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Hemoglobin
international journal for hemoglobin research
Volume 32, 2008 - Issue 5
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Original Article

Molecular Characterization of δβ-Thalassemia and Hereditary Persistence of Fetal Hemoglobin in the Indian Population

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Pages 425-433 | Received 28 Jan 2008, Accepted 16 Mar 2008, Published online: 07 Jul 2009

REFERENCES

  • Rochette J, Craig JE, Thein SL. Fetal hemoglobin levels in adults. Blood Rev 1994; 8(4)213–224
  • Bollekens JA, Forget BG. δβ Thalassemia and hereditary persistence of fetal hemoglobin. Hematol Oncol Clin North Am 1991; 5(3)399–421
  • Wood WG, Clegg JB, Weatherall DJ. Hereditary persistence of fetal hemoglobin (HPFH) and δβ-thalassaemia. Br J Hematol 1979; 43(4)509–520
  • Nakatsuji T, Gilman JG, Sukumaran PK, Huisman THJ. Restriction endonuclease gene mapping studies of an Indian (Aγδβ)0 thalassaemia, previously identified as Gγ-HPFH. Br J Haematol 1984; 57(4)663–670
  • Kutlar A, Gardiner MB, Headlee MG, Reese AL, Cleek MP, Nagle S, Sukumaran PK, Huisman THJ. Heterogeneity in the molecular basis of three types of hereditary persistence of fetal hemoglobin and the relative synthesis of the Gγ and Aγ type of γ chain. Biochem Genet 1984; 22(1–2)21–35
  • Dimovski AJ, Divoky V, Adekile AD, Baysal E, Wilson JB, Prior JF, Raven JL, Huisman THJ. A novel deletion of ∼27 kb including the β-globin gene and the locus control region 3′HS1 regulatory sequence: β0-thalassemia or hereditary persistence of fetal hemoglobin?. Blood 1994; 83(3)822–827
  • Fucharoen S, Fucharoen G, Sanchaisuriya K, Surapot S. Molecular characterization of thalassemia intermedia associated with HPFH-6/β-thalassemia and HPFH-6/Hb E in Thai patients. Acta Hematol 2002; 108(3)157–161
  • Motum PI, Hamilton TJ, Lindeman R, Le H, Trent RJ. Molecular characterization of Vietnamese HPFH. Hum Mutat 1993; 2(3)179–184
  • Old JM, Higgs DR. Gene analysis. The Thalassemias. Methods in Hematology, DJ Weatherall. Churchill Livingstone, Edinburgh 1982; 6: 74–102
  • Craig JE, Barnetson RA, Prior J, Raven JL, Thein SL. Rapid detection of deletions causing δβ thalassemia and hereditary persistence of fetal hemoglobin by enzymatic amplification. Blood 1994; 83(6)1673–1682
  • Xu XM, Li ZQ, Liu ZY, Zhong XL, Zhao YZ, Mo QH. Molecular characterization and PCR detection of deletion HPFH: application to rapid prenatal diagnosis for compound heterozygotes of this defect with β thalassemia in a Chinese family. Am J Hematol 2000, 65(3)183–188
  • Kleihauer E, Braun H, Betke K. Demonstration of fetal hemoglobin in erythrocytes of a blood smear. Klin Wochenschrift 1957; 35(12)367–368
  • Wood WG. Hereditary persistence of fetal hemoglobin and δβ-thalassemia. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, MH Steinberg, BG Forget, DR Higgs, RL Nagel. Cambridge University Press, Cambridge 2001; 356–388
  • Mishima N, Landman H, Huisman THJ, Gilman JG. The DNA deletion in an Indian δβ-thalassaemia begins one kilobase from the Aγ globin gene and ends in an L1 repetitive sequence. Br J Haematol 1989; 73(3)375–379
  • Jones RW, Old JM, Trent RJ, Clegg JB, Weatherall DJ. Restriction mapping of a new deletion responsible for Gγ(δβ)0 thalassemia. Nucleic Acids Res 1981; 9(24)6813–6825
  • Amin AB, Pandya NL, Diwin PP, Darbre PD, Kattamis C, Metaxatou-Mavromati A, White JM, Wood WG, Clegg JB, Weatherall DJ. A comparison of the homozygous states for Gγ and GγAγδβ thalassaemia. Br J Haematol 1979; 43(4)537–548
  • Trent RJ, Jones RW, Clegg JB, Weatherall DJ, Davidson R, Wood WG. (Aγδβ) Thalassaemia: similarity of phenotype in four different molecular defects including one newly described. Br J Haematol 1984; 57(2)279–289
  • Sukumaran PK, Nakatsuji T, Gardiner MB, Reese AL, Gilman JG, Huisman THJ. Gγ Thalassemia resulting from the deletion of a γ globin gene. Nucleic Acids Res 1983; 11(3)4635–4643
  • Henthorn PS, Mager DL, Huisman THJ, Smithies O. A gene deletion ending within a complex array of repeated sequences 3′ to the human β-globin gene cluster. Proc Natl Acad Sci USA 1986; 83(14)5194–5198
  • Weatherall DJ, Clegg JB. The molecular pathology of the thalassaemias. The Thalassaemia Syndromes, 4th, DJ Weatherall, JB Clegg. Blackwell Science, Oxford 2001; 179–181
  • Esteghamat F, Imanian H, Azarkeivan A, Pourfazad F, Almadani N, Najmabadi N. Screening of Iranian thalassemic families for the most common deletions of the β-globin gene cluster. Hemoglobin 2007; 31(4)463–469
  • Panyasai S, Fucharoen S, Surapot S, Fucharoen G, Sunchaisuruya K. Molecular basis and hematological characterization of δβ thalassemia and hereditary persistence of fetal hemoglobin in Thailand. Hematologica 2004; 89(7)777–781
  • Ottolenghi S, Giglioni B, Taramelli R, Comi P, Mazza U, Saglio G, Camaschella C, Izzo P, Cao A, Galanello R, Gimferrer E, Baiget M, Gianni AM. Molecular comparison of δβ thalassemia and hereditary persistence of fetal hemoglobin DNAs: evidence of a regulatory area?. Proc Natl Acad Sci USA 1982; 79(7)2347–2351

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