Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson’s disease

References

• Alam, M., Mayerhofer, A., & Schmidt, W. (2004). The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA. Behavioural Brain Research, 151(1–2), 117–124. doi:https://doi.org/10.1016/j.bbr.2003.08.014
   PubMed Web of Science ®Google Scholar
• Alder, S., & Zbinden, G. (1983). Neurobehavioral tests in single-and repeated-dose toxicity studies in small rodents. Archives of Toxicology, 54, 1–23. doi:https://doi.org/10.1007/BF00277811
   PubMed Web of Science ®Google Scholar
• Ali, A., Hamed, M., & El-Sayed, M. (1992). Effect of protein malnutrition on postnatal neurobehavioural response to drugs. M Sc. Thesis, Pharmacology, Faculty of Pharmacy, Cairo University. pp 59-160.
   Google Scholar
• Ballance, W. C., Qin, E. C., Chung, H. J., Gillette, M. U., & Kong, H. (2019). Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. Biomaterials, 217, 119292. doi:https://doi.org/10.1016/j.biomaterials.2019.119292
   PubMed Web of Science ®Google Scholar
• Bancroft, J. D., & Gamble, M. (2008). Theory and practice of histological techniques. 6th Edition, Churchill Livingstone, Elsevier, China.
   Google Scholar
• Ben-Ari, Y., Gaiarsa, J. L., Tyzio, R., & Khazipov, R. (2007 Oct). GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiological Reviews, 87(4), 1215–1284. doi:https://doi.org/10.1152/physrev.00017.2006. PMID: 17928584.
   PubMed Web of Science ®Google Scholar
• Bhide, N., Lindenbach, D., Surrena, M. A., Goldenberg, A. A., Bishop, C., Berger, S. P., Paquette, M. A. (2013). The effects of BMY-14802 against L-DOPA- and dopamine agonist-induced dyskinesia in the hemiparkinsonian rat. Psychopharmacology (Berl), 227, 533–544. doi:https://doi.org/10.1007/s00213-013-3001-4
   PubMed Web of Science ®Google Scholar
• Botsford, E., George, J., & Buckley, E. E. (2018). Parkinson’s disease and metal storage disorders: A systematic review. Brain Sciences, 8. doi:https://doi.org/10.3390/brainsci8110194
   PubMed Web of Science ®Google Scholar
• Costa, C. M., de Oliveira, G. L., Fonseca, A. C. S., Lana, R. D. C., Polese, J. C., Pernambuco, A. P. (2019). Levels of cortisol and neurotrophic factor brain-derived in parkinson’s disease. Neurosci. Lett, 708, 134359. doi:https://doi.org/10.1016/j.neulet.2019.134359
   PubMed Web of Science ®Google Scholar
• Cova, I., Leta, V., Mariani, C., Pantoni, L., & Pomati, S. (2019). Exploring cocoa properties: Is theobromine a cognitive modulator?. Psychopharmacology (Berl), 236(2), 561–572. doi:https://doi.org/10.1007/s00213-019-5172-0
   PubMed Web of Science ®Google Scholar
• Cunha, J. M., & Masur, J. (1978). Evaluation of psychotropic drugs with a modified open field test. Pharmacol, 16, 259–267. doi:https://doi.org/10.1159/000136777
   PubMed Web of Science ®Google Scholar
• Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88. IN191–9095. doi:https://doi.org/10.1016/0006-2952(61)90145-9
   PubMed Web of Science ®Google Scholar
• Ginsberg, Y., Khatib, N., Saadi, N., Ross, M. G., Weiner, Z., Beloosesky, R. (2018). Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model. Am. J. Obstet. Gynecol, 219, 113.e1–113.e9. doi:https://doi.org/10.1016/j.ajog.2018.04.040
   PubMed Web of Science ®Google Scholar
• Hamed, M., & El-Sayed, M. (1991). Influence of protein malnutrition on behavioral response to drugs in rats. JOURNAL OF DRUG RESEARCH-CAIRO, 20, 241.
   Google Scholar
• Hamed, M. R., Khayyal, M. T. E., Mansour, H. A. F., & Al-Ansary, D. M. (2006). Immunomodulatory effects of dimethyl- 4, 4- Dimethoxy-5,5,5,6- Dimethylene Dioxy-Biphenyl- Dicarboxylate (D.D.B). J Drug Res Egypt, 27(1–2), 32–43.
   Google Scholar
• Hassanzadeh, K., Rahimmi, A., & Hassanzadeh, K. (2014). Effect of N-acetylcysteine on TNF-α level of substantia nigra and striatum in rat model of parkinson’s disease. J. Mazandaran Univ. Med. Sci, 24(118), 40–48.
   Google Scholar
• Hirsch, E. C., & Hunot, S. (2009). Neuroinflammation in parkinson’s disease: A target for neuroprotection?. Lancet Neurology, 8(4), 382–397. doi:https://doi.org/10.1016/S1474-4422(09)70062-6
   PubMed Web of Science ®Google Scholar
• Hirsch, E. C., Hunot, S., & Hartmann, A. (2005). Neuroinflammatory processes in parkinson’s disease. Parkinson. Relat. Disord, 11(Suppl. 1), S9–S15. doi:https://doi.org/10.1016/j.parkreldis.2004.10.013
   PubMed Web of Science ®Google Scholar
• Ishola, I. O., Akinyede, A. A., Adeluwa, T. P., & Micah, C. (2018). Novel action of vinpocetine in the prevention of paraquat-induced parkinsonism in mice: Involvement of oxidative stress and neuroinflammation. Metab. Brain Dis, 33, 1493–1500. doi:https://doi.org/10.1007/s11011-018-0256-9
   PubMed Web of Science ®Google Scholar
• Kaur, G., Jabbar, Z., Athar, M., & Alam, M. S. (2006). Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem. Toxicol, 44, 984–993. doi:https://doi.org/10.1016/j.fct.2005.12.001
   PubMed Web of Science ®Google Scholar
• Kelly, M. J., Lawton, M. A., Baig, F., Ruffmann, C., Barber, T. R., Lo, C., Klein, J. C., Ben- Shlomo, Y., Hu, M. T. (2019). Predictors of motor complications in early parkinson’s disease: A prospective cohort study. Mov. Disord. doi:https://doi.org/10.1002/mds.27783.
   PubMed Web of Science ®Google Scholar
• Kilari, E. K., Rao, L. S. N., Sreemanthula, S., & Kola, P. K. (2015). Anti-stress and nootropic activity of aqueous extract of piper longum fruit, estimated by noninvasive biomarkers and Y-maze test in rodents. Environ Exp Biol, 13, 25–31.
   Google Scholar
• Kovalchuk, Y., Hanse, E., Kafitz, K. W., & Konnerth, A. (2002). Postsynaptic induction of BDNF-mediated long-term potentiation. Science. 295, 1729–1734.
   Google Scholar
• Kujawska, M., Jourdes, M., & Kurpik, M. (2019). Neuroprotective effects of pomegranate juice against parkinson’s disease and presence of ellagitannins-derived metabolite-Urolithin A-in the brain. International Journal of Molecular Sciences, 21(1), Published 2019 Dec 27, 202. doi:https://doi.org/10.3390/ijms21010202
   PubMed Web of Science ®Google Scholar
• Liu-T, H., Luo-C, L., Huang, B., & Lu-T, S. (2018). FuY-S 2018: the caffeine effects on rotenone-induced parkinson’s disease model in vitro and in vivo. Experimental Biology, 32(S1), 740.2.
   Google Scholar
• Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402–408. doi:https://doi.org/10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Malek, N., Kanavou, S., Lawton, M. A., Pitz, V., Grosset, K. A., Bajaj, N.,Barker, R. A., Ben Shlomo, Y., Burn, D. J., Foltynie, T., Hardy, J., Williams, N. M., Wood, N., Morris, H. R., Grosset, D. G. (2019). L-dopa responsiveness in early parkinson’s disease is associated with the rate of motor progression. Parkinsonism Relat. Disord. doi:https://doi.org/10.1016/j.parkreldis.2019.05.022.
   PubMed Web of Science ®Google Scholar
• Mazumder, M. K., Choudhury, S., & Borah, A. (2019). An in silico investigation on the inhibitory potential of the constituents of pomegranate juice on antioxidant defense mechanism: relevance to neurodegenerative diseases. IBRO Reports, 6, 153–159. doi:https://doi.org/10.1016/j.ibror.2019.05.003
   PubMedGoogle Scholar
• Medina, A. E. (2010). Vinpocetine as a potent antiinflammatory agent. PNAS, 107(22), 9921–9922. doi:https://doi.org/10.1073/pnas.1005138107
   PubMed Web of Science ®Google Scholar
• Messaoudi, M., Bisson, J.F., Nejdi, A., Rozan, P., & Javelot, H. (2008). Antidepressant-like effects of a cocoa polyphenolic extract in wistar-unilever rats. Nutr. Neurosci, 11, 269–276. doi:https://doi.org/10.1179/147683008X344165
   PubMed Web of Science ®Google Scholar
• Nadeem, R. I., Ahmed, H. I., & El-Sayeh, B. M. (2018). Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats. Naunyn. Schmiedebergs. Arch. Pharmacol, 3(91), 729–742. doi:https://doi.org/10.1007/s00210-018-1498-0
   Web of Science ®Google Scholar
• Petit-Paitel, A. (2010). [GSK-3beta: A central kinase for neurodegenerative diseases?]. Med. Sci. (Paris), 26, 516–521. doi:https://doi.org/10.1051/medsci/2010265516
   PubMed Web of Science ®Google Scholar
• Pfaffl, M. W. (2001). A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Research. 29, e45–e45.
   Google Scholar
• Rekha, K. R., & Inmozhi Sivakamasundari, R. (2018). Geraniol protects against the Protein and Oxidative stress induced by rotenone in an in vitro model of parkinson’s disease. Neurochem. Res, 43, 1947–1962. doi:https://doi.org/10.1007/s11064-018-2617-5
   PubMed Web of Science ®Google Scholar
• Safari, M., Sameni, H. R., Badban, L., Bandegi, A. R., Vafaei, A. A., Pour, A. R., Ghahari, L.,l (2015). Protective effects of water extract of propolis on dopaminergic neurons, brain derived neurotrophic factor and stress oxidative factors in the rat model of parkinson’s disease. International Journal of Pharmacology, 11(4), 300–308. doi:https://doi.org/10.3923/ijp.2015.300.308
   Web of Science ®Google Scholar
• Sanberg, P. R. (1988). The catalepsy test: Its ups and downs. Behavioral Neuroscience, 102(5), 748. doi:https://doi.org/10.1037/0735-7044.102.5.748
   PubMed Web of Science ®Google Scholar
• Sarter, M., Schneider, H. H., & Stephens, D. N. (1988). Treatment strategies for senile dementia: Antagonist β-carbolines. Trends in Neurosciences, 11, 13–17. doi:https://doi.org/10.1016/0166-2236(88)90042-2
   PubMed Web of Science ®Google Scholar
• Silva, J., Alves, C., Freitas, R., Martins, A., Pinteus, S., Ribeiro, J., Gaspar, H., Alfonso, A., Pedrosa, R. (2019). Antioxidant and neuroprotective potential of the brown seaweed bifurcaria bifurcata in an in vitro parkinson’s disease model. Mar. Drugs, 17. doi:https://doi.org/10.3390/md17020085
   PubMed Web of Science ®Google Scholar
• Sokolova, A. N., Pavlova, M. A., Klosterhalfena, S., & Enck, P. (2013). Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behaviour. Neuroscience and Biobehavioral Reviews, 37(10), 2445–2453. doi:https://doi.org/10.1016/j.neubiorev.2013.06.013
   PubMed Web of Science ®Google Scholar
• Tapias, V., Cannon, J. R., & Greenamyre, J. T. (2014). Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson’s disease. Neurobiology of Aging, 35, 1162–1176. doi:https://doi.org/10.1016/j.neurobiolaging.2013.10.077
   PubMed Web of Science ®Google Scholar
• Teixeira, M. D., Souza, C. M., Menezes, A. P., Carmo, M. R., & Fonteles, A. A. (2013). Catechin attenuates behavioral neurotoxicity induced by 6-OHDA in rats. Pharmacology, Biochemistry, and Behavior, 110, 1–7. doi:https://doi.org/10.1016/j.pbb.2013.05.012
   PubMed Web of Science ®Google Scholar
• Usman, U. Z., Bakar, A. B. A., & Mohamed, M. (2018). Propolis improves pregnancy outcomes and placental oxidative stress status in streptozotocin-induced diabetic rats. BMC Complement. Altern. Med, 18, 324. doi:https://doi.org/10.1186/s12906-018-2391-6
   PubMed Web of Science ®Google Scholar
• Van den Buuse, M., & De jong, W. (1989). Differential effects of dopaminergic drugs on open- field behavior of spontaneously hypertensive rats and normotensive wistar –kyoto rats. The Journal of Pharmacology and Experimental Therapeutics, 248(3), 1189–1196.
   PubMed Web of Science ®Google Scholar
• Vorhees, C. V. (1974). Some behavioral effects of maternal hypervitaminosis A in rats. Teratology, 10, 269–273. doi:https://doi.org/10.1002/tera.1420100309
   PubMedGoogle Scholar
• Vorhees, C. V., Klein, K. L., & Scott, W. J. (1982). Aspirin‐induced psychoteratogenesis in rats as a function of embryonic age. Teratogenesis, Carcinogenesis, and Mutagenesis. 2, 77–84. doi:https://doi.org/10.1002/1520-6866(1990)2:1<77:AID-TCM1770020108>3.0.CO;2-C
   Google Scholar
• Wichmann, T. (2019). Changing views of the pathophysiology of parkinsonism. Mov. Disord. doi:https://doi.org/10.1002/mds.27741
   PubMed Web of Science ®Google Scholar
• Yu, A. J., & Dayan, P. (2005). Uncertainty, neuromodulation, and attention. Neuron, 46(4), 681–692. doi:https://doi.org/10.1016/j.neuron.2005.04.026
   PubMed Web of Science ®Google Scholar
• Zaitone, S. A., Ahmed, E., Elsherbiny, N. M., Mehanna, E. T., El-Kherbetawy, M. K., ElSayed, M. H., Alshareef, D, M., Moustafa, Y. M. (2019). Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: relevance to parkinson’s disease therapy. Pharmacol. Rep, 71, 32–41. doi:https://doi.org/10.1016/j.pharep.2018.08.004
   PubMed Web of Science ®Google Scholar