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Review Articles

The annoying flaws of gerontological research

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Pages 95-100 | Received 24 Jan 2022, Accepted 25 Jan 2022, Published online: 04 Feb 2022

References

  • An G. 2018. The crisis of reproducibility, the denominator problem and the scientific role of multi-scale modeling. Bull Math Biol. 80(12):3071–3080.
  • Attarwala H. 2010. TGN1412: from discovery to disaster. J Young Pharm. 2(3):332–336.
  • Bailey J, Thew M, Balls M. 2014. An analysis of the use of animal models in predicting human toxicology and drug safety. Altern Lab Anim. 42(3):181–199.
  • Begley CG, Ioannidis JPA. 2015. Reproducibility in science: improving the standard for basic and preclinical research. Circ Res. 116(1):116–126.
  • Benayoun BA, Pollina EA, Brunet A. 2015. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 16(10):593–610.
  • Bua E, Johnson J, Herbst A, Delong B, McKenzie D, Salamat S, Aiken JM. 2006. Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet. 79(3):469–480.
  • Castellani RJ, Plascencia-Villa G, Perry G. 2019. The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation. Lab Invest. 99(7):958–970.
  • De Magalhaes JP. 2011. An introduction to gerontology. Cambridge: Cambridge University Press, p. 21–47.
  • Esquerda-Canals G, Montoliu-Gaya L, Güell-Bosch J, Villegas S. 2017. Mouse models of Alzheimer's disease. J Alzheimers Dis. 57(4):1171–1183.
  • Greaves LC, Barron MJ, Campbell-Shiel G, Kirkwood TB, Turnbull DM. 2011. Differences in the accumulation of mitochondrial defects with age in mice and humans. Mech Ageing Dev. 132(11–12):588–591.
  • Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, He L, Aravind C, Shi Y. 2015. DNA methylation on N6-adenine in C. elegans. Cell. 161(4):868–878.
  • Grube K, Bürkle A. 1992. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proce Natil Acad Sci. 89(24):11759–11763.
  • Guo X, Popadin KY, Markuzon N, Orlov YL, Kraytsberg Y, Krishnan KJ, Zsurka G, Turnbull DM, Kunz WS, Khrapko K. 2010. Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'. Trends Genet. 26(8):340–343.
  • Harman D. 1956. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 11(3):298–300.
  • Kamel NS, Gammack J, Cepeda O, Flaherty JH. 2006. Antioxidants and hormones as antiaging therapies: high hopes, disappointing results. Cleve Clin J Med. 73(12):1049–1056.
  • Kauppila TES, Kauppila JHK, Larsson NG. 2017. Mammalian mitochondria and aging: an update. Cell Metab. 25(1):57–71.
  • Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. 2006. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet. 38(5):518–520.
  • Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, et al. 2005. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 309(5733):481–484.
  • Lakshmanan LN, Yee Z, Ng LF, Gunawan R, Halliwell B, Gruber J. 2018. Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals. Aging Cell. 17(5):e12814.
  • Liu PP, Xie Y, Meng XY, Kang JS. 2019. History and progress of hypotheses and clinical trials for Alzheimer’s disease. Sig Transduct Target Ther. 4(1):29.
  • Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, et al. 2018. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 359(6375):555–559.
  • Mak IW, Evaniew NM, Ghert M. 2014. Lost in translation: animal models and clinical trials in cancer treatment. Am J Transl Res. 6(2):114–118.
  • Manning EL, Crossland J, Dewey MJ, Van Zant G. 2002. Influences of inbreeding and genetics on telomere length in mice. Mamm Genome. 13 (5):234–238.
  • Masoro EJ. 2000. Caloric restriction and aging: an update. Exp Gerontol. 35(3):299–305.
  • Meier B, Volkova NV, Hong Y, Schofield P, Campbell PJ, Gerstung M, Gartner A. 2018. Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers. Genome Res. 28(5):574–666.
  • Mendelsohn AR, Larrick JW. 2017. Epigenetic drift is a determinant of mammalian lifespan. Rejuvenation Res. 20(5):430–436.
  • Milholland B, Dong X, Zhang L, Hao X, Suh Y, Vijg J. 2017. Differences between germline and somatic mutation rates in humans and mice. Nat Commun. 8:15183.
  • Pérez VI, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardso A. 2009. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell. 8 (1):73–75.
  • Puzzo D, Gulisano W, Palmeri A, Arancio O. 2015. Rodent models for Alzheimer's disease drug discovery. Expert Opin Drug Discov. 10(7):703–711.
  • Raices M, Maruyama H, Dillin A, Karlseder J. 2005. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 1(3):e30.
  • Reyes A, Yang MY, Bowmaker M, Holt IJ. 2005. Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem. 280(5):3242–3250.
  • Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96(5):701–712.
  • Sadowska-Bartosz I, Bartos G. 2014. Effect of antioxidants supplementation on aging and longevity. Biomed Res Int. 2014:404617–404680.
  • Sen P, Shah PP, Nativio R, Berger SL. 2016. Epigenetic mechanisms of longevity and aging. Cell. 166(4):822–839.
  • Sohal RS, Forster MJ. 2014. Caloric restriction and the aging process: a critique. Free Radic Biol Med. 73:366–382.
  • Spalding KL, Bhardwaj RD, Buchholz BA, Druid H, Frisén J. 2005. Retrospective birth dating of cells in humans. Cell. 122(1):133–143.
  • Tichy ED, Liang L, Deng L, Tischfield J, Schwemberger S, Babcock G, Stambrook PJ. 2011. Mismatch and base excision repair proficiency in murine embryonic stem cells. DNA Repair. 10(4):445–451.
  • Tichy ED, Stambrook PJ. 2008. DNA repair in murine embryonic stem cells and differentiated cells. Exp Cell Res. 314(9):1929–1936.
  • Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, et al. 2008. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 135(4):609–622.
  • Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. 1999. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci. 54(11):B492–B501.
  • van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, Macleod MR. 2010. Can animal models of disease reliably inform human studies? PLoS Med. 7(3):e1000245.
  • Walter MF, Biessmann MR, Benitez C, Török T, Mason JM, Biessmann H. 2007. Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility. Chromosoma. 116(1):41–51.
  • Warner HR, Ingram D, Miller RA, Nadon NL, Richardson AG. 2000. Program for testing biological interventions to promote healthy aging. Mech Ageing Dev. 115(3):199–207.
  • Yang JN, Seluanov A, Gorbunova V. 2013. Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. PLoS One. 8(9):e73318.

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