Inflammation and Fat Mass as Determinants of Changes in Physical Capacity and Mobility in Older Adults Displaying A Large Variability in Body Composition: The NuAge Study

REFERENCES

• Ahima, R. S., & Flier, J. S. (2000). Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism, 11, 327–332. doi: 10.1016/S1043-2760(00)00301-5
   PubMed Web of Science ®Google Scholar
• Aleman, H., Esparza, J., Ramirez, F. A., Astiazaran, H., & Payette, H. (2011). Longitudinal evidence on the association between interleukin-6 and C-reactive protein with the loss of total appendicular skeletal muscle in free-living older men and women. Age and Ageing, 40, 469–475. doi: 10.1093/ageing/afr040
   PubMed Web of Science ®Google Scholar
• Angleman, S. B., Harris, T. B., & Melzer, D. (2006). The role of waist circumference in predicting disability in periretirement age adults. International Journal of Obesity, 30, 364–373. doi: 10.1038/sj.ijo.0803130
   Web of Science ®Google Scholar
• Beavers, K. M., Beavers, D. P., Houston, D. K., Harris, T. B., Hue, T. F., Koster, A., … Kritchevsky, S. B. (2013). Associations between body composition and gait-speed decline: Results from the Health, Aging, and Body Composition study. American Journal of Clinical Nutrition, 97, 552–560. doi: 10.3945/ajcn.112.047860
   PubMed Web of Science ®Google Scholar
• Bouchard, D. R., Choquette, S., Dionne, I. J., & Brochu, M. (2011). Is fat mass distribution related to impaired mobility in older men and women? Nutrition as a determinant of successful aging: The Quebec longitudinal study. Experimental Aging Research, 37, 346–357. doi: 10.1080/0361073X.2011.568848
   PubMed Web of Science ®Google Scholar
• Bouchard, D. R., Dionne, I. J., & Brochu, M. (2009). Sarcopenic/obesity and physical capacity in older men and women: Data from the Nutrition as a Determinant of Successful Aging (NuAge)—The Quebec longitudinal study. Obesity (Silver Spring, Md.), 17, 2082–2088. doi: 10.1038/oby.2009.109
   PubMed Web of Science ®Google Scholar
• Cesari, M., Onder, G., Zamboni, V., Capoluongo, E., Russo, A., Bernabei, R., … Landi, F. (2009). C-reactive protein and lipid parameters in older persons aged 80 years and older. The Journal of Nutrition, Health and Aging, 13, 587–594. doi: 10.1007/s12603-009-0168-9
   PubMed Web of Science ®Google Scholar
• Chaudhry, S. I., McAvay, G., Ning, Y., Allore, H. G., Newman, A. B., & Gill, T. M. (2010). Geriatric impairments and disability: The Cardiovascular Health Study. Journal of the American Geriatrics Society, 58, 1686–1692. doi: 10.1111/j.1532-5415.2010.03022.x
   PubMed Web of Science ®Google Scholar
• Chen, H., Bermudez, O. I., & Tucker, K. L. (2002). Waist circumference and weight change are associated with disability among elderly Hispanics. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57, M19–M25. doi: 10.1093/gerona/57.1.M19
   PubMed Web of Science ®Google Scholar
• Choquette, S., Bouchard, D. R., Doyon, C. Y., Senechal, M., Brochu, M., & Dionne, I. J. (2010). Relative strength as a determinant of mobility in elders 67–84 years of age. A nuage study: Nutrition as a determinant of successful aging. The Journal of Nutrition, Health & Aging, 14, 190–195. doi: 10.1007/s12603-010-0047-4
   PubMed Web of Science ®Google Scholar
• Corbeil, P., Simoneau, M., Rancourt, D., Tremblay, A., & Teasdale, N. (2001). Increased risk for falling associated with obesity: Mathematical modeling of postural control. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 9, 126–136. doi: 10.1109/7333.928572
   PubMed Web of Science ®Google Scholar
• Degens, H. (2007). Age-related skeletal muscle dysfunction: Causes and mechanisms. Journal of Musculoskeletal Neuronal Interaction, 7, 246–252.
   PubMedGoogle Scholar
• Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M. C., Cohen, H. J., … Havlik, R. J. (1999). Serum IL-6 level and the development of disability in older persons. Journal of the American Geriatrics Society, 47, 639–646. doi: 10.1111/jgs.1999.47.issue-6
   PubMed Web of Science ®Google Scholar
• Ferrucci, L., Penninx, B. W., Volpato, S., Harris, T. B., Bandeen-Roche, K., Balfour, J., & Md, J. M. (2002). Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. Journal of the American Geriatrics Society, 50, 1947–1954. doi: 10.1046/j.1532-5415.2002.50605.x
   PubMed Web of Science ®Google Scholar
• Fillenbaum, G. G., & Smyer, M. A. (1981). The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. Journal of Gerontology, 36, 428–434. doi: 10.1093/geronj/36.4.428
   PubMedGoogle Scholar
• Fjeldstad, C., Fjeldstad, A. S., Acree, L. S., Nickel, K. J., & Gardner, A. W. (2008). The influence of obesity on falls and quality of life. Dynamic Medicine, 7, 4. doi: 10.1186/1476-5918-7-4
   PubMedGoogle Scholar
• Fransson, E. I., Batty, G. D., Tabak, A. G., Brunner, E. J., Kumari, M., Shipley, M. J., & Kivimaki, M. (2010). Association between change in body composition and change in inflammatory markers: An 11-year follow-up in the Whitehall II Study. Journal of Clinical Endocrinology and Metabolism, 95, 5370–5374. doi: 10.1210/jc.2010-0730
   PubMed Web of Science ®Google Scholar
• Galic, S., Oakhill, J. S., & Steinberg, G. R. (2010). Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology, 316, 129–139. doi: 10.1016/j.mce.2009.08.018
   PubMed Web of Science ®Google Scholar
• Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., & Newman, A. B. (2006). The loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61, 1059–1064. doi: 10.1093/gerona/61.10.1059
   PubMed Web of Science ®Google Scholar
• Guallar-Castillon, P., Sagardui-Villamor, J., Banegas, J. R., Graciani, A., Fornes, N. S., Lopez Garcia, E., & Rodriguez-Artalejo, F. (2007). Waist circumference as a predictor of disability among older adults. Obesity (Silver Spring, Md.), 15, 233–233. doi: 10.1038/oby.2007.532
   PubMed Web of Science ®Google Scholar
• Guralnik, J. M., Fried, L. P., & Salive, M. E. (1996). Disability as a public health outcome in the aging population. Annual Review of Public Health, 17, 25–46. doi: 10.1146/annurev.pu.17.050196.000325
   PubMed Web of Science ®Google Scholar
• Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., & Wallace, R. B. (1994). A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. Journal of Gerontology, 49, M85–M94. doi: 10.1093/geronj/49.2.M85
   PubMedGoogle Scholar
• Houston, D. K., Stevens, J., & Cai, J. (2005). Abdominal fat distribution and functional limitations and disability in a biracial cohort: The Atherosclerosis Risk in Communities Study. International Journal of Obesity, 29, 1457–1463. doi: 10.1038/sj.ijo.0803043
   PubMed Web of Science ®Google Scholar
• Hsu, F. C., Kritchevsky, S. B., Liu, Y., Kanaya, A., Newman, A. B., Perry, S. E., … Nicklas, B. J. (2009). Association between inflammatory components and physical function in the Health, Aging, and Body Composition Study: A principal component analysis approach. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64A, 581–589. doi: 10.1093/gerona/glp005
   Web of Science ®Google Scholar
• Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. (2002). Longitudinal changes in body composition in older men and women: Role of body weight change and physical activity. American Journal of Clinical Nutrition, 76, 473–481.
   PubMed Web of Science ®Google Scholar
• Jones, C. J., Rikli, R. E., & Beam, W. C. (1999). A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Research Quarterly for Exercise and Sport, 70, 113–119. doi: 10.1080/02701367.1999.10608028
   PubMed Web of Science ®Google Scholar
• Jones, T. G., Schinka, J. A., Vanderploeg, R. D., Small, B. J., Graves, A. B., & Mortimer, J. A. (2002). 3MS normative data for the elderly. Archives of Clinical Neuropsychology, 17, 171–177. doi: 10.1093/arclin/17.2.171
   PubMed Web of Science ®Google Scholar
• Kershaw, E. E., & Flier, J. S. (2004). Adipose tissue as an endocrine organ. The Journal of Clinical Endocrinology & Metabolism, 89, 2548–2556. doi: 10.1210/jc.2004-0395
   PubMed Web of Science ®Google Scholar
• Kuk, J. L., Katzmarzyk, P. T., Nichaman, M. Z., Church, T. S., Blair, S. N., & Ross, R. (2006). Visceral fat is an independent predictor of all-cause mortality in men. Obesity (Silver Spring, Md.), 14, 336–341. doi: 10.1038/oby.2006.43
   PubMed Web of Science ®Google Scholar
• Li, Y. P., Chen, Y., John, J., Moylan, J., Jin, B., Mann, D. L., & Reid, M. B. (2005). TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. Journal of the Federation of American Societies for Experimental Biology, 19, 362–370. doi: 10.1096/fj.04-2364com
   PubMed Web of Science ®Google Scholar
• Lin, M. R., Hwang, H. F., Hu, M. H., Wu, H. D., Wang, Y. W., & Huang, F. C. (2004). Psychometric comparisons of the timed up and go, one-leg stand, functional reach, and Tinetti balance measures in community-dwelling older people. Journal of the American Geriatrics Society, 52, 1343–1348. doi: 10.1111/(ISSN)1532-5415
   PubMed Web of Science ®Google Scholar
• Menegoni, F., Galli, M., Tacchini, E., Vismara, L., Cavigioli, M., & Capodaglio, P. (2009). Gender-specific effect of obesity on balance. Obesity (Silver Spring, Md.), 17, 1951–1956. doi: 10.1038/oby.2009.82
   PubMed Web of Science ®Google Scholar
• Panagiotakos, D. B., Pitsavos, C., Yannakoulia, M., Chrysohoou, C., & Stefanadis, C. (2005). The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study. Atherosclerosis, 183, 308–315. doi: 10.1016/j.atherosclerosis.2005.03.010
   PubMed Web of Science ®Google Scholar
• Pedersen, M., Steensberg, A., Keller, C., Osada, T., Zacho, M., Saltin, B., … Pedersen, B. K. (2004). Does the aging skeletal muscle maintain its endocrine function? Exercise Immunology Review, 10, 42–55.
   PubMed Web of Science ®Google Scholar
• Penninx, B. W., Nicklas, B. J., Newman, A. B., Harris, T. B., Goodpaster, B. H., Satterfield, S., … Kritchevsky, S. B. (2009). Metabolic syndrome and physical decline in older persons: Results from the Health, Aging And Body Composition Study Journal of Gerontolology A: Biological Sciences and Medical Sciences, 64(1), 96–102.
   PubMed Web of Science ®Google Scholar
• Penninx, B. W., Kritchevsky, S. B., Newman, A. B., Nicklas, B. J., Simonsick, E. M., Rubin, S., & Pahor, M. (2004). Inflammatory markers and incident mobility limitation in the elderly. Journal of the American Geriatrics Society, 52, 1105–1113. doi: 10.1111/jgs.2004.52.issue-7
   PubMed Web of Science ®Google Scholar
• Podsiadlo, D., & Richardson, S. (1991). The timed “Up & Go”: A test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39, 142–148. doi: 10.1111/jgs.1991.39.issue-2
   PubMed Web of Science ®Google Scholar
• Pratesi, A., Tarantini, F., & Di Bari, M. (2013). Skeletal muscle: An endocrine organ. Clinical Cases Miner Bone Metabolism, 10, 11–14.
   PubMedGoogle Scholar
• Reed, R. L., Den Hartog, R., Yochum, K., Pearlmutter, L., Ruttinger, A. C., & Mooradian, A. D. (1993). A comparison of hand-held isometric strength measurement with isokinetic muscle strength measurement in the elderly. Journal of the American Geriatrics Society, 41, 53–56. doi: 10.1111/jgs.1993.41.issue-1
   PubMed Web of Science ®Google Scholar
• Spyropoulos, P., Pisciotta, J. C., Pavlou, K. N., Cairns, M. A., & Simon, S. R. (1991). Biomechanical gait analysis in obese men. Archives of Physical Medicine Rehabilitation, 72, 1065–1070.
   PubMed Web of Science ®Google Scholar
• Stenholm, S., Alley, D., Bandinelli, S., Griswold, M. E., Koskinen, S., Rantanen, T., … Ferrucci, L. (2009). The effect of obesity combined with low muscle strength on decline in mobility in older persons: Results from the InCHIANTI study. International Journal of Obesity, 33, 635–644. doi: 10.1038/ijo.2009.62
   PubMed Web of Science ®Google Scholar
• Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000). Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 55, M709–M715. doi: 10.1093/gerona/55.12.M709
   PubMed Web of Science ®Google Scholar
• Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2012). High-sensitivity C-reactive protein and mobility disability in older adults. Age and Ageing, 41, 541–545. doi: 10.1093/ageing/afs038
   PubMed Web of Science ®Google Scholar
• Verghese, J., Holtzer, R., Oh-Park, M., Derby, C. A., Lipton, R. B., & Wang, C. (2011). Inflammatory markers and gait speed decline in older adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66A, 1083–1089. doi: 10.1093/gerona/glr099
   Web of Science ®Google Scholar
• Visser, M., Bouter, L. M., McQuillan, G. M., Wener, M. H., & Harris, T. B. (1999). Elevated C-reactive protein levels in overweight and obese adults. Journal of Americain Medical Association, 282, 2131–2135. doi: 10.1001/jama.282.22.2131
   PubMed Web of Science ®Google Scholar
• Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., … Harris, T. B. (2002). Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57, M326–M332. doi: 10.1093/gerona/57.5.M326
   PubMed Web of Science ®Google Scholar
• Voisin, L., Breuille, D., Combaret, L., Pouyet, C., Taillandier, D., Aurousseau, E., … Attaix, D. (1996). Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+-activated, and ubiquitin-proteasome proteolytic pathways. Journal of Clinical Investigation, 97, 1610–1617. doi: 10.1172/JCI118586
   PubMed Web of Science ®Google Scholar
• Washburn, R. A., Smith, K. W., Jette, A. M., & Janney, C. A. (1993). The Physical Activity Scale for the Elderly (PASE): Development and evaluation. Journal of Clinical Epidemiology, 46, 153–162. doi: 10.1016/0895-4356(93)90053-4
   PubMed Web of Science ®Google Scholar
• Zamboni, M., Turcato, E., Santana, H., Maggi, S., Harris, T. B., Pietrobelli, A., … Bosello, O. (1999). The relationship between body composition and physical performance in older women. Journal of the American Geriatrics Society, 47, 1403–1408. doi: 10.1111/jgs.1999.47.issue-12
   PubMed Web of Science ®Google Scholar
• Zoico, E., Rossi, A., Di Francesco, V., Sepe, A., Olioso, D., Pizzini, F., … Zamboni, M. (2010). Adipose tissue infiltration in skeletal muscle of healthy elderly men: Relationships with body composition, insulin resistance, and inflammation at the systemic and tissue level. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65, 295–299. doi: 10.1093/gerona/glp155
   PubMed Web of Science ®Google Scholar