1,719
Views
81
CrossRef citations to date
0
Altmetric
Review Article

Systemic drugs that influence titanium implant osseointegration

, , , , , , , , & show all
Pages 92-104 | Received 22 Nov 2016, Accepted 27 Dec 2016, Published online: 23 Jan 2017

References

  • Abdelhamid AI. (2011). Scanning electron microscope evaluation of the effect of systemic administration of aspirin on the osseointegration of dental implants (experimental study). J Pak Dent Assoc 20:260–265.
  • Abramson SB, Furst DE, Romain PL. (2016). Aspirin: mechanism of action, major toxicities, and use in rheumatic diseases [online]. UpToDate. In: Post TW, ed. Waltham, MA: UpToDate. Available from: http://www.uptodate.com/contents/aspirin-mechanism-of-action-major-toxicities-and-use-in-rheumatic-diseases [last accessed 4 Aug 2016].
  • Agholme F, Isaksson H, Kuhstoss S, Aspenberg P. (2011). The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions. Bone 48:988–996.
  • Agholme F, Macias B, Hamang M, et al. (2014). Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing. J Orthop Res 32:471–476.
  • Albrektsson T, Brånemark PI, Hansson HA, et al. (1983). The interface zone of inorganic implants in vivo: titanium implants in bone. Ann Biomed Eng 11:27.
  • Alissa R, Sakk S, Oliver R, et al. (2009). Influence of ibuprofen on bone healing around dental implants: a randomised double-blind placebo controlled clinical study. Eur J Oral Implantol 2:185–199.
  • Aspenberg P, Agholme F, Magnusson P, Fahlgren A. (2011). Targeting RANKL for reduction of bone loss around unstable implants: OPG-Fc compared to alendronate in a model for mechanically induced loosening. Bone 48:225–230.
  • Ayukawa Y, Ogino Y, Moriyama Y, et al. (2010). Simvastatin enhances bone formation around titanium implants in rat tibiae. J Oral Rehabil 37:123–130.
  • Ayukawa Y, Okamura A, Koyano K. (2004). Simvastatin promotes osteogenesis around titanium implants. Clin Oral Implants Res 15:346–350.
  • Bernhardsson M, Sandberg O, Aspenberg P. (2015). Anti-RANKL treatment improves screw fixation in cancellous bone in rats. Injury 46:990–995.
  • Bikle DD. (2014). Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 21:319–329.
  • Bobyn JD, Hacking SA, Krygier JJ, et al. (2005). Zoledronic acid causes enhancement of bone growth into porous implants. J Bone Joint Surg Br 87:416–420.
  • Botting R, Ayoub SS. (2005). COX-3 and the mechanism of action of paracetamol/acetaminophen. Prostagland Leukotrienes Essent Fatty Acids 72:85–87.
  • Botting RM. (2003). Mechanism of action of acetaminophen: is there a cyclooxygenase 3? Clin Infect Dis 31:S202–S210.
  • Brouwers J, van Rietbergen B, Huiskes R, Ito K. (2009). Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT. Osteoporos Int 20:1823–1835.
  • Bryce G, Bomfim DI, Bassi GS. (2014). Pre- and post-operative management of dental implant placement. Part 1: Management of post-operative pain. Br Dent J 217:123–127.
  • Callahan BC, Lisecki EJ, Banks RE, et al. (1995). The effect of warfarin on the attachment of bone to hydroxyapatite-coated and uncoated porous implants. J Bone Joint Surg Am 77:225–230.
  • Cannata-Andia JB, Rodriguez-Garcia M, Gómez-Alonso C. (2010). Action mechanism of strontium ranelate. Rev Osteoporos Metab Miner 2:S5–S9.
  • Cardeemil C, Omar OM, Norlindh B, et al. (2013). The effects of a systemic single dose of zoledronic acid on post-implantation bone remodelling and inflammation in an ovariectomised rat model. Biomaterials 34:1546–1561.
  • Chacon GE, Stine EA, Larsen PE, et al. (2006). Effect of alendronate on endosseous implant integration: an in vivo study in rabbits. J Oral Maxillofac Surg 64:1005–1009.
  • Chen B, Li Y, Yang X, et al. (2013). Zoledronic acid enhances bone–implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats. Osteoporos Int 24:2115–2121.
  • Chen BL, Xie DH, Zheng ZM, et al. (2011). Comparison of the effects of alendronate sodium and calcitonin on bone-prosthesis osseointegration in osteoporotic rats. Osteoporos Int 22:265–270.
  • Chikazu D, Tomizuka K, Ogasawara T, et al. (2007). Cyclooxygenase-2 activity is essential for the osseointegration of dental implants. Int J Oral Maxillofac Surg 36:441–446.
  • Coetzee M, Kruger MC. (2004). Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment? South Med J 97:506–511.
  • Cook SD, Barrack RL, Dalton JE, et al. (1995). Effects of indomethacin on biologic fixation of porous-coated titanium implants. J Arthroplasty 10:351–358.
  • Dayer R, Badoud I, Rizzoli R, Ammann P. (2007). Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate. J Bone Miner Res 22:1526–1533.
  • Dayer R, Brennan TC, Rizzoli R, Ammann P. (2010). PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein diet. Osteoporos Int 21:957–967.
  • Du Z, Chen J, Yan F, Xiao Y. (2009). Effects of simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implants Res 20:145–150.
  • Duarte PM, de Vasconcelos Gurgel BC, Sallum AW, et al. (2005). Alendronate therapy may be effective in the prevention of bone loss around titanium implants inserted in estrogen-deficient rats. J Periodontol 76:107–114.
  • Eberhardt C, Schwarz M, Kurth AH. (2005). High dosage treatment of nitrogen-containing bisphosphonate ibandronate is required for osseointegration of cementless metal implants. J Orthop Sci 10:622–626.
  • Eberhardt C, Stumpf U, Brankamp J, et al. (2006). Osseointegration of cementless implants with different bisphosphonate regimens. Clin Orthop Relat Res 447:195–200.
  • Eriksen EF. (2006). Effects of anticatabolic and anabolic therapies oat the tissue level. Clin Rev Bone Miner Metabol 4:177–196.
  • Fonseca JE, Brandi ML. (2010). Mechanism of action of strontium ranelate: what are the facts? Clin Cases Miner Bone Metab 7:17–18.
  • Fu JH, Bashutski JD, Al-Hezaimi K, Wang HL. (2012). Statins, glucocorticoids, and nonsteroidal anti-inflammatory drugs: their influence on implant healing. Implant Dent 21:362–367.
  • Galea GL, Price JS, Lanyon LE. (2013). Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling. Bonekey Rep 2:413.
  • Gasparyan A, Watson T, Lip GH. (2008). The role of aspirin in cardiovascular prevention: implications of aspirin resistance. J Am Coll Cardiol 51:1829–1843.
  • Giro G, Gonçalves D, Sakakura CE, et al. (2008). Influence of estrogen deficiency and its treatment with alendronate and estrogen on bone density around osseointegrated implants: a radiographic study in female rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:162–167.
  • Gomes FIF, Aragäo MGB, Pinto V, de PT, et al. (2015). Effects of nonsteroidal anti-inflammatory drugs on osseointegration: a review. J Oral Implantol 41:219–230.
  • Gong L, Altman RB, Klein TE. (2011). Bisphosphonates pathway. Pharmacogenet Genom 21:50–53.
  • Graham S, Gamie Z, Polyzois I, et al. (2009). Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: in vivo and in vitro evidence. Expert Opin Investig Drugs 18:746–766.
  • Hayashi K, Fotovati A, Abu Ali S, et al. (2010). Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants in ovariectomized rats. J Biomed Mater Res A 92:1202–1209.
  • Hayashi K, Fotovati A, Ali SA, et al. (2005). Prostaglandin EP4 receptor agonist augments fixation of hydroxyapatite-coated implants in a rat model of osteoporosis. J Bone Joint Surg Br 87:1150–1156.
  • Jacobsson SA, Djerf K, Ivarsson I, Wahlström O. (1994). Effect of diclofenac on fixation of hydroxyapatite-coated implants. An experimental study. J Bone Joint Surg Br 76:831–833.
  • Javed F, Al Amri MD, Kellesarian SV, et al. (2016a). Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review. Clin Oral Investig 20:649–658.
  • Javed F, Malmstrom H, Kellesarian SV, et al. (2016b). Efficacy of vitamin D3 supplementation on osseointegration of implants. Implant Dent 25:281–287.
  • Jeffcoat MK, Reddy MS, Wang IC, et al. (1995). The effect of systemic flurbiprofen on bone supporting dental implants. J Am Dent Assoc 126:305–311.
  • Jensen TB, Bechtold JE, Chen X, Søballe K. (2007). Systemic alendronate treatment improves fixation of press-fit implants: a canine study using nonloaded implants. J Orthop Res 25:772–778.
  • Kurth AH, Eberhardt C, Müller S, et al. (2005). The biphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats. Bone 37:204–210.
  • Lau HK, Mounsey A, Mackler L. (2012). Human parathyroid hormone for treating osteoporosis. Am Fam Phys. 85:1–2.
  • Li M, Wang W, Geng L, et al. (2015). Inhibition of RANKL-induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium-particle-induced osteolysis. Int J Mol Med 36:1335–1344.
  • Li Y, Feng G, Gao Y, et al. (2010). Strontium ranelate treatment enhances hydroxyapatite-coated titanium screws fixation in osteoporotic rats. J Orthop Res 28:578–582.
  • Linderback P, Agholme F, Wermelin K, et al. (2012). Weak effect of strontium on early implant fixation in rat tibia. Bone 50:350–356.
  • Lionberger DR, Noble PC. (2005). Celecoxib does not affect osteointegration of cementless total hip stems. J Arthroplasty 20:115–122.
  • Liu AS, Irish J, Sena K, et al. (2015). Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis. J Bone Joint Surg Am 97:133–140.
  • Long M, Rack HJ. (1998). Titanium alloys in total joint replacement—a materials science perspective. Biomaterials 19:1621–1639.
  • Lütjering G, Williams JC. (2007). Titanium. 2nd ed. Berlin Heidelberg: Springer-Verlag.
  • Mangravite LM, Thorn CF, Krauss RM. (2012). Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther 92:414–417.
  • Mardas N, Schwarz F, Petrie A, et al. (2011). The effect of SLActive surface in guided bone formation in osteoporotic-like conditions. Clin Oral Implants Res 22:406–415.
  • Masi L, Brandi ML. (2007). Calcitonin and calcitonin receptors. Clin Cases Miner Bone Metab 4:117–122.
  • Matziolis G, Perka C, Disch A, Zippel H. (2003). Effects of fondaparinux compared with dalteparin, enoxaparin and unfractionated heparin on human osteoblasts. Calcif Tissue Int 73:370–379.
  • Mavrogenis AF, Dimitriou R, Parvizi J, Babis GC. (2009). Biology of implant osseointegration. J Musculoskelet Neuronal Interact 9:61–71.
  • Murai K, Takeshita F, Ayukawa Y, et al. (1996). Light and electron microscopic studies of bone—titanium interface in the tibiae of young and mature rats. J Biomed Mater Res 30:523–533.
  • Nakamura Y, Hayashi K, Abu-Ali S, et al. (2008). Effect of preoperative combined treatment with alendronate and calcitriol on fixation of hydroxyapatite-coated implants in ovariectomized rats. J Bone Joint Surg Am 90:824–832.
  • Narai S, Nagahata S. (2003). Effects of alendronate on the removal torque of implants in rats with induced osteoporosis. Int J Oral Maxillofac Implants 18:218–223.
  • Nellie AKW. (2008). Regulation of sclerostin expression in osteocytes by mechanical loading. Thesis (PhD). University of Missouri-Kansas City.
  • Nociti FHJ, Sallum AW, Sallum AS, Duarte PM. (2002). Effect of estrogen replacement and calcitonin therapies on bone around titanium implants placed in ovariectomized rats: a histometric study. Int J Oral Maxillofac Implants 17:786–792.
  • Nociti FHJ, Sallum EA, Toledo S, et al. (1999). Effect of calcitonin on bone healing following titanium implant insertion. J Oral Sci 41:77–80.
  • Olivares-Navarrete R, Hyzy S, Wieland M, et al. (2010). The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. Biomaterials 31:2015–2024.
  • Oshida Y. (2013). Bioscience and bioengineering of titanium materials. Amsterdam: Elsevier.
  • Pablos AB, Ramalho SA, König B, Jr, et al. (2008). Effect of meloxicam and diclofenac sodium on peri-implant bone healing in rats. J Periodontol 79:300–306.
  • Peters M, Hemptenmacher J, Kumpfert J, Leyens C. (2003). Structure and properties of titanium and titanium alloys: fundamentals and applications. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA.
  • Pinzone JJ, Hall BM, Thudi NK, et al. (2009). The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood J 113:517–525.
  • Puleo DA, Nanci A. (1999). Understanding and controlling the bone–implant interface. Biomaterials 20:2311–2321.
  • Purroy J, Spurr NK. (2002). Molecular genetics of calcium sensing bone cells. Hum Mol Genet 20:2377–2384.
  • Qi H, Hu J, Li J, et al. (2012). Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits. Bone 50:119–127.
  • Ramalho-Ferreira G, Faverani LP, Prado FB, et al. (2015). Raloxifene enhances peri-implant bone healing in osteoporotic rats. Int J Oral Maxillofac Surg 44:798–805.
  • Reddy MS, Jeffcoat MK, Richardson RC. (1990). Assessment of adjunctive flurbiprofen therapy in root-form implant healing with digital subtraction radiography. J Oral Implantol 16:272–276.
  • Rey JRC, Cervino EV, Rentero ML, et al. (2009). Raloxifene: mechanism of action, effects on bone tissue, and applicability in clinical traumatology practice. Open Orthop J 3:14–21.
  • Ribeiro FV, César-Neto JB, Nociti FH, Jr, et al. (2006). Selective cyclooxygenase-2 inhibitor may impair bone healing around titanium implants in rats. J Periodontol 77:1731–1735.
  • Rosen HN. (2016). Pharmacology of biphosphonates [online]. UpToDate. In: Post TW, ed. Waltham, MA: UpToDate. Available from: http://www.uptodate.com/contents/pharmacology-of-bisphosphonates [last accessed 29 May 2016].
  • Ruan F, Zheng Q, Wang J. (2012). Mechanisms of bone anabolism regulated by statins. Biosci Rep 32:511–519.
  • Russell RGG, Watts NB, Ebetino FH, Rogers MJ. (2008). Mechanisms of action of biphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 19:733–759.
  • Saari TM, Digas G, Kärrholm JN. (2014). Risedronate does not enhance fixation or BMD in revision cups: randomised study with three years follow-up. Hip Int 24:49–55.
  • Serada M, Sakurai-Tanikawa A, Igarashi M, et al. (2012). The role of the liver and kidneys in the pharmacokinetics of subcutaneously administered teriparatide acetate in rats. Xenobiotica 42:398–407.
  • Shin JM, Kim N. (2013). Pharmacokinetics and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Motil 19:25–35.
  • Skoglund B, Holmertz J, Aspenberg P. (2004). Systemic and local ibandronate enhance screw fixation. J Orthop Res 22:1108–1113.
  • Sköldenberg O, Rysinska A, Eisler T, et al. (2016). Denosumab for treating periprosthetic osteolysis; study protocol for a randomized, double-blind, placebo-controlled trial. BMC Musculoskelet Disord 17:174.
  • Sköldenberg OG, Salemy MO, Bodėn HS, et al. (2011). The effect of weekly risendronate on periprosthetic bone resorption following total hip arthroplasty: a randomized, double-blind, placebo-controlled trial. J Bone Joint Surg Am 93:1857–1864.
  • Skripitz R, Aspenberg P. (2001). Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg Br 83:437–440.
  • Stepan JJ. 2013. Strontium ranelate: in search for the mechanism of action. J Bone Miner Metab 31:606–612.
  • Stevenson JC. 1990. New techniques in metabolic bone disease. London: Butterworth & Co.
  • Stroup J, Kane M, Abu-Baker A. (2008). Teriparatide in the treatment of osteoporosis. Am J Health Syst Pharm 65:532–539.
  • Subaie AA, Emami E, Tamimi I, et al. (2016). Systemic administration of omeprazole interferes with bone healing and implant osseointegration: an in vivo study on rat tibiae. J Clin Periodontol 43:193–203.
  • Tallarico M, Canullo L, Xhanari E, Meloni SM. (2015). Dental implants treatments outcomes in patient under active therapy with alendronate: a 3-year follow-up results of a multicentric prospective observational study. Clin Oral Implants Res 27:943–949.
  • Tang XL, Meng HX, Zhang L. (2008). Effects of calcitriol on the expression of vitamin D receptor, RANKL and osteoprotegerin in human periodontal ligament cells. Zhonghua Kou Qiang Yi Xue Za Zhi 43:732–736.
  • Tao ZS, Zhou WS, Tu KK, et al. (2015). The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on osseous integration of hydroxyapatite coated titanium implants in the femur of ovariectomized rats. Injury 45:2164–2169.
  • The glossary of prosthodontic terms. (2005). J Prosthet Dent 94:10–92.
  • Thomsen P, Larsson C, Ericson LE, et al. (1997). Structure of the interface between rabbit cortical bone and implants of gold, zirconium and titanium. J Mater Sci Mater Med 8:653–665.
  • Tong X, Lu W, You T, et al. (2016). The function of narginin in inducing secretion of osteoprotegerin and inhibiting formation of osteoclasts. Evid Based Complement Altern Med. 2016:8981650.
  • Trancik T, Mills W, Vinson N. (1989). The effect of indomethacin, aspirin, and ibuprofen on bone ingrowth into a porous-coated implant. Clin Orthopaed Relat Res 249:113–121.
  • Turku University Hospital. (2013). Denosumab in enhancement of bone bonding of hip prosthesis in postmenopausal women (ProliaHip) [online]. Bethesda (MD): National Library of Medicine. Available from: https://clinicaltrials.gov/ct2/show/NCT01926158 [last accessed 28 Jul 2016].
  • Viera-Negron YE, Ruan WH, Winger JN, et al. (2008). Effect of ovariectomy and alendronate on implant osseointegration in rat maxillary bone. J Oral Implantol 34:76–82.
  • Virdi AS, Liu M, Sena K, et al. (2012). Sclerostin antibody increases bone volume and enhances implant fixation in a rat model. J Bone Joint Surg Am 94:1670–1680.
  • von Knoch M, Wedemeyer C, Pingsmann A, et al. (2005). The decrease of particle-induced osteolysis after a single dose of bisphosphonate. Biomaterials 36:1803–1808.
  • Weir EC, Horowitz MC, Baron R, et al. (1993). Macrophage colony-stimulating factor release and receptor expression in bone cells. J Bone Miner Res 8:1507–1518.
  • Wolozin B, Wang SW, Li NC, et al. (2007). Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med 5:20.
  • Wu X, Al-Abedalla K, Rastikerdar E, et al. (2014). Selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure: a cohort study. J Dent Res 93:1054–1061.
  • Wurnig C, Schwameis E, Bitzan P, Kainberger F. (1993). Six-year results of a cementless stem with prophylaxis against heterotopic bone. Clin Orthopaed Relat Res 361:150–158.
  • Yamashita M, Otsuka F, Mukai T, et al. (2010). Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. Regul Pept 162:99–108.
  • Yang Y, Blair HC, Shapiro IM, Wang B. (2015). The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway. J Biol Chem 290:16918–16928.
  • Yildiz A, Esen E, Kürkçü M, et al. (2010). Effect of zoledronic acid on osseointegration of titanium implants: an experimental study in an ovariectomized rabbit model. J Oral Maxillofac Surg 68:515–523.
  • Zhou C, Li Y, Wang X, et al. (2012). 1,25-Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats. Oral Surg Med Oral Pathol Oral Radiol 114:174–178.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.