Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 44, 2020 - Issue 3
164
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Association of Hb A2 Variants with Several Forms of α- and β-Thalassemia in Thailand

ORCID Icon &
Pages 179-183 | Received 16 Apr 2020, Accepted 26 Apr 2020, Published online: 01 Jun 2020

References

  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014;42:D1063–D1069.
  • Piel FB, Weatherall DJ. The α-thalassemias. N Engl J Med. 2014;371(20):1908–1916.
  • Mankhemthong K, Phusua A, Suanta S, et al. Molecular characteristics of thalassemia and hemoglobin variants in prenatal diagnosis program in northern Thailand. Int J Hematol. 2019;110(4):474–481.
  • Saechan V, Nopparatana C, Nopparatana C, et al. Molecular basis and hematological features of hemoglobin variants in Southern Thailand. Int J Hematol. 2010;92(3):445–450.
  • Yimniam W, Jindadamrongwech S. Scanning for α-hemoglobin variants by high-resolution melting analysis. J Clin Lab Anal. 2016;30(5):633–640.
  • Fucharoen S, Winichagoon P. Haemoglobinopathies in Southeast Asia. Indian J Med Res. 2011;134(4):498–506.
  • Fucharoen S, Winichagoon P, Pootrakul P, et al. Variable severity of Southeast Asian β0-thalassemia/Hb E disease. Birth Defects Orig Artic Ser. 1987;23(5A):241–248.
  • Leung KF, Ma ES, Chan AY, et al. Clinical phenotype of Haemoglobin Q-H disease. J Clin Pathol. 2004;57(1):81–82.
  • Chaibunruang A, Fucharoen G, Fucharoen S. First description of a Hb A2 variant in Thailand. Identification of Hb A2-Melbourne [δ43(CD2)Glu→Lys] in Thai individuals. Hemoglobin. 2012;36(1):80–84.
  • Intasai N, Phasit A, Panyasai S, et al. A Case report of compound heterozygosity for β0/β+-Thalassemia resulting from under diagnosed β-thalassemia found in a Hb A2′ sample. Hemoglobin. 2019;43(1):63–65.
  • Nuinoon M, Jeenduang N, Kesornsit A, et al. Hematological and molecular characterization of a novel Hb A2 variant with homozygous α-thalassemia-2 in a Southern Thai Individual. Hemoglobin. 2017;41(3):213–215.
  • Panyasai S, Fucharoen G, Fucharoen S. Known and new Hemoglobin A2 variants in Thailand and implication for β-thalassemia screening. Clin Chim Acta. 2015;438:226–230.
  • Pornprasert S, Phusua A, Suanta S, et al. Detection of α-thalassemia-1 Southeast Asian type using real-time gap-PCR with SYBR Green1 and high resolution melting analysis. Eur J Haematol. 2008;80(6):510–514.
  • Pornprasert S, Wiengkum T, Srithep S, et al. Detection of α-thalassemia-1 Southeast Asian and Thai type deletions and β-thalassemia 3.5-kb deletion by single-tube multiplex real-time PCR with SYBR Green1 and high-resolution melting analysis. Korean J Lab Med. 2011;31(3):138–142.
  • Jomoui W, Panichchob P, Rujirachaivej P, et al. Coinheritance of Hb A2-Melbourne (HBD: c.130G>A) and Hb E (HBB: c.79G>A) in Laos and simultaneous high resolution melt detection of Hb A2-Melbourne and Hb A2-Lampang (HBD: c.142G>A) in a single tube. Hemoglobin. 2019;43(3):214–217.
  • Fucharoen S, Fucharoen G, Sanchaisuriya K, et al. Molecular analysis of a Thai β-thalassaemia heterozygote with normal Haemoglobin A2 level: implication for population screening. Ann Clin Biochem. 2002;39(Pt 1):44–49.
  • Fucharoen S, Sanchaisuriya K, Fucharoen G, et al. Interaction of Hemoglobin E and several forms of α-thalassemia in Cambodian families. Haematologica. 2003;88(10):1092–1098.
  • Old J, Harteveld CL, Traeger-Synodinos J, et al. Editors. Prevention of Thalassemias and other Haemoglobin Disorders. Vol. 2: Laboratory Protocols. Nicosia (Cyprus): Thalassemia International Federation; 2012.
  • Fucharoen G, Fucharoen S, Sanchaisuriya K, et al. Frequency distribution and haplotypic heterogeneity of βE-globin gene among eight minority groups of northeast Thailand. Hum Hered. 2002;53(1):18–22.
  • Chaibunruang A, Prommetta S, Yamsri S, et al. Molecular and hematological studies in a large cohort of α0-thalassemia in northeast Thailand: data from a single referral center. Blood Cells Mol Dis. 2013;51(2):89–93.
  • Waneesorn J, Panyasai S, Kongthai K, et al. Comparison between capillary electrophoresis and high performance liquid chromatography for detection and quantification of Hb constant spring [Hb CS; α142, Term→Gln (TAA>CAA in α2)]. Hemoglobin. 2011;35(4):338–345.
  • Oleske DA, Huang RS, Dasgupta A, et al. Higher sensitivity of capillary electrophoresis in detecting Hemoglobin A2′ compared to traditional gel electrophoresis. Ann Clin Lab Sci. 2014;44(3):291–293.
  • Spurdle AB, Krause A, Ramsay M, et al. The high frequency of the Hb B2 variant in the Herero population: a founder effect? Hemoglobin. 1994;18(4–5):317–323.
  • Bennani M, Mombo LE, Chaventre A, et al. Origin of Hb A2′ (Hb B2) [δ16(A13)Gly→Arg (GGC→CGC)]. Hemoglobin. 2003;27(2):105–110.
  • Daar S, Al Zadjali S, Gravell D, et al. Hb A2′ (Hb B2) in the Omani population and diagnostic significance. Hemoglobin. 2011;35(2):117–124.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.