Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism

References

• Ajandouz el H, Berdah S, Moutardier V, Bege T, Birnbaum DJ, Perrier J, Di Pasquale E, Maresca M. 2016. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches. Toxins (Basel). 8(8):232.
   PubMed Web of Science ®Google Scholar
• Berthiller F, Krska R, Domig KJ, Kneifel W, Juge N, Schuhmacher R, Adam G. 2011. Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. Toxicol Lett. 206(3):264–267.
   PubMed Web of Science ®Google Scholar
• Birr T, Jensen T, Preußke N, Sönnichsen FD, De Boevre M, De Saeger S, Hasler M, Verreet JA, Klink H. 2021. Occurrence of fusarium mycotoxins and their modified forms in forage maize cultivars. Toxins (Basel). 13(2):110.
   PubMed Web of Science ®Google Scholar
• Bracarense APFL, Pierron A, Pinton P, Gerez JR, Schatzmayr G, Moll WD, Zhou T, Oswald IP. 2020. Reduced toxicity of 3-epi-deoxynivalenol and de-epoxy-deoxynivalenol through deoxynivalenol bacterial biotransformation: In vivo analysis in piglets. Food Chem Toxicol. 140:111241.
   PubMed Web of Science ®Google Scholar
• Brera C, de Santis B, Debegnach F, Miano B, Moretti G, Lanzone A, Del Sordo G, Buonsenso D, Chiaretti A, Hardie L, et al. 2015. Experimental study of deoxynivalenol biomarkers in urine. EFS3. 12(6):818E.
   Google Scholar
• Broekaert N, Devreese M, De Mil T, Fraeyman S, Antonissen G, De Baere S, De Backer P, Vermeulen A, Croubels S. 2015. Oral bioavailability, hydrolysis, and comparative toxicokinetics of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol in broiler chickens and pigs. J Agric Food Chem. 63(39):8734–8742.
   PubMed Web of Science ®Google Scholar
• Broekaert N, Devreese M, van Bergen T, Schauvliege S, De Boevre M, De Saeger S, Vanhaecke L, Berthiller F, Michlmayr H, Malachova A, et al. 2017. In vivo contribution of deoxynivalenol-3-beta-d-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics. Arch Toxicol. 91(2):699–712.
   PubMed Web of Science ®Google Scholar
• Bryla M, Waśkiewicz A, Ksieniewicz-Woźniak E, Szymczyk K, Jędrzejczak R. 2018. Modified Fusarium mycotoxins in cereals and their products-metabolism, occurrence, and toxicity: an updated review. Molecules. 23(4):963.
   PubMed Web of Science ®Google Scholar
• Carere J, Hassan YI, Lepp D, Zhou T. 2018a. The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway. Microb Biotechnol. 11(6):1106–1111.
   PubMed Web of Science ®Google Scholar
• Carere J, Hassan YI, Lepp D, Zhou T. 2018b. The identification of DepB: an enzyme responsible for the final detoxification step in the deoxynivalenol epimerization pathway in Devosia mutans 17-2-E-8. Front Microbiol. 9:1573.
   PubMed Web of Science ®Google Scholar
• Catteuw A, Devreese M, De Baere S, Antonissen G, Ivanova L, Uhlig S, Martens A, De Saeger S, De Boevre M, Croubels S. 2020. Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets. Arch Toxicol. 94(2):417–425.
   PubMed Web of Science ®Google Scholar
• Chen L, Yu M, Wu Q, Peng Z, Wang D, Kuca K, Yao P, Yan H, Nussler AK, Liu L, et al. 2017. Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review. J Appl Toxicol. 37(1):60–70.
   PubMed Web of Science ®Google Scholar
• Clark ES, Flannery BM, Pestka JJ. 2015. Murine anorectic response to deoxynivalenol (vomitoxin) is sex-dependent. Toxins (Basel). 7(8):2845–2859.
   PubMed Web of Science ®Google Scholar
• de Loubresse NG, Prokhorova I, Holtkamp W, Rodnina MV, Yusupova G, Yusupov M. 2014. Structural basis for the inhibition of the eukaryotic ribosome. Nature. 513(7519):517–522.
   PubMed Web of Science ®Google Scholar
• De Nijs M, Van den Top HJ, Portier L, Oegema G, Kramer E, Van Egmond HP, Hoogenboom LAP. 2012. Digestibility and absorption of deoxynivalenol-3-beta-glucoside in in vitro models. World Mycotoxin J. 5(3):319–324.
   Web of Science ®Google Scholar
• Deng CL, Li CL, Zhou S, Wang XD, Xu HB, Wang D, Gong YY, Routledge MN, Zhao YF, Wu YN. 2018. Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method. Sci Rep. 8(1):3901.
   PubMed Web of Science ®Google Scholar
• Deng Y, You L, Nepovimova E, Wang X, Musilek K, Wu QH, Wu WD, Kuca K. 2021. Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans. Trends Food Sci Technol. 110:551–558.
   Web of Science ®Google Scholar
• Devreese M, Antonissen G, Broekaert N, De Mil T, De Baere S, Vanhaecke L, De Backer P, Croubels S. 2015. Toxicokinetic study and oral bioavailability of deoxynivalenol in turkey poults, and comparative biotransformation between broilers and turkeys. World Mycotoxin J. 8(4):533–539.
   Web of Science ®Google Scholar
• Ediage EN, Di Mavungu JD, Song SQ, Sioen I, De Saeger S. 2013. Multimycotoxin analysis in urines to assess infant exposure: a case study in Cameroon. Environ Int. 57-58:50–59.
   PubMed Web of Science ®Google Scholar
• Eriksen GS, Knutsen HK, Sandvik M, Brantsæter AL. 2021. Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups. Environ Int. 157:106804.
   PubMed Web of Science ®Google Scholar
• Gardiner SA, Boddu J, Berthiller F, Hametner C, Stupar RM, Adam G, Muehlbauer GJ. 2010. Transcriptome analysis of the barley-deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification. Mol Plant Microbe Interact. 23(7):962–976.
   PubMed Web of Science ®Google Scholar
• Gonçalves RA, Navarro-Guillén C, Gilannejad N, Dias J, Schatzmayr D, Bichl G, Czabany T, Moyano FJ, Rema P, Yúfera M, et al. 2018. Impact of deoxynivalenol on rainbow trout: growth performance, digestibility, key gene expression regulation and metabolism. Aquaculture. 490:362–372.
   Web of Science ®Google Scholar
• Goncalves RA, Schatzmayr D, Albalat A, Mackenzie S. 2020. Mycotoxins in aquaculture: feed and food. Rev Aquacult. 12(1):145–175.
   Web of Science ®Google Scholar
• Gratz SW, Currie V, Richardson AJ, Duncan G, Holtrop G, Farquharson F, Louis P, Pinton P, Oswald IP. 2018. Porcine small and large intestinal microbiota rapidly hydrolyze the masked mycotoxin deoxynivalenol-3-glucoside and release deoxynivalenol in spiked batch cultures in vitro. Appl Environ Microbiol. 84(2):e02106–02117.
   PubMed Web of Science ®Google Scholar
• Gratz SW, Dinesh R, Yoshinari T, Holtrop G, Richardson AJ, Duncan G, MacDonald S, Lloyd A, Tarbin J. 2017. Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro. Mol Nutr Food Res. 61(4):1600680.
   Web of Science ®Google Scholar
• Gratz SW, Duncan G, Richardson AJ. 2013. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol. Appl Environ Microbiol. 79(6):1821–1825.
   PubMed Web of Science ®Google Scholar
• Guo H, Ji J, Wang JS, Sun X. 2020. Deoxynivalenol: masked forms, fate during food processing, and potential biological remedies. Compr Rev Food Sci Food Saf. 19(2):895–926.
   PubMed Web of Science ®Google Scholar
• He JW, Bondy GS, Zhou T, Caldwell D, Boland GJ, Scott PM. 2015. Toxicology of 3-epi-deoxynivalenol, a deoxynivalenol-transformation product by Devosia mutans 17-2-E-8. Food Chem Toxicol. 84:250–259.
   PubMed Web of Science ®Google Scholar
• He JW, Hassan YI, Perilla N, Li XZ, Boland GJ, Zhou T. 2016. Bacterial epimerization as a route for deoxynivalenol detoxification: the influence of growth and environmental conditions. Front Microbiol. 7:572.
   PubMed Web of Science ®Google Scholar
• He WJ, Shi MM, Yang P, Huang T, Zhao Y, Wu AB, Dong WB, Li HP, Zhang JB, Liao YC. 2020. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chem. 321:126703.
   PubMed Web of Science ®Google Scholar
• He WJ, Zhang LM, Yi SY, Tang XL, Yuan QS, Guo MW, Wu AB, Qu B, Li HP, Liao YC. 2017. An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain. Sci Rep. 7(1):9549.
   PubMed Web of Science ®Google Scholar
• Ito M, Sato I, Ishizaka M, Yoshida S, Koitabashi M, Yoshida S, Tsushima S. 2013. Bacterial cytochrome P450 system catabolizing the Fusarium toxin deoxynivalenol. Appl Environ Microbiol. 79(5):1619–1628.
   PubMed Web of Science ®Google Scholar
• Jin J, Spenkelink A, Beekmann K, Baccaro M, Xing F, Rietjens IMCM. 2021. Species differences in in vitro and estimated in vivo kinetics for intestinal microbiota mediated metabolism of acetyl-deoxynivalenols. Mol Nutr Food Res. 65(9):e2001085.
   PubMed Web of Science ®Google Scholar
• Khan MK, Pandey A, Athar T, Choudhary S, Deval R, Gezgin S, Hamurcu M, Topal A, Atmaca E, Santos PA, et al. 2020. Fusarium head blight in wheat: contemporary status and molecular approaches. 3 Biotech. 10(4):172.
   PubMedGoogle Scholar
• Khatibi PA, Newmister SA, Rayment I, McCormick SP, Alexander NJ, Schmale DG. 2011. Bioprospecting for trichothecene 3-O-acetyltransferases in the fungal genus Fusarium yields functional enzymes with different abilities to modify the mycotoxin deoxynivalenol. Appl Environ Microbiol. 77(4):1162–1170.
   PubMed Web of Science ®Google Scholar
• Kluger B, Bueschl C, Lemmens M, Michlmayr H, Malachova A, Koutnik A, Maloku I, Berthiller F, Adam G, Krska R, et al. 2015. Biotransformation of the mycotoxin deoxynivalenol in Fusarium resistant and susceptible near isogenic wheat lines. PLoS One. 10(3):e0119656.
   PubMed Web of Science ®Google Scholar
• Kouadio JH, Lattanzio VM, Ouattara D, Kouakou B, Visconti A. 2014. Assessment of mycotoxin exposure in Côte d'ivoire (Ivory Coast) through multi-biomarker analysis and possible correlation with food consumption patterns. Toxicol Int. 21(3):248–257.
   Google Scholar
• Lemmens M, Scholz U, Berthiller F, Dall'Asta C, Koutnik A, Schuhmacher R, Adam G, Buerstmayr H, Mesterhazy A, Krska R, et al. 2005. The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for fusarium head blight resistance in wheat. MPMI. 18(12):1318–1324.
   PubMed Web of Science ®Google Scholar
• Li X, Shin S, Heinen S, Dill-Macky R, Berthiller F, Nersesian N, Clemente T, McCormick S, Muehlbauer GJ. 2015. Transgenic wheat expressing a barley UDP-glucosyltransferase detoxifies deoxynivalenol and provides high levels of resistance to Fusarium graminearum. Mol Plant Microbe Interact. 28(11):1237–1246.
   PubMed Web of Science ®Google Scholar
• Malachova A, Stockova L, Wakker A, Varga E, Krska R, Michlmayr H, Adam G, Berthiller F. 2015. Critical evaluation of indirect methods for the determination of deoxynivalenol and its conjugated forms in cereals. Anal Bioanal Chem. 407(20):6009–6020.
   PubMed Web of Science ®Google Scholar
• Mandala G, Tundo S, Francesconi S, Gevi F, Zolla L, Ceoloni C, D'Ovidio R. 2019. Deoxynivalenol detoxification in transgenic wheat confers resistance to Fusarium head blight and crown rot diseases. Mol Plant Microbe Interact. 32(5):583–592.
   PubMed Web of Science ®Google Scholar
• Maresca M. 2013. From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. Toxins (Basel). 5(4):784–820.
   PubMed Web of Science ®Google Scholar
• Maul R, Warth B, Schebb NH, Krska R, Koch M, Sulyok M. 2015. In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes. Arch Toxicol. 89(6):949–960.
   PubMed Web of Science ®Google Scholar
• Mengelers M, Zeilmaker M, Vidal A, De Boevre M, De Saeger S, Hoogenveen R. 2019. Biomonitoring of deoxynivalenol and deoxynivalenol-3-glucoside in human volunteers: renal excretion profiles. Toxins (Basel). 11(8):466.
   PubMed Web of Science ®Google Scholar
• Miro-Abella E, Torrell H, Herrero P, Canela N, Arola L, Borrull F, Ras R, Fontanals N. 2018. Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing. Food Chem Toxicol. 121:124–130.
   PubMed Web of Science ®Google Scholar
• Nagl V, Woechtl B, Schwartz-Zimmermann HE, Hennig-Pauka I, Moll WD, Adam G, Berthiller F. 2014. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs. Toxicol Lett. 229(1):190–197.
   PubMed Web of Science ®Google Scholar
• Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. 2016. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch Toxicol. 90(12):2931–2957.
   PubMed Web of Science ®Google Scholar
• Pestka JJ, Clark ES, Schwartz-Zimmermann HE, Berthiller F. 2017. Sex is a determinant for deoxynivalenol metabolism and elimination in the mouse. Toxins. 9(8):240.
   PubMed Web of Science ®Google Scholar
• Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense AP, Schatzmayr G, He JW, Zhou T, Moll WD, et al. 2016. Microbial biotransformation of DON: molecular basis for reduced toxicity. Sci Rep. 6:29105.
   PubMed Web of Science ®Google Scholar
• Riahi I, Perez-Vendrell AM, Ramos AJ, Brufau J, Esteve-Garcia E, Schulthess J, Marquis V. 2021. Biomarkers of deoxynivalenol toxicity in chickens with special emphasis on metabolic and welfare parameters. Toxins. 13(3):217.
   PubMed Web of Science ®Google Scholar
• Schwartz-Zimmermann HE, Fruhmann P, Danicke S, Wiesenberger G, Caha S, Weber J, Berthiller F. 2015. Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys. Toxins (Basel). 7(11):4706–4729.
   PubMed Web of Science ®Google Scholar
• Schwartz-Zimmermann HE, Hametner C, Nagl V, Fiby I, Macheiner L, Winkler J, Danicke S, Clark E, Pestka JJ, Berthiller F. 2017. Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows. Arch Toxicol. 91(12):3857–3872.
   PubMed Web of Science ®Google Scholar
• Schwartz-Zimmermann HE, Hametner C, Nagl V, Slavik V, Moll W-D, Berthiller F. 2014. Deoxynivalenol (DON) sulfonates as major DON metabolites in rats: from identification to biomarker method development, validation and application. Anal Bioanal Chem. 406(30):7911–7924.
   PubMed Web of Science ®Google Scholar
• Slobodchikova I, Sivakumar R, Rahman MS, Vuckovic D. 2019. Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry. Toxins (Basel). 11(8):433.
   PubMed Web of Science ®Google Scholar
• Solfrizzo M, Gambacorta L, Visconti A. 2014. Assessment of multi-mycotoxin exposure in southern Italy by urinary multi-biomarker determination. Toxins (Basel). 6(2):523–538.
   PubMed Web of Science ®Google Scholar
• Stanic A, Uhlig S, Solhaug A, Rise F, Wilkins AL, Miles CO. 2015. Nucleophilic Addition of Thiols to Deoxynivalenol. J Agric Food Chem. 63(34):7556–7566.
   PubMed Web of Science ®Google Scholar
• Tag AG, Garifullina GF, Peplow AW, Ake C, Phillips TD, Hohn TM, Beremand MN. 2001. A novel regulatory gene, Tri10, controls trichothecene toxin production and gene expression. Appl Environ Microbiol. 67(11):5294–5302.
   PubMed Web of Science ®Google Scholar
• Turner P C, Hopton RP, Lecluse Y, White KL, Fisher J, Lebailly P. 2010. Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France. J Agric Food Chem. 58(8):5206–5212.
   Google Scholar
• Turner P C, Hopton RP, White KL, Fisher J, Cade JE, Wild CP. 2011. Assessment of deoxynivalenol metabolite profiles in UK adults. Food Chem Toxicol. 49(1):132–135.
   Google Scholar
• Uhlig S, Ivanova L, Fæste CK. 2013. Enzyme-assisted synthesis and structural characterization of the 3-, 8-, and 15-glucuronides of deoxynivalenol. J Agric Food Chem. 61(8):2006–2012.
   PubMed Web of Science ®Google Scholar
• Uhlig S, Stanic A, Hofgaard IS, Kluger B, Schuhmacher R, Miles CO. 2016. Glutathione-conjugates of deoxynivalenol in naturally contaminated grain are primarily linked via the epoxide group. Toxins. 8(11):329.
   PubMed Web of Science ®Google Scholar
• Valgaeren B, Theron L, Croubels S, Devreese M, De Baere S, Van Pamel E, Daeseleire E, De Boevre M, De Saeger S, Vidal A, et al. 2019. The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: from field observations to toxicokinetics. Arch Toxicol. 93(2):293–310.
   PubMed Web of Science ®Google Scholar
• Veršilovskis A, Geys J, Huybrechts B, Goossens E, Saeger SD, Callebaut A. 2012. Simultaneous determination of masked forms of deoxynivalenol and zearalenone after oral dosing in rats by LC-MS/MS. World Mycotoxin J. 5(3):303–318.
   Web of Science ®Google Scholar
• Vidal A, Claeys L, Mengelers M, Vanhoorne V, Vervaet C, Huybrechts B, De Saeger S, De Boevre M. 2018. Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. Sci. Rep. 8(1):5225.
   PubMed Web of Science ®Google Scholar
• Wan D, Huang L, Pan Y, Wu Q, Chen D, Tao Y, Wang X, Liu Z, Li J, Wang L, et al. 2014. Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection. J Agric Food Chem. 62(1):288–296.
   PubMed Web of Science ®Google Scholar
• Wang HW, Sun SL, Ge WY, Zhao LF, Hou BQ, Wang K, Lyu ZF, Chen LY, Xu SS, Guo J, et al. 2020. Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat. Science. 368(6493):eaba5435.
   PubMed Web of Science ®Google Scholar
• Wang J, Jin Y, Wu S, Yu H, Zhao Y, Fang H, Shen J, Zhou C, Fu Y, Li R, et al. 2019. Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells. J Anim Physiol Anim Nutr. 103(6):1663–1674.
   PubMed Web of Science ®Google Scholar
• Warth B, Del Favero G, Wiesenberger G, Puntscher H, Woelflingseder L, Fruhmann P, Sarkanj B, Krska R, Schuhmacher R, Adam G, et al. 2016. Identification of a novel human deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells. Sci Rep. 6:33854.
   PubMed Web of Science ®Google Scholar
• Warth B, Sulyok M, Fruhmann P, Berthiller F, Schuhmacher R, Hametner C, Adam G, Frohlich J, Krska R. 2012. Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. Toxicol Lett. 211(1):85–90.
   PubMed Web of Science ®Google Scholar
• Woelflingseder L, Warth B, Vierheilig I, Schwartz-Zimmermann H, Hametner C, Nagl V, Novak B, Sarkanj B, Berthiller F, Adam G, et al. 2019. The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol. Arch Toxicol. 93(6):1729–1743.
   PubMed Web of Science ®Google Scholar
• Wu QH, Qin ZH, Kuca K, You L, Zhao YY, Liu AM, Musilek K, Chrienova Z, Nepovimova E, Oleksak P, et al. 2020. An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment. Arch Toxicol. 94(11):3645–3669.
   PubMed Web of Science ®Google Scholar
• Wu QH, Wang X, Nepovimova E, Miron A, Liu Q, Wang Y, Su D, Yang H, Li L, Kuca K. 2017. Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential. Arch Toxicol. 91(12):3737–3785.
   PubMed Web of Science ®Google Scholar
• Wu QH, Wang X, Yang W, Nussler AK, Xiong LY, Kuca K, Dohnal V, Zhang XJ, Yuan ZH. 2014. Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch Toxicol. 88(7):1309–1326.
   PubMed Web of Science ®Google Scholar
• You L, Zhao Y, Kuca K, Wang X, Oleksak P, Chrienova Z, Nepovimova E, Jacevic V, Wu Q, Wu W. 2021. Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON). Arch Toxicol. 95(6):1899–1915.
   PubMed Web of Science ®Google Scholar
• Young JC, Zhou T, Yu H, Zhu H, Gong J. 2007. Degradation of trichothecene mycotoxins by chicken intestinal microbes. Food Chem Toxicol. 45(1):136–143.
   PubMed Web of Science ®Google Scholar
• Zhang J, Qin X, Guo Y, Zhang Q, Ma Q, Ji C, Zhao L. 2020a. Enzymatic degradation of deoxynivalenol by a novel bacterium, Pelagibacterium halotolerans ANSP101. Food Chem Toxicol. 140:111276.
   PubMed Web of Science ®Google Scholar
• Zhang J, You L, Wu W, Wang X, Chrienova Z, Nepovimova E, Wu Q, Kuca K. 2020b. The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): current status and future perspectives. Food Chem Toxicol. 145:111676.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Nie D, Fan K, Yang J, Guo W, Meng J, Zhao Z, Han Z. 2020c. A systematic review of plant-conjugated masked mycotoxins: occurrence, toxicology, and metabolism. Crit Rev Food Sci Nutr. 60(9):1523–1537.
   PubMed Web of Science ®Google Scholar
• Zhao L, Zhang L, Xu Z, Liu X, Chen L, Dai J, Karrow NA, Sun L. 2021. Occurrence of Aflatoxin B(1), deoxynivalenol and zearalenone in feeds in China during 2018-2020. J Anim Sci Biotechnol. 12(1):74.
   PubMed Web of Science ®Google Scholar