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Mycotoxin patulin in food matrices: occurrence and its biological degradation strategies

ORCID Icon, ORCID Icon, &
Pages 105-120 | Received 27 Nov 2018, Accepted 13 Feb 2019, Published online: 22 Apr 2019

References

  • Abramson D, Lombaert G, Clear RM, Sholberg P, Trelka R, Rosin E. 2009. Production of patulin and citrinin by Penicillium expansum from British Columbia (Canada) apples. Mycotoxin Res. 25:85–88.
  • Ake M, Eba B, Malan AK, Atindehou E. 2001. Détermination de la Patuline dans le Jus de Fruits Commercialisésen Côte d’Ivoire. Sci Aliments. 21:199–206.
  • Al-Hazmi NA. 2010. Determination of patulin and ochratoxin A using HPLC in apple juice samples in Saudi Arabia. Saudi J Biol Sci. 17:353–359.
  • Alves I, Oliveira NG, Laires A, Rodrigues AS, Rueff J. 2000. Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity. Mutagenesis. 15:229–234.
  • Anslow WK, Raistrick H, Smith G. 1943. Antifungal substances from moulds. Part I. Patulin, a metabolic product of Penicillium patulum banier and Penicillium expansum (Link). J Chem Technol Biotechnol. 62:236.
  • Arafat, W, Kern, D, Dirheimer, G. 1985. Inhibition of aminoacyl-tRNA synthetases by the mycotoxin patulin. Chem Biol Interact. 56:333–349.
  • Ashoor, SH, Chu, FS. 1973. Inhibition of muscle aldolase by penicillic acid and patulin in vitro. Food Cosmet Toxicol. 11:995–1000.
  • Arafat W, , Musa MN. 1995. Patulin-induced inhibition of protein synthesis in hepatomatissue culture. Res Commun Mol Pathol Pharmacol. 87:177–186.
  • Assatarakul K, Churey JJ, Manns DC, Worobo RW. 2012. Patulin reduction in apple juice from concentrate by UV radiation and comparison of kinetic degradation models between apple juice and apple cider. J Food Prot. 75:717–724.
  • Assuncao R, Martins C, Dupont D, Alvito P. 2016. Patulin and ochratoxin A co-occurrence and their bioaccessibility in processed cereal-based foods: a contribution for Portuguese children risk assessment. Food Chem Toxicol. 96:205–214.
  • Baert K, Meulenaer B, Kamala A, Kasase C, Devlieghere F. 2006. Occurrence of patulin in organic, conventional, and handcrafted apple juices marketed in Belgium. J Food Prot. 69:1371–1378.
  • Barhoumi, R, Burghardt, R C. 1996. Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. Fundam Appl Toxicol. 30:290–297.
  • Barreira MJ, Alvito PC, Almeida C. 2010. Occurrence of patulin in apple-based-foods in Portugal. Food Chem. 121:653–658.
  • Becci PJ, Hess FG, Johnson WD, Gallo MA, Babish JG, Dailey RE, Parent RA. 1981. Long-term carcinogenicity and toxicity studies of patulin in the rat. J Appl Toxicol. 1:256–261.
  • Bennett JW, Klich M. 2003. Mycotoxins. Clin Microbiol Rev. 16:497–516.
  • Berestets’kyi OO, Synyts’kyi VM. 1973. Phytotoxic activity in different strains of Penicillium urticae banier. Mikrobiol Zh. 35:349.
  • Beretta B, Gaiaschi A, Galli CL, Restani P. 2000. Patulin in apple-based foods: occurrence and safety evaluation. Food Addit Contam. 17:399–406.
  • Bergel F, Morrison AL, Klein R, Moss AR, Rinderknecht J, Ward JL. 1943. An antibiotic substance from Aspergillus clavatus and Penicillium claviforme and its probable identity with patulin. Nature. 152:750.
  • Birkinshaw JH, Bracken A, Michael SE, Raistrick H. 1943. Patulin in the common cold. II. Biochemistry and chemistry. Lancet. 15:625–630.
  • Boonzaaijer G, Bobeldijk I, Van Osenbruggen WA. 2005. Analysis of patulin in Dutch food, an evaluation of an SPE based method. Food Control. 16:587–591.
  • Bourdiol D, Escoula L, Salvayre R. 1990. Effect of patulin on microbicidal activity of mouse peritoneal macrophages. Food Chem Toxicol. 28:29–33.
  • Brackett RE, Marth EH. 1979. Ascorbic acid and ascorbate cause disappearance of patulin from buffer solutions and apple juice. J Food Prot. 42:864–866.
  • Brian PW, Elson GW, Lowe D. 1956. Production of patulin in apple fruits by Penicillium expansum. Nature. 178:263–264.
  • Bullerman LB, Olivigni FJ. 1974. Mycotoxin producing potential of molds isolated from cheddar cheese. J Food Sci. 39:1166–1168.
  • Burda K. 1992. Incidence of patulin in apple, pear, and mixed fruit products marketed in New South Wales. J Food Prot. 55:796–798.
  • Burghardt, RC, Barhoumi, R, Lewis, EH, Bailey, RH, Pyle, KA, Clement, BA, Phillips, TD. 1992. Patulin-induced cellular toxicity: a vital fluorescence study. Toxicol Appl Pharmacol. 112:235–244.
  • Burroughs LF. 1977. Stability of patulin to sulfur dioxide and to yeast fermentation. J Assoc Off Anal Chem. 60:100.
  • Canãs P, Aranda M. 1996. Decontamination and inhibition of patulin-induced cytotoxicity. Environ Toxicol Water Qual. 11:249–253.
  • Castoria R, Mannina L, Duran-Patron R, Maffei F, Sobolev AP, De Felice DV, Pinedo-Rivilla C, Ritieni A, Ferracane R, Wright SA. 2011. Conversion of the mycotoxin patulin to the less toxic desoxypatulinic acid by the biocontrol yeast Rhodosporidium kratochvilovae strain LS11. J Agric Food Chem. 59:11571–11578.
  • Chain E, Florey HW, Jennings MA. 1942. An antibacterial substance produced by Penicillium claviforme. Br J Exp Pathol. 23:202.
  • Chalmers I, Clarke M. 2004. Commentary: the 1944 patulin trial: the first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int J Epidemiol. 33:253–260.
  • Chen Y, Peng H, Wang X, Li B, Long M, Tian S. 2017. Biodegradation mechanisms of patulin in Candida guilliermondii: an iTRAQ-based proteomic analysis. Toxins. 9:1–13.
  • Cheraghali AM, Mohammadi HR, Amirahmadi M, Yazdanpanah H, Abouhossain G, Zamanian F, Khansari MG, Afshar M. 2005. Incidence of patulin contamination in apple juice produced in Iran. Food Control. 16:165–167.
  • Cho MS, Kim K, Seo E, Kassim N, Mtenga AB, Shim W, Lee S, Chung D. 2010. Occurrence of patulin in various fruit juices from South Korea: an exposure assessment. Food Sci Biotechnol. 19:1–5.
  • Ciegler, A, Beckwith, AC, Jackson, LK. 1976. Teratogenicity of patulin and patulin adducts formed with cysteine. Appl Environ Microbiol. 31:664–667.
  • Ciegler A, Detroy RW, Lillehoj EB. 1971. Patulin, penicillic acid, and other carcinogenic lactones. In: Ciegler A, Kadis S, Ajl SJ, editors. Microbial toxins. Vol. 6. New York and London: Academic Press; p. 409.
  • Ciegler A, Vesonder R, Jackson L. 1977. Production and biological activity of patulin and citrinin from Penicillium expansum. Appl Environ Microbiol. 4:1004–1006.
  • CODEX. 2003. Maximum level for patulin in apple juice and apple juice ingredients and other beverages. In: Codex Alimentarius Commission, editor. Rome, Italy: Codex Alimentarius Commission; p. 235.
  • Coelho AR, Celli MG, Sataque EY, Hoffmann FL, Pagnocca FC, Garcia S, Sabino M, Harada K, Wosiacki G, Hirooka EY. 2008. Patulin biodegradation using Pichia ohmeri and Saccharomyces cerevisiae. World Mycotoxin J. 1:325–331.
  • Cooray, R, Kiessling, K-H, Lindahl-Kiessling, K. 1982. The effects of patulin and patulin-cysteine mixtures on dna synthesis and the frequency of sister-chromatid exchanges in human lymphocytes. Food Chem Toxicol. 20:893–898.
  • Commission Regulation. 2003. (EC) No. 1425/2003 of 11 August amending Regulation (EC) N°466/2001 as regards patulin. Off J Eur Union L. 203/13.
  • Cunha SC, Faria MA, Pereira VL, Oliveira TM, Lima AC, Pinto E. 2014. Patulin assessment and fungi identification in organic and conventional fruits and derived products. Food Control. 44:185–190.
  • de Melo FT, de Oliveira IM, Greggio S, Dacosta JC, Guecheva TN, Saffi J, Henriques JAP, Rosa RM. 2012. DNA damage in organs of mice treated acutely with patulin, a known mycotoxin. Food Chem Toxicol. 50:3548–3555.
  • Demirci M, Arici M, Gumus T. 2003. Presence of patulin in fruit and fruit juices produced in Turkey. Ernaehrungs-Umschau. 50:262–263.
  • DeRosnay CD, Martin-Dupont Jensen R. 1952. An antibiotic, myocin. C J Med Bordeaux Sud-Ouest. 129:189.
  • Deshpande SS. 2002. Handbook of food toxicology. Vol. 920. New York (NY): Marcel Dekker Inc.
  • De-Sylos CM, Rodriguez-Amaya DB. 1999. Incidence of patulin in fruits and fruit juices marketed in Campinas, Brazil. Food Addit Contam. 16:71–74.
  • Devaraj H, Devaraj N. 1987. Rat intestinal lipid changes in patulin toxicity. Indian J Exp Biol. 25:637–638.
  • Devaraj H, Suseela RE, Devaraj N. 1986. Patulin toxicosis in chicks. Curr Sci. 55:998–999.
  • Dickens, F, Jones, HEH. 1961. Carcinogenic Activity of a Series of Reactive Lactones and Related Substances. Br J Cancer. 15:85–100.
  • Dong Q, Manns DC, Feng G, Yue T, Churey JJ, Worobo RW. 2010. Reduction of patulin in apple cider by UV radiation. J Food Prot. 73:69–74.
  • Dong X, Jiang W, Li C, Ma N, Xu Y, Meng X. 2015. Patulin biodegradation by marine yeast Kodameae ohmeri. Food Addit Contam A. 32:352-360.
  • Doyle MP, Marth EH. 1978. Aflatoxin is degraded by mycelia from toxigenic and nontoxigenic strains of Aspergilli grown on different substrates. Mycopathologia. 63:145–153.
  • Ekinci R, Otağ M, Kadakal Ç. 2014. Patulin & ergosterol: new quality parameters together with aflatoxins in hazelnuts. Food Chem. 150:17–21.
  • Escoula, L, Moré, J, Baradat, C. 1977. The toxins by Byssochlamys nivea Westling. I. Acute toxicity of patulin in adult rats and mice. Ann Rech Vet. 8:41–49.
  • Escoula L, Bourdiol D, Linas MD, Recco P, Seguela JP. 1988a. Enhancing resistance and modulation of humoral immune response to experimental Candida albicans infection by patulin. Mycopathologia. 103:153–156.
  • Escoula L, Thomsen M, Bourdiol D, Pipy B, Peuriere S, Roubinet S. 1988b. Patulin immunotoxicology: effect on phagocyte activation and the cellular and humoral immune system of mice and rabbits. Int J Immunopharmacol. 10:983–989.
  • FAO. 2003. Manual on the application of the HACCP system in mycotoxin prevention and control. FAO Food Nutr Pap. 73:1–124.
  • Fernández-Cruz ML, Mansilla ML, Tadeo JL. 2010. Mycotoxins in fruits and their processed products: analysis, occurrence and health implications. J Adv Res. 1:113–122.
  • Fliege, R, Metzler, M. 1999. The mycotoxin patulin induces intra- and intermolecular protein crosslinks in vitro involving cysteine, lysine, and histidine side chains, and α-amino groups. Chem.-Biol. Interact.123:85–103.
  • Frisvad JC, Smedsgaard J, Larsen TO, Samson RA. 2004. Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus Penicillium. Stud Mycol. 49:201–242.
  • Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmuller S. 2008. Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria. Food Chem Toxicol. 46:1398–1407.
  • Funes GJ, Gómez PL, Resnik SL, Alzamora SM. 2013. Application of pulsed light to patulin reduction in McIlvaine buffer and apple products. Food Control. 30:405–410.
  • Funes GJ, Resnik SL. 2009. Determination of patulin in solid and semisolid apple and pear products marketed in Argentina. Food Control. 20:277–280.
  • Garza HC, Swanson BG, Branen AL. 1977. Toxicology study of patulin in monkeys. J Food Sci. 42:1229–1231.
  • Gaspar E, Lucena A. 2009. Improved HPLC methodology for food control-furfurals and patulin as markers of quality. Food Chem. 114:1576–1582.
  • Gokmen V, Akar J. 1998. Incidence of patulin in apple juice concentrates produced in Turkey. J Chromatogr. 815:99–102.
  • Gökmen V, Artık N, Acar J, Kahraman N, Poyrazoğlu E. 2001. Effects of various clarification treatments on patulin, phenolic compound and organic acid compositions of apple juice. Eur Food Res Technol. 213:194–199.
  • Guo C, Yuan Y, Yue T, Hatab S, Wang Z. 2012a. Binding mechanism of patulin to heat-treated yeast cell. Lett Appl Microbiol. 55:453–459.
  • Guo C, Yue T, Hatab S, Yuan Y. 2012b. Ability of inactivated yeast powder to adsorb patulin from apple juice. J Food Prot. 75:585–590.
  • Guo C, Yue T, Yuan Y, Wang Y, Guo Y, Wang L, Li Z. 2013. Biosorption of patulin from apple juice by caustic treated waste cider yeast biomass. Food Control. 32:99–104.
  • Hao H, Zhou T, Koutchma T, Wu F, Warriner K. 2016. High hydrostatic pressure assisted degradation of patulin in fruit and vegetable juice blends. Food Control. 62:237–242.
  • Harris KL, Bobe G, Bourquin LD. 2009. Patulin surveillance in apple cider and juice marketed in Michigan. J Food Prot. 72:1255–1261.
  • Hatab S, Yue T, Mohamad O. 2012a. Removal of patulin from apple juice using inactivated lactic acid bacteria. J Appl Microbiol. 112:892–899.
  • Hatab S, Yue T, Mohamad O. 2012b. Reduction of patulin in aqueous solution by lactic acid bacteria. J Food Sci. 77:238–241.
  • Hatey, F, Gaye, P. 1978. Inhibition of translation in reticulocyte lysate by the mycotoxin patulin. FEBS Lett. 95:252–256.
  • Hawar S, Vevers W, Karieb S, Ali BK, Billington R, Beal J. 2013. Biotransformation of patulin to hydroascladiol by Lactobacillus plantarum. Food Control. 34:502–508.
  • Hayes, AW, Phillips, TD, Williams, WL, Ciegler, A. 1979. Acute toxicity of patulin in mice and rats. Toxicol. 13:91–100.
  • He J, Zhou T. 2010. Patented techniques for detoxification of mycotoxins in feeds and food matrices. Recent Pat Food Nutr Agric. 2:96–104.
  • Hopkins, J. 1993. The toxicological hazards of patulin. Br Ind Biol Res Assoc Bull. 32:3–4.
  • Houbraken J, Samson RA, Frisvad JC. 2006. Byssochlamys: significance of heat resistance and mycotoxin production. Adv Exp Med Biol. 571:211–224.
  • Ianiri G, Idnurm A, Wright SAI, Durán-Patrón R, Mannina L, Ferracane R, Ritieni A, Castoria R. 2013. Searching for genes responsible for patulin degradation in a biocontrol yeast provides insight into the basis for resistance to this mycotoxin. Appl Environ Microbiol. 79:3101–3115.
  • Ianiri G, Pinedo C, Fratianni A, Panfili G, Castoria R. 2017. Patulin degradation by the biocontrol yeast Sporobolomyces sp. is an inducible process. Toxins. 9:61.
  • IARC. 1986. Some naturally occurring and synthetic food components, furocoumarins and ultraviolet radiation. In: Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Lyon, France: IARC; p. 83–98.
  • Iha MH, Sabino M. 2008. Incidence of patulin in Brazilian apple-based drinks. Food Control. 19:417–422.
  • Ioi JD, Zhou T, Tsao R, Marcone MF. 2017. Mitigation of patulin in fresh and processed foods and beverages. Toxins. 9:2–18.
  • Iqbal SZ, Malik S, Asi MR, Selamat J, Malik N. 2018. Natural occurrence of patulin in different fruits, juices and smoothies and evaluation of dietary intake in Punjab, Pakistan. Food Control. 84:370–374.
  • Iyengar MR, Starkey RL. 1953. Synergism of auxin by antibiotics. Science. 118:357.
  • Ji X, Li R, Yang H, Qi P, Xiao Y, Qian M. 2017. Occurrence of patulin in various fruit products and dietary exposure assessment for consumers in China. Food Control. 78:100–107.
  • Josefson E, Andersson A. 1976. Analysis of patulin in apple beverages sold in Sweden. Vår Foda. 28:189–196.
  • Kim S, Lee H, Lee S, Lee J, Ha J, Choi Y, Yoon Y, Choi KH. 2017. Invited review: microbe-mediated aflatoxin decontamination of dairy products and feeds. J Dairy Sci. 100:871–880.
  • Knasmüller S, Steinkellner H, Hirschl AM, Rabot S, Nobis EC, Kassie F. 2001. Impact of bacteria in dairy products and of the intestinal microflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Mutat Res. 480:129–138.
  • Korte, A, Rückert, G. 1980. Chromosomal analysis in bone-marrow cells of Chinese hamsters after treatment with mycotoxins. Mutat Res Toxicol. 78:41–49.
  • Korzybski T, Kowszyk-Gindifier Z, Kurylowicz S. 1967. Antibiotics origin, nature, and properties. Vol. II. New York: Pergamon Press; p. 1223–1230.
  • Leblanc JC, Tard A, Volatier JL, Verger P. 2005. Estimated dietary exposure to principal food mycotoxins from the first French total Diet Study. Food Addit Contam. 22:652–672.
  • Lee, KS, Röschenthaler, R. 1987. Strand scissions of DNA by patulin in the presence of reducing agents and cupric ions. J Antibiot. 40:692–696.
  • Lee, KS, Röschenthaler, RJ. 1986. DNA-damaging activity of patulin in Escherichia coli. Appl Environ Microbiol. 52:1046–1054.
  • Lee TP, Sakai R, Manaf NA, Rodhi AM, Saad B. 2014. High performance liquid chromatography method for the determination of patulin and 5-hydroxymethylfurfural in fruit juices marketed in Malaysia. Food Control. 38:142–149.
  • Leggott NL, Shephard GS. 2001. Patulin in South African commercial apple products. Food Control. 12:73–76.
  • Li X, Peng X, Wang Q, Zuo H, Meng X, Liu B. 2017. Effective detoxification of patulin from aqueous solutions by immobilized porcine pancreatic lipase. Food Control. 78:48–56.
  • Li X, Tang H, Yang C, Meng X, Liu B. 2019. Detoxification of mycotoxin patulin by the yeast Rhodotorula mucilaginosa. Food Control. 96:47–52.
  • Lindroth S, Niskanen A. 1978. Comparison of potential patulin hazard in homemade and commercial apple products. J Food Sci. 43:446–448.
  • Liu, BH, Wu, TS, Yu, FY, Su, CC. 2006. Induction of Oxidative Stress Response by the Mycotoxin Patulin in Mammalian Cells. Toxicol Sci. 95:340–347.
  • Liu B, Peng X, Meng X. 2018. Effective biodegradation of mycotoxin patulin by porcine pancreatic lipase. Front Microbiol. 9:615.
  • Liu BH, Wu TS, Yu FY, Su CC. 2007. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci. 95:340–347.
  • Liu BH, Yu FY, Wu TS, Li SY, Su MC, Wang MC, Shih SM. 2003. Evaluation of genotoxic risk and oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin. Toxicol Appl Pharmacol. 191:255–263.
  • Luo Y, Li Z, Yuan Y, Yue T. 2016a. Bioadsorption of patulin from kiwi fruit juice onto a superior magnetic chitosan. J Alloys Compd. 667:101–108.
  • Luo Y, Wang J, Liu B, Wang Z, Yuan Y, Yue T. 2015. Effect of yeast cell morphology, cell wall physical structure and chemical composition on patulin adsorption. J Pone. 10:1–16.
  • Luo Y, Wang ZL, Yuan YH, Zhou ZK, Yue TL. 2016b. Patulin adsorption of a superior microorganism strain with low flavor-affection of kiwi fruit juice. World Mycotoxin J. 9:195–203.
  • Mahfoud, R, Maresca, M, Garmy, N, Fantini, J. 2002. The mycotoxin patulin alters thebarrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathione. Toxicol Appl Pharmacol. 18:1209–1218.
  • Manchisky M, Mídio AF. 1996. Incidencia de patulina en jugo de manzana industrializado. Alimentari. 276:61–64.
  • Marín S, Mateo EM, Sanchis V, Valle-Algarra FM, Ramos AJ, Jiménez M. 2011. Patulin contamination in fruit derivatives, including baby food, from the Spanish market. Food Chem. 124:563–568.
  • Mayer, VW, Legator, MS. 1969. Production of petite mutants of Saccharomyces cerevisiae by patulin. J Agric Food Chem. 17:454–456.
  • McKinley ER, Carlton WW, Boon GD. 1982. Patulin mycotoxicosis in the rat: toxicology, pathology and clinical pathology. Food Chem Toxicol. 20:289–300.
  • McKinley ER, Carlton WW. 1980a. Patulin mycotoxicosis in Swiss ICR mice. Food Cosmet Toxicol. 18:181–187.
  • McKinley ER, Carlton WW. 1980b. Patulin mycotoxicosis in the Syrian hamster. Food Cosmet Toxicol. 18:173–179.
  • McKinley ER, Carlton WW. 1991. Patulin. In: Sharma RP, Salunkhe DK, editors. Mycotoxins and phytoalexins. Boca Raton (FL): CRC Press; p. 191–236.
  • Miura, S, Hasumi, K, Endo, A. 1993. Inhibition of protein prenylation by patulin. FEBS Lett. 318:88–90.
  • Moake MM, Padilla-Zakour OI, Worobo RW. 2005. Comprehensive review of patulin control methods in foods. Comp Rev Food Sci Food Saf. 1:8–21.
  • Moss MO, Long MT. 2002. Fate of patulin in the presence of the yeast Saccharomyces cerevisiae. Food Addit Contam. 19:387–399.
  • Moukas A, Panagiotopoulou V, Markaki P. 2008. Determination of patulin in fruit juices using HPLC-DAD and GC-MSD techniques. Food Chem. 109:860–867.
  • Moule, Y, Hatey, F. 1977. Mechanism of the in vitro inhibition of transcription by patulin, a mycotoxin from Byssochlamys nivea. FEBS Lett. 74:121–125.
  • Murillo-Arbizu M, González-Peñas E, Amézqueta S. 2010. Comparison between capillary electrophoresis and high performance liquid chromatography for the study of the occurrence of patulin in apple juice intended for infants. Food Chem Toxicol. 48:2429–2434.
  • Nakazato M, Morozumi S, Saito K, Fujinuma K, Nishima T, Kasai N. 1990. Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Appl Environ Microbiol. 56:1465–1470.
  • Norstadt FA, McCalla TM. 1963. Phytotoxic substance from a species of Penicillium. Science. 140:410–411.
  • Oroian M, Amariei S, Gutt G. 2014. Patulin in apple juices from the Romanian market. Food Addit Contam B Surveill. 7:147–150.
  • Oswald H, Frank HK, Komitowski D, Winter H. 1978. Long-term testing of patulin administered orally to Sprague-Dawley rats and Swiss mice. Food Cosmet Toxicol. 16:243–247.
  • Oswald IP, Comera C. 1998. Immunotoxicity of mycotoxins. Rev Med Vet. 149:585–590.
  • Oteiza JM, Khaneghah AM, Campagnollo FB, Granato D, Mahmoudi MR, Sant’Ana AS, Gianuzzi L. 2017. Influence of production on the presence of patulin and ochratoxin A in fruit juices and wines of Argentina. LWT-Food Sci Technol. 80:200–207.
  • Pattono D, Grosso A, Stocco PP, Pazzi M, Zeppa G. 2013. Survey of the presence of patulin and ochratoxin a in traditional semi-hard cheeses. Food Control. 33:54–57.
  • Paucod JC, Krivobok S, Vidal D. 1990. Immunotoxicity testing of mycotoxins T-2 and patulin on Balb/c mice. Acta Microbiol Hung. 37:331–339.
  • Peng X, Liu B, Chen W, Li X, Wang Q, Meng X, Wang D. 2016. Effective biosorption of patulin from apple juice by cross-linked xanthated chitosan resin. Food Control. 63:140–146.
  • Pfeiffer, E. 1998. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis. 19:1313–1318.
  • Pfeiffer E, Gross K, Metzler M. 1998. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis. 19:1313–1318.
  • Phillips TD, Hayes W. 1978. Effects of patulin on the kinetics of substrate and cationic ligand and activation of adenosine triphosphatase in mouse brain. J Pharmacol Exp Ther. 205:606–616.
  • Phillips, TD, Hayes, AW. 1977. Effects of patulin on adenosine triphosphatase activities in the mouse. Toxicol Appl Pharmacol. 42:175–187. 
  • Philpot FJ. 1943. A penicillin-like substance from Aspergillus giganteus Wehm. Nature. 152:725.
  • Piemontese L, Solfrizzo M, Visconti A. 2005. Occurrence of patulin in conventional and organic fruit products in Italy and subsequent exposure assessment. Food Addit Contam A. 22:437–442.
  • Piqué E, Vargas-Murga L, Gomez-Catalan J, Lapuente J, Llobet JM. 2013. Occurrence of patulin in organic and conventional apple-based food marketed in Catalonia and exposure assessment. Food Chem Toxicol. 60:199–204.
  • Plunkett LM, Turnbull D, Rudricks JV. 1992. Differences between adults and children affecting exposure assessment. In: Guelian PS, Henry CJ, Olin SS, editors. Similarities and differences between children and adults. Washington: ILSI Press; p. 79–94.
  • Prado G, Oliveira MS, Cunha MR, Gomides MF, Abrantes FM, Santos LG. 2000. Occurrence of patulin in apple juice marketed in Brazil by high performance liquid chromatography. Rev Inst Adolfo Lutz. 59:21–25.
  • Prieta J, Moreno MA, Diaz S, Suarez G, Dominguez L. 1994a. Survey of patulin in apple juice and children’s apple food by diphasic dialysis membrane procedure. J Agric Food Chem. 42:1701–1703.
  • Prieta J, Moreno MA, Díaz S, Suárez G, Dominguez L. 1994b. La patulina como indicador de calidad em productos elaborados com manzana. Alimentaria. 254:75–80.
  • Puel O, Galtier P, Oswald I. 2010. Biosynthesis and toxicological effects of patulin. Toxins (Basel). 2:613–631.
  • Qiu Y, Guo H, Guo C, Zheng J, Yue T, Yuan Y. 2018. One-step preparation of nano-Fe3O4 modified inactivated yeast for the adsorption of patulin. Food Control. 86:310–318.
  • Raistrick J, Birkinshaw JH, Bracken A, Michael SE, Hopkins WA, Gye WE. 1943. Patulin in the common cold. Collaborative research on a derivative of Penicillium patulum banier. Lancet. 245:625.
  • Reddy KR, Spadaro D, Gullino ML, Garibaldi A. 2011. Potential of two Metschnikowia pulcherrima (yeast) strains for in vitro biodegradation of patulin. J Food Prot. 74:154–156.
  • Reiss, J. 1977. Inhibition of urease by the mycotoxin patulin. Naturwissenschaften. 64:97.
  • Ricelli A, Baruzzi F, Solfrizzo M, Morea M, Fanizzi FP. 2007. Biotransformation of patulin by Gluconobacter oxydans. Appl Environ Microbiol. 73:785–792.
  • Riley, RT, Showker, JL. 1991. The mechanism of patulin's cytotoxicity and the antioxidant activity of indole tetramic acids. Toxicol Appl Pharmacol. 109:108–126. 
  • Ritieni A. 2003. Patulin in Italian commercial apple products. J Agric Food Chem. 51:6086–6090.
  • Roll, R, Matthiaschk, G, Korte, A. 1990. Embryotoxicity and mutagenicity of mycotoxins. J Environ Pathol Toxicol Oncol. 10:1–7.
  • Sahin G, Unuvar S, Baydar T. 2011. Patulin: its toxicity and possible contamination of products used in baby nutrition. Turk Arch Ped. 46:266–270.
  • Sajid M, Mehmood S, Niu C, Yuan Y, Yue T. 2018. Effective adsorption of patulin from apple juice by using non-cytotoxic heat-inactivated cells and spores of Alicyclobacillus strains. Toxins. 10:344.
  • Samson RA, Houbraken J, Varga J, Frisvad JC. 2009. Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs. Persoonia. 22:14–27.
  • Sarubbi F, Formisano G, Auriemma G, Arrichiello A, Palomba R. 2016. Patulin in homogenized fruits and tomato products. Food Control. 59:420–423.
  • Saxena N, Dwivedi PD, Ansari KM, Das M. 2008. Patulin in apple juices: incidence and likely intake in an Indian population. Food Addit Contam B Surveill. 1:140–146.
  • Sekiguchi J, Shimamoto T, Yamada Y, Gaucher GM. 1983. Patulin biosynthesis: enzymatic and nonenzymatic transformations of the mycotoxin (E)-ascladiol. Appl Environ Microbiol. 45:1939–1942.
  • Selmanoglu, G, Koçkaya, E A. 2004. Investigation of the effects of patulin on thyroid and testis, and hormone levels in growing male rats. Food Chem Toxicol. 42:721–727.
  • Shapira R. 2004. Detection and control. In: Magan N, Olsen M, editors. Mycotoxins in food. Boca Raton (FL): CRC Press; p. 207.
  • Sommer NF, Buchanan JR, Fortlage RJ, Hsieh DPH. 1974. Paulin a mycotoxin in fruit products. Proc IV Int Congress Food Sci Technol. 3:266.
  • Songsermsakul P, Razzazi-Fazeli E. 2008. A review of recent trends in applications of liquid chromatography–mass spectrometry for determination of mycotoxins. J Liq Chromatogr Relat Technol. 31:1641–1648.
  • Sorenson WG, Gerberick GF, Lewis DM, Castranova V. 1986. Toxicity of mycotoxins for the rat pulmonary macrophage in vitro. Environ Health Perspect. 66:45–53.
  • Spadaro D, Ciavorella A, Frati S, Garibaldi A, Gullino ML. 2007. Incidence and level of patulin contamination in pure and mixed apple juices marketed in Italy. Food Control. 18:1098–1102.
  • Speijers GJA, Franken MAM, Van Leeuwen FXR, Van Egmond HP, Boot R, Loeber JG. 1986. Subchronic oral toxicity study of patulin in the rat. Report No. 618314: 001. Rijksinstituut voor Volksgezondheid en Milieuhygiëne.
  • Speijers GJA, Kolkman R, Franken MAM, Van Leeuwen FXR, Danse L. 1985. Subacute toxiciteit van patulin in de rat. Rapport nr. 617903: 001. Rijksinstituut voor Volksgezondheid en Milieuhygiëne.
  • Stansfield JM, Francis AE, Stuart-Harris CH. 1944. Laboratory and clinical trials of patulin. Lancet. 2:370.
  • Steiner I, Werner D, Washüttl J. 1999. Patulin in fruit juices. Part 1. Analysis and control in Austrian apple and pear juices. Ernährung Nutr. 23:202–208.
  • Stinson EE, Osman SF, Huhtanen CN, Bills DD. 1978. Disappearance of patulin during alcoholic fermentation of apple juice. Appl Environ Microbiol. 36:620–622.
  • Stott WT, Bullerman LB. 1975. Patulin: a mycotoxin of potential concern in foods. J Milk Food Technol. 38:695–705.
  • Subramanian V. 2002. DNA shuffling to produce nucleic acids for mycotoxin detoxification. United States patent WO2000020573A2.
  • Sumbu ZL, Thonart P, Bechet J. 1983. Action of patulin on a yeast. Appl Environ Microbiol. 45:110–115.
  • Suzuki T, Takeda M, Tanabe H. 1971. A new mycotoxin produced by Aspergillus clavatus. Chem Pharm Bull. 19:1786–1788.
  • Tang H, Peng X, Li X, Meng X, Liu B. 2018. Biodegradation of mycotoxin patulin in apple juice by calcium carbonate immobilized porcine pancreatic lipase. Food Control. 88:69–74.
  • Tangni EK, Theys R, Mignolet E, Maudoux M, Michelet JY, Larondelle Y. 2003. Patulin in domestic and imported apple-based drinks in Belgium: occurrence and exposure assessment. Food Addit Contam. 20:482–489.
  • Tannous J, Snini SP, El Khoury R, Canlet C, Pinton P, Lippi Y, Alassane-Kpembi I, Gauthier T, El Khoury A, Atoui A, et al. 2017. Patulin transformation products and last intermediates in its biosynthetic pathway, E-, and Z-ascladiol, are not toxic to human cells. Arch Toxicol. 91:2455–2467.
  • Thust R, Kneist S, Mendel J. 1982. Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro. Mutat Res. 103:91–97.
  • Topcu A, Bulat T, Wishah R, Boyaci IH. 2010. Detoxification of aflatoxin B1 and patulin by Enterococcus faecium strains. Int J Food Microbiol. 139:202–205.
  • Torović L, Dimitrov N, Lopes A, Martins C, Alvito P, Assunção R. 2018. Patulin in fruit juices: occurrence, bioaccessibility, and risk assessment for Serbian population. Food Addit Contam A. 35:1–11.
  • Ueno, Y, Matsumoto, H, Ishii, K, Kukita, K-I. 1976. Inhibitory effects of mycotoxins on Na+-dependent transport of glycine in rabbit reticulocytes. Biochem Pharmacol. 25:2091–2095.
  • USDA (United States Department of Agriculture). 2003. Statistics of fruits, tree nuts, and horticultural specialties. Washington (DC): National Agricultural Statistics Service (NASS); [accessed 2019 Mar 5]. https://www.usda.gov/nass/pubs/agr02/02_ch5.pdf.
  • USFDA. 2004. Compliance policy guide. Compliance policy guidance for FDA staff. Sec. 510.150. Apple juice, apple juice concentrates, and apple juice products-adulteration with patulin; [accessed Mar 2]. http://www.fda.gov/ora/compliance_ref/cpg/cpgfod/cpg510-150.htm.
  • Vaclavikova M, Dzuman Z, Lacina O, Fenclova M, Veprikova Z, Zachariasova M, Hajslova J. 2015. Monitoring survey of patulin in variety of fruit based products using a sensitive UHPL-MS/MS analytical producer. Food Control. 47:577–584.
  • Van de Perre E, Jacxsens L, Van Der Hauwaert W, Haesaert I, De Meulenaer B. 2014. Screening for the presence of patulin in molded fresh produce and evaluation of its stability in the production of tomato products. J Agric Food Chem. 62:304–309.
  • Van Egmond HP. 1989. Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis. Food Addit Contam. 6:138–188.
  • Van Luijk A. 1938. Antagonism of Penicillium spp. versus Pythium debaryanum. Chron Bot. 4:210.
  • Varga J, Due M, Frisvad JC, Samson RA. 2007. Taxonomic revision of Aspergillus section Clavati based on molecular, morphological and physiological data. Stud Mycol. 59:89–106.
  • Varga J, Péteri Z, Tábori K, Téren J, Vágvölgyi C. 2005. Degradation of ochratoxin A and other mycotoxins by Rhizopus isolates. Int J Food Microbiol. 99:321–328.
  • Walker, K, Wiesner, B. 1944. Patulin and clavicin. Lancet. 243:294.
  • Wang L, Wang Z, Yuan Y, Cai R, Niu C, Yue T. 2015b. Identification of key factors involved in the biosorption of patulin by inactivated lactic acid bacteria (LAB) cells. PLoS One. 10:1–19.
  • Wang L, Yue T, Yuan Y, Wang Z, Ye M, Cai R. 2015. A new insight into the adsorption mechanism of patulin by the heat-inactive lactic acid bacteria cells. Food Control. 50:104–110.
  • Watanabe M, Shimizu H. 2005. Detection of patulin in apple juices marketed in the Tohoku District, Japan. J Food Prot. 68:610–612.
  • Watkins KL, Fazekas G, Palmer MV. 1990. Patulin in Australian apple juice. Food Aust. 42:438–439.
  • WHO. 1998. Joint FAO/WHO Expert Committee on Food Additives (JECFA), Position paper on patulin, 30th session, The Hague, The Netherlands, 9–13 March.
  • Wichmann G, Herbarth O, Lehmann I. 2002. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Environ Toxicol. 17:211–218.
  • Wright SA. 2015. Patulin in food. Curr Opin Food Sci. 5:105–109.
  • Wu Q, Jezkova A, Yuan Z, Pavlikova L, Dohnal V, Kuca K. 2009. Biological degradation of aflatoxins. Drug Metab Rev. 41:1–7.
  • Würgler, FE, Friederich, U, Schlatter, J. 1991. Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102. Mutat Res. 261:209–216.
  • Yiannikouris A, Francois J, Poughon L, Dussap CG, Bertin GG, Jeminet G, Jouany JP. 2004. Adsorption of zearalenone by β-d-glucans in the Saccharomyces cerevisiae cell wall. J Food Prot. 67:1195–1200.
  • Yuan Y, Wang X, Hatab S, Wang Z, Wang Y, Luo Y, Yue T. 2014. Patulin reduction in apple juice by inactivated Alicyclobacillus spp. Lett Appl Microbiol. 59:603–609.
  • Yuan Y, Zhuang H, Zhang T, Liu J. 2010. Patulin content in apple products marketed in Northeast China. Food Control. 21:1488–1491.
  • Yue T, Dong Q, Guo C, Worobo RW. 2011. Reducing patulin contamination in apple juice by using inactive yeast. J Food Prot. 74:149–153.
  • Yue T, Guo C, Yuan Y, Wang Z, Luo Y, Wang L. 2013. Adsorptive removal of patulin from apple juice using Ca-alginate-activated carbon beads. J Food Sci. 78:1629–1635.
  • Yurdun T, Omurtag GZ, Ersoy O. 2001. Incidence of patulin in apple juices marketed in Turkey. J Food Prot. 64:1851–1853.
  • Zaied C, Abid S, Hlel W, Bacha H. 2013. Occurrence of patulin in apple-based foods largely consumed in Tunisia. Food Control. 31:263–267.
  • Zbyňovská K, Petruška P, Kalafová A, Capcarová M. 2016. Patulin – a contaminant of food and feed: a review. Acta Fytotechn Zootechn. 19:64–67.
  • Zhang B, Peng X, Li G, Xu Y, Xia X, Wang Q. 2015. Oxidative stress is involved in patulin induced apoptosis in HEK293 cells. Toxicon. 94:1–7.
  • Zhang X, Guo Y, Ma Y, Chai Y, Li Y. 2016. Biodegradation of patulin by a Byssochlamys nivea strain. Food Control. 64:142–150.
  • Zhu R, Feussner K, Wu T, Yan F, Karlovsky P, Zheng X. 2015. Detoxification of mycotoxin patulin by the yeast Rhodosporidium paludigenum. Food Chem. 179:1–5.
  • Zhu Y, Hassan YI, Watts C, Zhou T. 2016. Innovative technologies for the mitigation of mycotoxins in animal feed and ingredients—a review of recent patents. Anim Feed Sci Technol. 216:19–29.
  • Zhu Y, Koutchma T, Warriner K, Shao S, Zhou T. 2013. Kinetics of patulin degradation in model solution, apple cider and apple juice by ultraviolet radiation. Food Sci Technol Int. 19:291–303.
  • Zhu Y, Koutchma T, Warriner K, Zhou T. 2014. Reduction of patulin in apple juice products by UV light of different wavelengths in the UVC range. J Food Prot. 77:963–971.
  • Zouaoui N, Sbaii N, Bacha H, Abid-Essefi S. 2015. Occurrence of patulin in various fruit juice marketed in Tunisia. Food Control. 51:356–360.

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