226
Views
14
CrossRef citations to date
0
Altmetric
Research Article

New Horizon of MDR1 (P-glycoprotein) Study

, Ph.D. &
Pages 489-510 | Published online: 09 Oct 2008

References

  • Alvarez, F., Berg, P. A., Bianchi, F. B., , et al. (1999). International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis. J. Hepatol. 31:929–938. [PUBMED], [INFOTRIEVE], [CSA]
  • Asakura, K., Uchida, H., Miyachi, H., Kobayashi, H., Miyakawa, Y., Nimer, S. D., Takahashi, H., Ikeda, Y., Kizaki, M. (2004). TEL/AML1 overcomes drug resistance through transcripitional repression of multidrug resistance-1 gene expression. Mol. Cancer Res. 2:339–347. [PUBMED], [INFOTRIEVE], [CSA]
  • Bai, S., Stepkowski, S. M., Kahan, B. D., Brunner, L. J. (2004). Metabolic interaction between cyclosporine and sirolimus. Transplantation 77:1507–1512. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Bonhomme-Faivre, L., Devocelle, A., Saliba, F., Chatled, S., Maccario, J., Farinotti, R., Picard, V. (2004). MDR-1 C3435T polymorphysm influences cyclosporine a dose requirement in liver-transplant recipients. Transplantation 78:21–25. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Borst, P., Oude Elferink, R. (2002). Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 71:537–592. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Bortolotti, F., Muratori, L., Jara, P., Hierro, L., Verucchi, G., Giacchino, R., Barbera, C., Zancan, L., Guido, M., Resti, M., Pedditzi, S., Bianchi, F., Gatta, A. (2003). Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children. J. Pediatr. 142:185–190. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Carrier, I., Julien, M., Gros, P. (2003). Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein. Biochemistry 42:12875–12885. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., Roninson, I. B. (1986). Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381–389. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Chen, Q., Yang, Y., Liu, Y., Han, B., Zhang, J.-T. (2002). Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1. Biochemistry 41:9052–9062. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Chen, E. Y., Bartlett, M. C., Loo, T. M., Clarke, D. M. (2004). The ΔF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 279:39620–39627. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Choi, C. H., Kim, J. H., Kim, S. H. (2004). Reversal of P-glycoprotein-mediated MGR by 5,7-pentamethoxyflavone and SAR. Biochem. Biophys. Res. Commun. 320:672–679. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Clemente, M. G., Meloni, A., Obermayer-Straub, P., Frau, F., Manns, M. P., De Virgiliis, S. (1998). Two cytochrome P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1. Gastroenterology 114:324–328. [PUBMED], [INFOTRIEVE], [CSA]
  • Costa, M., Rodriguez-Sanchez, J. L., Czaja, A. J., Gelpi, C. (2000). Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from pateints with type-1 autoimmune hepatitis. Clin. Exp. Immunol. 121:364–374., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Dalekos, G. N., Zachou, K., Liaskos, C., Gatselis, N. (2002). Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview. Eur. J. Intern. Med. 13:293–303. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • de Rosa, M. F., Sillence, D., Ackerley, C., Lingwood, C. (2004). Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. J. Biol. Chem. 279:7867–7876. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • de Wet, H., McIntosh, D. B., Conseil, G., Baubichon-Cortay, H., Krell, T., Jault, J.-M., Daskiewicz, J.-B., Barron, D., Pietro, A. D. (2001). Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure–activity relationships for flavonoid binding. Biochemistry 40:10382–10391. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Diederichs, K., Diez, J., Greller, G., Muller, C., Breed, J., Schnell, C., Vonrheim, C., Boos, W., Welte, W. (2000). Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19:5951–5961. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Druley, T. E., Stein, W. D., Roninson, I. B. (2001a). Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry 40:4312–4322. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Druley, T. E., Stein, W. D., Ruth, A., Roninson, I. B. (2001b). P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry 40:4323–4331. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Fagegaltier, D., Hubert, N., Yamada, K., Mizutani, T., Carbon, P., Krol, A. (2000). Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. EMBO J. 19:4796–4805. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Gaudet, R., Wiley, D. C. (2001). Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 20:4964–4972. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Geick, A., Eichelbaum, M., Burk, O. (2001). Nuclear receptor response mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276:14581–14587. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Gerrad, G., Payne, E., Baker, R. J., Jones, D. T., Potter, M., Prentice, H. G., Ethell, M., McCullough, H., Burgess, M., Meta, A. B., Ganeshaguru, K. (2004). Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine. Haematologica 89:782–790. [CSA]
  • Gonzales, F. J. (2003). Role of gene knockout and transgenic mice in the study of xenobiotic metabolism. Drug Metab. Rev. 35:319–335. [CSA], [CROSSREF]
  • Gottesman, M. M. (2002). Mechanisms of cancer drug resistance. Annu. Rev. Med. 53:615–627. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Greiner, B., Eichelbaum, M., Fritz, P., Kreishgauer, H. P., von Richter, O., Zundler, J., Kroemer, H. K. (1999). The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest. 104:147–153. [PUBMED], [INFOTRIEVE], [CSA]
  • Henderson, C. J., Otto, D. M. E., McLaren, A. W., Carrie, D., Wolf, C. R. (2003a). Knockout mice in xenobiotic metabolism. Drug Metab. Rev. 35:385–392. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Henderson, C. J., Otto, D. M. E., Carrie, D., Magnuson, M. A., McLaren, A. W., Rosewell, I., Wolf, C. R. (2003b). Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem. 278:13480–13486. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Hendriske, N. H., Schinkel, A. H., de Vries, E. G. E., Fluks, E., van der Graaf, W. T. A., Willemsen, A. T. M., vaalburg, W., Franssen, E. J. F. (1998). Complete in vivo reversal of P-glycoprotein pump function in the blood–brain barrier visualized with position emission tomography. Br. J. Pharmacol. 124:1413–1418. [CSA], [CROSSREF]
  • Hirano, Y., Mizutani, T. (2003). Study of inhibition of CYP2A6 by some drugs derived from quinoline. J. Pharm. Pharmacol. 55:1667–1672. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmoller, J., Hohne, A., Cascobi, I., Gerloff, T., Roots, I., Eichelbaum, M., Brinkmann, U. (2000). Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. U. S. A. 97:3473–3478., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Hopfner, K.-P., Karcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., Tainer, J. A. (2000). Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101:789–800. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Howard, E. M., Roepe, P. D. (2003). Purified human MDR1 modurates membrane potential in reconstituted proteoliposomes. Biochemistry 42:3544–3555. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Hung, L.-W., Wang, I. X., Nikaido, K., Liu, P.-Q., Ames, G. F.-L., Kim, S.-H. (1998). Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396:703–707. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Izumi, Y., Kaneko, A., Oku, K., Kimura, M., Tanaka, S., Tada, H., Tatsumi, K., Takano, T., Hidaka, Y., Amino, N. (2002). Development of liver dysfunction after delivery is possibly due to postpartum autoimmune hepatitis. J. Intern. Med. 252:361–367. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Jang, S. H., Wientjes, M. G., Au, J. L.-S. (2003). Interdependent effect of P-glycoprotein-mediated drug efflux and intracellular drug binding on intracellular paclitaxel pharmacokinetics: application of computational modeling. J. Pharmacol. Exp. Ther. 304:773–780. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Joly, N., Bohm, A., Boos, W., Richet, E. (2004). MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator MalT by antagonizing inducer binding. J. Biol. Chem. 279:33123–33130. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Kanou, M., Saeki, K., Kato, T., Takahashi, K., Mizutani, T. (2002). Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes. Fundam. Clin. Pharmacol. 16:513–517. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Karpowich, N., Martsinkevich, O., Millen, L., Yuan, Y.-R., Dai, P., MacVey, K., Thomas, P. J., Hunt, J. F. (2001). Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter. Structure 9:571–586. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Karwatsky, J., Lincoln, M. C., Georges, E. (2003). A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity. Biochemistry 42:12163–12173. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Kerkar, N., Choudhuri, K., Mahmoud, A., Bogdanos, D. P., Muratori, L., Bianchi, F., Williams, R., Mieli-Vergani, G., Vergani, D. (2003). Cytochrome P4502D6(193–212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J. Immunol. 170:1481–1489. [PUBMED], [INFOTRIEVE], [CSA]
  • Kranitz, L., Benabdelhak, H., Horn, C., Blight, M. A., Holland, I. B., Schmitt, L. (2002). Crystallization and preliminary X-ray analysis of the ATP-binding domain of the ABC transporter haemolysin B from Escherichia coli. Acta Crystallogr. D58:539–541. [CSA]
  • Labialle, S., Dayan, G., Gayet, L., Rigal, D., Gambrelle, J., Baggetto, L. G. (2004). New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LPR130 protein. Nucleic Acids Res. 32:3864–3876. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Lala, P., Ito, S., Lingwood, C. A. (2000). Retroviral transfection of Madin–Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 105- to 106-fold increased cell sensitivity to verocytotoxin. J. Biol. Chem. 275:6246–6251. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Leveson-Gower, D. B., Michnick, S. W., Ling, V. (2004). Detection of TAP family dimerizations by an in vivo assay in mammalian cells. Biochemistry 43:14257–14264. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Li, Y. C., Fung, K. P., Kwok, T. T., Lee, C. Y., Suen, Y. K., Kong, S. K. (2004). Motochondria-targeting oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells. Chemotherapy 50:55–62. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Lin, J. H., Yamazaki, M. (2003a). Clinical relevance of P-glycoprotein in drug therapy. Drug Metab. Rev. 35:417–454. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Lin, J. H., Yamazaki, M. (2003b). Role of P-glycoprotein in pharmacokinetic: clinical implications. Clin. Pharmacokinet. 42:59–98. [PUBMED], [INFOTRIEVE], [CSA]
  • Locher, K. P., Lee, A. T., Rees, D. C. (2002). The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science 296:1091–1098. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Loo, T. W., Clarke, D. M. (2001a). Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil. J. Biol. Chem. 276:14972–14979., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Loo, T. W., Clarke, D. M. (2001b). Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers. J. Biol. Chem. 276:36877–36880. [PUBMED], [INFOTRIEVE], [CSA]
  • Loo, T. W., Bartlett, M. C., Clarke, D. M. (2003a). Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. J. Biol. Chem. 278:13603–13606. [PUBMED], [INFOTRIEVE], [CSA]
  • Loo, T. W., Bartlett, M. C., Clarke, D. M. (2003b). Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains. J. Biol. Chem. 278:1575–1578. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Loo, T. W., Bartlett, M. C., Clarke, D. M. (2003c). Simultaneous binding of two different drugs in the biding pocket of the human multidrug resistance P-glycoprotein. J. Biol. Chem. 278:39706–39710. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Loo, T. W., Bartlett, M. C., Clarke, D. M. (2004). The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium. Biochemistry 43:12081–12089. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Ma, Y., Thomas, M. G., Okamoto, M., Bogdanos, D. P., Nagl, S., Kerkar, N., Lopes, A. R., Muratori, L., Lenzi, M., Bianchi, F. B., Mieli-Vergani, G., Vergani, D. (2002). Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule. J. Immunol. 169:277–285. [PUBMED], [INFOTRIEVE], [CSA]
  • Martin, C., Higgins, C. F., Callaghan, R. (2001). The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein. Biochemistry 40:15733–15742. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Mathieu, M.-C., Lapierre, I., Brault, K., Raymond, M. (2001). Aromatic hydrocarbon receptor (AhR)/AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. J. Biol. Chem. 276:4819–4827. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Mizutani, T. (2003). PM frequencies of major CYPs in Asians and Caucasians. Drug Metab. Rev. 35:99–106. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Mizutani, T., Goto, C. (2000). Eukaryotic selenocysteine tRNA has the 9/4 secondary structure. FEBS Lett. 466:359–362. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Mizutani, T., Shinoda, M., Tanaka, Y., Kuno, T., Hattori, A., Usui, T., Kuno, N., Osaka, T., Matsufuji, S. (2005). Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. Drug. Metab. Rev. 37:235–252. [PUBMED], [INFOTRIEVE], [CSA]
  • Muratori, L., Parola, M., Ripalti, A., Robino, G., Muratori, P., Bellomo, G., Carini, R., Lenzi, M., Landini, M. P., Albano, E., Bianchi, F. B. (2000). Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane. Gut 46:553–561. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Norris-Cervetto, E., Callaghan, R., Platt, F. M., Dwek, R. A., Butters, T. D. (2004). Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. J. Biol. Chem. 279:40412–40418. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Obermayer-Straub, P., Strassburg, C. P., Manns, M. P. (2000). Target proteins in human autoimmunity: cytochrome P450 and UDP-glucuronosyltransferase. Can. J. Gastroenterol. 14:429–439. [PUBMED], [INFOTRIEVE], [CSA]
  • Omote, H., Figler, R. A., Polar, M. K., Al-Shawi, M. K. (2004). Improved energy coupling of human P-glycoprotein by the glycine 185 to valine mutation. Biochemistry 43:3917–3928. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Perniola, R., Falorni, A., Clemente, M. G., Forini, F., Accogli, E., Lobreglio, G. (2000). Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Eur. J. Endocrinol. 143:497–503. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Robin, M. A., Descatoire, V., Le Roy, M., Berson, A., Lebreton, F. P., Maratrat, M., Ballet, F., Loeper, J., Pessayre, D. (2000). Vesicular transport of newly synthesized cytochrome P4501A to the outside of rat hepatocyte plasma membranes J. Pharmacol. Exp. Ther. 294:1063–1067. [CSA]
  • Rosenberg, M. F., Kamis, A. B., Callaghan, R., Higgins, F., Ford, R. C. (2000). Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J. Biol. Chem. x278:8294–8299. [CSA], [CROSSREF]
  • Rosenberg, M. F., Callaghan, R., Modak, S., Higgins, F., Ford, R. C. (2005). Three-dimensional structure of P-glycoprotein. J. Biol. Chem. 280:2857–2862. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Ruth, A., Stein, W. D., Rose, E., Roninson, I. B. (2001). Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry 40:4332–4339. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Sauna, Z. E., Muller, M., Peng, X.-H., Ambudkar, S. V. (2002). Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1). Biochemistry 41:13989–14000. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Waganaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. J., Berns, A. J. M., Borst, P. (1994). Distribution of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs. Cell 77:491–502. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Schinkel, A. H., Wagenaar, E., van Deemter, L., Nol, C. A. A. M., Borst, P. (1995). Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96:1698–1705. [PUBMED], [INFOTRIEVE], [CSA]
  • Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A. A. M., van Deemter, L., Smit, J. J. M., van der Valk, M. A., Voordouw, A. C., Sprits, H., van Tellingen, O., Zijlmans, J. M. J. M., Fibbe, W. E., Borst, P. (1997). Normal viablity and altered pharmacokinetics in mice lacking mdr-1 type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. U. S. A. 94:4028–4033. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Schumacher, M. A., Miller, M. C., Brennan, R. G. (2004). Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. EMBO J. 23:2823–2930. [CSA]
  • Shinoda, M., Tanaka, Y., Kuno, T., Matsufuji, T., Matsufuji, S., Murakami, Y., Mizutani, T. (2004). High levels of autoantibodies against drug-metabolizing enzymes in SLA/LP-positive AIH-1 sera. Autoimmunity 37:473–480. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Smith, P. C., Karpowich, N., Millen, L., Moody, J. E., Rosen, J., Thomas, P. J., Hunt, J. F. (2002). ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol. Cell 10:139–149. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Sparreboom, A., van Asperen, J., Mayer, U., Schinkel, A. H., Smit, J. W., Meijer, D. K. F., Borst, P., Nooijen, W. J., Beijen, J. H., van Tellingen, O. (1997). Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc. Natl. Acad. Sci. U. S. A. 94:2031–2035. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Steinfels, E., Orelle, C., Fabtino, J.-R., Dalmas, O., Rigaud, J.-L., Denizot, F., Di Pietro, A., Jault, J.-M. (2004). Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis. Biochemistry 43:7491–7502. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Taylor, J. C., Horvath, A. R., Higgins, C. F., Begley, G. S. (2001). The multidrug resistance P-glycoprotein. J. Biol. Chem. 276:36075–36078. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Tombline, G., Bartholomew, L. A., Tyndall, G. A., Gimi, K., Urbatsch, I. L., Senior, A. E. (2004). Properties of P-glycoprotein with mutations in the “catalytic carboxylate” clutamate residues. J. Biol. Chem. 279:46518–46526. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Urbatsch, I. L., Julien, M., Carrier, I., Rousseau, M.-E., Cayrol, R., Gros, P. (2000). Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein. Biochemistry 39:14138–14149. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Van Veen, H. W., Venema, K., Bolhuis, H., Oussenko, I., Kok, J., Poolman, B., Driessen, A. J., Konings, W. N. (1996). Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Proc. Natl. Acad. Sci. U. S. A. 93:10668–10672. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Williams, P. A., Cosme, J., Ward, A., Angrove, H. C., Vinkovic, D. M., Jhoti, H. (2003). Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature 424:464–468. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Williams, P. A., Cosme, J., Vinkovic, D. M., Ward, A., Angrove, H. C., Day, P. J., Vonrheim, C., Tickle, I. J., Jhoti, H. (2004). Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science 305:683–686. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Wu, J. E., Basso, F., Shamburek, R. D., Amar, M. J. A., Vaisman, B., Szakacs, G., Joyce, C., Tansey, T., Freeman, L., Paigen, B. J., Thomas, F., Brewer, H. B., Santamaria-Fojo, S. (2004). Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J. Biol. Chem. 279:22913–22925. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Xu, D., Kang, H., Fisher, M., Juliano, R. L. (2004). Strategies for inhibition of MDR1 gene expression. Mol. Pharmacol. 66:268–275. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Yague, E., Armesilla, A. L., Harrison, G., Elliott, J., Sardini, A., Higgins, C. F., Raguz, S. (2003). P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation. J. Biol. Chem. 278:10344–10352. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Yuan, Y.-R., Blecker, S., Martsinkevich, O., Millen, L., Thomas, P. J., Hunt, J. F. (2001). The crystal structure of the MJ0796 ATP-binding cassette. J. Biol. Chem. 276:32313–32321. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.