Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 32, 2008 - Issue 5
159
Views
5
CrossRef citations to date
0
Altmetric
Short Communications

Five Variants of the β-Globin Gene without Clinical or Hematological Effects: Hb Maryland [β47(CD6)Asp→His], Hb Kent [β37(C3)Trp→Cys], Hb Visayan [β136(H14)Gly→Cys], Hb Cutlerville [β138(H16)Ala→Val] and Hb Hornchurch [β43(CD2)Glu→Lys]

, , , &
Pages 471-477 | Received 12 Feb 2008, Accepted 16 Mar 2008, Published online: 07 Jul 2009

REFERENCES

  • Hardison RC, Chui DHK, Giardine B, Riemer C, Patrinos GP, Anagnou N, Miller W, Wajcman H. Hb Var: a relational database of human hemoglobin variants and thalassemia mutation at the globin gene server. Hum Mutat 2002; 19(3)225–232,
  • Schneider RG. Differentiation of electrophoretically similar hemoglobins – such as S, D, G and P; or A2, C, E and O – by electrophoresis of the globin chains. Clin Chem 1974; 20(9)1111–1115
  • Carrell RW, Kay R. A simple method for the detection of unstable haemoglobins. Br J Haematol 1972; 23(5)615–619
  • Dacie JV, Grimes AJ, Meisler A, Steingold L, Hemsted EH, Beaven GH, White JC. Hereditary Heinz-body anaemia: a report of the studies of five patients with mild anaemia. Br J Haematol 1964; 10: 388–402
  • Schneider RG, Barwick RC. Measuring relative electrophoretic mobilities of mutant hemoglobins and globin chains. Hemoglobin 1978; 2(5)417–435
  • Hoyer JD, Wick MJ, Thibodeau SN, Kechteiger KS, Cook JD, Fairbanks VF. Hb Silver Springs [β131(H9)Glu→His], a new hemoglobin variant found in six African-Americans. Hemoglobin 1998; 22(1)37–44
  • Sack JS, Andrews LC, Magnus KA, Hanson JC, Rubin J, Love WE. Location of amino acid residues in human deoxyhemoglobin. Hemoglobin 1978; 2(2)153–169
  • Yamaoka K. Hemoglobin Hirose: α2β2 37(C3) tryptophan→serine. Blood 1971; 38(6)730–738
  • Ohba Y, Hattori Y, Fuyuno K, Takeda I, Matsuoka M, Yoshinaka H, Satoh T, Miyaji T. Two further examples of Hb Hirose, β37(C3)Trp→Ser. Hemoglobin 1983; 7(2)191–193
  • Owen MC, Ockelford PA, Wells RMG. Hb Howick [β37(C3)Trp→Gly]: a new high oxygen affinity variant of the α1β2 contact. Hemoglobin 1993; 17(6)513–521
  • Gacon G, Belkhodja O, Wajcman H, Labie D. Structural and functional studies of Hb Rothschild β(C3)Trp→Arg. A new variant of the α1β2 contact. FEBS Lett. 1977; 82(2)243–246
  • Craik CS, Vallette I, Beychok S, Waks M. Refolding defects in Hemoglobin Rothschild. J Biol Chem 1980; 255(13)6219–6223
  • Stinson RA. Asymmetric hybrids formed with Hemoglobin British Columbia (α2β2101 GLU→LYS). Hemoglobin 1984; 8(5)483–496
  • Minnich V, Hill RJ, Khuri PD, Anderson ME. Hemoglobin Hope: a β chain variant. Blood 1965; 25(5)830–838
  • Jones RT, Schneider RG, Hightower B, Hosty TS, Ryder H, Tomlin G, Atkins R, Brimhall B. Abnormal hemoglobins in a quarter million people. Blood 1976; 48(5)629–637
  • Moo-Penn WF, Jue DL, Johnson MH, Olsen KW, Shih D, Jones RT, Lux SE, Rodgers P, Arnone A. Hb Brockton [β138 (H16) Ala→Pro]: an unstable variant near the C-terminus of the β subunits with normal oxygen-binding properties. Biochemistry 1988; 27(20)7614–7619

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.