The Endoplasmic Reticulum in Xenobiotic Toxicity

References

• Abramowicz, M., Edelmann, C. M. Jr. (1968). Nephrotoxicity of anti-infective drugs. Clin. Pediatr. (Phila.) 7(7):389–390. [CSA]
   PubMed Web of Science ®Google Scholar
• Adams, J. D. Jr, et al. (1995). Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. Chem. Biol. Interact. 95(1–2):57–77. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Aithal, G. P., , et al. (2004). Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology 39(5):1430–1440. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Aoyama, T., , et al. (1990). Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. Proc. Natl. Acad. Sci. U. S. A. 87(12):4790–4793. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bedard, K. (2002). Endoplasmic reticulum stress proteins in chemically mediated cytotoxicity. In: Biomedical Sciences. Charlottetown: University of Prince Edward Island.
   Google Scholar
• Bedard, K., , et al. (2004). Cytoprotection following endoplasmic reticulum stress protein induction in continuous cell lines. Basic Clin. Pharmacol. Toxicol. 94(3):124–131. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Belloc, C., , et al. (1997). Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis. Pharmacogenetics 7(3):181–186. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Berridge, M. J. (2002). The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32(5–6):235–249. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Berridge, M. J., Lipp, P., Bootman, M. D. (2000). The versatility and universality of calcium signalling. Nat. Rev., Mol. Cell. Biol. 1(1):11–21. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bertolotti, A., , et al. (2000). Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2(6):326–332. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Birge, R. B., , et al. (1991). The arylation of microsomal membrane proteins by acetaminophen is associated with the release of a 44 kDa acetaminophen-binding mouse liver protein complex into the cytosol. Toxicol. Appl. Pharmacol. 109(3):443–454. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bock, K. W., Lilienblum, W., von Bahr, C. (1984). Studies of UDP-glucuronyltransferase activities in human liver microsomes. Drug Metab. Dispos. 12(1):93–97. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Boelsterli, U. A. (2003). Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Toxicol. Appl. Pharmacol. 192(3):307–322. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bourdi, M., , et al. (1990). Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. J. Clin. Invest. 85(6):1967–1973., [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bourdi, M., , et al. (1992). Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug. Mol. Pharmacol. 42(2):280–285. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bourdi, M., , et al. (1996). Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chem. Res. Toxicol. 9(7):1159–1166. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Boya, P., , et al. (2002). Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ. 9(4):465–467. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Breckenridge, D. G., , et al. (2002). The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proc. Natl. Acad. Sci. U. S. A. 99(7):4331–4336. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Breckenridge, D. G., , et al. (2003). Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22(53):8608–8618. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bulera, S. J., , et al. (1995). Identification of the mouse liver 44-kDa acetaminophen-binding protein as a subunit of glutamine synthetase. Toxicol. Appl. Pharmacol. 134(2):313–320. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bush, K. T., , et al. (1999). Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion. Am. J. Physiol. 277(2 Pt. 2):F211–F218. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Calfon, M., , et al. (2002). IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415(6867):92–96. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cashman, J. R. (1995). Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem. Res. Toxicol. 8(2):166–181. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chae, H. J., , et al. (2004). BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell 15(3):355–366. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chatterjee, S., , et al. (1994). Induction of M(r) 78,000 glucose-regulated stress protein in poly(adenosine diphosphate-ribose) polymerase- and nicotinamide adenine dinucleotide-deficient V79 cell lines and its relation to resistance to the topoisomerase II inhibitor etoposide. Cancer Res. 54(16):4405–4411. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Chatterjee, P. K., , et al. (2001). Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59(6):2073–2083. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cribb, A. (2004) Predicting idiosyncratic reactions. In: Borchart, R., ed. Lead Optimization During Drug Development. AAPS, Vol. In press.
   Google Scholar
• Cribb, A. E., , et al. (1996). Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection. Chem. Res. Toxicol. 9(2):500–507. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cribb, A. E., , et al. (1997). Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins. J. Pharmacol. Exp. Ther. 282(2):1064–1071. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cribb, A. E., Bedard, K., Ryan, P., MacDonald, N., Collins, J. (2002). Role of endoplasmic reticulum stress proteins in in vitro toxicity. In Invitox. Formia, Italy.
   Google Scholar
• Cribb, A. E., Ryan, P., Bedard, K. (2004b). Disruption of the endoplasmic reticulum in oxidant-induced cell death. Drug Metab. Rev. 36(s1):230. [CSA]
   Google Scholar
• Cybulsky, A. V., , et al. (2002). Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J. Biol. Chem. 277(44):41342–41351. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dalet-Beluche, I., , et al. (1992). Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms. Eur. J. Biochem. 204(2):641–648. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• De Berardinis, V., , et al. (2000). Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. Mol. Pharmacol. 58(3):542–551. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• de Waziers, I., , et al. (1990). Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253(1):387–394. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• de Wildt, S. N., , et al. (1999). Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin. Pharmacokinet. 36(6):439–452. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• DeGracia, D. J., , et al. (2002). Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death. J. Cereb. Blood Flow Metab. 22(2):127–141. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Delescluse, C., , et al. (2001). Induction of cytochrome P450 1A1 Gene Expr.ession, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem. Pharmacol. 61(4):399–407. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Delpino, A., Castelli, M. (2002). The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation. Biosci. Rep. 22(3–4):407–420. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Delpino, A., , et al. (1998). Cell surface localization of the 78 kD glucose regulated protein (GRP 78) induced by thapsigargin. Mol. Membr. Biol. 15(1):21–26. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ding, V. D., Pickett, C. B. (1985). Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene. Arch. Biochem. Biophys. 240(2):553–559. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Distlerath, L. M., , et al. (1985). Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem. 260(15):9057–9067. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Donato, M. T., , et al. (2000). CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers. Drug Metab. Dispos. 28(11):1321–1326. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Dostal, L. A., , et al. (1986). Cytosolic glutathione S-transferases in various rat tissues differ in stereoselectivity with polycyclic arene and alkene oxide substrates. Drug Metab. Dispos. 14(3):303–309. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Doutheil, J., , et al. (1999). Recovery of neuronal protein synthesis after irreversible inhibition of the endoplasmic reticulum calcium pump. Cell Calcium 25(6):419–428. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Doutheil, J., , et al. (2000). Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism. Cell Calcium 27(2):107–115. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Edwards, R. J., , et al. (1998). Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. Biochem. Pharmacol. 56(3):377–387. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Eliasson, E., Kenna, J. G. (1996). Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol. Pharmacol. 50(3):573–582. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Finnie, J. W., O'Shea, J. D. (1989). Acute hepatotoxicity with resultant pulmonary and cerebral embolism in guinea pigs given tunicamycin. Pathology 21(3):194–199. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Fischer, H., , et al. (2002). Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293(2):722–726. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Freedman, R. B., Hirst, T. R., Tuite, M. F. (1994). Protein disulphide isomerase: building bridges in protein folding. Trends Biochem. Sci. 19(8):331–336. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Fujita, E., , et al. (2002). Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells. Cell Death Differ. 9(10):1108–1114. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ged, C., , et al. (1989). The increase in urinary excretion of 6 β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br. J. Clin. Pharmacol. 28(4):373–387. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Gerbal-Chaloin, S., , et al. (2001). Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab. Dispos. 29(3):242–251. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Gerbal-Chaloin, S., , et al. (2002). Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. J. Biol. Chem. 277(1):209–217. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Gilmore, W. J., Kirby, G. M. (2004). Endoplasmic reticulum stress due to altered cellular redox status positively regulates murine hepatic CYP2A5 expression. J. Pharmacol. Exp. Ther. 308(2):600–608. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gilmore, W. J., , et al. (2003). Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression. Toxicology 184(2–3):211–226. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Goering, P. L., Fisher, B. R., Kish, C. L. (1993). Stress protein synthesis induced in rat liver by cadmium precedes hepatotoxicity. Toxicol. Appl. Pharmacol. 122(1):139–148. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Goering, P. L., , et al. (2000). Mercury induces regional and cell-specific stress protein expression in rat kidney. Toxicol. Sci. 53(2):447–457. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gonzalez, F. J. (1992). Human cytochromes P450: problems and prospects. Trends Pharmacol. Sci. 13(9):346–352. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gonzalez, F. J., Gelboin, H. V. (1994). Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 26(1–2):165–183. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Groenendyk, J., Lynch, J., Michalak, M. (2004). Calreticulin, Ca2 + , and calcineurin—signaling from the endoplasmic reticulum. Mol. Cells 17(3):383–389. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Grover, A. K., Kwan, C. Y., Samson, S. E. (2003). Effects of peroxynitrite on sarco/endoplasmic reticulum Ca2 + pump isoforms SERCA2b and SERCA3a. Am. J. Physiol., Cell Physiol. 285(6):C1537–C1543. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Guengerich, F. P., , et al. (1999). Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. Mutat. Res. 428(1–2):115–124. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Gut, J., Christen, U., Huwyler, J. (1993). Mechanisms of halothane toxicity: novel insights. Pharmacol. Ther. 58(2):133–155. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hacki, J., , et al. (2000). Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 19(19):2286–2295. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Haining, R. L., , et al. (1997). Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization. Drug Metab. Dispos. 25(7):790–797. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Halleck, M. M., , et al. (1997). Reduction of trans-4,5-dihydroxy-1,2-dithiane by cellular oxidoreductases activates gadd153/chop and grp78 transcription and induces cellular tolerance in kidney epithelial cells. J. Biol. Chem. 272(35):21760–21766. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hankinson, O. (1995). The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35:307–340. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harding, H. P., Zhang, Y., Ron, D. (1999). Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397(6716):271–274. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harding, H. P., , et al. (2002). Transcriptional and translational control in the Mammalian unfolded protein response. Annu. Rev. Cell Dev. Biol. 18:575–599. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harding, H. P., , et al. (2003). An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11(3):619–633. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harman, A. W., Maxwell, M. J. (1995). An evaluation of the role of calcium in cell injury. Annu. Rev. Pharmacol. Toxicol. 35:129–144. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harriman, J. F., , et al. (2002). Endoplasmic reticulum Ca(2 + ) signaling and calpains mediate renal cell death. Cell Death Differ. 9(7):734–741. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hayes, J. D., Pulford, D. J. (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30(6):445–600. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Haze, K., , et al. (1999). Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10(11):3787–3799. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Holownia, A., Braszko, J. J. (2004). Acetaminophen alters microsomal ryanodine Ca2 + channel in HepG2 cells overexpressing CYP2E1. Biochem. Pharmacol. 68(3):513–521., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Horibe, T., , et al. (2001). Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem. Biophys. Res. Commun. 289(5):967–972. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Horibe, T., , et al. (2002a). Aminoglycoside antibiotics bind to protein disulfide isomerase and inhibit its chaperone activity. J. Antibiot. (Tokyo) 55(5):528–530. [CSA]
   PubMed Web of Science ®Google Scholar
• Horibe, T., , et al. (2002b). The chaperone activity of protein disulfide isomerase is affected by cyclophilin B and cyclosporin A in vitro. J. Biochem. (Tokyo) 132(3):401–407. [CSA]
   PubMed Web of Science ®Google Scholar
• Horibe, T., , et al. (2004). Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity. Biochem. Biophys. Res. Commun. 323(1):281–287. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hosokawa, M., Maki, T., Satoh, T. (1988). Differences in the induction of carboxylesterase isozymes in rat liver microsomes by xenobiotics. Biochem. Pharmacol. 37(13):2708–2711. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hosokawa, M., Hattori, K., Satoh, T. (1993). Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 α-carbonitrile. Biochem. Pharmacol. 45(11):2317–2322. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Howell, S. R., Hazelton, G. A., Klaassen, C. D. (1986). Depletion of hepatic UDP-glucuronic acid by drugs that are glucuronidated. J. Pharmacol. Exp. Ther. 236(3):610–614. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Huang, Q., , et al. (2001). Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol. Sci. 63(2):196–207. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hung, C. C., , et al. (2003). Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J. Biol. Chem. 278(31):29317–29326. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hwang, C., Sinskey, A. J., Lodish, H. F. (1992). Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257(5076):1496–1502. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Jaeschke, H., , et al. (2002). Mechanisms of hepatotoxicity. Toxicol. Sci. 65(2):166–176. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jakobsson, P. J., , et al. (1997). Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. J. Biol. Chem. 272(36):22934–22939. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jarosch, E., Lenk, U., Sommer, T. (2003). Endoplasmic reticulum-associated protein degradation. Int. Rev. Cyt. 223:39–81. [CSA]
   PubMed Web of Science ®Google Scholar
• Ji, C., Kaplowitz, N. (2003). Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124(5):1488–1499. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jia, Z., , et al. (2004). Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells. Am. J. Physiol., Renal Physiol. 287(6):F1113–F1122. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jimbo, A., , et al. (2003). ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation. Exp. Cell Res. 283(2):156–166. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jin, Q. H., Zhao, B., Zhang, X. J. (2004). Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418. Cell. Mol. Life Sci. 61(14):1816–1825. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jones, D. P., , et al. (1983). Inhibition of ATP-dependent microsomal Ca2 + sequestration during oxidative stress and its prevention by glutathione. J. Biol. Chem. 258(10):6390–6393. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Justo, P., , et al. (2003). Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis. J. Am. Soc. Nephrol. 14(12):3072–3080. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kaufman, R. J. (1999a). Molecular chaperones and the heat shock response. Biochim. Biophys. Acta 1423(1):R13–R27. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Kaufman, R. J. (1999b). Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13(10):1211–1233. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kenna, J. G., Neuberger, J., Williams, R. (1988). Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis. Hepatology 8(6):1635–1641. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ketterman, A. J., Bowles, M. R., Pond, S. M. (1989). Purification and characterization of two human liver carboxylesterases. Int. J. Biochem. 21(12):1303–1312., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Kimura, S., Gonzalez, F. J., Nebert, D. W. (1986). Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Mol. Cell. Biol. 6(5):1471–1477. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Koen, Y. M., Hanzlik, R. P. (2002). Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene. Chem. Res. Toxicol. 15(5):699–706. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kretz-Rommel, A., Boelsterli, U. A. (1994). Selective protein adducts to membrane proteins in cultured rat hepatocytes exposed to diclofenac: radiochemical and immunochemical analysis. Mol. Pharmacol. 45(2):237–244. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lame, M. W., , et al. (2000). Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells. J. Biol. Chem. 275(37):29091–29099. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lamkanfi, M., Kalai, M., Vandenabeele, P. (2004). Caspase-12: an overview. Cell Death Differ. 11(4):365–368. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lecoeur, S., , et al. (1994). Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs. Chem. Res. Toxicol. 7(3):434–442. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ledoux, S., , et al. (2003). Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response. Cancer Res. 63(21):7284–7290. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lee, A. S. (2001). The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem. Sci. 26(8):504–510. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lee, S. S., , et al. (1996). Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol. Chem. 271(20):12063–12067. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lee, J., , et al. (1999). 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins. J. Neurosci. Res. 57(1):48–61. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Leeder, J. S., , et al. (1996). Epitope mapping studies with human anti-cytochrome P450 3A antibodies. Mol. Pharmacol. 49(2):234–243. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lehmann, J. M., , et al. (1998). The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 Gene Expr.ession and cause drug interactions. J. Clin. Invest. 102(5):1016–1023. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lewis, D. F. (2004). 57 varieties: the human cytochromes P450. Pharmacogenomics 5(3):305–318. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Li, J., Holbrook, N. J. (2004). Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress. Exp. Gerontol. 39(5):735–744. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lieber, C. S. (1997). Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257(1):59–84. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Limaye, P. B., , et al. (2003). Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 191(3):211–226. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Little, E., , et al. (1994). The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit. Rev. Eukaryot. Gene Expr. 4(1):1–18. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Liu, X., Schnellmann, R. G. (2003). Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death. J. Pharmacol. Exp. Ther. 304(1):63–70. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu, H., , et al. (1997). Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2 + disturbances, and cell death in renal epithelial cells. J. Biol. Chem. 272(35):21751–21759. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu, H., , et al. (1998). Endoplasmic reticulum stress proteins block oxidant-induced Ca2 + increases and cell death. J. Biol. Chem. 273(21):12858–12862. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu, X., , et al. (2001). Calpains mediate acute renal cell death: role of autolysis and translocation. Am. J. Physiol., Renal Physiol. 281(4):F728–F738. [CSA]
   PubMed Web of Science ®Google Scholar
• Liu, X., Harriman, J. F., Schnellmann, R. G. (2002a). Cytoprotective properties of novel nonpeptide calpain inhibitors in renal cells. J. Pharmacol. Exp. Ther. 302(1):88–94., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu, C. Y., , et al. (2002b). The protein kinase/endoribonuclease IRE1α that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J. Biol. Chem. 277(21):18346–18356. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu, X., Van Vleet, T., Schnellmann, R. G. (2004). The role of calpain in oncotic cell death. Annu. Rev. Pharmacol. Toxicol. 44:349–370. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lluis, J. M., , et al. (2003). Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 124(3):708–724. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lodish, H. F., Kong, N. (1990). Perturbation of cellular calcium blocks exit of secretory proteins from the rough endoplasmic reticulum. J. Biol. Chem. 265(19):10893–10899. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Loeper, J., , et al. (1993). Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology 104(1):203–216. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Loeper, J., , et al. (2001). Human epoxide hydrolase is the target of germander autoantibodies on the surface of human hepatocytes: enzymatic implications. Adv. Exp. Med. Biol. Expr. 500:121–124. [CSA]
   PubMed Web of Science ®Google Scholar
• Lorz, C., , et al. (2004). Paracetamol-induced renal tubular injury: a role for ER stress. J. Am. Soc. Nephrol. 15(2):380–389. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Luhe, A., , et al. (2003). A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays. Toxicol. Sci. 73(2):315–328. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lund-Pero, M., , et al. (1994). Non-specific steroidal esterase activity and distribution in human and other mammalian tissues. Clin. Chim. Acta 224(1):9–20. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lytton, J., Westlin, M., Hanley, M. R. (1991). Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266(26):17067–17071. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lytton, J., , et al. (1992). Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J. Biol. Chem. 267(20):14483–14489. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Maki, T., , et al. (1991). Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis. Jpn. J. Cancer Res. 82(7):800–806. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Manchanda, T., , et al. (2002). Haptenation of sulfonamide reactive metabolites to cellular proteins. Mol. Pharmacol. 62(5):1011–1026. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mandic, A., , et al. (2003). Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J. Biol. Chem. 278(11):9100–9106. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Masubuchi, Y., Horie, T. (1998). Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes. Drug Metab. Dispos. 26(4):338–342. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Masubuchi, Y., Horie, T. (1999). Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes. Chem. Res. Toxicol. 12(10):1028–1032. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• McCracken, N. W., Blain, P. G., Williams, F. M. (1993). Human xenobiotic metabolizing esterases in liver and blood. Biochem. Pharmacol. 46(7):1125–1129. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• McCullough, K. D., , et al. (2001). Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21(4):1249–1259. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Meacham, R. H. Jr, et al. (1986). Inhibition of ciramadol glucuronidation by benzodiazepines. Drug Metab. Dispos. 14(4):430–436. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Meyer, U. A. (1996). Overview of enzymes of drug metabolism. J. Pharmacokinet. Biopharm. 24(5):449–459. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Mimura, M., , et al. (1993). Characterization of cytochrome P-450 2B6 in human liver microsomes. Drug Metab. Dispos. 21(6):1048–1056. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Miners, J. O., Mackenzie, P. I. (1991). Drug glucuronidation in humans. Pharmacol. Ther. 51(3):347–369. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Miners, J. O., , et al. (2004). Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches. Annu. Rev. Pharmacol. Toxicol. 44:1–25., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Miyazaki, T., , et al. (2004). 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin. J. Biol. Chem. 279(17):17295–17300. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mizunaga, T., , et al. (1990). Purification and characterization of yeast protein disulfide isomerase. J. Biochem. (Tokyo) 108(5):846–851. [CSA]
   PubMed Web of Science ®Google Scholar
• Moore, L., Rodman Davenport, G., Landon, E. J. (1976). Calcium uptake of a rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride. J. Biol. Chem. 251(4):1197–1201. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Moore, L. B., , et al. (2000). Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 275(20):15122–15127. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Morgenstern, R., , et al. (1984). The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms. Biochem. Pharmacol. 33(22):3609–3614. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Morishima, N., , et al. (2002). An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277(37):34287–34294. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Murray, G. I., , et al. (1988). The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450. Br. J. Clin. Pharmacol. 25(4):465–475. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Nakagawa, T., Yuan, J. (2000). Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 150(4):887–894. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nakagawa, T., , et al. (2000). Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403(6765):98–103. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nelson, D. R., , et al. (2004). Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14(1):1–18. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Neuberger, J., Williams, R. (1989). Immune mechanisms in tienilic acid associated hepatotoxicity. Gut 30(4):515–519. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Neumar, R. W., , et al. (2003). Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J. Biol. Chem. 278(16):14162–14167. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Nicholson, D. W., Thornberry, N. A. (1997). Caspases: killer proteases. Trends Biochem. Sci. 22(8):299–306. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Outinen, P. A., , et al. (1998). Characterization of the stress-inducing effects of homocysteine. Biochem. J. 332(Pt. 1):213–221. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Outinen, P. A., , et al. (1999). Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in Gene Expr.ession in human vascular endothelial cells. Blood 94(3):959–967. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Oyadomari, S., Mori, M. (2004). Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11(4):381–389. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Parkinson, A. (1996) Biotransformation of xenobiotics. In: Casarett & Doull's Toxicology: The Basic Science of Poisons. New-York: McGraw-Hill, pp. 113–186.
   Google Scholar
• Paschen, W., Frandsen, A. (2001). Endoplasmic reticulum dysfunction-a common denominator for cell injury in acute and degenerative diseases of the brain? J. Neurochem. 79(4):719–725. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Paschen, W. (2000). Role of calcium in neuronal cell injury: which subcellular compartment is involved? Brain Res. Bull. 53(4):409–413. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Paschen, W. (2001). Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states. Cell Calcium 29(1):1–11. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Paschen, W. (2003a). Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain. Cell Calcium 34(4–5):365–383. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Paschen, W. (2003b). Mechanisms of neuronal cell death: diverse roles of calcium in the various subcellular compartments. Cell Calcium 34(4–5):305–310., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pascussi, J. M., , et al. (2000). Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol. 58(2):361–372. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Paslaru, L., Pinto, M., Morange, M. (1994). GRP78 induction by cyclosporin A in human HeLa cells. FEBS Lett. 350(2–3):304–308. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Patil, C., Walter, P. (2001). Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 13(3):349–355. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pelkonen, O., , et al. (1998). Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28(12):1203–1253. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Phillips, I. R., , et al. (1995). The molecular biology of the flavin-containing monooxygenases of man. Chem. Biol. Interact. 96(1):17–32. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pichard, L., , et al. (1990). Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes. Drug Metab. Dispos. 18(5):595–606. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Pirmohamed, M., , et al. (2002). The danger hypothesis-potential role in idiosyncratic drug reactions. Toxicology 181–182:55–63. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Plaa, G. L. (2000). Chlorinated methanes and liver injury: highlights of the past 50 years. Annu. Rev. Pharmacol. Toxicol. 40:42–65. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Prabhu, K. S., , et al. (2004). Characterization of a class α glutathione-S-transferase with glutathione peroxidase activity in human liver microsomes. Arch. Biochem. Biophys. 424(1):72–80. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pumford, N. R., Halmes, N. C. (1997). Protein targets of xenobiotic reactive intermediates. Annu. Rev. Pharmacol. Toxicol. 37:91–117. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pumford, N. R., , et al. (1993). Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac. Chem. Res. Toxicol. 6(2):147–150. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pumford, N. R., Halmes, N. C., Hinson, J. A. (1997). Covalent binding of xenobiotics to specific proteins in the liver. Drug Metab. Rev. 29(1–2):39–57. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Radominska-Pandya, A., , et al. (1999). Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab. Rev. 31(4):817–899. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rahimtula, A. D., Chong, X. (1991). Alterations in calcium homeostasis as a possible cause of ochratoxin A nephrotoxicity. IARC Sci. Publ. 115):207–214. [CSA]
   PubMedGoogle Scholar
• Rao, R. V., , et al. (2001). Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J. Biol. Chem. 276(36):33869–338674. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rao, R. V., , et al. (2002a). Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 514(2–3):122–128. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Rao, R. V., , et al. (2002b). Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J. Biol. Chem. 277(24):21836–21842. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Reddy, R. K., Lu, J., Lee, A. S. (1999). The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2 + )-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis. J. Biol. Chem. 274(40):28476–28483. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Reid, M. J., , et al. (1998). Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes. J. Biochem. Mol. Toxicol. 12(3):157–166. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Reilly, T. P., , et al. (2000). A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J. Invest. Dermatol. 114(6):1164–1173. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rendic, S., Di Carlo, F. J. (1997). Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 29(1–2):413–580. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Riley, R. J., , et al. (1993). Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s). Biochem. Biophys. Res. Commun. 191(1):32–40., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Robbi, M., Beaufay, H. (1983). Purification and characterization of various esterases from rat liver. Eur. J. Biochem. 137(1–2):293–301. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Robin, M. A., , et al. (1995). Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes. Gastroenterology 108(4):1110–1123. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rushmore, T. H., , et al. (1990). Regulation of glutathione S-transferase Ya subunit Gene Expr.ession: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci. U. S. A. 87(10):3826–3830. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sakaida, I., Thomas, A. P., Farber, J. L. (1991). Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. J. Biol. Chem. 266(2):717–722. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Saleh, M., , et al. (2004). Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429(6987):75–79. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sandoval, R. M., Molitoris, B. A. (2004). Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am. J. Physiol., Renal Physiol. 286(4):F617–F624. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Satoh, T., Hosokawa, M. (1998). The mammalian carboxylesterases: from molecules to functions. Annu. Rev. Pharmacol. Toxicol. 38:257–288. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Scherer, N. M., Deamer, D. W. (1986). Oxidation of thiols in the Ca2 + -ATPase of sarcoplasmic reticulum microsomes. Biochim. Biophys. Acta 862(2):309–317. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Schafer, M., , et al. (2001). Modulation of early [Ca2 + ]i rise in metabolically inhibited endothelial cells by xestospongin C. Am. J. Physiol., Heart Circ. Physiol. 280(3):H1002–H1010. [CSA]
   PubMed Web of Science ®Google Scholar
• Schnellmann, R. G., Williams, S. W. (1998). Proteases in renal cell death: calpains mediate cell death produced by diverse toxicants. Ren. Fail. 20(5):679–686. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Schuetz, E. G., , et al. (1993). Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology 18(5):1254–1262. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Scoggan, K. A., Jakobsson, P. J., Ford-Hutchinson, A. W. (1997). Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. J. Biol. Chem. 272(15):10182–10187. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shaw, S., , et al. (1995). Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells. Clin. Exp. Pharmacol. Physiol. 22(12):924–933. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Shen, X., Zhang, K., Kaufman, R. J. (2004). The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum. J. Chem. Neuroanat. 28(1–2):79–92. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Shou, M., Gonzalez, F. J., Gelboin, H. V. (1996). Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. Biochemistry 35(49):15807–15813. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Skoda, R. C., , et al. (1988). Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. J. Biol. Chem. 263(3):1549–1554. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Steinhauer, L. S., , et al. (1986). Inhibition of carbon tetrachloride induced hepatotoxicity by dantrolene sodium. Res. Commun. Chem. Pathol. Pharmacol. 52(1):59–70. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Stevens, J. L., , et al. (2000). Linking Gene Expr.ession to mechanisms of toxicity. Toxicol. Lett. 112–113:479–486. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Strassburg, C. P., Manns, M. P., Tukey, R. H. (1998). Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J. Biol. Chem. 273(15):8719–8726. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Strassburg, C. P., , et al. (1999). Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem. J. 338(Pt. 2):489–498. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sueyoshi, T., , et al. (1999). The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274(10):6043–6046., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Summan, M., Cribb, A. E. (2002). Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells. Chem. Biol. Interact. 142(1–2):155–173. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Swanson, H. I., Bradfield, C. A. (1993). The AH-receptor: genetics, structure and function. Pharmacogenetics 3(5):213–230. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Szczesna-Skorupa, E., , et al. (2004). Gene Expr.ession changes associated with the endoplasmic reticulum stress response induced by microsomal cytochrome p450 overproduction. J. Biol. Chem. 279(14):13953–13961. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Szeliga, J., Dipple, A. (1998). DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides. Chem. Res. Toxicol. 11(1):1–11. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Takeda, K., , et al. (2003). Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct. Funct. 28(1):23–29. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Terada, K., , et al. (1995). Secretion, surface localization, turnover, and steady state expression of protein disulfide isomerase in rat hepatocytes. J. Biol. Chem. 270(35):20410–20416. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Thummel, K. E., Wilkinson, G. R. (1998). In vitro and in vivo drug interactions involving human CYP3A. Annu. Rev. Pharmacol. Toxicol. 38:389–430. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tournier, C., , et al. (2000). Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288(5467):870–874. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tu, B. P., Weissman, J. S. (2004). Oxidative protein folding in eukaryotes: mechanisms and consequences. J. Cell Biol. 164(3):341–346. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tukey, R. H., Strassburg, C. P. (2000). Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol. 40:581–616. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Udono, H., Levey, D. L., Srivastava, P. K. (1994). Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8 + T cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 91(8):3077–3081. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Uehleke, H., Werner, T. (1975). A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo. Arch. Toxicol. 34(4):289–308. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Uetrecht, J. P. (1999). New concepts in immunology relevant to idiosyncratic drug reactions: the “danger hypothesis” and innate immune system. Chem. Res. Toxicol. 12(5):387–395. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Urano, F., Bertolotti, A., Ron, D. (2000a). IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell. Sci. 113(Pt. 21):3697–3702. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Urano, F., , et al. (2000b). Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287(5453):664–666. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Van, P. N., Peter, F., Soling, H. D. (1989). Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles. J. Biol. Chem. 264(29):17494–17501. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Van de Craen, M., , et al. (1997). Characterization of seven murine caspase family members. FEBS Lett. 403(1):61–69. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• van De Water, B., , et al. (1999). Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment. Chem. Res. Toxicol. 12(10):943–951. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• van der Vlies, D., , et al. (2002). Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem. J. 366(Pt. 3):825–830. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• van der Vlies, D., Woudenberg, J., Post, J. A. (2003). Protein oxidation in aging: endoplasmic reticulum as a target. Amino Acids 25(3–4):397–407. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Villeneuve, J. P., Pichette, V. (2004). Cytochrome P450 and liver diseases. Curr. Drug Metab. 5(3):273–282. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Vittozzi, L., Nastainczyk, W. (1987). Binding of reactive metabolites of CCl4 to specific microsomal proteins. Biochem. Pharmacol. 36(9):1401–1406., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wade, L. T., Kenna, J. G., Caldwell, J. (1997). Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen. Chem. Res. Toxicol. 10(5):546–555. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Waris, G., Tardif, K. D., Siddiqui, A. (2002). Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-κB and STAT-3. Biochem. Pharmacol. 64(10):1425–1430. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Welihinda, A. A., Tirasophon, W., Kaufman, R. J. (1999). The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr. 7(4–6):293–300. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Werstuck, G. H., , et al. (2001). Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J. Clin. Invest. 107(10):1263–1273. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Williams, F. M. (1985). Clinical significance of esterases in man. Clin. Pharmacokinet. 10(5):392–403. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Williams, D. P., Park, B. K. (2003). Idiosyncratic toxicity: the role of toxicophores and bioactivation. Drug Discov. Today 8(22):1044–1050. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Witzmann, F. A., , et al. (1996). Two-dimensional electrophoretic analysis of compartment-specific hepatic protein charge modification induced by thioacetamide exposure in rats. Fundam. Appl. Toxicol. 31(1):124–132. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Wu, M. J., Lai, L. W., Lien, Y. H. (2004). Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells. J. Cell. Physiol. 200(3):395–399. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yoneda, T., , et al. (2001). Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276(17):13935–13940. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Yoshida, H., , et al. (2000). ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20(18):6755–6767. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yoshida, H., , et al. (2001). XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107(7):881–891. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yu, Z., , et al. (1999). The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp. Neurol. 155(2):302–314. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhang, K., Kaufman, R. J. (2004). Signaling the unfolded protein response from the endoplasmic reticulum. J. Biol. Chem. 279(25):25935–25938. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhao, F., , et al. (2001). Dantrolene inhibition of ryanodine receptor Ca2 + release channels. Molecular mechanism and isoform selectivity. J. Biol. Chem. 276(17):13810–13816. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Zhou, L. X., , et al. (1995). Cytochrome P450 catalyzed covalent binding of methoxychlor to rat hepatic, microsomal iodothyronine 5′-monodeiodinase, type I: does exposure to methoxychlor disrupt thyroid hormone metabolism? Arch. Biochem. Biophys. 322(2):390–394. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhou, L., , et al. (1996). The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases. Chem. Res. Toxicol. 9(7):1176–1182. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ziegler, D. M. (1993). Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. Annu. Rev. Pharmacol. Toxicol. 33:179–199. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar