Advanced search
Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 45, 2021 - Issue 5
Submit an article Journal homepage
104
Views
1
CrossRef citations to date
0
Altmetric
Short Communications

Eleven Cases of Hb J-Paris-I [HBA2: c.38C>A (or HBA1)]: A Stable α Chain Variant Elutes in the P3 Window on High-Performance Liquid Chromatography

Mohamed S.M. Khalila Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut Governorate, EgyptCorrespondence[email protected]
View further author information
,
Adele T. Timbsb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, UKView further author information
,
Shirley J. Hendersonb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, UKView further author information
,
Anna Schuhc Molecular Haematology, Molecular Diagnostics Centre and Department of Oncology, Churchill Hospital, Oxford, Oxfordshire, UKView further author information
&
John M. Oldb National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, UKView further author information
Pages 322-324 | Received 20 Sep 2021, Accepted 15 Oct 2021, Published online: 16 Nov 2021

References

  • Rosa J, Maleknia N, Vergoz D, et al. A new abnormal hemoglobin: hemoglobin Ja-Paris 12 ala–asp [in French]. Nouv Rev Fr Hématol. 1965;6(3):423–426.
  • Trincao C, De Melo JM, Lorkin PA, et al. Haemoglobin J Paris in the south of Portugal (Algarve). Acta Haematol. 1968;39(5):291–298.
  • Rahbar S, Sooudi H, Daneshmand P. Hemoglobin J Paris (α12 alanine→aspartic acid) in two Iranian families. Acta Haematol. 1972;47(1):43–48.
  • Niazi GA, Efremov GD, Nikolov N, et al. Hemoglobin-Strumica or alpha 2 112(G19) His replaced by Arg beta 2. (With an addendum: hemoglobin-J-Paris-I, alpha 2 12(A10) Ala replaced by Asp beta 2, in the same population). Biochim Biophys Acta. 1975;412(1):181–186.
  • Marinucci M, Mavilio F, Tentori L, et al. Occurrence of Hb J Paris in an Italian family and recombination studies on the free abnormal α-chain. Hemoglobin. 1979;3(6):465–469.
  • Dash S, Huisman THJ. First observation of hemoglobin J Paris I [alpha-2-12(A10)alanine-aspartic acid beta-2] in the Indian subcontinent. Acta Haematol. 1988;79(2):117.
  • Moradkhani K, Préhu C, Old J, et al. Mutations in the paralogous human alpha-globin genes yielding identical hemoglobin variants. Ann Hematol. 2009;88(6):535–543.
  • de la Fuente-Gonzalo F, Nieto JM, Villegas A, et al. Characterization of deletional and non-deletional alpha globin variants in a large cohort from Spain between 2009 and 2014. Ann Hematol. 2019;98(7):1537–1545.
  • Khalil MSM, Timbs AT, Henderson SJ, et al. A wide spectrum study of α-globin chain variants: cases from the UK. Hemoglobin. 2020;44(3):195–200.
  • Basset P, Beuzard Y, Garel MC, et al. Isolectric focusing of human hemoglobin: its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins. Blood. 1978;51(5):971–982.
  • Khalil MS, Timbs A, Henderson S, et al. Haemoglobin (Hb) G-Philadelphia, Hb Stanleyville-II, Hb G-Norfolk, Hb Matsue-Oki and Hb Mizushi can form a panel of α-chain variants that overlap in their phenotype: the novel use of StyI to screen for Hb G-Philadelphia. Int J Lab Hematol. 2011;33(3):318–325.
  • Patrinos GP, Giardine B, Riemer C, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res. 2004;32(Database issue):D537–D541.
  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014;42(Database issue):D1063–D1069.
  • Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory. Clin Chem. 2004;50(10):1736–1747.
  • Szuberski J, Oliveira JL, Hoyer JD. A comprehensive analysis of hemoglobin variants by high-performance liquid chromatography (HPLC). Int J Lab Hematol. 2012;34(6):594–604.
  • Nakatsuji T, Abraham BL, Lam H, et al. Hb Winnipeg or α2 75(EF4)Asp→TγRβ2 in a large Caucasian family living in Georgia, USA. Hemoglobin. 1983;7(1):105–110.
  • Nakatsuji T, Carver J, Wilson JB, et al. Alpha chain and gamma chain abnormal hemoglobins in newborn babies: structural and genetic aspects. Am J Hematol. 1983;14(2):121–132.
  • Giordano PC, Maatman RG, Niessen RW, et al. Beta thalassemia IVS-I-5(G- ->C) heterozygosity masked by the presence of HbJ-Meerut in a Dutch-Indian patient. Haematologica. 2006;91(12 Suppl):ECR56.
  • Dungul DC, Ozdag H, Akar N. Hemoglobin alpha 2 gene +861 G>A polymorphism in Turkish population. Egyptian J Med Hum Genet. 2011;12(1):59–62.
  • Gupta M, Thalquotra M, Rao P. P3 Fraction: effect on HbA1c values by HPLC. J Clin Diagn Res. 2016;10(9):BC12–BC14.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.