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Original Articles

A longitudinal study assessing depression in hepatitis C: Does gender play a role in the new-onset depression during interferon-alpha treatment?

, ORCID Icon, , &
Pages 181-195 | Received 02 May 2017, Accepted 06 Feb 2018, Published online: 24 Jul 2018

References

  • Akuta, N., F. Suzuki, Y. Kawamura, H. Yatsuji, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi, M. Kobayashi, Y. Arase, K. Ikeda, and H. Kumada. 2007. Predictors of viral kinetics to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b. Journal of Medical Virology 79:1686–95. doi:10.1002/jmv.20979.
  • Asnis, G. M., and R. De La Garza. 2006. Interferon-induced depression in chronic hepatitis C: A review of its prevalence, risk factors, biology, and treatment approaches. Journal of Clinical Gastroenterology 40:322–35. doi:10.1097/01.mcg.0000210099.36500.fe.
  • Azorin, J. M., R. Belzeaux, E. Fakra, A. Kaladjian, E. Hantouche, S. Lancrenon, and M. Adida. 2014. Gender differences in a cohort of major depressive patients: Further evidence for the male depression syndrome hypothesis. Journal of Affective Disorders 167:85–92. doi:10.1016/j.jad.2014.05.058.
  • Baranyi, A., A. Meinitzer, A. Stepan, C. Putz-Bankuti, R. J. Breitenecker, R. Stauber, H.P. Kapfhammer, and H. B. Rothenhäusler. 2013. A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection. Psychotherapy and Psychosomatics 82:332–40. doi:10.1159/000348587.
  • Baranyi, A., A. Meinitzer, R. J. Breitenecker, O. Amouzadeh-Ghadikolai, R. Stauber, and H. B. Rothenhäusler. 2015. Quinolinic acid responses during interferon-α-induced depressive symptomatology in patients with chronic hepatitis c infection - a novel aspect for depression and inflammatory hypothesis. PLoS One 10 (9):e0137022. doi:10.1371/journal.pone.0137022.
  • Belvederi Murri, M., A. C. Cecere, M. Masotti, G. Sammito, A. La Marca, G. V. Torres, I. Bonfitto, E. Cuozzo, L. Rossi, G. Serviddio, R. Villani, A. Picciotto, A. Bellomo, and M. Amore. 2017. Biopsychosocial predictors of interferon-related depression in patients with Hepatitis C. Asian Journal of Psychiatry 26:24–28. doi:10.1016/j.ajp.2017.01.001.
  • Benova, L., Y. A. Mohamoud, C. Calvert, and L. J. Abu-Raddad. 2014. Vertical transmission of hepatitis C virus: Systematic review and meta-analysis. Clinical Infectious Diseases 59:765–73. doi:10.1093/cid/ciu447.
  • Buchanan, R., and K. L. Nash. 2015. Hepatitis C. Medicine 43:607–12. doi:10.1016/j.mpmed.2015.07.008.
  • Capuron, L., and A. H. Miller. 2004. Cytokines and psychopathology: Lessons from interferon?. Biological Psychiatry 56:819–24. doi: 10.1016/j.biopsych.2004.02.009.
  • Capuron, L., F. B. Fornwalt, B. T. Knight, P. D. Harvey, P. T. Ninan, and A. H. Miller. 2009. Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? Journal of Affective Disorders 119:181–85. doi:10.1016/j.jad.2009.02.017.
  • Capuron, L., G. Pagnoni, D. F. Drake, B. J. Woolwine, J. R. Spivey, R. J. Crowe, J. R. Votaw, M. M. Goodman, and A. H. Miller. 2012. Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. Archives of General Psychiatry 69:1044–53. doi:10.1001/archgenpsychiatry.2011.2094.
  • Capuron, L., G. Pagnoni, M. F. Demetrashvili, D. H. Lawson, F. B. Fornwalt, B. Woolwine, G. S. Berns, C. B. Nemeroff, and A. H. Miller. 2007. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-α therapy. Neuropsychopharmacology 32:2384–92. doi:10.1038/sj.npp.1301362.
  • Capuron, L., J. F. Gumnick, D. L. Musselman, D. H. Lawson, A. Reemsnyder, C. B. Nemeroff, and A. H. Miller. 2002. Neurobehavioral effects of interferon-α in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26:643–52. doi:10.1016/S0893-133X(01)00407-9.
  • Cohen, J. 1992. A power primer. Psychological Bulletin 112:155–59. doi:10.1037/0033-2909.112.1.155.
  • Conjeevaram, H. S., M. W. Fried, L. J. Jeffers, N. A. Terrault, T. E. Wiley-Lucas, N. Afdhal, R. S. Brown, S. H. Belle, J. H. Hoofnagle, D. E. Kleiner, and C. D. Howell. 2006. Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology 131:470–77. doi:10.1053/j.gastro.2006.06.008.
  • Feld, J. J. 2012. Treatment indication and response to standard of care with peginterferon and ribavirin in acute and chronic HCV infection. Best Practice & Research. Clinical Gastroenterology 26:429–44. doi:10.1016/j.bpg.2012.09.013.
  • First, M. B., R. L. Spitzer, M. Gibbon, and J. B. W. Williams. 1996. Structured clinical interview for DSM- IV Axis I disorders, clinician version (SCID-CV). Washington, DC: American Psychiatric Press Inc.
  • Grebely, J., K. Page, R. Sacks-Davis, M. S. Van Der Loeff, T. M. Rice, J. Bruneau, M. D. Morris, B. Hajarizadeh, J. Amin, A. L. Cox, A. Y. Kim, B. H. Mcgovern, J. Schinkel, J. George, N. H. Shoukry, G. M. Lauer, L. Maher, A. R. Lloyd, M. Hellard, G. J. Dore, and M. Prins. 2014. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. Hepatology 59:109–20. doi:10.1002/hep.26639.
  • Hamilton, M. 1960. A rating scale for depression. Journal of Neurology, Neurosurgery & Psychiatry 23 (1):56–62. doi:10.1136/jnnp.23.1.56.
  • Hardeveld, F., J. Spijker, R. De Graaf, W. A. Nolen, and A. T. F. Beekman. 2013. Recurrence of major depressive disorder and its predictors in the general population: Results from The Netherlands mental health survey and incidence study (NEMESIS). Psychological Medicine 43:39–48. doi:10.1017/S0033291712002395.
  • Hauser, P., J. Khosla, H. Aurora, J. Laurin, M. A. Kling, J. Hill, M. Gulati, A. J. Thornton, R. L. Schultz, A. D. Valentine, C. A. Meyers, and C. D. Howell. 2002. A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Molecular Psychiatry 7:942–47. doi:10.1038/sj.mp.4001119.
  • Hayashi, J., Y. Kishihara, K. Ueno, K. Yamaji, Y. Kawakami, N. Furusyo, Y. Sawayama, and S. Kashiwagi. 1998. Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection. Archives of Internal Medicine 158:177–81. doi:10.1001/archinte.158.2.177.
  • Hayley, S., J. Scharf, and H. Anisman. 2013. Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: A mini-review and original experiments. Brain, Behavior, and Immunity 31:115–27. doi:10.1016/j.bbi.2012.07.023.
  • Huckans, M., B. Fuller, V. Wheaton, S. Jaehnert, C. Ellis, M. Kolessar, D. Kriz, J. R. Anderson, K. Berggren, H. Olavarria, A. W. Sasaki, M. Chang, K. D. Flora, and J. M. Loftis. 2015. A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C. Journal of Psychosomatic Research 78:184–92. doi:10.1016/j.jpsychores.2014.07.020.
  • Hullegie, S. J., M. A. Claassen, G. E. van den Berk, J. T. van der Meer, D. Posthouwer, F. N. Lauw, E. M. Leyten, P. P. Koopmans, C. Richter, A. van Eeden, W. F. Bierman, A. M. Newsum, J. E. Arends, and B. J. Rijnders. 2016. Boceprevir, peginterferon and ribavirin for acute hepatitis C in HIV infected patients. Journal of Hepatology 64:807–12. doi:10.1016/j.jhep.2015.12.004.
  • Jacobson, I. M., J. G. McHutchison, G. Dusheiko, A. M. Di Bisceglie, K. R. Reddy, N. H. Bzowej, P. Marcellin, A. J. Muir, P. Ferenci, R. Flisiak, J. George, M. Rizzetto, D. Shouval, R. Sola, R. A. Terg, E. M. Yoshida, N. Adda, L. Bengtsson, A. J. Sankoh, T. L. Kieffer, S. George, R. S. Kauffman, and S. Zeuzem. 2011. Telaprevir for previously untreated chronic hepatitis C virus infection. New England Journal of Medicine 364:2405–16. doi:10.1056/nejmoa1012912.
  • Kendler, K. S., and C. O. Gardner. 2014. Sex differences in the pathways to major depression: A study of opposite-sex twin pairs. American Journal of Psychiatry 171:426–35. doi:10.1176/appi.ajp.2013.13101375.
  • Kendler, K. S., C. O. Gardner, and C. A. Prescott. 2002. Toward a comprehensive developmental model for major depression in women. American Journal of Psychiatry 159:1133–45. doi:10.1176/appi.ajp.159.7.1133.
  • Kendler, K. S., L. M. Thornton, and C. O. Gardner. 2000. Stressful Life events and previous episodes in the etiology of major depression in women: An evaluation of the “kindling” hypothesis. American Journal of Psychiatry 157:1243–51. doi:10.1176/appi.ajp.157.8.1243.
  • Kessler, R. C., K. A. McGonagle, M. Swartz, D. G. Blazer, and C. B. Nelson. 1993. Sex and depression in the national comorbidity survey I: Lifetime prevalence, chronicity and recurrence. Journal of Affective Disorders 29:85–96. doi:10.1016/0165-0327(93)90026-G.
  • Krogh, J., M. E. Benros, M. B. Jørgensen, L. Vesterager, B. Elfving, and M. Nordentoft. 2014. The association between depressive symptoms, cognitive function, and inflammation in major depression. Brain, Behavior, and Immunity 35:70–76. doi:10.1016/j.bbi.2013.08.014.
  • Loftis, J. M., A. L. Patterson, C. J. Wilhelm, H. McNett, B. J. Morasco, M. Huckans, T. Morgan, S. Saperstein, A. Asghar, and P. Hauser. 2013. Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: A 16-week prospective study. Journal of Psychosomatic Research 74:57–63. doi:10.1016/j.jpsychores.2012.10.012.
  • Loftis, J. M., and P. Hauser. 2004. The phenomenology and treatment of interferon-induced depression. Journal of Affective Disorders 82:175–90. doi:10.1016/j.jad.2004.04.002.
  • McHutchison, J. G., E. J. Lawitz, M. L. Shiffman, A. J. Muir, G. W. Galler, J. McCone, L. M. Nyberg, W. M. Lee, R. H. Ghalib, E. R. Schiff, J. S. Galati, B. R. Bacon, M. N. Davis, P. Mukhopadhyay, K. Koury, S. Noviello, L. D. Pedicone, C. A. Brass, J. K. Albrecht, and M. S. Sulkowski. 2009. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. New England Journal of Medicine 361:580–93. doi:10.1056/NEJMoa0808010.
  • Mohd Hanafiah, K., J. Groeger, A. D. Flaxman, and S. T. Wiersma. 2013. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology 57:1333–42. doi:10.1002/hep.26141.
  • Musselman, D. L., D. H. Lawson, J. F. Gumnick, A. K. Manatunga, S. Penna, R. S. Goodkin, K. Greiner, C. B. Nemeroff, and A. H. Miller. 2001. Paroxetine for the prevention of depression induced by high-dose interferon alfa. New England Journal of Medicine 344:961–66. doi:10.1056/nejm200103293441303.
  • Nanni, V. H., R. Uher, and A. Danese. 2012. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: A meta-analysis. American Journal of Psychiatry 169:141–51. doi:10.1176/appi.ajp.2011.11020335.
  • Operskalski, E. A., W. J. Mack, H. D. Strickler, A. L. French, M. Augenbraun, P. C. Tien, M. C. Villacres, L. Y. Spencer, M. Degiacomo, and A. Kovacs. 2008. Factors associated with hepatitis C viremia in a large cohort of HIV-infected and-uninfected women. Journal of Clinical Virology 41:255–63. doi:10.1016/j.jcv.2007.08.021.
  • Parker, G., K. Fletcher, A. Paterson, J. Anderson, and M. Hong. 2014. Gender differences in depression severity and symptoms across depressive sub-types. Journal of Affective Disorders 167:351–57. doi:10.1016/j.jad.2014.06.018.
  • Piccinelli, M., and G. Wilkison. 2000. Gender differences in depression. British Journal of Psychiatry 177:486–92. doi:10.1192/bjp.177.6.486.
  • Poordad, F., J. McCone Jr., B. R. Bacon, S. Bruno, M. P. Manns, M. S. Sulkowski, I. M. Jacobson, K. R. Reddy, Z. D. Goodman, N. Boparai, M. J. DiNubile, V. Sniukiene, C. A. Brass, J. K. Albrecht, and J.-P. Bronowicki. 2011. Boceprevir for untreated chronic HCV genotype 1 infection. New England Journal of Medicine 364:1195–206. doi:10.1056/nejmoa1010494.
  • Raison, C. L., R. Dantzer, K. W. Kelley, M. A. Lawson, B. J. Woolwine, G. Vogt, J. R. Spivey, K. Saito, and A. H. Miller. 2010. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: Relationship to CNS immune responses and depression. Molecular Psychiatry 15:393–403. doi:10.1038/mp.2009.116.
  • Romans, S. E., J. Tyas, M. M. Cohen, and T. Silverstone. 2007. Gender differences in the symptoms of major depressive disorder. The Journal of Nervous and Mental Disease 195:905–11. doi:10.1097/nmd.0b013e3181594cb7.
  • Ryder, S. D. 2015. Chronic hepatitis C–What do the new drugs offer and who should get them first? Clinical Medicine 15:197–200. doi:10.7861/clinmedicine.15-2-197.
  • Schaefer, M., L. Capuron, A. Friebe, C. Diez-Quevedo, G. Robaeys, S. Neri, G. R. Foster, A. Kautz, D. Forton, and C. M. Pariante. 2012. Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement. Journal of Hepatology 57:1379–90. doi:10.1016/j.jhep.2012.07.037.
  • Schuch, J. J., A. M. Roest, W. A. Nolen, B. W. Penninx, and P. De Jonge. 2014. Gender differences in major depressive disorder: Results from the Netherlands study of depression and anxiety. Journal of Affective Disorders 156:156–63. doi:10.1016/j.jad.2013.12.011.
  • Simoes, P., A. Asaad, J. Abed, E. S. Engelson, and D. P. Kotler. 2015. Effect of gender on the response to hepatitis C treatment in an inner-city population. Women’s Health Issues 25:289–93. doi:10.1016/j.whi.2015.02.008.
  • Tabachnick, B., and L. Fidell. 2013. Using multivariate statistics, 6th ed. Boston: Pearson.
  • Tracy, D., J. A. Hahn, C. F. Lewis, J. Evans, A. Briceño, M. D. Morris, and K. Page. 2014. Higher risk of incident hepatitis C virus among young women who inject drugs compared with young men in association with sexual relationships: A prospective analysis from the UFO Study cohort. BMJ Open 4 (5):e004988. doi:10.1136/bmjopen-2014-004988.
  • Udina, M., P. Castellví, J. Moreno-España, R. Navinés, M. Valdés, X. Forns, X. K. Langohr, R. Solà, E. Vieta, and R. Martín-Santos. 2012. Interferon-induced depression in chronic hepatitis C: A systematic review and meta-analysis. Journal of Clinical Psychiatry 73:1128–38. doi:10.4088/JCP.12r07694.
  • van Loo, H. M., S. H. Aggen, C. O. Gardner, and K. S. Kendler. 2015. Multiple risk factors predict recurrence of major depressive disorder in women. Journal of Affective Disorders 180:52–61. doi:10.1016/j.jad.2015.03.045.
  • Villa, E., A. Karampatou, C. Cammà, A. Di Leo, M. Luongo, A. Ferrari, S. Petta, L. Losi, G. Taliani, P. Trande, B. Lei, A. Graziosi, V. Bernabucci, R. Critelli, P. Pazienza, M. Rendina, A. Antonelli, and A. Francavilla. 2011. Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C. Gastroenterology 140:818–29. doi:10.1053/j.gastro.2010.12.027.
  • Whale, R., R. Fialho, M. Rolt, J. Eccles, M. Pereira, M. Keller, A. File, I. Haq, and J. Tibble. 2015. Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort. Journal of Psychosomatic Research 79:640–45. doi:10.1016/j.jpsychores.2015.06.003.
  • Wichers, M. C., G. Kenis, G. H. Koek, G. Robaeys, N. A. Nicolson, and M. Maes. 2007. Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. Journal of Psychosomatic Research 62:207–14. doi:10.1016/j.jpsychores.2006.09.007.

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