Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects

References

• Agarwal DP. 2002. Cardioprotective effects of light-moderate consumption of alcohol: a review of putative mechanisms. Alcohol Alcohol. 37(5):409–415.
   PubMed Web of Science ®Google Scholar
• Agarwal DP, Goedde HW. 1989. Human aldehyde dehydrogenases: their role in alcoholism. Alcohol. 6(6):517–523.
   PubMed Web of Science ®Google Scholar
• Albert CM, Manson JE, Cook NR, Ajani UA, Gaziano JM, Hennekens CH. 1999. Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation. 100(9):944–950.
   PubMed Web of Science ®Google Scholar
• Al-Sader H, Abdul JH, Allawi Z, Haba Y. 2009. Alcohol and breast cancer: the mechanisms explained. J Clin Med Res. 1(3):125–131.
   PubMedGoogle Scholar
• Anderson LA, Cantwell MM, Watson RGP, Johnston BT, Murphy SJ, Ferguson HR, McGuigan J, Comber H, Reynolds JV, Murray LJ. 2009. The association between alcohol and reflux esophagitis, barrett’s esophagus, and esophageal adenocarcinoma. Gastroenterology. 136(3):799–805.
   PubMed Web of Science ®Google Scholar
• Angus RM, Sambrook PN, Pocock NA, Eisman JA. 1988. Dietary intake and bone mineral density. Bone Miner. 4(3):265–277.
   PubMedGoogle Scholar
• ANSES. 2010. Evaluation des risques de l’éthanol en population professionnelle | Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail [Internet]. [accessed 2019 Oct 16]. https://www.anses.fr/fr/content/evaluation-des-risques-de-l%E2%80%99%C3%A9thanol-en-population-professionnelle-0
   Google Scholar
• Arfsten DP, Silbergeld EK, Loffredo CA. 2004. Fetal ADH2*3, maternal alcohol consumption, and fetal growth. Int J Toxicol. 23(1):47–54.
   PubMed Web of Science ®Google Scholar
• Arranz S, Chiva-Blanch G, Valderas-Martínez P, Medina-Remón A, Lamuela-Raventós RM, Estruch R. 2012. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients. 4(7):759–781.
   PubMed Web of Science ®Google Scholar
• Barr T, Helms C, Grant K, Messaoudi I. 2016. Opposing effects of alcohol on the immune system. Prog Neuro-Psychopharmacol Biol Psychiat. 65:242–251.
   PubMed Web of Science ®Google Scholar
• Bau PFD, Bau CHD, Rosito GA, Manfroi WC, Fuchs FD. 2007. Alcohol consumption, cardiovascular health, and endothelial function markers. Alcohol. 41(7):479–488.
   PubMed Web of Science ®Google Scholar
• Belleville J. 2002. The French paradox: possible involvement of ethanol in the protective effect against cardiovascular diseases. Nutrition. 18(2):173–177.
   PubMed Web of Science ®Google Scholar
• Bergmann MM, Rehm J, Klipstein-Grobusch K, Boeing H, Schutze M, Drogan D, Overvad K, Tjonneland A, Halkjaer J, Fagherazzi G. 2013. The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Epidemiol. 42(6):1772–1790.
   PubMed Web of Science ®Google Scholar
• Bianchini F, Vainio H. 2003. Wine and resveratrol: mechanisms of cancer prevention? Eur J Cancer Prev. 12(5):417–425.
   PubMed Web of Science ®Google Scholar
• Bismuth C, Baud F, Conso F, Dally S, Frejaville JP, Garnier R. 2000. Toxicologie clinique. Paris: Médecine-Sciences Flammarion.
   Google Scholar
• Bonnard N, Falcy M, Jargot D, Pasquier E. 2011. Ethanol – Fiche toxicologique n°48 [Internet]. Institut National de Recherche et de Sécurité [accessed 2018 Jul 3]. Available from: http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_48&section=bibliographieAuteurs
   Google Scholar
• Brancato A, Lavanco G, Cavallaro A, Plescia F, Cannizzaro C. 2017. Acetaldehyde motivation and stress: behavioral evidence of an addictive ménage à trois. Front Behav Neurosci. 11:23.
   PubMed Web of Science ®Google Scholar
• Bühler M, Mann K. 2011. Alcohol and the human brain: a systematic review of different neuroimaging methods: alcohol and the human brain. Alcohol Clin Exp Res. 35(10):1771–1793.
   PubMed Web of Science ®Google Scholar
• Burton R, Sheron N. 2018. No level of alcohol consumption improves health. The Lancet. 392(10152):987–988.
   PubMed Web of Science ®Google Scholar
• Carlé A, Bülow Pedersen I, Knudsen N, Perrild H, Ovesen L, Rasmussen LB, Jørgensen T, Laurberg P. 2013. Graves′ hyperthyroidism and moderate alcohol consumption: evidence for disease prevention. Clin Endocrinol. 79(1):111–119.
   PubMed Web of Science ®Google Scholar
• Carle A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Rasmussen LB, Jørgensen T, Laurberg P. 2012. Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case-control study. Eur J Endocrinol. 167(4):483–490.
   PubMed Web of Science ®Google Scholar
• Cederbaum AI. 2012. Alcohol metabolism. Clin Liver Dis. 16(4):667–685.
   PubMed Web of Science ®Google Scholar
• Charness ME. 1993. Brain lesions in alcoholics. Alcohol Clin Exp Res. 17(1):2–11.
   PubMed Web of Science ®Google Scholar
• Chen C-H, Walker J, Momenan R, Rawlings R, Heilig M, Hommer DW. 2012. Relationship between liver function and brain shrinkage in patients with alcohol dependence: relationship between liver function and brain shrinkage. Alcohol Clin Exp Res. 36(4):625–632.
   PubMed Web of Science ®Google Scholar
• Council of the Netherlands TH. 2000. Ethanol, evaluation of the effects on reproduction, recommendation for classification. Committee for Compounds toxic to reproduction, a committee of the Health.
   Google Scholar
• Crabb DW. 1995. Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease. Prog Liver Dis. 13:151–172.
   PubMedGoogle Scholar
• Das S, Santani DD, Dhalla NS. 2007. Experimental evidence for the cardioprotective effects of red wine. Exp Clin Cardiol. 12(1):5–10.
   PubMedGoogle Scholar
• Davies M. 2003. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiat Neurosci. 28(4):263–274.
   PubMed Web of Science ®Google Scholar
• De la Monte S, Longato L, Tong M, DeNucci S, Wands J. 2009. The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids. Int J Environ Res Pub Health. 6(7):2055–2075.
   PubMed Web of Science ®Google Scholar
• de la Monte SM. 1988. Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch Neurol. 45(9):990–992.
   PubMedGoogle Scholar
• Di Castelnuovo A. 2006. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med. 166(22):2437.
   PubMed Web of Science ®Google Scholar
• Di Giuseppe D, Alfredsson L, Bottai M, Askling J, Wolk A. 2012. Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study. BMJ. 345:e4230.
   PubMed Web of Science ®Google Scholar
• Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S. 1989. Ethanol reduces bone formation and may cause osteoporosis. Am J Med. 86(3):282–288.
   PubMed Web of Science ®Google Scholar
• Ding Z-M, Ingraham CM, Rodd ZA, McBride WJ. 2015. The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. J Psychopharmacol. 29(6):725–733.
   PubMed Web of Science ®Google Scholar
• Duddempudi AT. 2012. Immunology in alcoholic liver disease. Clin Liver Dis. 16(4):687–698.
   PubMed Web of Science ®Google Scholar
• Edenberg HJ. 2000. Regulation of the mammalian alcohol dehydrogenase genes. Prog Nucl Acid Res Mol Biol. 64:295–341.
   PubMed Web of Science ®Google Scholar
• Ekström G, Ingelman-Sundberg M. 1989. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol. 38(8):1313–1319.
   PubMed Web of Science ®Google Scholar
• Engler PA, Ramsey SE, Smith RJ. 2013. Alcohol use of diabetes patients: the need for assessment and intervention. Acta Diabetol. 50(2):93–99.
   PubMed Web of Science ®Google Scholar
• Fan S, Meng Q, Gao B, Grossman J, Yadegari M, Goldberg ID, Rosen EM. 2000. Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines. Cancer Res. 60(20):5635–5639.
   PubMed Web of Science ®Google Scholar
• Faris RF, Henein MY, Coats A. 2003. Influence of gender and reported alcohol intake on mortality in nonischemic dilated cardiomyopathy. Heart Dis. 5(2):89–94.
   PubMedGoogle Scholar
• Felson DT, Zhang Y, Hannan MT, Kannel WB, Kiel DP. 1995. Alcohol intake and bone mineral density in elderly men and women. The Framingham Study. Am J Epidemiol. 142(5):485–492.
   PubMed Web of Science ®Google Scholar
• Fernandezsola J, Fatjo F, Sacanella E, Estruch R, Bosch X, Urbanomarquez A, Nicolas J. 2006. Evidence of apoptosis in alcoholic cardiomyopathy. Hum Pathol. 37(8):1100–1110.
   PubMed Web of Science ®Google Scholar
• Fragopoulou E, Choleva M, Antonopoulou S, Demopoulos CA. 2018. Wine and its metabolic effects. A comprehensive review of clinical trials. Metabolism. 83:102–119.
   PubMed Web of Science ®Google Scholar
• Ganry O, Baudoin C, Fardellone P. 2000. Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS Study. Epidémiologie de l’Ostéoporose. Am J Epidemiol. 151(8):773–780.
   PubMed Web of Science ®Google Scholar
• Garro AJ, Espina N, Farinati F, Salvagnini M. 1986. The effects of chronic ethanol consumption on carcinogen metabolism and on O6-methylguanine transferase-mediated repair of alkylated DNA. Alcohol Clin Exp Res. 10(s1):73S–77S.
   PubMed Web of Science ®Google Scholar
• Gicquel T, Le Daré B, Boichot E, Lagente V. 2017. Purinergic receptors: new targets for the treatment of gout and fibrosis. Fundam Clin Pharmacol. 31(2):136–146.
   PubMed Web of Science ®Google Scholar
• Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Toda M, Miyake Y, Mifuji-Moroka R, Iwasa M, Morser J, Gabazza EC, Takei Y, et al. 2011. Atherosclerosis amelioration by moderate alcohol consumption is associated with increased circulating levels of stromal cell-derived factor-1. Circ J. 75(9):2269–2279.
   PubMed Web of Science ®Google Scholar
• Girre C, Hispard E, Tuszynski T. 1995. Toxicité de l’éthanol. Encyclopédie Médico-Chirurgicale Toxicologie-Pathologie professionnelle. Paris: Elsevier.
   Google Scholar
• Gmel G, Gutjahr E, Rehm J. 2003. How stable is the risk curve between alcohol and all-cause mortality and what factors influence the shape? A precision-weighted hierarchical meta-analysis. Eur J Epidemiol. 18(7):631–642.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Quintela A, Alende R, Gude F, Campos J, Rey J, Meijide LM, Fernandez-Merino C, Vidal C. 2007. Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities: serum immunoglobulin levels in adults. Clin Exp Immunol. 151(1):42–50.
   PubMed Web of Science ®Google Scholar
• Goulden R. 2016. Moderate alcohol consumption is not associated with reduced all-cause mortality. Am J Med. 129(2):180–186.
   PubMed Web of Science ®Google Scholar
• Grewal P, Viswanathen VA. 2012. Liver cancer and alcohol. Clin Liver Dis. 16(4):839–850.
   PubMed Web of Science ®Google Scholar
• Griswold MG, Fullman N, Hawley C, Arian N, Zimsen SRM, Tymeson HD, Venkateswaran V, Tapp AD, Forouzanfar MH, Salama JS, et al. 2018. Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 392(10152):1015–1035.
   PubMed Web of Science ®Google Scholar
• Guo R, Hu N, Kandadi MR, Ren J. 2012. Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts. Autophagy. 8(4):593–608.
   PubMed Web of Science ®Google Scholar
• Gupta KK, Gupta VK, Shirasaka T. 2016. An update on fetal alcohol syndrome-pathogenesis, risks, and treatment. Alcohol Clin Exp Res. 40(8):1594–1602.
   PubMed Web of Science ®Google Scholar
• Gürtl B, Kratky D, Guelly C, Zhang L, Gorkiewicz G, Das SK, Tamilarasan KP, Hoefler G. 2009. Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy: animal model of metabolic cardiomyopathy. Int J Exp Pathol. 90(3):338–346.
   PubMed Web of Science ®Google Scholar
• Haddad GE, Saunders L, Carles M, Crosby SD, del Monte F, Macgillivray TE, Semigran MJ, Dec GW, Hajjar RJ, Doye AA, et al. 2008. Fingerprint profile of alcohol-associated heart failure in human hearts. Alcohol Clin Exp Res. 32(5):814–821.
   PubMed Web of Science ®Google Scholar
• Hamitouche S, Poupon J, Dreano Y, Amet Y, Lucas D. 2006. Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes. Toxicol Lett. 167(3):221–230.
   PubMed Web of Science ®Google Scholar
• Hamon M. 2014. Bases neurobiologiques des traitements de l’alcoolo-dépendance – Quelles perspectives?. Eur Psychiat. 29(8):539.
   Web of Science ®Google Scholar
• Hansson GK, Libby P, SchöNbeck U, Yan Z-Q. 2002. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 91(4):281–291.
   PubMed Web of Science ®Google Scholar
• Hardy CJ, Palmer BP, Muir KR, Sutton AJ, Powell RJ. 1998. Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study. Ann Rheum Dis. 57(8):451–455.
   PubMed Web of Science ®Google Scholar
• Harrison NL, Skelly MJ, Grosserode EK, Lowes DC, Zeric T, Phister S, Salling MC. 2017. Effects of acute alcohol on excitability in the CNS. Neuropharmacology. 122:36–45.
   PubMed Web of Science ®Google Scholar
• Heller M, Burd L. 2014. Review of ethanol dispersion, distribution, and elimination from the fetal compartment: fetal alcohol exposure. Birth Defects Res Part A. 100(4):277–283.
   PubMed Web of Science ®Google Scholar
• Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. 2000. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 9(10):1099–1105.
   PubMed Web of Science ®Google Scholar
• Hines RN, McCarver DG. 2002. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther. 300(2):355–360.
   PubMed Web of Science ®Google Scholar
• Hoffman PL, Rabe CS, Moses F, Tabakoff B. 1989. N-methyl-d-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production. J Neurochem. 52(6):1937–1940.
   PubMed Web of Science ®Google Scholar
• Holbrook TL, Barrett-Connor E. 1993. A prospective study of alcohol consumption and bone mineral density. BMJ. 306(6891):1506–1509.
   PubMed Web of Science ®Google Scholar
• Holland MG, Ferner RE. 2017. A systematic review of the evidence for acute tolerance to alcohol – the “Mellanby effect”. Clin Toxicol. 55(6):545–556.
   PubMed Web of Science ®Google Scholar
• Howard AA, Arnsten JH, Gourevitch MN. 2004. Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med. 140(3):211.
   PubMed Web of Science ®Google Scholar
• Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME. 2016. Ethanol and other short-chain alcohols inhibit nlrp3 inflammasome activation through protein tyrosine phosphatase stimulation. J Immunol. 197(4):1322–1334.
   PubMed Web of Science ®Google Scholar
• Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian XI, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME. 2017. Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Redox Biol. 12:883–896.
   PubMed Web of Science ®Google Scholar
• Inserm. 2012. Médicaments psychotropes: Consommations et pharmacodépendances [Internet]. Paris: Les éditions Inserm [accessed 2018 Aug 9]. Available from: http://www.ipubli.inserm.fr/bitstream/handle/10608/2072/?sequence=30&wb48617274=5B7365DD
   Google Scholar
• Jayasekara H, English DR, Room R, MacInnis RJ. 2014. Alcohol consumption over time and risk of death: a systematic review and meta-analysis. Am J Epidemiol. 179(9):1049–1059.
   PubMed Web of Science ®Google Scholar
• Ji C. 2012. Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem Res Int. 2012:1–12.
   Google Scholar
• Jin Z, Xiang C, Cai Q, Wei X, He J. 2014. Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis. 73(11):1962–1967.
   PubMed Web of Science ®Google Scholar
• Jokelainen K, Matysiak-Budnik T, Mäkisalo H, Höckerstedt K, Salaspuro M. 1996. High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets. Gut. 39(1):100–104.
   PubMed Web of Science ®Google Scholar
• Jonsson I-M, Verdrengh M, Brisslert M, Lindblad S, Bokarewa M, Islander U, Carlsten H, Ohlsson C, Nandakumar KS, Holmdahl R, et al. 2007. Ethanol prevents development of destructive arthritis. Proc Natl Acad Sci. 104(1):258–263.
   PubMed Web of Science ®Google Scholar
• Kawamoto R, Kohara K, Tabara Y, Miki T, Ohtsuka N, Kusunoki T, Abe M. 2009. Alcohol consumption is associated with decreased insulin resistance independent of body mass index in Japanese community-dwelling men. Tohoku J Exp Med. 218(4):331–337.
   PubMed Web of Science ®Google Scholar
• Keller DL. 2016. Benefits of moderate alcohol consumption not disproven. Am J Med. 129(8):e149.
   PubMed Web of Science ®Google Scholar
• Keyel PA. 2014. How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1. Cytokine. 69(1):136–145.
   PubMed Web of Science ®Google Scholar
• Klarich DS, Brasser SM, Hong MY. 2015. Moderate alcohol consumption and colorectal cancer risk. Alcohol Clin Exp Res. 39(8):1280–1291.
   PubMed Web of Science ®Google Scholar
• Klatsky AL, Armstrong MA, Friedman GD. 1992. Alcohol and mortality. Ann Intern Med. 117(8):646–654.
   PubMed Web of Science ®Google Scholar
• Knott C, Bell S, Britton A. 2015. Alcohol consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of more than 1.9 million individuals from 38 observational studies. Diab Care. 38(9):1804–1812.
   PubMed Web of Science ®Google Scholar
• Konrad A, Vucurevic G, Lorscheider M, Bernow N, Thümmel M, Chai C, Pfeifer P, Stoeter P, Scheurich A, Fehr C. 2012. Broad disruption of brain white matter microstructure and relationship with neuropsychological performance in male patients with severe alcohol dependence. Alcohol Alcohol. 47(2):118–126.
   PubMed Web of Science ®Google Scholar
• Kovář J, Zemánková K. 2015. Moderate alcohol consumption and triglyceridemia. Physiol Res. 64:371–375.
   Web of Science ®Google Scholar
• Kunitoh S, Asai H, Imaoka S, Funae Y, Monna T. 1996. Metabolism of acetaldehyde to acetate by rat hepatic P-450s: presence of different metabolic pathway from acetaldehyde dehydrogenase system. Alcohol Clin Exp Res. 20(s1):22A–24A.
   PubMed Web of Science ®Google Scholar
• Läck AK, Ariwodola OJ, Chappell AM, Weiner JL, McCool BA. 2008. Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology. 55(5):661–668.
   PubMed Web of Science ®Google Scholar
• Laonigro I, Correale M, Di Biase M, Altomare E. 2009. Alcohol abuse and heart failure. Eur J Heart Fail. 11(5):453–462.
   PubMed Web of Science ®Google Scholar
• Le Daré B, Victoni T, Bodin A, Vlach M, Vene E, Loyer P. 2018. Ethanol upregulates the P2X7 purinergic receptor in human macrophages. Fundam Clin Pharmacol. 33(1):63–74.
   PubMed Web of Science ®Google Scholar
• Li S, Wang N, Tan H-Y, Hong M, Yuen M-F, Li H, Feng Y. 2018. Expansion of granulocytic, myeloid-derived suppressor cells in response to ethanol-induced acute liver damage. Front Immunol. 9:1524.
   PubMed Web of Science ®Google Scholar
• Lin CC, Potter JJ, Mezey E. 1984. Erythrocyte aldehyde dehydrogenase activity in alcoholism. Alcohol Clin Exp Res. 8(6):539–541.
   PubMed Web of Science ®Google Scholar
• Littleton J. 1998. Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res World. 22(1):13–24.
   PubMedGoogle Scholar
• Liu H-J, Pan X-X, Liu B-Q, Gui X, Hu L, Jiang C-Y, Yuan H, Yi-Xin F, Yu-Lin T, Wen-Tao L. 2017. Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflamm. 14(1):74.
   PubMed Web of Science ®Google Scholar
• Longnecker MP. 1994. Alcoholic beverage consumption in relation to risk of breast cancer: meta-analysis and review. Cancer Causes Control. 5(1):73–82.
   PubMed Web of Science ®Google Scholar
• Lopes da Silva A, Ruginsk SG, Uchoa ET, Crestani CC, Scopinho AA, Correa FMA, De Martinis BS, Elias LLK, Resstel LB, Antunes-Rodrigues J, et al. 2013. Time-course of neuroendocrine changes and its correlation with hypertension induced by ethanol consumption. Alcohol Alcohol. 48(4):495–504.
   PubMed Web of Science ®Google Scholar
• Lu Y, Cederbaum AI. 2008. CYP2E1 and oxidative liver injury by alcohol. Free Rad Biol Med. 44(5):723–738.
   PubMed Web of Science ®Google Scholar
• Machackova J, Barta J, Dhalla NS. 2006. Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies. Can J Cardiol. 22(11):953–968.
   PubMed Web of Science ®Google Scholar
• Markoski MM, Garavaglia J, Oliveira A, Olivaes J, Marcadenti A. 2016. Molecular properties of red wine compounds and cardiometabolic benefits. Nutr Metab Insights. 9:NMI.S32909.
   Web of Science ®Google Scholar
• Matsui T, Sakurai H, Toyama T, Yoshimura A, Matsushita S, Higuchi S. 2012. Clinical application of neuroimaging to alcohol-related dementia. Nihon Arukoru Yakubutsu Igakkai Zasshi. 47(3):125–134.
   PubMedGoogle Scholar
• Maurel DB, Boisseau N, Benhamou CL, Jaffre C. 2012. Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int. 23(1):1–16.
   PubMed Web of Science ®Google Scholar
• Mayfield J, Ferguson L, Harris RA. 2013. Neuroimmune signaling: a key component of alcohol abuse. Curr Opin Neurobiol. 23(4):513–520.
   PubMed Web of Science ®Google Scholar
• McClintick JN, Tischfield JA, Deng L, Kapoor M, Xuei X, Edenberg HJ. 2019. Ethanol activates immune response in lymphoblastoid cells. Alcohol. 79:81–91.
   PubMed Web of Science ®Google Scholar
• McEvily AJ, Holmquist B, Auld DS, Vallee BL. 1988. 3.beta.-Hydroxy-5.beta.-steroid dehydrogenase activity of human liver alcohol dehydrogenase is specific to.gamma.-subunits. Biochemistry. 27(12):4284–4288.
   PubMed Web of Science ®Google Scholar
• McGovern PE, Zhang J, Tang J, Zhang Z, Hall GR, Moreau RA, Nunez A, Butrym ED, Richards MP, Wang C-S, et al. 2004. Fermented beverages of pre- and proto-historic China. Proc Natl Acad Sci. 101(51):17593–17598.
   PubMed Web of Science ®Google Scholar
• Mikosch P. 2014. Alcohol and bone. Wien Med Wochenschr. 164(1–2):15–24.
   PubMedGoogle Scholar
• Müller CP, Kalinichenko LS, Tiesel J, Witt M, Stöckl T, Sprenger E, Fuchser J, Beckmann J, Praetner M, Huber SE, et al. 2017. Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol. 133(3):463–483.
   PubMed Web of Science ®Google Scholar
• Muralidharan S, Ambade A, Fulham MA, Deshpande J, Catalano D, Mandrekar P. 2014. Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance. J Immunol. 193(4):1975–1987.
   PubMed Web of Science ®Google Scholar
• Nagata C, Fujita S, Iwata H, Kurosawa Y, Kobayashi K, Kobayashi M, Motegi K, Omura T, Yamamoto M, Nose T, et al. 1995. Systemic lupus erythematosus: a case-control epidemiologic study in Japan. Int J Dermatol. 34(5):333–337.
   PubMed Web of Science ®Google Scholar
• Nurmi K, Virkanen J, Rajamäki K, Niemi K, Kovanen PT, Eklund KK. 2013. Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages – a novel anti-inflammatory action of alcohol. PLoS ONE. 8(11):e78537.
   PubMed Web of Science ®Google Scholar
• O’Shea KS, Kaufman MH. 1979. The teratogenic effect of acetaldehyde: implications for the study of the fetal alcohol syndrome. J Anat. 128:65–76.
   PubMed Web of Science ®Google Scholar
• Obad A, Peeran A, Little JI, Haddad GE, Tarzami ST. 2018. Alcohol-mediated organ damages: heart and brain. Front Pharmacol. 9:81.
   Web of Science ®Google Scholar
• Osna NA, Donohue TM, Kharbanda KK. 2017. Alcoholic liver disease: pathogenesis and current management. Alcohol Res. 38(2):147–161.
   PubMed Web of Science ®Google Scholar
• Paganini-Hill A, Kawas CH, Corrada MM. 2016. Lifestyle factors and dementia in the oldest-old: the 90+ study. Alzheimer Dis Assoc Disord. 30(1):21–26.
   PubMed Web of Science ®Google Scholar
• Panchenko LF, Moiseev VS, Pirozhkov SV, Terebilina NN, Naumova TA, Baronets VI, Goncharov AS. 2015. Blood content of markers of inflammation and cytokines in patients with alcoholic cardiomyopathy and ischemic heart disease at various stages of heart failure. Kardiologiia. 55(3):41–48.
   Web of Science ®Google Scholar
• Pang M, Bala S, Kodys K, Catalano D, Szabo G. 2011. Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12(1):55.
   PubMed Web of Science ®Google Scholar
• Peters R, Peters J, Warner J, Beckett N, Bulpitt C. 2008. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing. 37(5):505–512.
   PubMed Web of Science ®Google Scholar
• Pichini S, Morini L, Marchei E, Palmi I, Rotolo MC, Vagnarelli F, Garcia-Algar O, Vall O, Zuccaro P. 2009. Ethylglucuronide and ethylsulfate in meconium to assess gestational ethanol exposure: preliminary results in two Mediterranean cohorts. Can J Clin Pharmacol. 16(2):e370–e375.
   PubMedGoogle Scholar
• Polsky S, Akturk HK. 2017. Alcohol consumption, diabetes risk, and cardiovascular disease within diabetes. Curr Diab Rep. 17(12):136
   PubMed Web of Science ®Google Scholar
• Porter R. 1987. Jean-Charles Sournia, Histoire de l’alcoolisme, Paris, Flammarion, 1986, 8vo, pp. 323, Fr. 125.00 (paperback). Med Hist. 31(3):372–373.
   Google Scholar
• Rajakulendran S, Gadsby K, Deighton C. 2008. Rheumatoid arthritis, alcohol, leflunomide and methotrexate. Can changes to the BSR guidelines for leflunomide and methotrexate on alcohol consumption be justified? Musculoskelet Care. 6(4):233–246.
   PubMedGoogle Scholar
• Rasheed A, Hines RN, McCarver-May DG. 1997. Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome? Toxicol Appl Pharmacol. 144(2):396–400.
   PubMed Web of Science ®Google Scholar
• Renner F, Kersbergen I, Field M, Werthmann J. 2018. Dutch courage? Effects of acute alcohol consumption on self-ratings and observer ratings of foreign language skills. J Psychopharmacol. 32(1):116–122.
   PubMed Web of Science ®Google Scholar
• Rodrigues P, Santos-Ribeiro S, Teodoro T, Gomes FV, Leal I, Reis JP, Goff DC, Gonçalves A, Lima JAC. 2018. Association between alcohol intake and cardiac remodeling. J Am Coll Cardiol. 72(13):1452–1462.
   PubMed Web of Science ®Google Scholar
• Rohwer RD, Liu S, You N-C, Buring JE, Manson JE, Song Y. 2015. Interrelationship between alcohol intake and endogenous sex-steroid hormones on diabetes risk in postmenopausal women. J Am Coll Nutr. 34(4):273–280.
   PubMed Web of Science ®Google Scholar
• Romeo J, Wärnberg J, Díaz LE, González-Gross M, Marcos A. 2007. Effects of moderate beer consumption on first-line immunity of healthy adults. J Physiol Biochem. 63(2):153–159.
   PubMed Web of Science ®Google Scholar
• Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. 2011. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ. 342:d671.
   PubMed Web of Science ®Google Scholar
• Sánchez-Sellero I, San-Román-Rodríguez E, Santos-Pérez S, Rossi-Izquierdo M, Soto-Varela A. 2018. Alcohol consumption in Menière’s disease patients. Nutr Neurosci. 1–7. DOI:10.1080/1028415X.2018.1470372
   PubMed Web of Science ®Google Scholar
• Schapira D. 1990. Alcohol abuse and osteoporosis. Semin Arthritis Rheum. 19(6):371–376.
   PubMed Web of Science ®Google Scholar
• Schoonen WM, Salinas CA, Kiemeney LALM, Stanford JL. 2005. Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer. 113(1):133–140.
   PubMed Web of Science ®Google Scholar
• Schrieks IC, Heil ALJ, Hendriks HFJ, Mukamal KJ, Beulens JWJ. 2015. The effect of alcohol consumption on insulin sensitivity and glycemic status: a systematic review and meta-analysis of intervention studies. Diab Care. 38(4):723–732.
   PubMed Web of Science ®Google Scholar
• Schröck A, Henzi A, Bütikofer P, König S, Weinmann W. 2018. Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors. Alcohol. 73:1–7.
   PubMed Web of Science ®Google Scholar
• Scott J, Hassett AL, Schrepf AD, Brummett CM, Harris RE, Clauw DJ, Harte SE. 2018. Moderate alcohol consumption is associated with reduced pain and fibromyalgia symptoms in chronic pain patients. Pain Med. 19(12):2515.
   PubMed Web of Science ®Google Scholar
• Seitz HK, Simanowski UA, Garzon FT, Rideout JM, Peters TJ, Koch A, Berger MR, Einecke H, Maiwald M. 1990. Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology. 98(2):406–413.
   PubMed Web of Science ®Google Scholar
• Seitz HK, Stickel F. 2007. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 7(8):599–612.
   PubMed Web of Science ®Google Scholar
• Sergent O, Pereira M, Belhomme C, Chevanne M, Huc L, Lagadic-Gossmann D. 2005. Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes. J Pharmacol Exp Ther. 313(1):104–111.
   PubMed Web of Science ®Google Scholar
• Shabtai Y, Bendelac L, Jubran H, Hirschberg J, Fainsod A. 2018. Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. Sci Rep. 8(1):347.
   PubMed Web of Science ®Google Scholar
• Shabtai Y, Fainsod A. 2018. Competition between ethanol clearance and retinoic acid biosynthesis in the induction of fetal alcohol syndrome. Biochem Cell Biol. 96(2):148–160.
   PubMed Web of Science ®Google Scholar
• Shai I, Rimm EB, Schulze MB, Rifai N, Stampfer MJ, Hu FB. 2004. Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men. Diabetologia. 47(10):1760–1767.
   PubMed Web of Science ®Google Scholar
• Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T. 2011. Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice. Bone. 48(5):1075–1086.
   PubMed Web of Science ®Google Scholar
• Silva SM, Silva S, Meireles M, Leal S. 2015. nNOS is involved in cardiac remodeling induced by chronic ethanol consumption. Toxicology. 329:98–105.
   PubMed Web of Science ®Google Scholar
• Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C. et al. 2018. Association of alcohol consumption with allergic disease and asthma: a multicenter Mendelian Randomization analysis. Addiction. 114(2):216–225.
   PubMed Web of Science ®Google Scholar
• Smith C, Gasparetto M, Jordan C, Pollyea DA, Vasiliou V. 2015. The effects of alcohol and aldehyde dehydrogenases on disorders of hematopoiesis. In: Vasiliou V, Zakhari S, Seitz HK, Hoek JB, editors. Biological basis of alcohol-induced cancer. Cham: Springer International Publishing; p. 349–359.
   Google Scholar
• Steinbigler P, Haberl R, König B, Steinbeck G. 2003. P-wave signal averaging identifies patients prone to alcohol-induced paroxysmal atrial fibrillation. Am J Cardiol. 91(4):491–494.
   PubMed Web of Science ®Google Scholar
• Sureshchandra S, Raus A, Jankeel A, Ligh BJK, Walter NAR, Newman N, Grant KA, Messaoudi I. 2019a. Dose-dependent effects of chronic alcohol drinking on peripheral immune responses. Sci Rep. 9(1):7847.
   PubMed Web of Science ®Google Scholar
• Sureshchandra S, Stull C, Ligh BJK, Nguyen SB, Grant KA, Messaoudi I. 2019b. Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages. EBioMedicine. 43:594–606.
   PubMed Web of Science ®Google Scholar
• Tetrault JM, O’Connor PG. 2008. Substance abuse and withdrawal in the critical care setting. Crit Care Clin. 24(4):767–788.
   PubMed Web of Science ®Google Scholar
• Tizabi Y, Getachew B, Ferguson CL, Csoka AB, Thompson KM, Gomez-Paz A, Ruda-Kucerova J, Taylor RE. 2018. Low vs. high alcohol: central benefits vs. detriments. Neurotox Res. 34(4):860.
   PubMed Web of Science ®Google Scholar
• Tsuchiya T, Sakai A, Menuki K, Mori T, Takeuchi Y, Kanoh S, Utsunomiya H, Murai T, Isse T, Kawamoto T, Nakamura T. 2013. Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice. Bone. 53(2):358–368.
   PubMed Web of Science ®Google Scholar
• Urbano-Márquez A, Fernández-Solà J. 2004. Effects of alcohol on skeletal and cardiac muscle: alcoholic Myopathy. Muscle Nerve. 30(6):689–707.
   PubMed Web of Science ®Google Scholar
• Uusi-Oukari M, Korpi ER. 2010. Regulation of GABAA receptor subunit expression by pharmacological agents. Pharmacol Rev. 62(1):97–135.
   PubMed Web of Science ®Google Scholar
• Valenzuela CF, Bhave S, Hoffman P, Harris RA. 1998. Acute effects of ethanol on pharmacologically isolated kainate receptors in cerebellar granule neurons: comparison with NMDA and AMPA receptors. J Neurochem. 71(4):1777–1780.
   PubMed Web of Science ®Google Scholar
• Vasiliou V, Pappa A. 2000. Polymorphisms of human aldehyde dehydrogenases. Pharmacology. 61(3):192–198.
   PubMed Web of Science ®Google Scholar
• Vetreno RP, Hall JM, Savage LM. 2011. Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment. Neurobiol Learn Memory. 96(4):596–608.
   PubMed Web of Science ®Google Scholar
• Victor M. 1994. Alcoholic dementia. Can J Neurol Sci. 21(2):88–99.
   PubMed Web of Science ®Google Scholar
• Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. 2000. Identification of DNA adducts of acetaldehyde. Chem Res Toxicol. 13(11):1149–1157.
   PubMed Web of Science ®Google Scholar
• Wang MQ, Nicholson ME, Mahoney BS, Li Y, Perko MA. 1993. Proprioceptive responses under rising and falling BACs: a test of the Mellanby effect. Percept Mot Skills. 77(1):83–88.
   PubMed Web of Science ®Google Scholar
• Wattendorf DJ, Muenke M. 2005. Fetal alcohol spectrum disorders. Am Fam Phys. 72(2):279–282.
   PubMed Web of Science ®Google Scholar
• Wei X, Shi X, Zhong W, Zhao Y, Tang Y, Sun W, Yin X, Bogdanov B, Kim S, McClain C, et al. 2013. Chronic alcohol exposure disturbs lipid homeostasis at the adipose tissue-liver axis in mice: analysis of triacylglycerols using high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling. PLoS ONE. 8(2):e55382.
   PubMed Web of Science ®Google Scholar
• Wimer W, Russel J, Kaplan H. 1983. Alcohols toxicology. Park Ridge: Noyes Data Corp.
   Google Scholar
• World Health Organization. 2011. Global status report on alcohol and health [Internet] [accessed 2018 Sept 22]. Available from: http://www.who.int/substance_abuse/publications/global_alcohol_report/msbgsruprofiles.pdf
   Google Scholar
• Yasar S. 2018. Relation between alcohol consumption in midlife and dementia in late life. BMJ. 362:k3164.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zheng J, Li S, Zhou T, Zhang P, Li H-B. 2016. Alcoholic beverage consumption and chronic diseases. Int J Environ Res Pub Health. 13(6):522.
   PubMed Web of Science ®Google Scholar
• Zhukov A, Ingelman-Sundberg M. 1999. Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. Biochem J. 340(Pt 2):453–458.
   PubMed Web of Science ®Google Scholar