63
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Evaluate the relative efficiency of a targeted clinical trial design to an untargeted design under the issue of cost

Pages 12336-12344 | Received 25 Apr 2016, Accepted 09 Feb 2017, Published online: 31 Aug 2017

References

  • Caraco, Y. 2004. Genes and the response to drugs. The New England Journal of Medicine 351 (27):2867–9.
  • Eichebaum, M., N. Spannbrucker, B. Steincke, and et al. 1979. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. The European Journal of Clinical Pharmacology 16:183–7.
  • Fukuoka, M., S. Yano, G. Giaccone, and et al. 2003. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology 21 (12):2237–46.
  • Kallioniemi, A., O. P. Kallioniemi, D. Sudar, and et al. 1992. Comparative genomic hy-bridization for molecular cytogenetic analysis of solid tumors. Science 258 (5083):818–21.
  • Mahgoab, A., J. R. Idle, L. G. Drig, and et al. 1977. Polymorphic hydroxylation of debriso-quine in man. Lancet 2:584–6.
  • Maitournam, A., and R. Simon. 2005. On the efficiency of targeted clinical trials. Statistics in Medicine 24:329–39.
  • Paez, J. G., P. A. Janne, J. C. Lee, and et al. 2004. EGFR mutations in lung cancer: corre-lation with clinical response to gefitinib therapy. Science 304 (5676):1497–500.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.