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Hemoglobin
international journal for hemoglobin research
Volume 42, 2018 - Issue 2
109
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Short Communication

Compound Heterozygosity for Hb Adana (HBA2: c.179G>A) and the –α3.7/αα Thalassemia Deletion in Greece: Clinical Phenotype and Genetic Counseling

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Pages 129-131 | Received 31 Jan 2018, Accepted 06 Apr 2018, Published online: 20 Jul 2018

References

  • Wajcman H, Traeger-Synodinos J, Papassotiriou I, et al. Unstable and thalassemic α chain hemoglobin variants: a cause of Hb H disease and thalassemia intermedia. Hemoglobin. 2008;32(4):327–349.
  • Nainggolan I, Harahap A, Ambarwati D, et al. Interaction of Hb Adana (HBA2: c.179G>A) with deletional and nondeletional α+-thalassemia mutations: diverse hematological and clinical features. Hemoglobin. 2013;37(3):297–305.
  • Nainggolan IM, Harahap A, Setianingsih I. Hydrops fetalis associated with homozygosity for Hb Adana [α59(Ε8)Gly→Asp (α2)]. Hemoglobin. 2010;34(4):394–401.
  • Cürük MA, Dimovski AJ, Baysal E, et al. Hb Adana or α259(E8)Gly→Aspβ2, a severely unstable α1-globin variant, observed in combination with the –(α)20.5 kb α-thal-1 deletion in two Turkish patients. Am J Hematol. 1993;44(4):270–275.
  • Douna V, Papassotiriopu I, Garoufi A, et al. A rare thalassemic syndrome caused by interaction of Hb Adana [α59(Ε8)Gly→Asp] with an α+-thalassemia deletion: clinical aspects in two cases. Hemoglobin. 2008;32(4):361–369.
  • Chan V, Chan VW, Tang M, et al. Molecular defects in Hb H hydrops fetalis. Br J Haematol. 1997;96(2):224–228.
  • Henderson S, Pitman M, McCarthy J, et al. Prenatal diagnosis of Hb H hydrops fetalis due to compound heterozygosity for the Filipino α0 thalassaemia deletion and Hb Adana, α2 codon 59 GGC→GAC. Br J Hematol. 2007;147(Suppl 1):72.
  • Economou M, Papadopoulou E, Tsatra I, Athanassiou-Metaxa M. A case of mild thalassemic syndrome caused by interaction of Hb Adana with an α+-thalassemia deletion. J Pediatr Hematol Oncol. 2010;32(2):167–168.
  • Zainal NZ, Alauddin H, Ahmad S, Hussin NH. α-Τhalassemia with Hemoglobin Adana mutation: prenatal diagnosis. Malaysian J Pathol. 2014;36(3):207–211.
  • Megawati D, Nainggolan IM, Swastika M, et al. Severe α-thalassemia intermedia due to compound heterozygosity for the highly unstable Hb Adana (HBA2: c.179G>A) and a novel codon 24 (HBA2: c.75T>A) mutation. Hemoglobin. 2014;38(2):149–151.
  • Kanavakis E, Papassotiriou I, Karagiorga M, et al. Phenotypic and molecular diversity of Haemoglobin H disease: a Greek experience. Br J Haematol. 2000;111(3):915–923.
  • Voscaridou E, Ladis V, Kattamis A, et al. A national registry of haemoglobinopathies in Greece: deducted demographics, trends in mortality and affected births. Ann Hematol. 2012;91(9):1451–1458.

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