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Review Articles

Zinc-based metal–organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study

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Pages 356-377 | Received 03 Mar 2019, Accepted 10 Jun 2019, Published online: 09 Jul 2019

References

  • Abazari R, Mahjoub AR, Ataei F, Morsali A, Carpenter-Warren CL, Mehdizadeh K, Slawin AMZ. 2018. Chitosan immobilization on bio-MOF nanostructures: a biocompatible pH-responsive nanocarrier for doxorubicin release on MCF-7 cell lines of human breast cancer. Inorg Chem. 57:13364–13379.
  • Agostoni V, Chalati T, Horcajada P, Willaime H, Anand R, Semiramoth N, Baati T, Hall S, Maurin G, Chacun H, et al. 2013. Towards an improved anti-HIV activity of NRTI via metal-organic frameworks nanoparticles. Adv Healthc Mater. 2:1630–1637.
  • Alghool S, Slebodnick C. 2014. One dimensional structure of Zn(II) metal organic framework (MOF) assembled rapidly at room temperature: structural, thermal study, and luminescent properties. J Inorg Organomet Polym. 24:644–651.
  • Alvarez E, Marquez AG, Devic T, Steunou N, Serre C, Bonhomme C, Gervais C, Izquierdo-Barba I, Vallet-Regi M, Laurencin D, et al. 2013. A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect? Cryst Eng Comm. 15:9899.
  • An J, Geib SJ, Rosi NL. 2009. Cation-triggered drug release from a porous zinc-adeninate metal-organic framework. J Am Chem Soc. 131:8376–8377.
  • An J, Shade CM, Chengelis-Czegan DA, Petoud S, Rosi NL. 2011. Zinc-adeninate metal-organic framework for aqueous encapsulation and sensitization of near-infrared and visible emitting lanthanide cations. J Am Chem Soc. 133:1220–1223.
  • Azizi Vahed T, Naimi-Jamal MR, Panahi L. 2019. Alginate-coated ZIF-8 metal-organic framework as a green and bioactive platform for controlled drug release. J Drug Deliv Sci Technol. 49:570–576.
  • Baati T, Njim L, Neffati F, Kerkeni A, Bouttemi M, Gref R, Najjar MF, Zakhama A, Couvreur P, Serre C, et al. 2013. In depth analysis of the in vivo toxicity of nanoparticles of porous iron (III) metal–organic frameworks. Chem Sci. 4:1597–1607.
  • Bag PP, Wang D, Chen Z, Cao R. 2016. Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier. Chem Commun. 52:3669–3672.
  • Bag S, Durstock MF. 2016. Efficient semi-transparent planar perovskite solar cells using a ‘molecular glue’. Nano Energy. 30:542–548.
  • Bahr DF, Reid JA, Mook WM, Bauer CA, Stumpf R, Skulan AJ, Moody NR, Simmons BA, Shindel MM, Allendorf MD, et al. 2007. Mechanical properties of cubic zinc carboxylate IRMOF-1 metal-organic framework crystals. Phys Rev B. 76:184106.
  • Bahrani S, Ghaedi M, Dashtian K, Ostovan A, Mansoorkhani MJK, Salehi A. 2017. MOF-5(Zn)-Fe2O4 nanocomposite based magnetic solid-phase microextraction followed by HPLC-UV for efficient enrichment of colchicine in root of colchicium extracts and plasma samples. J Chromatogr B. 1067:45–52.
  • Bahrani S, Ghaedi M, Ostovan A, Javadian H, Mansoorkhani MJK, Taghipour T. 2018. A facile and selective approach for enrichment of l-cysteine in human plasma sample based on zinc organic polymer: optimization by response surface methodology. J Pharm Biomed Anal. 149:166–171.
  • Beg S, Rahman M, Jain A, Saini S, Midoux P, Pichon C, Ahmad FJ, Akhter S. 2017. Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications. Drug Discov Today. 22:625–637.
  • Bellarosa L, Castillo JMl, Vlugt T, Calero S, López N. 2012. On the mechanism behind the instability of isoreticular metal-organic frameworks (IRMOFs) in humid environments. Chem Eur J. 18:12260–12266.
  • Berchel M, Gall TL, Denis C, Hir SL, Quentel F, Elléouet C, Montier T, Rueff JM, Salaün JY, Haelters JP, et al. 2011. A silver-based metal–organic framework material as a ‘reservoir’ of bactericidal metal ions. New J Chem. 35:1000.
  • Bhardwaj N, Pandey SK, Mehta J, Bhardwaj SK, Kim KH, Deep A. 2018. Bioactive nano-metal–organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria. Toxicol Res. 7:931–941.
  • Bian R, Wang T, Zhang L, Li L, Wang C. 2015. A combination of tri-modal cancer imaging and in vivo drug delivery by metal-organic framework based composite nanoparticles. Biomater Sci. 3:1270–1278.
  • Burrows AD, Jurcic M, Keenan LL, Lane RA, Mahon MF, Warren MR, Nowell H, Paradowski M, Spencer J. 2013. Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks. Chem Commun. 49:11260–11262.
  • Burtch NC, Jasuja H, Walton KS. 2014. Water stability and adsorption in metal-organic frameworks. Chem Rev. 114:10575–10612.
  • Cattaneo D, Warrender SJ, Duncan MJ, Kelsall CJ, Doherty MK, Whitfield PD, Megson IL, Morris RE. 2016. Tuning the nitric oxide release from CPO-27 MOFs. RSC Adv. 6:14059–14067.
  • Cavaco LM, Hasman H, Aarestrup FM. 2011. Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance. Vet Microbiol. 150:344–348.
  • Chedid G, Yassin A. 2018. Recent trends in covalent and metal organic frameworks for biomedical applications. Nanomaterials. 8:916.
  • Chen B, Wang X, Zhang Q, Xi X, Cai J, Qi H, Shi S, Wang J, Yuan D, Fang M, et al. 2010. Synthesis and characterization of the interpenetrated MOF-5. J Mater Chem. 20:3758.
  • Chen Y, Chen T, Dai L. 2015. Layer‐by‐layer growth of CH3NH3PbI3− xClx for highly efficient planar heterojunction perovskite solar cells. Adv Mater. 27:1053–1059.
  • Chen Z, Yang G, Zheng X, Lei H, Chen C, Ma J, Wang H, Fang G. 2017. Bulk heterojunction perovskite solar cells based on room temperature deposited hole-blocking layer: suppressed hysteresis and flexible photovoltaic application. J Power Sources. 351:123–129.
  • Chowdhury MA. 2017. Metal-organic-frameworks for biomedical applications in drug delivery, and as MRI contrast agents. J Biomed Mater Res A. 105:1184–1194.
  • Colinas IR, Rojas-Andrade MD, Chakraborty I, Oliver SRJ. 2018. Two structurally diverse Zn-based coordination polymers with excellent antibacterial activity. Cryst Eng Comm. 20:3353–3362.
  • Cui Y, Xu H, Yue Y, Guo Z, Yu J, Chen Z, Gao J, Yang Y, Qian G, Chen B, et al. 2012. A luminescent mixed-lanthanide metal-organic framework thermometer. J Am Chem Soc. 134:3979–3982.
  • Cunha D, Ben Yahia M, Hall S, Miller SR, Chevreau H, Elkaïm E, Maurin G, Horcajada P, Serre C. 2013. Rationale of drug encapsulation and release from biocompatible porous metal–organic frameworks. Chem Mater. 25:2767–2776.
  • de Cires-Mejias C, Tanase S, Reedijk J, González-Vı́lchez F, Vilaplana R, Mills AM, Kooijman H, Spek AL. 2004. Extended structures based on hydrogen bonding and π–π interactions: synthesis and characterization of two zinc complexes: [Zn(dap)Cl2] and [Zn(dap)2Cl2]. Inorganica Chimica Acta. 357:1494–1498.
  • Di Giacomo F, et al. 2016. Progress, challenges and perspectives in flexible perovskite solar cells. Energy Environ Sci. 9:3007–3035.
  • Di Giacomo F, Zardetto V, D'Epifanio A, Pescetelli S, Matteocci F, Razza S, Di Carlo A, Licoccia S, Kessels WMM, Creatore M, et al. 2015. Flexible perovskite photovoltaic modules and solar cells based on atomic layer deposited compact layers and UV‐irradiated TiO2 scaffolds on plastic substrates. Adv Energy Mater. 5:1401808.
  • Ding G, Yuan J, Jin F, Zhang Y, Han L, Ling X, Zhao H, Ma W. 2017. High-performance all-polymer nonfullerene solar cells by employing an efficient polymer-small molecule acceptor alloy strategy. Nano Energy. 36:356–365.
  • Dong K, Zhang Y, Zhang L, Wang Z, Ren J, Qu X. 2019. Facile preparation of metal-organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment. Talanta. 194:703–708.
  • Duan LN, Dang QQ, Han CY, Zhang XM. 2015. An interpenetrated bioactive nonlinear optical MOF containing a coordinated quinolone-like drug and Zn(II) for pH-responsive release. Dalton Trans. 44:1800–1804.
  • Eddaoudi M, et al. 2002. Systematic design of pore size and functionality in isoreticular MOFs and their application in methane storage. Science. 295:469–472.
  • Feng J, Yang Z, Yang D, Ren X, Zhu X, Jin Z, Zi W, Wei Q, Liu SF. 2017. E-beam evaporated Nb2O5 as an effective electron transport layer for large flexible perovskite solar cells. Nano Energy. 36:1–8.
  • Ferey G. 2008. Hybrid porous solids: past, present, future. Chem Soc Rev. 37:191–214.
  • Finn M, Martens CJ, Zaretski AV, Roth B, Søndergaard RR, Krebs FC, Lipomi DJ. 2018. Mechanical stability of roll-to-roll printed solar cells under cyclic bending and torsion. Sol Energy Mater Sol Cells. 174:7–15.
  • Fox S, Wilkinson TS, Wheatley PS, Xiao B, Morris RE, Sutherland A, Simpson AJ, Barlow PG, Butler AR, Megson IL, et al. 2010. NO-loaded Zn(2+)-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy. Acta Biomater. 6:1515–1521.
  • Fu Y, Lv Z, Hou S, Wu H ,Wang D, Zhang C, Chu Z, Cai X, Fan X, Wang ZL, et al. 2011. Conjunction of fiber solar cells with groovy micro-reflectors as highly efficient energy harvesters. Energy Environ Sci. 4:3379–3383.
  • Gu ZY, Chen YJ, Jiang JQ, Yan XP. 2011. Metal-organic frameworks for efficient enrichment of peptides with simultaneous exclusion of proteins from complex biological samples. Chem Commun. 47:4787–4789.
  • Gu Z, Zuo L, Larsen-Olsen TT, Ye T, Wu G, Krebs FC, Chen H. 2015. Interfacial engineering of self-assembled monolayer modified semi-roll-to-roll planar heterojunction perovskite solar cells on flexible substrates. J Mater Chem A. 3:24254–24260.
  • Guo C, Xu S, Arshad A, Wang L. 2018. A pH-responsive nanoprobe for turn-on (19)F-magnetic resonance imaging. Chem Commun. 54:9853–9856.
  • Guo P, Dutta D, Wong-Foy AG, Gidley DW, Matzger AJ. 2015. Water sensitivity in Zn4O-based MOFs is structure and history dependent. J Am Chem Soc. 137:2651–2657.
  • Ha J, Kim H, Lee H, Lim KG, Lee TW, Yoo S. 2017. Device architecture for efficient, low-hysteresis flexible perovskite solar cells: replacing TiO2 with C60 assisted by polyethylenimine ethoxylated interfacial layers. Sol Energy Mater Sol Cells. 161:338–346.
  • Hinks NJ, McKinlay AC, Xiao B, Wheatley PS, Morris RE. 2010. Metal organic frameworks as NO delivery materials for biological applications. Micropor Mesopor Mat. 129:330–334.
  • Horcajada P, Chalati T, Serre C, Gillet B, Sebrie C, Baati T, Eubank JF, Heurtaux D, Clayette P, Kreuz C, et al. 2010. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature Mater. 9:172.
  • Horcajada P, Gref R, Baati T, Allan PK, Maurin G, Couvreur P, Férey G, Morris RE, Serre C. 2012. Metal-organic frameworks in biomedicine. Chem Rev. 112:1232–1268.
  • Horcajada P, Serre C, Vallet-Regí M, Sebban M, Taulelle F, Férey G. 2006. Metal-organic frameworks as efficient materials for drug delivery. Angew Chem. 45:5974–5978.
  • Howarth AJ, Liu Y, Li P, Li Z, Wang TC, Hupp JT, Farha OK. 2016. Chemical, thermal and mechanical stabilities of metal–organic frameworks. Nat Rev Mater. 1:15018.
  • Hubin TJ, Amoyaw PNA, Roewe KD, Simpson NC, Maples RD, Carder Freeman TRN, Cain AN, Le JG, Archibald SJ, Khan SI, et al. 2014. Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands. Bioorg Med Chem. 22:3239–3244.
  • Huong TTT, Thanh PN, Son DN. 2016. Metal–organic frameworks: state-of-the-art material for gas capture and storage. VNU J Sci. 32:67–85.
  • Huxford RC, Della Rocca J, Lin W. 2010. Metal-organic frameworks as potential drug carriers. Curr Opin Chem Biol. 14:262–268.
  • Imaz I, Rubio-Martínez M, An J, Solé-Font I, Rosi NL, Maspoch D. 2011. Metal-biomolecule frameworks (MBioFs). Chem Commun. 47:7287–7302.
  • Imaz I, Rubio-Martínez M, García-Fernández L, García F, Ruiz-Molina D, Hernando J, Puntes V, Maspoch D. 2010. Coordination polymer particles as potential drug delivery systems. Chem Commun. 46:4737–4739.
  • Jeon I, Chiba T, Delacou C, Guo Y, Kaskela A, Reynaud O, Kauppinen EI, Maruyama S, Matsuo Y. 2015. Single-walled carbon nanotube film as electrode in indium-free planar heterojunction perovskite solar cells: investigation of electron-blocking layers and dopants. Nano Lett. 15:6665–6671.
  • Jung S, Lee J, Seo J, Kim U, Choi Y, Park H. 2018. Development of annealing-free, solution-processable inverted organic solar cells with n-doped graphene electrodes using zinc oxide nanoparticles. Nano Lett. 18:1337–1343.
  • Kaltenbrunner M, Adam G, Głowacki ED, Drack M, Schwödiauer R, Leonat L, Apaydin DH, Groiss H, Scharber MC, White MS, et al. 2015. Flexible high power-per-weight perovskite solar cells with chromium oxide–metal contacts for improved stability in air. Nature Mater. 14:1032.
  • Karimzadeh Z, Javanbakht S, Namazi H. 2018. Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent. Bioimpacts. 9:5–13.
  • Keskin S, Kızılel S. 2011. Biomedical applications of metal organic frameworks. Ind Eng Chem Res. 50:1799–1812.
  • Keskin S, Sholl DS. 2009. Efficient methods for screening of metal organic framework membranes for gas separations using atomically detailed models. Langmuir. 25:11786–11795.
  • Kim JH, Chueh CC, Williams ST, Jen AKY. 2015. Room-temperature, solution-processable organic electron extraction layer for high-performance planar heterojunction perovskite solar cells. Nanoscale. 7:17343–17349.
  • Kim T, Kim JH, Kang TE, Lee C, Kang H, Shin M, Wang C, Ma B, Jeong U, Kim TS, et al. 2015. Flexible, highly efficient all-polymer solar cells. Nat Commun. 6:8547.
  • Kirillov AM, Wieczorek SW, Lis A, Guedes da Silva MFC, Florek M, Król J, Staroniewicz Z, Smoleński P, Pombeiro AJL. 2011. 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA═O): new diamondoid building block for design of three-dimensional metal–organic frameworks. Cryst Growth Des. 11:2711–2716.
  • Kitagawa S, Kitaura R, Noro S. 2004. Functional porous coordination polymers. Angew Chem Int Ed Engl. 43:2334–2375.
  • Kitao T, Zhang Y, Kitagawa S, Wang B, Uemura T. 2017. Hybridization of MOFs and polymers. Chem Soc Rev. 46:3108–3133.
  • Kreno LE, Leong K, Farha OK, Allendorf M, Van Duyne RP, Hupp JT. 2012. Metal-organic framework materials as chemical sensors. Chem Rev. 112:1105–1125.
  • Kroncke KD, Suschek CV. 2008. Adulterated effects of nitric oxide-generating donors. J Invest Dermatol. 128:258–260.
  • Lee YJ, Yeon C, Lim JW, Yun SJ. 2018. Flexible p-type PEDOT: PSS/a-Si: H hybrid thin film solar cells with boron-doped interlayer. Sol Energy. 163:398–404.
  • Li MH, Shen PS, Wang KC, Guo TF, Chen P. 2015. Inorganic p-type contact materials for perovskite-based solar cells. J Mater Chem A. 3:9011–9019.
  • Li Y, Zhang S, Song D. 2013. A luminescent metal-organic framework as a turn-on sensor for DMF vapor. Angew Chem Int Ed Engl. 52:710–713.
  • Li YW, Liu SJ, Hu TL, Bu XH. 2014. Doping cobalt into a [Zn(7)] cluster-based MOF to tune magnetic behaviour and induce fluorescence signal mutation. Dalton Trans. 43:11470–11473.
  • Li ZQ, Qiu LG, Wang W, Xu T, Wu Y, Jiang X. 2008. Fabrication of nanosheets of a fluorescent metal–organic framework [Zn(BDC)(H2O)]n (BDC = 1,4-benzenedicarboxylate): ultrasonic synthesis and sensing of ethylamine. Inorg Chem Commun. 11:1375–1377.
  • Lin J, Xin P, An L, Xu Y, Tao C, Tian Q, Zhou Z, Hu B, Yang S. 2019. Fe3O4-ZIF-8 assemblies as pH and glutathione responsive T2-T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo. Chem Commun. 55:478–481.
  • Lin Q, Lu L, Tavakoli MM, Zhang C, Lui GC, Chen Z, Chen X, Tang L, Zhang D, Lin Y, et al. 2016. High performance thin film solar cells on plastic substrates with nanostructure-enhanced flexibility. Nano Energy. 22:539–547.
  • Lin W, Hu Q, Jiang K, Cui Y, Yang Y, Qian G. 2017. A porous Zn-based metal-organic framework for pH and temperature dual-responsive controlled drug release. Micropor Mesopor Mat. 249:55–60.
  • Liu R, Yu T, Shi Z, Wang Z. 2016. The preparation of metal–organic frameworks and their biomedical application. Int J Nanomed. 11:1187.
  • Liu WL, Lo SH, Singco B, Yang CC, Huang HY, Lin CH. 2013. Novel trypsin–FITC@MOF bioreactor efficiently catalyzes protein digestion. J Mater Chem B. 1:928.
  • Liu W, Wang YM, Li YH, Cai SJ, Yin XB, He XW, Zhang YK. 2017. Fluorescent imaging‐guided chemotherapy‐and‐photodynamic dual therapy with nanoscale porphyrin metal–organic framework. Small. 13:1603459.
  • Lu H, Sun J, Zhang H, Lu S, Choy WCH. 2016. Room-temperature solution-processed and metal oxide-free nano-composite for the flexible transparent bottom electrode of perovskite solar cells. Nanoscale. 8:5946–5953.
  • Lucarelli G, Di Giacomo F, Zardetto V, Creatore M, Brown TM. 2017. Efficient light harvesting from flexible perovskite solar cells under indoor white light-emitting diode illumination. Nano Res. 10:2130–2145.
  • Lucena GN, Alves RC, Abuçafy MP, Chiavacci LA, da Silva IC, Pavan FR, Frem RCG. 2018. Zn-based porous coordination solid as diclofenac sodium carrier. J Solid State Chem. 260:67–72.
  • Lykourinou V, Chen Y, Wang XS, Meng L, Hoang T, Ming LJ, Musselman RL, Ma S. 2011. Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis. J Am Chem Soc. 133:10382–10385.
  • Ma DY, Xie J, Zhu Z, Huang H, Chen Y, Su R, Zhu H. 2017. Drug delivery and selective CO2 adsorption of a bio-based porous zinc-organic framework from 2,5-furandicarboxylate ligand. Inorg Chem Commun. 86:128–132.
  • Ma D, Li B, Zhou X, Zhou Q, Liu K, Zeng G, Li G, Shi Z, Feng S. 2013. A dual functional MOF as a luminescent sensor for quantitatively detecting the concentration of nitrobenzene and temperature. Chem Commun. 49:8964–8966.
  • McKinlay AC, Morris RE, Horcajada P, Férey G, Gref R, Couvreur P, Serre C. 2010. BioMOFs: metal-organic frameworks for biological and medical applications. Angew Chem. 49:6260–6266.
  • Mendiratta S, Usman M, Chang CC, Lee YC, Chen JW, Wu MK, Lin YC, Hsu CP, Lu KL. 2017. Zn(ii)-based metal–organic framework: an exceptionally thermally stable, guest-free low dielectric material. J Mater Chem C. 5:1508–1513.
  • Miller MR, Megson IL. 2007. Recent developments in nitric oxide donor drugs. Br J Pharmacol. 151:305–321.
  • Miller SR, Alvarez E, Fradcourt L, Devic T, Wuttke S, Wheatley PS, Steunou N, Bonhomme C, Gervais C, Laurencin D, et al. 2013. A rare example of a porous Ca-MOF for the controlled release of biologically active NO. Chem Commun. 49:7773–7775.
  • Miller SR, Heurtaux D, Baati T, Horcajada P, Grenèche JM, Serre C. 2010. Biodegradable therapeutic MOFs for the delivery of bioactive molecules. Chem Commun. 46:4526–4528.
  • Ming Y, Kumar N, Siegel DJ. 2017. Water adsorption and insertion in MOF-5. ACS Omega. 2:4921–4928.
  • Moon HR, Lim DW, Suh MP. 2013. Fabrication of metal nanoparticles in metal-organic frameworks. Chem Soc Rev. 42:1807–1824.
  • Motakef-Kazemi N, Shojaosadati SA, Morsali A. 2014. In situ synthesis of a drug-loaded MOF at room temperature. Micropor Mesopor Mat.186:73–79.
  • Mowbray M, Tan X, Wheatley PS, Morris RE, Weller RB. 2008. Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation. J Invest Dermatol. 128:352–360.
  • Murakami K, Imoto J, Matsubara H, Yoshida S, Yorimitsu H, Oshima K. 2013. Copper-catalyzed extended Pummerer reactions of ketene dithioacetal monoxides with alkynyl sulfides and ynamides with an accompanying oxygen rearrangement. Chem Eur J. 19:5625–5630.
  • Murphy DJ, Kwong RY. 2019. Contrast agents in cardiovascular magnetic resonance imaging. Cardiovasc Magn Reson Imaging. 127–143.
  • Novio F, Simmchen J, Vázquez-Mera N, Amorín-Ferré L, Ruiz-Molina D. 2013. Coordination polymer nanoparticles in medicine. Coord Chem Rev. 257:2839–2847.
  • Ou XL, Feng J, Xu M, Sun HB. 2017. Semitransparent and flexible perovskite solar cell with high visible transmittance based on ultrathin metallic electrodes. Opt Lett. 42:1958–1961.
  • Park M, Kim JY, Son HJ, Lee CH, Jang SS, Ko MJ. 2016. Low-temperature solution-processed Li-doped SnO2 as an effective electron transporting layer for high-performance flexible and wearable perovskite solar cells. Nano Energy. 26:208–215.
  • Park M, Park JS, Han IK, Oh JY. 2016. High-performance flexible and air-stable perovskite solar cells with a large active area based on poly (3-hexylthiophene) nanofibrils. J Mater Chem A. 4:11307–11316.
  • Pezeshkpour V, Khosravani SA, Ghaedi M, Dashtian K, Zare F, Sharifi A, Jannesar R, Zoladl M. 2018. Ultrasound assisted extraction of phenolic acids from broccoli vegetable and using sonochemistry for preparation of MOF-5 nanocubes: comparative study based on micro-dilution broth and plate count method for synergism antibacterial effect. Ultrason Sonochem. 40:1031–1038.
  • Pichon A, Lazuen-Garay A, James SL. 2006. Solvent-free synthesis of a microporous metal–organic framework. Cryst Eng Comm. 8:211.
  • Plum LM, Rink L, Haase H. 2010. The essential toxin: impact of zinc on human health. Int J Environ Res Pub Health. 7:1342–1365.
  • Prasad AS. 2008. Zinc in human health: effect of zinc on immune cells. Mol Med. 14:353–357.
  • Qin JS, Du DY, Li WL, Zhang JP, Li SL, Su ZM, Wang XL, Xu Q, Shao KZ, Lan YQ, et al. 2012. N-rich zeolite-like metal–organic framework with sodalite topology: high CO2 uptake, selective gas adsorption and efficient drug delivery. Chem Sci. 3:2114.
  • Qiu LG, Li ZQ, Wu Y, Wang W, Xua T, Jianga X. 2008. Facile synthesis of nanocrystals of a microporous metal-organic framework by an ultrasonic method and selective sensing of organoamines. Chem Commun. 2008:3642–3644.
  • Rana K, Singh J, Ahn JH. 2014. A graphene-based transparent electrode for use in flexible optoelectronic devices. J Mat Chem C. 2:2646–2656.
  • Ranjbar M, Pardakhty A, Amanatfard A, Asadipour A. 2018. Efficient drug delivery of beta-estradiol encapsulated in Zn-metal-organic framework nanostructures by microwave-assisted coprecipitation method. Drug Des Devel Ther. 12:2635–2643.
  • Ray Chowdhuri A, Bhattacharya D, Sahu SK. 2016. Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and as an MRI contrast agent. Dalton Trans. 45:2963–2973.
  • Reese MO, Gevorgyan SA, Jørgensen M, Bundgaard E, Kurtz SR, Ginley DS, Olson DC, Lloyd MT, Morvillo P, Katz EA, et al. 2011. Consensus stability testing protocols for organic photovoltaic materials and devices. Sol Energy Mater Sol Cells. 95:1253–1267.
  • Ren F, Yang B, Cai J, Jiang Y, Xu J, Wang S. 2014. Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro. J Hazard Mater. 271:283–291.
  • Ren J, Dyosiba X, Musyoka NM, Langmi HW, Mathe M, Liao S. 2017. Review on the current practices and efforts towards pilot-scale production of metal-organic frameworks (MOFs). Coord Chem Rev. 352:187–219.
  • Restrepo Jimmy, Serroukh Zakarias, Santiago-Morales Javier, Aguado Sonia, Gómez-Sal Pilar, Mosquera MEG, Rosal Roberto. 2017. Antibacterial Zn-MOF with Hydrazinebenzoate Linkers. Eur J Inorg Chem. 2017:574–580.
  • Rexit AA. 2009. A 2D Zn(II) metal-organic framework constructed from 4,4′-(perfluoropropane-2,2-diyl)dibenzoic acid, synthesis, structure and photoluminescence. J Coord Chem. 62:1373–1378.
  • Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR. 2006. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials. 27:3413–3431.
  • Rojas S, Carmona FJ, Maldonado CR, Horcajada P, Hidalgo T, Serre C, Navarro JAR, Barea E. 2016. Nanoscaled zinc pyrazolate metal-organic frameworks as drug-delivery systems. Inorg Chem. 55:2650–2663.
  • Rowsell JLC, Yaghi OM. 2004. Metal–organic frameworks: a new class of porous materials. Micropor Mesopor Mat. 73:3–14.
  • Ruyra À, Yazdi A, Espín J, Carné-Sánchez A, Roher N, Lorenzo J, Imaz I, Maspoch D. 2015. Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal-organic framework nanoparticles. Chem Eur J. 21:2508–2518.
  • Ryan P, Broadbelt LJ, Snurr RQ. 2008. Is catenation beneficial for hydrogen storage in metal-organic frameworks? Chem Commun. 2008:4132–4134.
  • Sava Gallis DF, et al. 2019. Antibacterial countermeasures via metal-organic framework-supported sustained therapeutic release. ACS Appl Mater Interfaces. 11:7782–7791.
  • Shanmugaraju S, Mukherjee PS. 2015. π-Electron rich small molecule sensors for the recognition of nitroaromatics. Chem Commun. 51:16014–16032.
  • Sharma D, Kumar P, Narasimhan B. 2012. Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir. Med Chem Res. 21:796–803.
  • Shearier E, Cheng P, Zhu Z, Bao J, Hu YH, Zhao F. 2016. Surface defection reduces cytotoxicity of Zn(2-methylimidazole)2 (ZIF-8) without compromising its drug delivery capacity. RSC Adv. 6:4128–4135.
  • Shimomura S, Higuchi M, Matsuda R, Yoneda K, Hijikata Y, Kubota Y, Mita Y, Kim J, Takata M, Kitagawa S, et al. 2010. Selective sorption of oxygen and nitric oxide by an electron-donating flexible porous coordination polymer. Nature Chem. 2:633–637.
  • Shin SS, Yang WS, Yeom EJ, Lee SJ, Jeon NJ, Joo YC, Park IJ, Noh JH, Seok SI. 2016. Tailoring of electron-collecting oxide nanoparticulate layer for flexible perovskite solar cells. J Phys Chem Lett. 7:1845–1851.
  • Slenters TV, Sagué JL, Brunetto PS, Zuber S, Fleury A, Mirolo L, Robin AY, Meuwly M, Gordon O, Landmann R, et al. 2010. Of chains and rings: synthetic strategies and theoretical investigations for tuning the structure of silver coordination compounds and their applications. Materials. 3:3407–3429.
  • Song BH, Ding X, Zhang ZF, An GF. 2018. Efficient drug delivery of 5-fluorouracil by a biocompatible Zn-metal–organic framework nanostructure and anti-liver cancer activity study. J Iran Chem Soc. 16:333–340.
  • Song X, Oh M, Lah MS. 2013. Hybrid bimetallic metal-organic frameworks: modulation of the framework stability and ultralarge CO2 uptake capacity. Inorg Chem. 52:10869–10876.
  • Stafford CM, Harrison C, Beers KL, Karim A, Amis EJ, VanLandingham MR, Kim HC, Volksen W, Miller RD, Simonyi EE, et al. 2004. A buckling-based metrology for measuring the elastic moduli of polymeric thin films. Nature Mater. 3:545.
  • Stock N, Biswas S. 2012. Synthesis of metal-organic frameworks (MOFs): routes to various MOF topologies, morphologies, and composites. Chem Rev. 112:933–969.
  • Su H, Sun F, Jia J, He H, Wang A, Zhu G. 2015. A highly porous medical metal-organic framework constructed from bioactive curcumin. Chem Commun. 51:5774–5777.
  • Sun CY, Qin C, Wang CG, Su ZM, Wang S, Wang XL, Yang GS, Shao KZ, Lan YQ, Wang EB, et al. 2011. Chiral nanoporous metal-organic frameworks with high porosity as materials for drug delivery. Adv Mater. 23:5629–5632.
  • Sun CY, Qin C, Wang XL, Su ZM. 2013. Metal-organic frameworks as potential drug delivery systems. Expert Opin Drug Deliv. 10:89–101.
  • Sun CY, Qin C, Wang XL, Yang GS, Shao KZ, Lan YQ, Su ZM, Huang P, Wang CG, Wang EB, et al. 2012. Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle. Dalton Trans. 41:6906.
  • Sun RWY, Zhang M, Li D, Zhang ZF, Cai H, Li M, Xian YJ, Ng SW, Wong AST. 2015. Dinuclear Gold(I) pyrrolidinedithiocarbamato complex: cytotoxic and antimigratory activities on cancer cells and the use of metal-organic framework. Chem Eur J. 21:18534–18538.
  • Szilágyi PÁ, Lutz M, Gascon J, Juan-Alcañiz J, van Esch J, Kapteijn F, Geerlings H, Dam B, van de Krol R. 2013. MOF@MOF core–shell vs. Janus particles and the effect of strain: potential for guest sorption, separation and sequestration. Cryst Eng Comm. 15:6003.
  • Taghipour T, Karimipour G, Ghaedi M, Asfaram A. 2018. Mild synthesis of a Zn(II) metal organic polymer and its hybrid with activated carbon: application as antibacterial agent and in water treatment by using sonochemistry: optimization, kinetic and isotherm study. Ultrason Sonochem. 41:389–396.
  • Tamames-Tabar C, García-Márquez A, Blanco-Prieto M, Serre C, Horcajada P. 2014. MOFs in pharmaceutical technology. In: Daniel R.-M., Fernando N., Claudio R., editors. Bio- and Bioinspired Nanomaterials. Weinheim, Germany: John Wiley & Sons. p. 83–112.
  • Tamames-Tabar C, Imbuluzqueta E, Guillou N, Serre C, Miller SR, Elkaïm E, Horcajada P, Blanco-Prieto MJ. 2015. A Zn azelate MOF: combining antibacterial effect. Cryst Eng Comm. 17:456–462.
  • Tamames-Tabar C, Cunha D, Imbuluzqueta E, Ragon F, Serre C, Blanco-Prieto MJ, Horcajada P. 2014. Cytotoxicity of nanoscaled metal–organic frameworks. J Mater Chem B. 2:262–271.
  • Taylor KM, Jin A, Lin W. 2008. Surfactant-assisted synthesis of nanoscale gadolinium metal-organic frameworks for potential multimodal imaging. Angew Chem. 47:7722–7725.
  • Taylor-Pashow KML, Della Rocca J, Xie Z, Tran S, Lin W. 2009. Postsynthetic modifications of Iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery. J Am Chem Soc. 131:14261–14263.
  • Vasconcelos IB, Silva TG, Militão GCG, Soares TA, Rodrigues NM, Rodrigues MO, Costa NB, Freire RO, Junior SA. 2012. Cytotoxicity and slow release of the anti-cancer drug doxorubicin from ZIF-8. RSC Adv. 2:9437–9442.
  • Wang C, Tian L, Zhu W, Wang S, Wang P, Liang Y, Zhang W, Zhao H, Li G. 2017. Dye@bio-MOF-1 composite as a dual-emitting platform for enhanced detection of a wide range of explosive molecules. ACS Appl Mater Interfaces. 9:20076–20085.
  • Wang H, Li T, Li J, Tong W, Gao C. 2019. One-pot synthesis of poly(ethylene glycol) modified zeolitic imidazolate framework-8 nanoparticles: size control, surface modification and drug encapsulation. Colloids Surf A Physicochem Eng Asp. 568:224–230.
  • Wang K, Yin Y, Li C, Geng Z, Wang Z. 2011. Facile synthesis of zinc(ii)-carboxylate coordination polymer particles and their luminescent, biocompatible and antibacterial properties. Cryst Eng Comm. 13:6231.
  • Wang X, Li Z, Xu W, Kulkarni SA, Batabyal SK, Zhang S, Cao A, Wong LH. 2015. TiO2 nanotube arrays based flexible perovskite solar cells with transparent carbon nanotube electrode. Nano Energy. 11:728–735.
  • Wang Y, Yang J, Liu YY, Ma JF. 2013. Controllable syntheses of porous metal-organic frameworks: encapsulation of Ln(III) cations for tunable luminescence and small drug molecules for efficient delivery. Chem Eur J. 19:14591–14599.
  • Wu H, Zhang C, Ding K, Wang L, Gao Y, Yang J. 2017. Efficient planar heterojunction perovskite solar cells fabricated by in-situ thermal-annealing doctor blading in ambient condition. Org Electron. 45:302–307.
  • Wu MX, Yang YW. 2017. Metal-organic framework (MOF)-based drug/cargo delivery and cancer therapy. Adv Mater. 29:1606134.
  • Xiao KJ, Luo JM, Ye KY, Wang Y, Huang PQ. 2010. Direct, one-pot sequential reductive alkylation of lactams/amides with Grignard and organolithium reagents through lactam/amide activation. Angew Chem. 49:3037–3040.
  • Xie Y, Yu Z, Huang X, Wang Z, Niu L, Teng M, Li J. 2007. Rational design of MOFs constructed from modified aromatic amino acids. Chem Eur J. 13:9399–9405.
  • Yang L, Sun C, Lin H, Gong X, Zhou T, Deng WT, Chen Z, Gao J. 2019. Sensitive contrast-enhanced magnetic resonance imaging of orthotopic and metastatic hepatic tumors by ultralow doses of zinc ferrite octapods. Chem Mater. 31:1381–1390.
  • Yang X, Tang Q, Jiang Y, Zhang M, Wang M, Mao L. 2019. Nanoscale ATP-responsive zeolitic imidazole framework-90 as a general platform for cytosolic protein delivery and genome editing. J Am Chem Soc. 141: 3782–3786.
  • Yang Y, Shen K, Lin J, Zhou Y, Liu Q, Hang C, Abdelhamid HN, Zhang Z, Chen H. 2016. A Zn-MOF constructed from electron-rich π-conjugated ligands with an interpenetrated graphene-like net as an efficient nitroaromatic sensor. RSC Adv. 6:45475–45481.
  • Yang Z, Chueh CC, Zuo F, Kim JH, Liang PW, Jen AKY. 2015. High‐performance fully printable perovskite solar cells via blade‐coating technique under the ambient condition. Adv Energy Mater. 5:1500328.
  • Yao J, Chen R, Wang K, Wang H. 2013. Direct synthesis of zeolitic imidazolate framework-8/chitosan composites in chitosan hydrogels. Micropor Mesopor Mat. 165:200–204.
  • Yap MH, Fow KL, Chen GZ. 2017. Synthesis and applications of MOF-derived porous nanostructures. Green Energy Environ. 2:218–245.
  • Ye J, Zhao L, Bogale RF, Gao Y, Wang X, Qian X, Guo S, Zhao J, Ning G. 2015. Highly selective detection of 2,4,6-trinitrophenol and Cu(2+) ions based on a fluorescent cadmium-pamoate metal-organic framework. Chem Eur J. 21:2029–2037.
  • Ye M, Wen X, Wang M, Iocozzia J, Zhang N, Lin C, Lin Z. 2015. Recent advances in dye-sensitized solar cells: from photoanodes, sensitizers and electrolytes to counter electrodes. Materials Today. 18:155–162.
  • Yin X, Chen P, Que M, Xing Y, Que W, Niu C, Shao J. 2016. Highly efficient flexible perovskite solar cells using solution-derived NiO x hole contacts. ACS Nano. 10:3630–3636.
  • Yoon S, Tak S, Kim J, Jun Y, Kang K, Park J. 2011. Application of transparent dye-sensitized solar cells to building integrated photovoltaic systems. Building Environ. 46:1899–1904.
  • Zhang H, Zhao M, Lin YS. 2019. Stability of ZIF-8 in water under ambient conditions. Micropor Mesopor Mat. 279:201–210.
  • Zhang H, Cheng J, Li D, Lin F, Mao J, Liang C, Jen AKY, Grätzel M, Choy WCH. 2017. Toward all room‐temperature, solution‐processed, high‐performance planar perovskite solar cells: a new scheme of pyridine‐promoted perovskite formation. Adv Mater. 29:1604695.
  • Zhang H, Liu D, Yao Y, Zhang B, Lin YS. 2015. Stability of ZIF-8 membranes and crystalline powders in water at room temperature. J Membrane Sci. 485:103–111.
  • Zhang Y, Wu Z, Li P, Ono LK, Qi Y, Zhou J, Shen H, Surya C, Zheng Z. 2018. Fully solution‐processed TCO‐free semitransparent perovskite solar cells for tandem and flexible applications. Adv Energy Mater. 8:1701569.
  • Zhang Z, Chen Y, He S, Zhang J, Xu X, Yang Y, Nosheen F, Saleem F, He W, Wang X. 2014. Hierarchical Zn/Ni-MOF-2 nanosheet-assembled hollow nanocubes for multicomponent catalytic reactions. Angew Chem. 53:12517–12521.
  • Zhang Z, Wei L, Qin X, Li Y. 2015. Carbon nanomaterials for photovoltaic process. Nano Energy. 15:490–522.
  • Zhao HX, Zou Q, Sun SK, Yu C, Zhang X, Li RJ, Fu YY. 2016. Theranostic metal–organic framework core-shell composites for magnetic resonance imaging and drug delivery. Chem Sci. 7:5294–5301.
  • Zhou N, Su F, Guo C, He L, Jia Z, Wang M, Jia Q, Zhang Z, Lu S. 2019. Two-dimensional oriented growth of Zn-MOF-on-Zr-MOF architecture: a highly sensitive and selective platform for detecting cancer markers. Biosens Bioelectron. 123:51–58.
  • Zhu H, Ka B, Murad F. 2007. Nitric oxide accelerates the recovery from burn wounds. World J Surg. 31:624–631.
  • Zhu Z, Xu JQ, Chueh CC, Liu H, Li Z, Li X, Chen H, Jen AKY. 2016. A low‐temperature, solution‐processable organic electron‐transporting layer based on planar coronene for high‐performance conventional perovskite solar cells. Adv Mater. 28:10786–10793.
  • Zimpel A, Preiß T, Röder R, Engelke H, Ingrisch M, Peller M, Rädler JO, Wagner E, Bein T, Lächelt U, et al. 2016. Imparting functionality to MOF nanoparticles by external surface selective covalent attachment of polymers. Chem Mater. 28:3318–3326.

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