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Hemoglobin
international journal for hemoglobin research
Volume 33, 2009 - Issue 3-4
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Original Article

Description of Two New α Variants: Hb Canuts [α85(F6)Asp→His (α1)] and Hb Ambroise Pare [α117(GH5)Phe→Ile (α2)]; Two New β Variants: Hb Beaujolais [β84(EF8)Thr→Asn] and Hb Monplaisir [β147 (Tyr-Lys-Leu-Ala-Phe-Phe-Leu-Leu-Ser-Asn-Phe-Tyr-158-COOH)] and One New δ Variant: Hb A2-North Africa [δ59(E3)Lys→Met]

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Pages 196-205 | Received 25 Jan 2009, Accepted 18 Feb 2009, Published online: 15 Sep 2009

REFERENCES

  • Hardison RC, Chui DHK, Giardine B, et al. HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mut. 2002; 19(3)225–233, (http://globin.cse.psu.edu)
  • Patrinos GP, Giardine B, Riemer C, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res. 2004; 32(Database issue)D537–D541, http://globin.cse.psu.edu
  • Lacan P, Kister J, Francina A, et al. Hemoglobin Debrousse [β96(FG3)Leu→Pro]: A new unstable hemoglobin with twofold increased oxygen affinity. Am J Hematol. 1996; 51(4)276–281
  • Morlé F, Francina A, Ducrocq R, et al. A new α chain variant Hb Sallanches [α2 104(G11)Cys→Tyr] associated with Hb H disease in one homozygous patient. Br J Haematol. 1995; 91(3)608–611
  • Zanella-Cleon I, Becchi M, Lacan P, Giordano PC, Wajcman H, Francina A. Detection of a thalassemic α-chain variant (Hemoglobin Groene Hart) by reversed phase liquid chromatography. Clin Chem. 2008;54, 6: 1053–1059
  • Lacan P, Becchi M, Zanella-Cleon I, Aubry M, Quinsat D, Couprie N. Francina A. Identification by mass spectrometry of a hemoglobin variant with an elongated beta-globin chain. Clin Chem. 2005; 51(1)213–215
  • Carrell RW, Kay R. A simple method for the detection of unstable hemoglobins. Br J Haematol. 1972; 23(5)615–619
  • PeptideMass. Available at: http://www.expasy.org/tools/peptide-mass.html. A tool from the ExPASy Proteomics Server. (Accession number P68871): http://www.expasy.org
  • Aguinaga MdP, Kutlar F, Turner EA, Park D. Hb Inkster [α85(F6)Asp→Val] found in a Caucasian male with polycythemia. Hemoglobin. 2000; 24(4)333–339
  • Wajcman H, Galacteros F. Hemoglobins with high oxygen affinity leading to erythrocytosis. New variants and new concepts. Hemoglobin. 2005; 29(2)91–106
  • Feng L, Gell DA, Zhou S, et al. Molecular mechanism of AHSP-mediated stabilization of α-hemoglobin. Cell. 2004; 119(5)629–640
  • Feng L, Zhou S, Gu L, et al. Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005; 435(7042)697–701
  • Wajcman H, Traeger-Synodinos J, Papassotiriou I, et al. Unstable and thalassemic α chain hemoglobin variants: a cause of Hb H disease and thalassemia intermedia. Hemoglobin. 2008; 32(4)327–349
  • Lacerra G, Scarano C, Musollino G, Flagiello A, Pucci P, Hb Carestia C. Foggia or α117(GH5)Phe→Ser: A new α2 globin allele affecting αHb-AHSP interaction. Haematologica. 2008; 93(1)141–142
  • Imai K., Lehmann H. The oxygen affinity of Haemoglobin Tak, a variant with an elongated β chain. Biochim Biophys Acta. 1975; 412(2)288–294
  • Moi P, Paglietti E, Sanna A, et al. Delineation of the molecular basis of δ- and normal Hb A2 β‐thalassemia. Blood. 1998; 72(2)530–533
  • Grosso M, Rescigno G, Zevino C, Matarazzo M, Poggi V, Izzo P. A rare case of compond heterozygosity for δ+27 and Hb Neapolis (Dhonburi) associated with an atypical β-thalassemia phenotype. Haematologica. 2001; 86(9)985–986

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