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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 26, 2000 - Issue 4
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Original Articles

A Nicotinic Cholinergic Agonist (GTS - 21) andEyeblink Classical Conditioning: Acquisition, Retention, and Relearning in Older Rabbits

Pages 323-336 | Published online: 11 Nov 2010

References

  • Bahro , M. , Schreurs , B. G. , Sunderland , T. and Molchan , S. E. 1995 . The e? ects of scopolamine, lorazepam, and glycopyrrolate on classical conditioning of the human eyeblink response . Psychopharmacology , 122 : 395 – 400 .
  • Berger , T. W. , Rinaldi , P. C. , Weisz , D. J. and Thompson , R. F. 1983 . Single-unit analysis of di? erent hippocampal cell types during classical conditioning of rabbit nictitating membrane response . Journal of Neurophysiology , 50 : 1197 – 1219 .
  • Berger , T. W. and Thompson , R. F. 1978 . Identification of pyramidal cells as critical in hippocampal neuronal plasticity during learning . Proceedings of the National Academy of Science, USA , 75 : 1572 – 1576 .
  • Coffin , J. M. and Woodru? -Pak , D. S. 1993 . Delay classical conditioning in young and older rabbits: Acquisition and retention at 12 and 18 months . Behavioral Neuroscience , : 1763 – 71 .
  • Daum , I. and Schugens , M. M. 1996 . On the cerebellum and classical conditioning . Current Directions in Psychological Science , 5 : 58 – 61 .
  • De Fiebre , C. M. , Meyer , E. M. , Henry , J. C. , Muraskin , S. I. , Kem , W. R. and Papke , R. L. 1995 . Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha7/125I-alpha-bungarotoxin receptor subtypes . Molecular Pharmacology , 47 : 164 – 171 .
  • Harvey , J. A. , Gormezano , I. and Cool-Hauser , V. A. 1983 . E? ects of scopolamine and methylscopolamine on classical conditioning of the rabbit nictitating membrane response . Journal of Pharmacology and Experimental Therapeutics , 22 : 42 – 49 .
  • Kem , W. R. , Mahnir , V. M. , Papke , R. L. and Lingle , C. J. 1997 . Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors . Pharmacology and Experimental Therapeutics , 283 : 979 – 992 .
  • Kitagawa , H. , Moriyama , A. , Takenouchi , T. , Wesnes , K. , Kramer , W. and Clody , D. E. 1998 . Phase I studies of GTS-21 to assess the safety, tolerability, PK and e? ects on measures of cognitive function in normal volunteers . Neurobiology of Aging , 19 ( 4S ) : S182
  • Lemieux , S. K. and Woodru? -Pak , D. S. 2000 . “ Functional MRI studies of eyeblink classical conditioning ” . In Eyeblink Classical Conditioning Volume I : Applications in humans , Edited by: Woodru? -Pak , D. S. and Steinmetz , J. E. 71 – 93 . Boston : Kluwer Academic Publishers .
  • Logan , C. G. and Grafton , S. T. 1995 . Functional anatomy of human eyeblink conditioning determined with regional cerebral glucose metabolism and positron-emission tomography . Proceedings of the National Academy of Sciences, USA , 92 : 7500 – 7504 .
  • Salvatierra , A. T. and Berry , S. D. 1989 . Scopolamine disruption of septo-hippocampal activity and classical conditioning . Behavioral Neuroscience , 103 : 715 – 721 .
  • Solomon , P. R. , Barth , C. L. , Wood , M. S. , Velasquez , E. , Groccia-Ellison , M. E. and Yang , B. Y. 1995 . Age-related deficits in retention of the classically conditioned eyeblink response in rabbits . Behavioral Neuroscience , 109 : 18 – 23 .
  • Solomon , P. R. , Groccia-Ellison , M. , Flynn , D. , Mirak , J. , Edwards , K. R. , Dunehew , A. and Stanton , M. E. 1993 . Disruption of human eyeblink conditioning after central cholinergic blockade with scopolamine . Behavioral Neuroscience , 107 : 271 – 279 .
  • Steinmetz , J. E. 1996 . “ The brain substrates of classical eyeblink conditioning in rabbits ” . In The acquisition of motor behavior in vertebrates , Edited by: Bloedel , J. R. , Ebner , T. J. and Wise , S. P. 89 – 114 . Cambridge, MA : MIT Press .
  • Thompson , R. F. and Krupa , D. J. 1994 . Organization of memory traces in the mammalian brain . Annual Review of Neuroscience , 17 : 519 – 549 .
  • Wesnes , K. A. , Simpson , P. M. and Christmas , L. 1987 . “ The assessment of human information processing abilities in psychopharmacology ” . In Human psychopharmacolog y : Measures and methods , Edited by: Hindmarch , I. and Stonier , P. Vol. 1 , 79 – 92 . New York : Wiley .
  • Woodru? -Pak , D. S. 1995 . Evaluation of cognition-enhancing drugs: Utility of the model system of eyeblink classical conditioning . CNS Drug Reviews , 1 : 107 – 128 .
  • Woodru? -Pak , D. S. 1997 . “ Evidence for the role of cerebellum in classical conditioning in humans ” . In The cerebellum and cognition , Edited by: Schmahmann , J. D. 341 – 366 . San Diego : Academic Press .
  • Woodru? -Pak , D. S. and Hinchli? e , R. M. 1997 . Scopolamine- or mecamylamine-induced learning impairment: Reversed by nefiracetam . Psychopharmacology , 131 : 130 – 139 .
  • Woodru? -Pak , D. S. , Lavond , D. G. , Logan , C. G. and Thompson , R. F. 1987 . Classicalconditioning in 3-, 30-, and 45-month-old rabbits: Behavioral learning and hippocampal unit activity . Neurobiology of Aging , 8 : 101 – 108 .
  • Woodru? -Pak , D. S. , Li , Y.-T. , Kazmi , A. and Kem , W. R. 1994 . Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits . Behavioral Neuroscience , 108 : 486 – 493 .
  • Woodru? -Pak , D. S. , Li , Y.-T. and Kem , W. R. 1994 . A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain . Brain Research , 645 : 309 – 317 .

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