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Hemoglobin
international journal for hemoglobin research
Volume 42, 2018 - Issue 5-6
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Original Article

Haplotype Analysis of Three Common β-Thalassemia Mutations in Syrian Patients

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Pages 302-305 | Received 03 Sep 2018, Accepted 20 Nov 2018, Published online: 22 Jan 2019

References

  • Galanello R, Origa R. β-Thalassemia. Orphanet J Rare Dis. 2010;5:11.
  • Cao A, Moi P, Galanello R. Recent advances in β-thalassemias. Pediatr Rep. 2011;3(2):e17.
  • Hardison RC, Chui DHK, Giardine B, et al. HbVar: a relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mutat. 2002;19(3):225–233 (http://globin.cse.psu.edu).
  • Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704–712.
  • Murad H, Moasses F, Dabboul A, et al. Geographical distribution of β-globin gene mutations in Syria. Hematology. 2018;23(9):697–704.
  • Orkin SH, Kazazian HH Jr, Antonarakis SE, et al. Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature. 1982;296(5858):627–631.
  • Wainscoat JS. The origin of mutant β-globin genes in human populations. Acta Haematol. 1987;78(2-3):154–158.
  • Liu L, Muralidhar S, Singh M, et al. High-density SNP genotyping to define β-globin locus haplotypes. Blood Cells Mol Dis. 2009;42(1):16–24.
  • Bilgen T, Arikan Y, Canatan D, et al. The association between intragenic SNP haplotypes and mutations of the β globin gene in a Turkish population. Blood Cells Mol Dis. 2011;46(3):226–229.
  • Falchi A, Giovannoni L, Vacca L, et al. β-Globin gene cluster haplotypes associated with β-thalassemia on Corsica island. Am J Hematol. 2005;78(1):27–32.
  • Beshara A, Editor. The Origins of Syrian Nationhood Histories, Pioneers and Identity. Abingdon (Oxfordshire, UK); New York (NY, USA): Routledge, Taylor & Francis Group; 2011.
  • Hamamy HA, Al-Allawi NA. Epidemiological profile of common haemoglobinopathies in Arab countries. J Community Genet. 2013;4(2):147–167.
  • Makhoul NJ, Wells RS, Kaspar H, et al. Genetic heterogeneity of β thalassemia in Lebanon reflects historic and recent population migration. Ann Hum Genet. 2005;69(Pt 1):55–66.
  • El-Latif MA, Filon D, Rund D, et al. The β+-IVS-I-6 (T→C) mutation accounts for half of the thalassemia chromosomes in the Palestinian populations of the mountain regions. Hemoglobin. 2002;26(1):33–40.
  • Lemsaddek W, Picanço I, Seuanes F, et al. The β-thalassemia mutation/haplotype distribution in the Moroccan population. Hemoglobin. 2009;28(1):25–37.
  • Bahadır A, Öztürk O, Atalay A, et al. β Globin gene cluster haplotypes of the β thalassemia mutations observed in the Denizli province of Turkey. Turk J Hematol. 2009;26(3):129–137.
  • Fattoum S. Hemoglobinopathies in Tunisia. An updated review of the epidemiologic and molecular data. Tunis Med. 2006;84(11):687–696.
  • Perrin P, Bouhassa R, Mselli L, et al. Diversity of sequence haplotypes associated with β-thalassemia mutations in Algeria: implications for their origin. Gene. 1998;213(1-2):169–177.
  • Flint J, Harding RM, Clegg JB, et al. Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants. Hum Genet. 1993;91(2):91–117.
  • Piras I, Vona G, Falchi A, et al. β-Globin cluster haplotypes in normal individuals and β039-thalassemia carriers from Sardinia, Italy. Am J Hum Biol. 2005;17(6):765–772.
  • Baysal E, Indrak K, Bozkurt G, et al. The β-thalassaemia mutations in the population of Cyprus. Br J Haematol. 1992;81(4):607–609.
  • Lemsaddek W, Picanço I, Seuanes F, et al. Spectrum of β thalassemia mutations and Hb F levels in the heterozygous Moroccan population. Am J Hematol. 2003;73(3):161–168.
  • Tadmouri GO, Gulen RI. Deniz: the electronic database for β-thalassemia mutations in the Arab world. Saudi Med J. 2003;24(11):1192–1198.
  • Zahed L. The spectrum of β-thalassemia mutations in the Arab populations. J Biomed Biotechnol. 2001;1(3):129–132.
  • Indrak K, Brabec V, Indrakova J, et al. Molecular characterization of β-thalassemia in Czechoslovakia. Hum Genet. 1992;88(4):399–404.
  • Villegas A, Ropero P, Gonzalez FA, et al. The thalassemia syndromes: molecular characterization in the Spanish population. Hemoglobin. 2001;25(3):273–283.
  • Rigoli L, Meo A, Miceli MR, et al. Molecular analysis of β-thalassaemia patients in a high incidence area of southern Italy. Clin Lab Haematol. 2001;23(6):373–378.
  • Agouti I, Badens C, Abouyoub A, et al. Molecular basis of β-thalassemia in Morocco: possible origins of the molecular heterogeneity. Genet Test. 2008;12(4):563–568.
  • Haj Khelil A, Denden S, Leban N, et al. Hemoglobinopathies in North Africa: a review. Hemoglobin. 2010;34(1):1–23.

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