Reinforcing our defense or weakening the enemy? A comparative overview of defensive and offensive strategies developed to confront COVID-19

References

• Abbott TR, Dhamdhere G, Liu Y, Lin X, Goudy L, Zeng L, Chemparathy A, Chmura S, Heaton NS, Debs R, et al. 2020. Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza. Cell. 181(4):865–876.e12.
   PubMed Web of Science ®Google Scholar
• Abd-Elsalam S, Soliman S, Esmail ES, Khalaf M, Mostafa EF, Medhat MA, Ahmed OA, Abd El Ghafar MS, Alboraie M, Hassany SM. 2020. Do zinc supplements enhance the clinical efficacy of hydroxychloroquine?: a randomized, multicenter trial. Biol Trace Elem Res. DOI:https://doi.org/10.1007/s12011-020-02512-1.
   Google Scholar
• Abraham J. 2020. Passive antibody therapy in COVID-19. Nat Rev Immunol. 20(7):401–403.
   PubMed Web of Science ®Google Scholar
• Aguirre C, Meca-Lallana V, Barrios-Blandino A, Del Río B, Vivancos J. 2020. Covid-19 in a patient with multiple sclerosis treated with natalizumab: may the blockade of integrins have a protective role? Mult Scler Relat Disord. 44:102250.
   PubMed Web of Science ®Google Scholar
• Al-Horani RA, Kar S, Aliter KF. 2020. Potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle: structures, mechanisms, and clinical trials. IJMS. 21(15):5224.
   Google Scholar
• Ali N. 2020. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 13(10):1373–1380.
   PubMed Web of Science ®Google Scholar
• Alvarez CP, Lasala F, Carrillo J, Muñiz O, Corbí AL, Delgado R. 2002. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol. 76(13):6841–6844.
   PubMed Web of Science ®Google Scholar
• Amraei R, Napoleon M, Yin W, Berrigan J, Suder E, Zhao G, Olejnik J, Gummuluru S, Muhlberger E, Chitalia V. 2020. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells. BioRxiv. DOI:https://doi.org/10.1101/2020.06.22.165803.
   Google Scholar
• Anderson E, Thomas L, Hayflick J, Thomas G. 1993. Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J Biol Chem. 268(33):24887–24891.
   PubMed Web of Science ®Google Scholar
• Arabi YM, Shalhoub S, Mandourah Y, Al-Hameed F, Al-Omari A, Al Qasim E, Jose J, Alraddadi B, Almotairi A, Al Khatib K, et al. 2020. Ribavirin and interferon therapy for critically ill patients with middle east respiratory syndrome: a multicenter observational study. Clin Infect Dis. 70(9):1837–1844.
   PubMed Web of Science ®Google Scholar
• Arora K, Rastogi R, Arora NM, Parashar D, Paliwal J, Naqvi A, Srivastava A, Singh SK, Kalyanaraman S, Potdar S. 2020. Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate. BioRxiv. DOI:https://doi.org/10.1101/2020.05.18.099234.
   Google Scholar
• Atherton J, Kratzing C, Fisher A. 1978. The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus. Arch Virol. 56(3):195–199.
   PubMed Web of Science ®Google Scholar
• Aucoin M, Cooley K, Saunders PR, Cardozo V, Remy D, Cramer H, Abad CN, Hannan N. 2020. The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: a rapid review. Adv Integr Med. 7(4):247–251.
   PubMed Web of Science ®Google Scholar
• Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham C-AD. 2015. Early administration of azithromycin and prevention of severe lower respiratory tract illnesses in preschool children with a history of such illnesses: a randomized clinical trial. JAMA. 314(19):2034–2044.
   PubMed Web of Science ®Google Scholar
• Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, et al. 2021. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 384(5):403–416.
   PubMed Web of Science ®Google Scholar
• Barrangou R, Horvath P. 2017. A decade of discovery: CRISPR functions and applications. Nat Microbiol. 2(7):1–9.
   Web of Science ®Google Scholar
• Bassi DE, Zhang J, Renner C, Klein‐Szanto AJ. 2017. Targeting proprotein convertases in furin‐rich lung cancer cells results in decreased in vitro and in vivo growth. Mol Carcinog. 56(3):1182–1188.
   PubMed Web of Science ®Google Scholar
• Batlle D, Wysocki J, Satchell K. 2020. Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? Clin Sci. 134(5):543–545.
   PubMed Web of Science ®Google Scholar
• Beddingfield BJ, Iwanaga N, Chapagain PP, Zheng W, Roy CJ, Hu TY, Kolls JK, Bix GJ. 2021. The integrin binding peptide, ATN-161, as a novel therapy for SARS-CoV-2 infection. JACC Basic Transl Sci. 6(1):1–8. DOI:https://doi.org/10.1016/j.jacbts.2020.10.003. 33102950.
   PubMedGoogle Scholar
• Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, et al. 2020. Remdesivir for the treatment of Covid-19—preliminary report. N Engl J Med. 383(19):1813–1826.
   PubMed Web of Science ®Google Scholar
• Belete TM. 2021. Review on up-to-date status of candidate vaccines for COVID-19 disease. Infect Drug Resist. 14:151.
   PubMed Web of Science ®Google Scholar
• Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, et al. 2020. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 3(9):e202000786.
   PubMed Web of Science ®Google Scholar
• Bian H, Zheng Z-H, Wei D, Zhang Z, Kang W-Z, Hao C-Q, Dong K, Kang W, Xia J-L, Miao J-L, et al. 2020. Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial. MedRxiv. DOI:https://doi.org/10.1101/2020.03.21.20040691.
   Google Scholar
• Blanco-Melo D, Nilsson-Payant B, Liu W-C, Møller R, Panis M, Sachs D, Albrecht RA, tenOever BR. 2020. SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems. BioRxiv. DOI:https://doi.org/10.1101/2020.03.24.004655.
   Google Scholar
• Blanco-Melo D, Nilsson-Payant BE, Liu W-C, Uhl S, Hoagland D, Møller R, Jordan TX, Oishi K, Panis M, Sachs D. 2020. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell. 181(5):1036–1045.
   PubMed Web of Science ®Google Scholar
• Borriello G, Ianniello A. 2020. COVID-19 occurring during Natalizumab treatment: a case report in a patient with extended interval dosing approach. Mult Scler Relat Disord. 41:102165.
   PubMed Web of Science ®Google Scholar
• Bouwman JJ, Visseren FL, Bouter PK, Diepersloot RJ. 2004. Azithromycin inhibits interleukin-6 but not fibrinogen production in hepatocytes infected with cytomegalovirus and chlamydia pneumoniae. J Lab Clin Med. 144(1):18–26.
   PubMed Web of Science ®Google Scholar
• Bozek A, Winterstein J. 2020. Montelukast’s ability to fight COVID-19 infection. J Asthma. :1–2.
   PubMed Web of Science ®Google Scholar
• Breining P, Frølund AL, Højen JF, Gunst JD, Staerke NB, Saedder E, Cases‐Thomas M, Little P, Nielsen LP, Søgaard OS, et al. 2021. Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety. Basic Clin Pharmacol Toxicol. 128(2):204–212.
   PubMed Web of Science ®Google Scholar
• Cai Y, Li Y-F, Tang L-P, Tsoi B, Chen M, Chen H, Chen X-M, Tan R-R, Kurihara H, He R-R. 2015. A new mechanism of vitamin C effects on A/FM/1/47 (H1N1) virus-induced pneumonia in restraint-stressed mice. BioMed Res Int. 2015
   Web of Science ®Google Scholar
• Cantorna MT, Snyder L, Lin Y-D, Yang L. 2015. Vitamin D and 1, 25 (OH) 2D regulation of T cells. Nutrients. 7(4):3011–3021.
   PubMed Web of Science ®Google Scholar
• Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, Kallio K, Kaya T, Anastasina M, Smura T, et al. 2020. Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system. BioRxiv. DOI:https://doi.org/10.1101/2020.06.07.137802.
   Google Scholar
• Carr AC. 2020. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care. 24(1):1–2.
   PubMed Web of Science ®Google Scholar
• Carr AC, Maggini S. 2017. Vitamin C and immune function. Nutrients. 9(11):1211.
   PubMed Web of Science ®Google Scholar
• Chan VS, Chan KY, Chen Y, Poon LL, Cheung AN, Zheng B, Chan K-H, Mak W, Ngan HY, Xu X. 2006. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 38(1):38–46.
   PubMed Web of Science ®Google Scholar
• Chen X, Yang X, Zheng Y, Yang Y, Xing Y, Chen Z. 2014. SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex. Protein Cell. 5(5):369–381.
   PubMed Web of Science ®Google Scholar
• Chen Y-N, Hsueh Y-H, Hsieh C-T, Tzou D-Y, Chang P-L. 2016. Antiviral activity of graphene–silver nanocomposites against non-enveloped and enveloped viruses. Int J Environ Res Public Health. 13(4):430.
   PubMed Web of Science ®Google Scholar
• Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y. 2005. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 191(5):755–760.
   PubMed Web of Science ®Google Scholar
• Chilvers M, McKean M, Rutman A, Myint B, Silverman M, O'Callaghan C. 2001. The effects of coronavirus on human nasal ciliated respiratory epithelium. Eur Respir J. 18(6):965–970.
   PubMed Web of Science ®Google Scholar
• Clapham PR, McKnight Á. 2001. HIV-1 receptors and cell tropism. Br Med Bull. 58(1):43–59.
   PubMedGoogle Scholar
• Clarke NE, Fisher MJ, Porter KE, Lambert DW, Turner AJ. 2012. Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling. PLoS One. 7(4):e34747.
   PubMed Web of Science ®Google Scholar
• Coleman CM, Liu YV, Mu H, Taylor JK, Massare M, Flyer DC, Glenn GM, Smith GE, Frieman MB. 2014. Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice. Vaccine. 32(26):3169–3174.
   PubMed Web of Science ®Google Scholar
• Colson P, Rolain J-M, Lagier J-C, Brouqui P, Raoult D. 2020. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 55(4):105932–101016.
   PubMed Web of Science ®Google Scholar
• Colunga Biancatelli RML, Berrill M, Marik PE. 2020. The antiviral properties of vitamin C. Expert Rev Anti Infect Ther. 18(2):99-101.
   Google Scholar
• Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. 2020. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 57:279–283.
   PubMed Web of Science ®Google Scholar
• Cotten M, Weber JM. 1995. The adenovirus protease is required for virus entry into host cells. Virology. 213(2):494–502.
   PubMed Web of Science ®Google Scholar
• Coutard B, Valle C, de Lamballerie X, Canard B, Seidah N, Decroly E. 2020. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 176:104742.
   PubMed Web of Science ®Google Scholar
• Crinelli R, Bianchi M, Gentilini L, Palma L, Sørensen MD, Bryld T, Babu RB, Arar K, Wengel J, Magnani M. 2004. Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity. Nucleic Acids Res. 32(6):1874–1885.
   PubMed Web of Science ®Google Scholar
• Dagan N, Barda N, Kepten E, Miron O, Perchik S, Katz MA, Hernán MA, Lipsitch M, Reis B, Balicer RD. 2021. BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. N Engl J Med. 384(15):1412–1423.
   PubMed Web of Science ®Google Scholar
• Daglia M. 2012. Polyphenols as antimicrobial agents. Curr Opin Biotechnol. 23(2):174–181.
   PubMed Web of Science ®Google Scholar
• Dahms SO, Jiao G-S, Than ME. 2017. Structural studies revealed active site distortions of human furin by a small molecule inhibitor. ACS Chem Biol. 12(5):1211–1216.
   PubMed Web of Science ®Google Scholar
• Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, et al. 2020. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 370(6518):861–865.
   Google Scholar
• de Borst MH, Vervloet MG, ter Wee PM, Navis G. 2011. Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol. 22(9):1603–1609.
   PubMed Web of Science ®Google Scholar
• de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA. 2013. Commentary: middle east respiratory syndrome coronavirus (mers-cov): announcement of the coronavirus study group. J Virol. 87(14):7790–7792.
   PubMed Web of Science ®Google Scholar
• Della-Torre E, Campochiaro C, Cavalli G, De Luca G, Napolitano A, La Marca S, Boffini N, Da Prat V, Di Terlizzi G, Lanzillotta M, et al. 2020. Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study. Ann Rheum Dis. 79(10):1277–1285.
   PubMed Web of Science ®Google Scholar
• Denaro M, Smeriglio A, Barreca D, De Francesco C, Occhiuto C, Milano G, Trombetta D. 2020. Antiviral activity of plants and their isolated bioactive compounds: an update. Phytother Res. 34(4):742–768.
   PubMed Web of Science ®Google Scholar
• Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R. 2000. A novel angiotensin-converting enzyme–related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 87(5):e1–e9.
   PubMed Web of Science ®Google Scholar
• Drugs C. 1997. Use of codeine-and dextromethorphan-containing cough remedies in children. Pediatrics. 99(6):918–920.
   PubMed Web of Science ®Google Scholar
• Du L, He Y, Zhou Y, Liu S, Zheng B-J, Jiang S. 2009. The spike protein of SARS-CoV—a target for vaccine and therapeutic development. Nat Rev Microbiol. 7(3):226–236.
   PubMed Web of Science ®Google Scholar
• Du T, Liang J, Dong N, Lu J, Fu Y, Fang L, Xiao S, Han H. 2018. Glutathione-capped Ag2S nanoclusters inhibit coronavirus proliferation through blockage of viral RNA synthesis and budding. ACS Appl Mater Interfaces. 10(5):4369–4378.
   PubMed Web of Science ®Google Scholar
• Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, Zhou M, Chen L, Meng S, Hu Y, et al. 2020. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. 117(17):9490–9496.
   PubMed Web of Science ®Google Scholar
• Duarte M, Pelorosso FG, Nicolosi L, Salgado MV, Vetulli H, Aquieri A, Azzato F, Basconcel M, Castro M, Coyle J, et al. 2020. Telmisartan for treatment of Covid-19 patients: an open randomized clinical trial. Preliminary report. MedRxiv. DOI:https://doi.org/10.1101/2020.08.04.20167205.
   Google Scholar
• Elavarasi A, Prasad M, Seth T, Sahoo RK, Madan K, Nischal N, Soneja M, Sharma A, Maulik SK, Garg P. 2020. Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a systematic review and meta-analysis. J Gen Intern Med. 35(11):3308–3314.
   PubMed Web of Science ®Google Scholar
• Fasting C, Schalley CA, Weber M, Seitz O, Hecht S, Koksch B, Dernedde J, Graf C, Knapp EW, Haag R. 2012. Multivalency as a chemical organization and action principle. Angew Chem Int Ed. 51(42):10472–10498.
   PubMed Web of Science ®Google Scholar
• Fidan C, Aydoğdu A. 2020. As a potential treatment of COVID-19: montelukast. Med Hypotheses. 142:109828.
   PubMed Web of Science ®Google Scholar
• Florindo HF, Kleiner R, Vaskovich-Koubi D, Acúrcio RC, Carreira B, Yeini E, Tiram G, Liubomirski Y, Satchi-Fainaro R. 2020. Immune-mediated approaches against COVID-19. Nat Nanotechnol. 15(8):630–645.
   PubMed Web of Science ®Google Scholar
• Foster M, Samman S. 2012. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients. 4(7):676–694.
   PubMed Web of Science ®Google Scholar
• Furtado RHM, Berwanger O, Fonseca HA, Corrêa TD, Ferraz LR, Lapa MG, Zampieri FG, Veiga VC, Azevedo LCP, Rosa RG, et al. 2020. Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial. Lancet. 396(10256):959–967.
   PubMed Web of Science ®Google Scholar
• Gao J, Tian Z, Yang X. 2020. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. BST. 14(1):72–73.
   Google Scholar
• Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L. 2020. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 368(6492):779–782.
   PubMed Web of Science ®Google Scholar
• Gautret P, Lagier J-C, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, et al. 2020. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 56(1):105949.
   PubMed Web of Science ®Google Scholar
• Geijtenbeek TB, Engering A, Van Kooyk Y. 2002. DC‐SIGN, a C‐type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukocyte Biol. 71(6):921–931.
   PubMed Web of Science ®Google Scholar
• Gielen V, Johnston SL, Edwards MR. 2010. Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J. 36(3):646–654.
   PubMed Web of Science ®Google Scholar
• Gironi LC, Damiani G, Zavattaro E, Pacifico A, Santus P, Pigatto PDM, Cremona O, Savoia P. 2021. Tetracyclines in COVID‐19 patients quarantined at home: literature evidence supporting real‐world data from a multicenter observational study targeting inflammatory & infectious dermatoses. Dermatol Ther. 34(1):e14694.
   PubMed Web of Science ®Google Scholar
• Glowacka I, Bertram S, Müller MA, Allen P, Soilleux E, Pfefferle S, Steffen I, Tsegaye TS, He Y, Gnirss K. 2011. Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 85(9):4122–4134.
   PubMed Web of Science ®Google Scholar
• Gombart AF, Borregaard N, Koeffler HP. 2005. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1, 25‐dihydroxyvitamin D3. FASEB J. 19(9):1067–1077.
   PubMed Web of Science ®Google Scholar
• Gombart AF, Pierre A, Maggini S. 2020. A review of micronutrients and the immune System–Working in harmony to reduce the risk of infection. Nutrients. 12(1):236.
   PubMed Web of Science ®Google Scholar
• Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Götte M. 2020. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J Biol Chem. 295(20):6785–6797.
   PubMed Web of Science ®Google Scholar
• Górski A, Międzybrodzki R, Żaczek M, Borysowski J. 2020. Phages in the fight against COVID-19? Future Med. 15:1095–1100.
   PubMed Web of Science ®Google Scholar
• Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. 2020. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 12(4):988.
   PubMed Web of Science ®Google Scholar
• Greiller C, Martineau A. 2015. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 7:4240–4270.
   PubMed Web of Science ®Google Scholar
• Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure F-X, et al. 2020. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 382(24):2327–2336.
   PubMed Web of Science ®Google Scholar
• Group RC. 2020. Dexamethasone in hospitalized patients with Covid-19—preliminary report. New Eng J Med.
   Web of Science ®Google Scholar
• Guo H-F, Vander Kooi CW. 2015. Neuropilin functions as an essential cell surface receptor. J Biol Chem. 290(49):29120–29126.
   PubMed Web of Science ®Google Scholar
• Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, Tan K-S, Wang D-Y, Yan Y. 2020. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Military Med Res. 7(1):1–10.
   PubMed Web of Science ®Google Scholar
• Gyebi GA, Ogunro OB, Adegunloye AP, Ogunyemi OM, Afolabi SO. 2021. Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants. J Biomol Struct Dyn. 39(9):3396–3408.
   PubMed Web of Science ®Google Scholar
• Haggag YA, El-Ashmawy NE, Okasha KM. 2020. Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection? Med Hypotheses. 144:109957.
   PubMed Web of Science ®Google Scholar
• Haiying L, Na H, Xiaoyuan X. 2003. The curative effects of glycyrrhizin on patients with SARS. Annual Meeting of The Society of Infectious and Parasitic Diseases, Chinese Medical Association, Wuhan, China.
   Google Scholar
• Han DP, Penn-Nicholson A, Cho MW. 2006. Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. Virology. 350(1):15–25.
   PubMed Web of Science ®Google Scholar
• Harcourt BH, Jukneliene D, Kanjanahaluethai A, Bechill J, Severson KM, Smith CM, Rota PA, Baker SC. 2004. Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity. J Virol. 78(24):13600–13612.
   PubMed Web of Science ®Google Scholar
• Haryanto B, Suksmasari T, Wintergerst E, Maggini S. 2015. Multivitamin supplementation supports immune function and ameliorates conditions triggered by reduced air quality. Vitam Miner. 4:1–15.
   Google Scholar
• Hasan A, Paray BA, Hussain A, Qadir FA, Attar F, Aziz FM, Sharifi M, Derakhshankhah H, Rasti B, Mehrabi M, et al. 2021. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin. J Biomol Struct Dyn. 39(8):3025–3029.
   PubMed Web of Science ®Google Scholar
• Hashemi A, Madhavan MV, Bikdeli B. 2020. Pharmacotherapy for prevention and management of thrombosis in COVID-19. Semin Thromb Hemost. 46(7):789-795.
   Google Scholar
• Haspel N, Zanuy D, Nussinov R, Teesalu T, Ruoslahti E, Aleman C. 2011. Binding of a C-end rule peptide to the neuropilin-1 receptor: a molecular modeling approach. Biochemistry. 50(10):1755–1762.
   PubMed Web of Science ®Google Scholar
• Hassanzadeh P. 2020. Nanotheranostics against COVID-19: from multivalent to immune-targeted materials. J Controlled Release. 328:112–126.
   PubMed Web of Science ®Google Scholar
• Heer CD, Sanderson DJ, Voth LS, Alhammad YM, Schmidt MS, Trammell SA, Perlman S, Cohen MS, Fehr AR, Brenner C. 2020. Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity. BioRxiv. DOI:https://doi.org/10.1101/2020.04.17.047480.
   Google Scholar
• Hemilä H. 1997. Vitamin C intake and susceptibility to pneumonia. Pediatr Infect Dis J. 16(9):836–837.
   PubMed Web of Science ®Google Scholar
• Hemilä H. 2003. Vitamin C and SARS coronavirus. J Antimicrob Chemother. 52(6):1049–1050.
   PubMed Web of Science ®Google Scholar
• Hemilä H, Chalker E. 2020. Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis. J Intensive Care. 8(1):15.
   PubMed Web of Science ®Google Scholar
• Hemilä H, Louhiala P. 2007. Vitamin C may affect lung infections. J Roy Soc Med. 100(11):495–498.
   PubMed Web of Science ®Google Scholar
• Hensel A, Bauer R, Heinrich M, Spiegler V, Kayser O, Hempel G, Kraft K. 2020. Challenges at the time of COVID-19: opportunities and innovations in antivirals from nature. Planta Med. 86(10):659.
   PubMed Web of Science ®Google Scholar
• Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu N-H, Nitsche A, et al. 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 181(2):271–280.e8.
   PubMed Web of Science ®Google Scholar
• Hofmann-Winkler H, Moerer O, Alt-Epping S, Bräuer A, Büttner B, Müller M, Fricke T, Grundmann J, Harnisch L-O, Heise D, et al. 2020. Camostat mesylate may reduce severity of coronavirus disease 2019 sepsis: a first observation. Crit Care Explorations. 2(11):e0284.
   PubMedGoogle Scholar
• Hughes-Visentin A, Paul ABM. 2020. Asthma and COVID-19: what do we know now. Clin Med Insights Circ Respir Pulm Med. 14:1179548420966242.
   Web of Science ®Google Scholar
• Hussein HA, Walker LR, Abdel-Raouf UM, Desouky SA, Montasser AKM, Akula SM. 2015. Beyond RGD: virus interactions with integrins. Arch Virol. 160(11):2669–2681.
   PubMed Web of Science ®Google Scholar
• Hynes RO. 2002. Integrins: bidirectional, allosteric signaling machines. Cell. 110(6):673–687.
   PubMed Web of Science ®Google Scholar
• Ibrahim MA, Abdeljawaad KA, Abdelrahman AH, Hegazy M-EF. 2020. Natural-like products as potential SARS-CoV-2 Mpro inhibitors: in-silico drug discovery. J Biomol Struct Dyn. :1–13.
   PubMedGoogle Scholar
• Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. 2006. A second, non‐canonical RNA‐dependent RNA polymerase in SARS Coronavirus. Embo J. 25(20):4933–4942.
   PubMed Web of Science ®Google Scholar
• Iturbe-Hernandez T, de Guadiana Romualdo LG, Ortega IG, Francés AM, Birlanga OM, Cerezo-Manchado JJ. 2020. Dabigatran, the oral anticoagulant of choice at discharge in patients with non-valvular atrial fibrillation and COVID-19 infection: the ANIBAL protocol. Drugs in Context. DOI:https://doi.org/10.7573/dic.2020-8-3.
   Google Scholar
• Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ, et al. 2020. An mRNA vaccine against SARS-CoV-2—preliminary report. N Engl J Med. 383(20):1920–1931.
   PubMed Web of Science ®Google Scholar
• Jang KJ, Lee N-R, Yeo W-S, Jeong Y-J, Kim D-E. 2008. Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase. Biochem Biophys Res Commun. 366(3):738–744.
   PubMed Web of Science ®Google Scholar
• Jeffers SA, Tusell SM, Gillim-Ross L, Hemmila EM, Achenbach JE, Babcock GJ, Thomas WD, Thackray LB, Young MD, Mason RJ, et al. 2004. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci. 101(44):15748–15753.
   PubMed Web of Science ®Google Scholar
• Johnston CS, Huang S. 1991. Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs. J Nutr. 121(1):126–130.
   PubMed Web of Science ®Google Scholar
• Kamboj M, Sepkowitz KA. 2007. Risk of transmission associated with live attenuated vaccines given to healthy persons caring for or residing with an immunocompromised patient. Infect Control Hosp Epidemiol. 28(6):702–707.
   PubMed Web of Science ®Google Scholar
• Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, He S, Zhou Z, Zhou Z, Chen Q, et al. 2020. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharm Sin B. 10(7):1228–1238.
   PubMed Web of Science ®Google Scholar
• Kaur SP, Gupta V. 2020. COVID-19 Vaccine: a comprehensive status report. Virus Res. 288:198114.
   PubMed Web of Science ®Google Scholar
• Khan AR, Misdary C, Yegya-Raman N, Kim S, Narayanan N, Siddiqui S, Salgame P, Radbel J, Groote FD, Michel C, et al. 2021. Montelukast in hospitalized patients diagnosed with COVID-19. J Asthma. DOI:https://doi.org/10.1080/02770903.2021.1881967.
   Google Scholar
• Kitabayashi C, Fukada T, Kanamoto M, Ohashi W, Hojyo S, Atsumi T, Ueda N, Azuma I, Hirota H, Murakami M. 2010. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int Immunol. 22(5):375–386.
   PubMed Web of Science ®Google Scholar
• Kong L-M, Liao C-G, Zhang Y, Xu J, Li Y, Huang W, Zhang Y, Bian H, Chen Z-N. 2014. A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis. Cancer Res. 74(14):3764–3778.
   PubMed Web of Science ®Google Scholar
• Koppikar P, Bromberg J. 2012. STATe-of-the-Art approach: using oligonucleotide decoys to target the “undruggable”. Cancer Discov. 2(8):670–672.
   PubMed Web of Science ®Google Scholar
• Kosugi T, Maeda K, Sato W, Maruyama S, Kadomatsu K. 2015. CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. Nephrol Dial Transplant. 30(7):1097–1103.
   PubMed Web of Science ®Google Scholar
• Krenn B, Gaudernak E, Holzer B, Lanke K, Van Kuppeveld F, Seipelt J. 2009. Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. J Virol. 83(1):58–64.
   PubMed Web of Science ®Google Scholar
• Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W. 2005. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nat Med. 11(8):875–879.
   PubMed Web of Science ®Google Scholar
• Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L. 2020. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 581(7807):215–220.
   PubMed Web of Science ®Google Scholar
• Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, et al. 2020. Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry. Nat Nanotechnol. 15(5):373–379.
   PubMed Web of Science ®Google Scholar
• Ledford H. 2020. Steroid is first drug shown to prevent deaths from COVID-19. London: Nature Publishing Group.
   Google Scholar
• LeDuc JW, Barry MA. 2004. SARS, the first pandemic of the 21st century. Emerg Infect Dis. 10(11):e26.
   Google Scholar
• Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, et al. 2003. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 348(20):1986–1994.
   PubMed Web of Science ®Google Scholar
• Lee SA. 2020. Coronavirus Anxiety Scale: a brief mental health screener for COVID-19 related anxiety. Death Stud. 44(7):393–401.
   PubMed Web of Science ®Google Scholar
• Lei C, Qian K, Li T, Zhang S, Fu W, Ding M, Hu S. 2020. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig. Nat Commun. 11(1):1–5.
   PubMed Web of Science ®Google Scholar
• Li F. 2016. Structure, function, and evolution of coronavirus spike proteins. Annu Rev Virol. 3:237–261.
   PubMed Web of Science ®Google Scholar
• Li Q, Kang C. 2020. Progress in developing inhibitors of SARS-CoV-2 3C-like protease. Microorganisms. 8(8):1250.
   PubMed Web of Science ®Google Scholar
• Liesenborghs L, Spriet I, Jochmans D, Belmans A, Gyselinck I, Teuwen L-A, Ter Horst S, Dreesen E, Geukens T, Engelen M. 2021. Itraconazole for COVID-19: preclinical studies and a proof-of-concept pilot clinical study. EBioMedicine. 66:103288.
   PubMed Web of Science ®Google Scholar
• Lin P-H, Sermersheim M, Li H, Lee PH, Steinberg SM, Ma J. 2017. Zinc in wound healing modulation. Nutrients. 10(1):16.
   PubMed Web of Science ®Google Scholar
• Liu T, Luo S, Libby P, Shi G-P. 2020. Cathepsin L-selective inhibitors: a potentially promising treatment for COVID-19 patients. Pharmacol Ther. 213:107587.
   PubMed Web of Science ®Google Scholar
• Lombard K, Peffley E, Geoffriau E, Thompson L, Herring A. 2005. Quercetin in onion (Allium cepa L.) after heat-treatment simulating home preparation. J Food Compos Anal. 18(6):571–581.
   Web of Science ®Google Scholar
• Longping VT, Hamilton AM, Friling T, Whittaker GR. 2014. A novel activation mechanism of avian influenza virus H9N2 by furin. J Virol. 88(3):1673–1683.
   PubMed Web of Science ®Google Scholar
• Luo P, Liu Y, Qiu L, Liu X, Liu D, Li J. 2020. Tocilizumab treatment in COVID‐19: a single center experience. J Med Virol. 92(7):814–818.
   PubMed Web of Science ®Google Scholar
• Lv X, Li Z, Guan J, Zhang J, Xu B, He W, Lan Y, Zhao K, Lu H, Song D. 2019. ATN-161 reduces virus proliferation in PHEV-infected mice by inhibiting the integrin α5β1-FAK signaling pathway. Vet Microbiol. 233:147–153.
   PubMed Web of Science ®Google Scholar
• Maggini S, Pierre A, Calder PC. 2018. Immune function and micronutrient requirements change over the life course. Nutrients. 10(10):1531.
   PubMed Web of Science ®Google Scholar
• Mani JS, Johnson JB, Steel JC, Broszczak DA, Neilsen PM, Walsh KB, Naiker M. 2020. Natural product-derived phytochemicals as potential agents against coronaviruses: a review. Virus Res. 284:197989.
   PubMed Web of Science ®Google Scholar
• Marovich M, Mascola JR, Cohen MS. 2020. Monoclonal antibodies for prevention and treatment of COVID-19. JAMA. 324(2):131–132.
   PubMed Web of Science ®Google Scholar
• Matsuyama S, Nagata N, Shirato K, Kawase M, Takeda M, Taguchi F. 2010. Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2. J Virol. 84(24):12658–12664.
   PubMed Web of Science ®Google Scholar
• Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, Collaboration HAS. 2020. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 395(10229):1033.
   PubMed Web of Science ®Google Scholar
• Millet JK, Whittaker GR. 2015. Host cell proteases: critical determinants of coronavirus tropism and pathogenesis. Virus Res. 202:120–134.
   PubMed Web of Science ®Google Scholar
• Million M, Gautret P, Colson P, Roussel Y, Dubourg G, Chabriere E, Honore S, Rolain J-M, Fenollar F, Fournier P-E. 2020. Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world. New Microbes New Infect. 38:100709.
   PubMed Web of Science ®Google Scholar
• Miyako E, Nagata H, Hirano K, Sakamoto K, Makita Y, Nakayama K-i, Hirotsu T. 2008. Photoinduced antiviral carbon nanohorns. Nanotechnology. 19(7):075106.
   PubMed Web of Science ®Google Scholar
• Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado del Pozo C, Prosper F, et al. 2020. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell. 181(4):905–913.e7.
   PubMed Web of Science ®Google Scholar
• Muchtaridi M, Fauzi M, Khairul Ikram NK, Mohd Gazzali A, Wahab HA. 2020. Natural flavonoids as potential angiotensin-converting enzyme 2 inhibitors for anti-SARS-CoV-2. Molecules. 25(17):3980.
   PubMed Web of Science ®Google Scholar
• Muhseen ZT, Hameed AR, Al-Hasani HM, Ul Qamar MT, Li G. 2020. Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: integrated computational approach. J Mol Liq. 320:114493.
   PubMed Web of Science ®Google Scholar
• Murdaca G, Pioggia G, Negrini S. 2020. Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Mol Allergy. 18(1):1–8.
   PubMedGoogle Scholar
• Nakaya T, Iwai S, Fujinaga K, Sato Y, Otsuka E, Ikuta K. 1997. Decoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev protein. Antimicrob Agents Chemother. 41(2):319–325.
   PubMed Web of Science ®Google Scholar
• Nalawansha DA, Samarasinghe KT. 2020. Double-Barreled CRISPR Technology as a Novel Treatment Strategy For COVID-19. ACS Pharmacol Transl Sci. 3(5):790–800.
   PubMedGoogle Scholar
• Naveja JJ, Madariaga-Mazón A, Flores-Murrieta F, Granados-Montiel J, Maradiaga-Ceceña M, Alaniz VD, Maldonado-Rodriguez M, García-Morales J, Senosiain-Peláez JP, Martinez-Mayorga K. 2021. Union is strength: antiviral and anti-inflammatory drugs for COVID-19. Drug Discov Today. 26(1):229–239.
   PubMed Web of Science ®Google Scholar
• Nejat R, Sadr AS. 2021. Are losartan and imatinib effective against SARS-CoV2 pathogenesis? A pathophysiologic-based in silico study. In Silico Pharmacol. 9(1):1–22.
   PubMedGoogle Scholar
• Noroozi R, Branicki W, Pyrc K, Łabaj PP, Pospiech E, Taheri M, Ghafouri-Fard S. 2020. Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions. Cytokine. 133:155143.
   PubMed Web of Science ®Google Scholar
• Omrani AS, Saad MM, Baig K, Bahloul A, Abdul-Matin M, Alaidaroos AY, Almakhlafi GA, Albarrak MM, Memish ZA, Albarrak AM. 2014. Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study. Lancet Infect Dis. 14(11):1090–1095.
   PubMed Web of Science ®Google Scholar
• Orecchioni M, Bedognetti D, Newman L, Fuoco C, Spada F, Hendrickx W, Marincola FM, Sgarrella F, Rodrigues AF, Ménard-Moyon C, et al. 2017. Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells. Nat Commun. 8(1):1–14.
   PubMedGoogle Scholar
• Ortego J, Escors D, Laude H, Enjuanes L. 2002. Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome. J Virol. 76(22):11518–11529.
   PubMed Web of Science ®Google Scholar
• Pang H-B, Braun GB, Friman T, Aza-Blanc P, Ruidiaz ME, Sugahara KN, Teesalu T, Ruoslahti E. 2014. An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability. Nat Commun. 5(1):1–12.
   Google Scholar
• Pang X, Cui Y, Zhu Y. 2020. Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication. Acta Pharmacol Sin. 41(9):1255–1257.
   PubMed Web of Science ®Google Scholar
• Park J-Y, Yuk HJ, Ryu HW, Lim SH, Kim KS, Park KH, Ryu YB, Lee WS. 2017. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. J Enzyme Inhib Med Chem. 32(1):504–512.
   PubMed Web of Science ®Google Scholar
• Park S, Park HH, Kim SY, Kim SJ, Woo K, Ko G. 2014. Antiviral properties of silver nanoparticles on a magnetic hybrid colloid. Appl Environ Microbiol. 80(8):2343–2350.
   PubMed Web of Science ®Google Scholar
• Park TJ, Lee S-K, Yoo SM, Yang S-M, Lee SY. 2011. Development of reflective biosensor using fabrication of functionalized photonic nanocrystals. J Nanosci Nanotechnol. 11(1):632–637.
   PubMed Web of Science ®Google Scholar
• Parra-Lara LG, Martínez-Arboleda JJ, Rosso F. 2020. Azithromycin and SARS-CoV-2 infection: where we are now and where we are going. J Glob Antimicrob Resist. 22:680–684.
   PubMed Web of Science ®Google Scholar
• Pashaei M, Rezaei N. 2020. Immunotherapy for SARS-CoV-2: potential opportunities. Expert Opin Biol Ther. 20(10):1111–1116.
   PubMed Web of Science ®Google Scholar
• Pashaki PA, Roudkenar MH, Rahim F, Ebrahimi A. 2020. From SARS-CoV to SARS-CoV2: a potential guide to better understanding of pathophysiology of the disease and potential therapeutic modality. Eur Rev Med Pharmacol Sci. 24:7816–7825.
   PubMed Web of Science ®Google Scholar
• Pillaiyar T, Manickam M, Namasivayam V, Hayashi Y, Jung S-H. 2016. An overview of severe acute respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: peptidomimetics and Small Molecule Chemotherapy . J Med Chem. 59(14):6595–6628.
   PubMed Web of Science ®Google Scholar
• Plein A, Fantin A, Ruhrberg C. 2014. Neuropilin regulation of angiogenesis, arteriogenesis, and vascular permeability. Microcirculation. 21(4):315–323.
   PubMed Web of Science ®Google Scholar
• Plummer EM, Manchester M. 2011. Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 3(2):174–196.
   PubMed Web of Science ®Google Scholar
• Poetker DM, Reh DD. 2010. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am. 43(4):753–768.
   PubMed Web of Science ®Google Scholar
• Pöhlmann S, Soilleux EJ, Baribaud F, Leslie GJ, Morris LS, Trowsdale J, Lee B, Coleman N, Doms RW. 2001. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc Natl Acad Sci U S A. 98(5):2670–2675.
   PubMed Web of Science ®Google Scholar
• Pöhlmann S, Zhang J, Baribaud F, Chen Z, Leslie GJ, Lin G, Granelli-Piperno A, Doms RW, Rice CM, McKeating JA. 2003. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J Virol. 77(7):4070–4080.
   PubMed Web of Science ®Google Scholar
• Presser V, Yeon SH, Vakifahmetoglu C, Howell CA, Sandeman SR, Colombo P, Mikhalovsky S, Gogotsi Y. 2012. Hierarchical porous carbide-derived carbons for the removal of cytokines from blood plasma . Adv Healthc Mater. 1(6):796–800.
   PubMed Web of Science ®Google Scholar
• Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. 2019. The role of zinc in antiviral immunity. Adv Nutr. 10(4):696–710.
   PubMed Web of Science ®Google Scholar
• Reinke LM, Spiegel M, Plegge T, Hartleib A, Nehlmeier I, Gierer S, Hoffmann M, Hofmann-Winkler H, Winkler M, Pöhlmann S. 2017. Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2. PLoS One. 12(6):e0179177.
   PubMed Web of Science ®Google Scholar
• Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, et al. 2020. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 586(7827):113–119.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Molinero A, Pérez-López C, Gálvez-Barrón C, Miñarro A, Macho O, López GF, Robles MT, Dapena MD, Martínez S, Rodríguez E, et al. 2020. Observational study of azithromycin in hospitalized patients with COVID-19. PloS One. 15(9):e0238681.
   PubMed Web of Science ®Google Scholar
• Rolain J-M, Colson P, Raoult D. 2007. Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int J Antimicrob Agents. 30(4):297–308.
   PubMed Web of Science ®Google Scholar
• Romano M, Fanelli G, Albany CJ, Giganti G, Lombardi G. 2019. Past, present, and future of regulatory T cell therapy in transplantation and autoimmunity. Front Immunol. 10:43.
   PubMed Web of Science ®Google Scholar
• Roscioli E, Jersmann HP, Lester S, Badiei A, Fon A, Zalewski P, Hodge S. 2017. Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD. COPD. Volume 12:3503–3510.
   Google Scholar
• Rosenkranz E, Metz CHD, Maywald M, Hilgers R-D, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, et al. 2016. Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Mol Nutr Food Res. 60(3):661–671.
   PubMed Web of Science ®Google Scholar
• Rossi JJ, Rossi D. 2020. Oligonucleotides and the COVID-19 pandemic: a perspective. Nucleic Acid Ther. 30(3):129–132.
   PubMed Web of Science ®Google Scholar
• Rothlin RP, Vetulli HM, Duarte M, Pelorosso FG. 2020. Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19. Drug Dev Res. 81(7):768–770.
   PubMed Web of Science ®Google Scholar
• Saeedi-Boroujeni A, Mahmoudian-Sani M-R. 2021. Anti-inflammatory potential of Quercetin in COVID-19 treatment. J Inflamm. 18(1):1–9.
   Google Scholar
• Sagi SSK, Mathew T, Patir H. 2014. Prophylactic administration of curcumin abates the incidence of hypobaric hypoxia induced pulmonary edema in rats: a molecular approach. J Pulm Respir Med. 4:164.
   Google Scholar
• Satyanarayanasetty D, Pawar K, Nadig P, Haran A. 2015. Multiple adverse effects of systemic corticosteroids: a case report. J Clin Diagn Res. 9(5):FD01–FD02.
   PubMed Web of Science ®Google Scholar
• Saxena M, Saxena J, Nema R, Singh D, Gupta A. 2013. Phytochemistry of medicinal plants. J Pharmacogn Phytochem. 1(6):168–182.
   Google Scholar
• Schneider M, Ackermann K, Stuart M, Wex C, Protzer U, Schätzl HM, Gilch S. 2012. Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. J Virol. 86(18):10112–10122.
   PubMed Web of Science ®Google Scholar
• Schoeman D, Fielding BC. 2019. Coronavirus envelope protein: current knowledge. Virol J. 16(1):1–22.
   PubMed Web of Science ®Google Scholar
• Schwalfenberg GK. 2011. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol Nutr Food Res. 55(1):96–108.
   PubMed Web of Science ®Google Scholar
• Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, et al. 2012. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov. 2(8):694–705.
   PubMed Web of Science ®Google Scholar
• Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, Li F. 2020. Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci U S A. 117(21):11727–11734.
   PubMed Web of Science ®Google Scholar
• Sharifi A, Vahedi H, Nedjat S, Rafiei H, Hosseinzadeh‐Attar MJ. 2019. Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial . APMIS. 127(10):681–687.
   PubMed Web of Science ®Google Scholar
• Sharifkashani S, Bafrani MA, Khaboushan AS, Pirzadeh M, Kheirandish A, Yavarpour Bali H, Hessami A, Saghazadeh A, Rezaei N. 2020. Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: potential therapeutic targeting. Eur J Pharmacol. 884:173455.
   PubMed Web of Science ®Google Scholar
• Sheikh A, Shamsuzzaman S, Ahmad SM, Nasrin D, Nahar S, Alam MM, Al Tarique A, Begum YA, Qadri SS, Chowdhury MI, et al. 2010. Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea. J Nutr. 140(5):1049–1056.
   PubMed Web of Science ®Google Scholar
• Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, Wang F, Li D, Yang M, Xing L, et al. 2020. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 323(16):1582–1589.
   PubMed Web of Science ®Google Scholar
• Shi Y, Liu T, Yao L, Xing Y, Zhao X, Fu J, Xue X. 2017. Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system. Sci Rep. 7(1):1–10.
   PubMedGoogle Scholar
• Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, et al. 2020. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 587(7835):657–610.
   PubMed Web of Science ®Google Scholar
• Shinde V, Bhikha S, Hossain Z, Archary M, Bhorat Q, Fairlie L, Lalloo U, Masilela MLS, Moodley D, Hanley S, et al. 2021. Preliminary Efficacy of the NVX-CoV2373 Covid-19 Vaccine Against the B. 1.351 Variant. MedRxiv. DOI:https://doi.org/10.1101/2021.02.25.21252477.
   Google Scholar
• Shittu MO, Afolami OI. 2020. Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives-a better synergy for future COVID-19 clinical trials. Infez Med. 28(2):192–197.
   PubMedGoogle Scholar
• Shum KT, Tanner JA. 2008. Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase. Chembiochem. 9(18):3037–3045.
   PubMed Web of Science ®Google Scholar
• Sigrist CJ, Bridge A, Le Mercier P. 2020. A potential role for integrins in host cell entry by SARS-CoV-2. Antiviral Res. 177:104759.
   PubMed Web of Science ®Google Scholar
• Simões C, Amoros M, Girre L. 1999. Mechanism of antiviral activity of triterpenoid saponins. Phytother Res. 13(4):323–328.
   PubMed Web of Science ®Google Scholar
• Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, et al. 2020. Zinc and respiratory tract infections: perspectives for COVID‑19 (Review). Int J Mol Med. 46(1):17–26.
   PubMed Web of Science ®Google Scholar
• Soilleux EJ, Morris LS, Rushbrook S, Lee B, Coleman N. 2002. Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: consequences for HIV infection and immunity . Hum Pathol. 33(6):652–659.
   PubMed Web of Science ®Google Scholar
• Soni VK, Mehta A, Ratre YK, Tiwari AK, Amit A, Singh RP, Sonkar SC, Chaturvedi N, Shukla D, Vishvakarma NK. 2020. Curcumin, a traditional spice component, can hold the promise against COVID-19? Eur J Pharmacol.886:173551.
   PubMed Web of Science ®Google Scholar
• Stopsack KH, Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW. 2020. TMPRSS2 and COVID-19: serendipity or opportunity for intervention? Cancer Discov. 10(6):779–782.
   PubMed Web of Science ®Google Scholar
• Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B. 2014. SARS-CoV ORF1b-encoded nonstructural proteins 12–16: replicative enzymes as antiviral targets. Antiviral Res. 101:122–130.
   PubMed Web of Science ®Google Scholar
• Sultana J, Cutroneo PM, Crisafulli S, Puglisi G, Caramori G, Trifirò G. 2020. Azithromycin in COVID-19 patients: pharmacological mechanism, clinical evidence and prescribing guidelines. Drug Saf. 43(8):691–698.
   PubMed Web of Science ®Google Scholar
• Takano T, Akiyama M, Doki T, Hohdatsu T. 2019. Antiviral activity of itraconazole against type I feline coronavirus infection. Vet Res. 50(1):5–6.
   PubMed Web of Science ®Google Scholar
• Tan SHS, Hong CC, Saha S, Murphy D, Hui JH. 2020. Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective. Int Orthop. 44(8):1599–1603.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Hruska KA, Seino Y, Malone JD, Nishii Y, Teitelbaum SL. 1991. Disassociation of the macrophage-maturational effects of vitamin D from respiratory burst priming. J Biol Chem. 266(17):10888–10892.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Muto N, Gohda E, Yamamoto I. 1994. Enhancement by ascorbic acid 2-glucoside or repeated additions of ascorbate of mitogen-induced IgM and IgG productions by human peripheral blood lymphocytes. Jpn J Pharmacol. 66(4):451–456.
   PubMedGoogle Scholar
• Tanner JA, Zheng B-J, Zhou J, Watt RM, Jiang J-Q, Wong K-L, Lin Y-P, Lu L-Y, He M-L, Kung H-F, et al. 2005. The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus. Chem Biol. 12(3):303–311.
   PubMedGoogle Scholar
• Te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. 2010. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 6(11):e1001176.
   PubMed Web of Science ®Google Scholar
• Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E. 2009. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci. 106(38):16157–16162.
   PubMed Web of Science ®Google Scholar
• Teymoori-Rad M, Shokri F, Salimi V, Marashi SM. 2019. The interplay between vitamin D and viral infections. Rev Med Virol. 29(2):e2032.
   PubMed Web of Science ®Google Scholar
• Tian D, Liu Y, Liang C, Xin L, Xie X, Zhang D, Wan M, Li H, Fu X, Liu H, et al. 2021. An update review of emerging small-molecule therapeutic options for COVID-19. Biomed Pharmacother. 137:111313.
   PubMed Web of Science ®Google Scholar
• Tian X, Li C, Huang A, Xia S, Lu S, Shi Z, Lu L, Jiang S, Yang Z, Wu Y, et al. 2020. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect. 9(1):382–385.
   PubMed Web of Science ®Google Scholar
• Titto M, Ankit T, Saumya B, Gausal A, Sarada S. 2020. Curcumin prophylaxis refurbishes alveolar epithelial barrier integrity and alveolar fluid clearance under hypoxia. Respir Physiol Neurobiol. 274:103336.
   PubMed Web of Science ®Google Scholar
• Tong S, Su Y, Yu Y, Wu C, Chen J, Wang S, Jiang J. 2020. Ribavirin therapy for severe COVID-19: a retrospective cohort study. Int J Antimicrob Agents. 56(3):106114.
   PubMed Web of Science ®Google Scholar
• Touret F, de Lamballerie X. 2020. Of chloroquine and COVID-19. Antiviral Res. 177:104762.
   PubMed Web of Science ®Google Scholar
• Tran A, Cheng-Lai A. 2011. Dabigatran etexilate: the first oral anticoagulant available in the United States since warfarin. Cardiol Rev. 19(3):154–161.
   PubMed Web of Science ®Google Scholar
• Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR, Natarajan R, Brophy DF, Sculthorpe R. 2019. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 322(13):1261–1270.
   PubMed Web of Science ®Google Scholar
• Uesato S, Kitagawa Y, Kaijima T, Tokuda H, Okuda M, Mou XY, Mukainaka T, Nishino H. 2001. Inhibitory effects of 6-O-acylated l-ascorbic acids possessing a straight-or branched-acyl chain on Epstein–Barr virus activation. Cancer Lett. 166(2):143–146.
   PubMed Web of Science ®Google Scholar
• Ulrich H, Pillat MM. 2020. CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement. Stem Cell Rev Rep. 16(3):434–437.
   PubMed Web of Science ®Google Scholar
• Uno Y. 2020. Camostat mesilate therapy for COVID-19. Intern Emerg Med. 15(8):1577–1572.
   PubMed Web of Science ®Google Scholar
• Van Damme E, De Meyer S, Bojkova D, Ciesek S, Cinatl J, De Jonghe S, Jochmans D, Leyssen P, Buyck C, Neyts J, et al. 2020. In vitro activity of itraconazole against SARS-CoV-2. BioRxiv. DOI:https://doi.org/10.1101/2020.11.13.381194.
   Google Scholar
• Verleden SE, Vandooren J, Vos R, Willems S, Dupont LJ, Verleden GM, Van Raemdonck DE, Opdenakker G, Vanaudenaerde BM. 2011. Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients. Transpl Immunol. 25(2–3):159–162.
   PubMed Web of Science ®Google Scholar
• Villar J, Ferrando C, Martínez D, Ambrós A, Muñoz T, Soler JA, Aguilar G, Alba F, González-Higueras E, Conesa LA, et al. 2020. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respir Med. 8(3):267–276.
   PubMed Web of Science ®Google Scholar
• Wanaguru M, Liu W, Hahn BH, Rayner JC, Wright GJ. 2013. RH5–Basigin interaction plays a major role in the host tropism of Plasmodium falciparum. Proc Natl Acad Sci. 110(51):20735–20740.
   PubMed Web of Science ®Google Scholar
• Wandtke T, Woźniak J, Kopiński P. 2015. Aptamers in diagnostics and treatment of viral infections. Viruses. 7(2):751–780.
   PubMed Web of Science ®Google Scholar
• Wang C, Li W, Drabek D, Okba NM, van Haperen R, Osterhaus AD, van Kuppeveld FJ, Haagmans BL, Grosveld F, Bosch B-J. 2020. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat Commun. 11(1):1–6.
   PubMed Web of Science ®Google Scholar
• Wang K, Chen W, Zhou Y-S, Lian J-Q, Zhang Z, Du P, Gong L, Zhang Y, Cui H-Y, Geng J-J, et al. 2020. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv. DOI:https://doi.org/10.1101/2020.03.14.988345.
   Google Scholar
• Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G. 2020. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30(3):269–271.
   PubMed Web of Science ®Google Scholar
• Wang S, Liu C, Liu X, He Y, Shen D, Luo Q, Dong Y, Dong H, Pang Z. 2017. Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines. Tumour Biol. 39(10):1010428317718192.
   Google Scholar
• Wessels I, Pupke JT, von Trotha K-T, Gombert A, Himmelsbach A, Fischer HJ, Jacobs MJ, Rink L, Grommes J. 2020. Zinc supplementation ameliorates lung injury by reducing neutrophil recruitment and activity. Thorax. 75(3):253–261.
   PubMed Web of Science ®Google Scholar
• Wessels I, Rolles B, Rink L. 2020. The potential impact of Zinc supplementation on COVID-19 pathogenesis. Front Immunol. 11:1712.
   PubMed Web of Science ®Google Scholar
• Wickham TJ, Filardo EJ, Cheresh DA, Nemerow GR. 1994. Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol. 127(1):257–264.
   PubMed Web of Science ®Google Scholar
• Williamson G, Kerimi A. 2020. Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction. Biochem Pharmacol. 178:114123.
   PubMed Web of Science ®Google Scholar
• Wimalawansa SJ. 2020. Global epidemic of coronavirus—Covid-19: what can we do to minimize risks. Eur J Biomed. 7(3):432–438.
   Google Scholar
• Wintergerst ES, Maggini S, Hornig DH. 2006. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 50(2):85–94.
   PubMed Web of Science ®Google Scholar
• Wintergerst ES, Maggini S, Hornig DH. 2007. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 51(4):301–323.
   PubMed Web of Science ®Google Scholar
• Wojewodzic MW. 2020. Bacteriophages could be a potential game changer in the trajectory of coronavirus disease (COVID-19). PHAGE. 1(2):60–65.
   Google Scholar
• Wondmkun YT, Mohammed OA. 2020. A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment. Biologics. 14:77–82.
   PubMed Web of Science ®Google Scholar
• Wong SK, Li W, Moore MJ, Choe H, Farzan M. 2004. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem. 279(5):3197–3201.
   PubMed Web of Science ®Google Scholar
• Wu C-J, Huang H-W, Liu C-Y, Hong C-F, Chan Y-L. 2005. Inhibition of SARS-CoV replication by siRNA. Antiviral Res. 65(1):45–48.
   PubMed Web of Science ®Google Scholar
• Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X, et al. 2020. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharm Sin B. 10(5):766–788.
   PubMed Web of Science ®Google Scholar
• Xian Y, Zhang J, Bian Z, Zhou H, Zhang Z, Lin Z, Xu H. 2020. Bioactive natural compounds against human coronaviruses: a review and perspective. Acta Pharm Sin B. 10(7):1163–1174.
   PubMed Web of Science ®Google Scholar
• Xiao J, Palefsky JM, Herrera R, Berline J, Tugizov SM. 2008. The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells. Virology. 370(2):430–442.
   PubMed Web of Science ®Google Scholar
• Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T, Chen Q. 2020. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 12(1):8–5.
   PubMed Web of Science ®Google Scholar
• Yan F, Huang F, Xu J, Yang P, Qin Y, Lv J, Zhang S, Ye L, Gong M, Liu Z, et al. 2020. Antihypertensive drugs are associated with reduced fatal outcomes and improved clinical characteristics in elderly COVID-19 patients. Cell Discov. 6(1):1–10.
   PubMed Web of Science ®Google Scholar
• Yan S, Sun H, Bu X, Wan G. 2020. New strategy for COVID-19: an evolutionary role for RGD motif in SARS-CoV-2 and potential inhibitors for virus infection. Front Pharmacol. 11:912.
   PubMed Web of Science ®Google Scholar
• Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, et al. 2005. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 3(10):e324.
   PubMed Web of Science ®Google Scholar
• Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, et al. 2003. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci. 100(23):13190–13195.
   PubMed Web of Science ®Google Scholar
• Yang N, Tanner JA, Wang Z, Huang J-D, Zheng B-J, Zhu N, Sun H. 2007. Inhibition of SARS coronavirus helicase by bismuth complexes. Chem Commun. (42):4413–4415.
   PubMed Web of Science ®Google Scholar
• Yang Z-Y, Huang Y, Ganesh L, Leung K, Kong W-P, Schwartz O, Subbarao K, Nabel GJ. 2004. pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J Virol. 78(11):5642–5650.
   PubMed Web of Science ®Google Scholar
• Yang Z-y, Kong W-p, Huang Y, Roberts A, Murphy BR, Subbarao K, Nabel GJ. 2004. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature. 428(6982):561–564.
   PubMed Web of Science ®Google Scholar
• Yates PA, Leone AM, Reichel E. 2020. A proposed randomized, double blind, placebo controlled study evaluating doxycycline for the prevention of COVID-19 infection and disease in healthcare workers with ongoing high risk exposure to COVID-19. MedRxiv. DOI:https://doi.org/10.1101/2020.05.11.20098525.
   Google Scholar
• Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q, Lu Z, Chen L, He Q, Han H. 2015. Antiviral activity of graphene oxide: how sharp edged structure and charge matter. ACS Appl Mater Interfaces. 7(38):21571–21579.
   PubMed Web of Science ®Google Scholar
• Ye Z-W, Yuan S, Yuen K-S, Fung S-Y, Chan C-P, Jin D-Y. 2020. Zoonotic origins of human coronaviruses. Int J Biol Sci. 16(10):1686–1697.
   PubMed Web of Science ®Google Scholar
• Yoshimoto FK. 2020. The proteins of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19. Protein J. 39(3):198–216.
   PubMed Web of Science ®Google Scholar
• Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, et al. 2004. Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem Biophys Res Commun. 319(3):746–752.
   PubMed Web of Science ®Google Scholar
• Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, Jamialahmadi T, Al‐Rasadi K, Banach M, Sahebkar A. 2020. Potential effects of curcumin in the treatment of COVID‐19 infection. Phytother Res. 34(11):2911–2920.
   PubMed Web of Science ®Google Scholar
• Zaki AM, Van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 367(19):1814–1820.
   PubMed Web of Science ®Google Scholar
• Zanasi A, Lanata L, Fontana G, Saibene F, Dicpinigaitis P, De Blasio F. 2015. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidis Res Med. 10(1):1–6.
   PubMedGoogle Scholar
• Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H, et al. 2020. High-dose vitamin C infusion for the treatment of critically ill COVID-19. Ann Intensive Care. DOI:https://doi.org/10.21203/rs.3.rs-52778/v2.
   Google Scholar
• Zhang Q, Honko A, Zhou J, Gong H, Downs SN, Vasquez JH, Fang RH, Gao W, Griffiths A, Zhang L. 2020. Cellular nanosponges inhibit SARS-CoV-2 infectivity. Nano Lett. 20(7):5570–5574.
   PubMed Web of Science ®Google Scholar
• Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, Si H-R, Zhu Y, Li B, Huang C-L, et al. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579(7798):270–273.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Simmons G. 2012. Development of novel entry inhibitors targeting emerging viruses. Expert Rev anti Infect Ther. 10(10):1129–1138.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Yang Y, Huang J, Jiang S, Du L. 2019. Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain. Viruses. 11(1):60.
   PubMed Web of Science ®Google Scholar