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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 49, 2023 - Issue 1
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Research Article

Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial

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Pages 1-17 | Received 18 Apr 2021, Accepted 28 Feb 2022, Published online: 06 Mar 2022

References

  • ACSM. (2003). Diretrizes do ACSM para os testes de esforço e sua prescrição. (3rd ed., G. Koogan, ed). Rio de Janeiro: American College of Sports Medicine.
  • American College of Sports Medicine. (2010). ACSM’s guidelines for exercise testing and prescription 8 th . Philadelphia: Lippincott Williams & Wilkins .
  • Arcoverde, C., Deslandes, A., Moraes, H., Almeida, C., de Araujo, N. B., Vasques, P. E., … Laks, J. (2014). Treinamento na esteira como um tratamento adicional para a doença de Alzheimer: Estudo piloto controlado randomizado. Arquivos de Neuro-Psiquiatria, 72(3), 190–196. doi:10.1590/0004-282X20130231
  • Baecke, J. A. H., Burema, J., & Frijters, J. E. R. (1982). A short questionnaire for the measurement of habitual physical activity in epidemiological studies. American Journal of Clinical Nutrition, 36(5), 936–942. doi:10.1093/ajcn/36.5.936
  • Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., Tiernan, A. M., … Suzanne, C. (2010). Aerobic exercise improves cognition for older adults with glucose intolerance, a risk for Alzheimer’s disease. Journal of Alzheimers Disease, 22(2), 569–579. doi:10.3233/JAD-2010-100768.Aerobic
  • Beato, R. G., Nitrini, R., Formigoni, A. P., & Caramelli, P. (2007). Brazilian version of the Frontal Assessment Battery (FAB) preliminary data on administration to healthy elderly. Dementia & Neuropsychologia, 1(1), 59–65. doi:10.1590/s1980-57642008dn10100010
  • Borg, G. A. V. (1982). Psychophysical bases of perceived exertion. Medicine and Science in Sports and Exercise, 14(5), 377–381. doi:10.1249/00005768-198205000-00012
  • Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & De Mello, M. T. (2012). Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience, 202, 309–317. doi:10.1016/j.neuroscience.2011.11.029
  • Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., … Tanzi, R. E. (2018). Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science, 361(6406), eaan8821. doi:10.1126/science.aan8821
  • Clemmons, D. R. (2012). metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinology and Metabolism Clinics of North America, 41(2), 425–443. doi:10.1016/j.ecl.2012.04.017
  • Coelho, F. G. M., Andrade, L. P., Pedroso, R. V., Santos-galduroz, R. F., Costa, J., & Luiz, B. (2013). Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer ’ s disease : A controlled trial. Geriatrics & Gerontology International, 13(1), 198–203. doi:10.1111/j.1447-0594.2012.00887.x
  • Deslandes, A., Moraes, H., Ferreira, C., Veiga, H., Silveira, H., Mouta, R., … Laks, J. (2009). Exercise and mental health: Many reasons to move. Neuropsychobiology, 59(4), 191–198. doi:10.1159/000223730
  • Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000). The FAB: A frontal assessment battery at bedside. Neurology, 55(11), 1621–1626. doi:10.1212/WNL.55.11.1621
  • Duzel, E., Van Praag, H., & Sendtner, M. (2016). Can physical exercise in old age improve memory and hippocampal function? Brain, 139(3), 662–673. doi:10.1093/brain/awv407
  • Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. doi:10.1016/0022-3956(75)90026-6
  • Foster, P. P., Rosenblatt, K. P., & Kuljiš, R. O. (2011, MAY(May)). Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer’s disease. Frontiers in Neurology, 1–15. doi:10.3389/fneur.2011.00028
  • Garuffi, M., Costa, J. L. R., Hernández, S. S. S., Vital, T. M., Stein, A. M., Santos, J. G. D., & Stella, F. (2013). Effects of resistance training on the performance of activities of daily living in patients with Alzheimer’s disease. Geriatrics & Gerontology International, 13(2), 322–328. doi:10.1111/j.1447-0594.2012.00899.x
  • Gasparini, L., & Xu, H. (2003). Potential roles of insulin and IGF-1 in Alzheimer’s disease. Trends in Neurosciences, 26(8), 404–406. doi:10.1016/S0166-2236(03)00163-2
  • Groot, C., Hooghiemstra, A. M., Raijmakers, P. G. H. M., van Berckel, B. N. M., Scheltens, P., Scherder, E. J. A., & Ossenkoppele, R. (2016). The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials. Ageing Research Reviews, 25, 13–23. doi:10.1016/j.arr.2015.11.005
  • Hernandez, S. S. S., Coelho, F. G. M., Gobbi, S., & Stella, F. (2010). Effects of physical activity on cognitive functions, balance and risk of falls in elderly patients with Alzheimer’s dementia. Revista Brasileira de Fisioterapia, 14(1), 68–74. doi:10.1590/S1413-35552010000100011
  • Hernandez, S. S., Sandreschi, P. F., Silva, F. C., Arancibia, B. A., da Silva, R., Gutierres, P. J., & Andrade, A. (2014). What are the benefits of exercise for Alzheimer s disease? A systematic review of past 10 years. Journal of Aging and Physical Activity, 23(4), 659–668. doi:10.1123/japa.2014-0180
  • Hoaglin, D. C., Iglewicz, B., & Tukey, J. W. (1986). Performance of some resistant performance rules for labeling outlier. Journal of the American Statistical Association, 81(396), 991–999. doi:10.1080/01621459.1986.10478363
  • Hoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., … Hasselbalch, S. G. (2015). Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease: A randomized controlled trial. Journal of Alzheimer’s Disease, 50(2), 443–453. doi:10.3233/JAD-150817
  • Kramer, A. F., & Erickson, K. I. (2007). Effects of physical activity on cognition, well-being, and brain: Human interventions. Alzheimer’s and Dementia, 3(2), 45–51. doi:10.1016/j.jalz.2007.01.008
  • Lezak, M. D. (1995). Neuropychological Assessment (3rd ed.). Oxford: University Press.
  • Lindholm, D., Carroll, P., Tzimagiorgis, G., & Thoenen, H. (1996). Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. European Journal of Neuroscience, 8(7), 1452–1460. doi:10.1111/j.1460-9568.1996.tb01607.x
  • Lourenco, M. V., Frozza, R. L., Freitas, G. B. D., Zhang, H., Kincheski, G. C., Ribeiro, F. C., … Prado, V. F. (2019). Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, 25(January), 165–175. doi:10.1038/s41591-018-0275-4
  • Maass, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., & Düzel, E. (2016). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage, 131, 142–154. doi:10.1016/j.neuroimage.2015.10.084
  • Montaño, M. B. M. M., & Ramos, L. R. (2005). Validity of the portuguese version of clinical dementia rating. Revista de Saúde Pública, 39(6), 912–917. doi:10.1590/S0034-89102005000600007
  • Morris, J. C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43(11), 2412–2414. doi:10.1212/WNL.43.11.2412-a
  • Morris, J. K., Vidoni, E. D., Johnson, D. K., Sciver, A. V., Mahnken, D., Honea, R. A., & Burns, J. M. (2017). Aerobic exercise for Alzheimer ’ s disease : A randomized controlled pilot trial. PLoS ONE, 12(2), 1–14. doi:10.7910/DVN/ER8ICT
  • Nakagawa, T., Ono-Kishino, M., Sugaru, E., Yamanaka, M., Taiji, M., & Noguchi, H. (2002). Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice. Diabetes/Metabolism Research and Reviews, 18(3), 185–191. doi:10.1002/dmrr.290
  • Nitrini, R., Lefèvre, B. H., Mathias, S. C., Caramelli, P., Carrilho, P. E., Sauaia, N., … Porto, C. S. (1994). Testes neuropsicológicos de aplicação simples para o diagnóstico de demência. Arquivos de Neuro-Psiquiatria, 52(4), 457–465. doi:10.1590/S0004-282X1994000400001
  • Phillips, C., Akif Baktir, M., Das, D., Lin, B., & Salehi, A. (2015). the link between physical activity and cognitive dysfunction in Alzheimer disease. Physical Therapy, 95(7), 1046–1060. doi:10.2522/ptj.20140212
  • Prince, M., Comas-Herrera, A., Knapp, M., Guerchet, M., & Karagiannidou, M. (2016). World Alzheimer report 2016 improving healthcare for people living with dementia. coverage, quality and costs now and in the future. Alzheimer’s Disease International (ADI), 1–140. https://www.alz.co.uk/research/world-report-2016
  • Prior, B. M., Lloyd, P. G., Yang, H. T., & Terjung, R. L. (2003). Exercise-induced vascular remodeling. Exerc Sport Sci Rev, 31(1), 26–33. doi:10.1097/00003677-200301000-00006
  • Rahe, J., Becker, J., Fink, G. R., Kessler, J., Kukolja, J., Rahn, A., & Kalbe, E 2015 Cognitive training with and without additional physical activity in healthy older adults: Cognitive effects, neurobiological mechanisms, and prediction of training success . Frontiers in aging neuroscience,7, . doi:10.3389/fnagi.2015.00187
  • Ricardo, N., Caramelli, P., Herrera Júnior, E., Porto, C. S., Charchat-Fichman, H., Carthery, M. T., & Lima, E. P. (2004). Performance of illiterate and literate nondemented elderly subjects in two tests of long-term memory. Journal of the International Neuropsychological Society : JINS, 10(4), 634–638. doi:10.1017/S1355617704104062
  • Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009). Role and therapeutic potential of VEGF in the nervous system. Physiological Reviews, 89(2), 607–648. doi:10.1152/physrev.00031.2008
  • Stein, A. M., Vital-Silva, T. M., Coelho, F. G. D. M., Arantes, F. J., Costa, J. L. R., Teodoro, E., & Santos-Galduróz, R. F. (2018). Physical exercise, IGF-1 and cognition: A systematic review of experimental studies in the elderly. Dementia e Neuropsychologia, 12(2), 114–122. doi:10.1590/1980-57642018dn12-020003
  • Stella, F., Canonici, A. P., Gobbi, S., Galduroz, R. F. S., Cação, J. D. C., & Gobbi, L. T. B. (2011). Attenuation of neuropsychiatric symptoms and caregiver burden in Alzheimer’s disease by motor intervention: A controlled trial. Clinics, 66(8), 1353–1360. doi:10.1590/S1807-59322011000800008
  • Sunderland, T., Hill, J. L., Mellow, A. M., Lawlor, B. A., Gundersheimer, J., Newhouse, P. A., & Grafman, J. H. (1989). Clock drawing in Alzheimer’s disease. Journal of the American Geriatrics Society, 37(8), 725–729. doi:10.1111/j.1532-5415.1989.tb02233.x
  • Um, H.-S., Kang, E.-B., Koo, J.-H., Kim, H.-T., Jin-Lee, Kim, E.-J., & Cho, J.-Y. (2011). Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer’s disease. Neuroscience Research, 69(2), 161–173. doi:10.1016/j.neures.2010.10.004
  • Vanzella, C., Neves, J. D., Vizuete, A. F., Aristimunha, D., Kolling, J., Longoni, A., & Netto, C. A. (2017). Treadmill running prevents age-related memory deficit and alters neurotrophic factors and oxidative damage in the hippocampus of Wistar rats. Behavioural Brain Research, 334, 78–85. December 2016. doi:10.1016/j.bbr.2017.07.034
  • Venturelli, M., Scarsini, R., & Schena, F. (2011). Six-month walking program changes cognitive and adl performance in patients with Alzheimer. American Journal of Alzheimer’s Disease and Other Dementias, 26(5), 381–388. doi:10.1177/1533317511418956
  • Vital, T. M., Stein, A. M., Coelho, F. G. D. M., Arantes, F. J., Teodorov, E., & Santos-Galduróz, R. F. (2014). Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review. Archives of Gerontology and Geriatrics, 59(2), 234–239. doi:10.1016/j.archger.2014.04.011
  • Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., … Kramer, A. F. (2013). Neurobiological markers of exercise-related brain plasticity in older adults. Brain, Behavior, and Immunity, 28, 90–99. doi:10.1016/j.bbi.2012.10.021
  • Vreugdenhil, A., Lecturer, S., Cannell, J., Physiotherapy, B., Lecturer, D., & Associate, G. R. (2012). A community-based exercise programme to improve functional ability in people with Alzheimer ’ s disease : A randomized controlled trial. Scandinavian Journal of Caring Sciences, 26(1), 12–19. doi:10.1111/j.1471-6712.2011.00895.x
  • Wasserman, K., & Mcilroy, M. B. (1964). Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. The American Journal of Cardiology, 14(6), 844–852. doi:10.1016/0002-9149(64)90012-8

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