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Hemoglobin
international journal for hemoglobin research
Volume 45, 2021 - Issue 4
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Eight Cases of Hb Winnipeg [HBA2: c.226G>T (or HBA1)]: A Detailed Study

Mohamed S.M. Khalila Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut Governorate, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4117-4299View further author information
ORCID Icon,
Adele T. Timbsb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, United KingdomView further author information
,
Shirley J. Hendersonb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, United KingdomView further author information
,
Anna Schuhc Molecular Haematology, Molecular Diagnostics Centre and Department of Oncology, Churchill Hospital, Oxford, Oxfordshire, United KingdomView further author information
&
John M. Oldb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, United KingdomView further author information
Pages 256-258 | Received 07 Jul 2021, Accepted 24 Aug 2021, Published online: 08 Sep 2021

References

  • Vella F, Wiltshire B, Lehmann H, et al. Hemoglobin Winnipeg: alpha2 75 Asp leads to Tyr beta2. Clin Biochem. 1973;6(2):66–70.
  • Nakatsuji T, Abraham BL, Lam H, et al. Hb Winnipeg or alpha 2 75(EF4)Asp leads to Tyr beta 2 in a large Caucasian family living in Georgia, USA. Hemoglobin. 1983;7(1):105–110.
  • Nakatsuji T, Carver J, Wilson JB, et al. alpha Chain and gamma chain abnormal hemoglobins in newborn babies: structural and genetic aspects. Am J Hematol. 1983;14(2):121–132.
  • Moradkhani K, Préhu C, Old J, et al. Mutations in the paralogous human α-globin genes yielding identical hemoglobin variants. Ann Hematol. 2009;88(6):535–543.
  • Khalil MSM, Timbs AT, Henderson SJ, et al. A wide spectrum study of α-globin chain variants: cases from the UK. Hemoglobin. 2020;44(3):195–200.
  • Basset P, Beuzard Y, Garel MC, et al. Isolectric focusing of human hemoglobin: its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins. Blood. 1978;51(5):971–982.
  • Khalil MS, Timbs A, Henderson S, et al. Haemoglobin (Hb) G-Philadelphia, Hb Stanleyville-II, Hb G-Norfolk, Hb Matsue-Oki and Hb Mizushi can form a panel of α-chain variants that overlap in their phenotype: the novel use of StyI to screen for Hb G-Philadelphia. Int J Lab Hematol. 2011;33(3):318–325.
  • Patrinos GP, Giardine B, Riemer C, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res. 2004;32(Database issue):D537–D541.
  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014;42(Database issue):D1063–D1069.
  • Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory. Clin Chem. 2004;50(10):1736–1747.
  • Szuberski J, Oliveira JL, Hoyer JD. A comprehensive analysis of hemoglobin variants by high-performance liquid chromatography (HPLC). Int J Lab Hematol. 2012;34(6):594–604.

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