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Hemoglobin
international journal for hemoglobin research
Volume 42, 2018 - Issue 2
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Original Article

Molecular Spectrum of α- and β-Thalassemia Mutations in a Large Ethnic Hakka Population in Southern China

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Pages 117-121 | Received 06 Feb 2018, Accepted 15 Mar 2018, Published online: 23 Jul 2018

References

  • Weatherall DJ. Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat Rev Genet. 2001;2(4):245–255.
  • Bank A. The thalassemia syndromes. Blood. 1978;51(3):369–384.
  • Taylor SM, Parobek CM, Fairhurst RM. Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(6):457–468.
  • Harteveld CL, Higgs DR. α-Thalassaemia. Orphanet J Rare Dis. 2010;5(1):13.
  • Lin M, Wen YF, Wu JR, et al. Hemoglobinopathy: molecular epidemiological characteristics and health effects on Hakka people in the Meizhou region, southern China. Plos One. 2013;8(2):e55024.
  • Zeng YT, Huang SZ. Disorders of haemoglobin in China. J Med Genet. 1987;24(10):578–583.
  • Lin M, Zhu JJ, Wang Q, et al. Development and evaluation of a reverse dot blot assay for the simultaneous detection of common α and β thalassemia in Chinese. Blood Cells Mol Dis. 2012;48(2):86–90.
  • Xu XM, Zhou YQ, Luo GX, et al. The prevalence and spectrum of α and β thalassaemia in Guangdong Province: implications for the future health burden and population screening. J Clin Pathol. 2004;57(5):517–522.
  • Li CG, Li CF, Li Q, et al. Thalassemia incidence and treatment in China with special reference to Shenzhen City and Guangdong Province. Hemoglobin. 2009;33(5):296–303.
  • Li Z, Li F, Li M, et al. The prevalence and spectrum of thalassemia in Shenzhen, Guangdong Province, People’s Republic of China. Hemoglobin. 2009;30(1):9–14.
  • Lau YL, Chan LC, Chan YY, et al. Prevalence and genotypes of α- and β-thalassemia carriers in Hong Kong – implications for population screening. N Engl J Med. 1997;336(18):1298–1301.
  • Yang Y, Li DZ. Early onset of fetal hydrops associated with the α-thalassemia – –THAI deletion. Hemoglobin. 2014;38(6):431–434.
  • Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704–712.
  • Angastiniotis M. The impact of migrations on the health services for rare diseases in Europe: the example of haemoglobin disorders. ScientificWorldJournal. 2013;2013(1):727905–727905.
  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014;42(Database issue):D1063–D1069 (http://globin.cse.psu.edu).

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