.; Afifi, S.; Abdel-Ghaffar, A.-R. B.; Borai, I. H. Effect of gamma-irradiation or/and extrusion on the nutritional value of soy flour. Biochem. Anal. Biochem. 2012, 1, 118. doi: 10.4172/2161-1009.1000118
   Google Scholar
• World Health Organisation (WHO). High-dose irradiation: Wholesomeness of food irradiated with doses above 10 KGy. Joint FAO/IAEA/WHO study group. Technical Report Series, No. 890. 1999, Geneva.
   Google Scholar