Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 45, 2021 - Issue 5
109
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Spectrum of β-Thalassemia Mutations in Some Areas of Guangxi Zhuang Autonomous Region of Southern China: A Study on a Pediatric Population Aged 0–15 Years

, , , , , , , & show all
Pages 318-321 | Received 01 Jul 2021, Accepted 19 Jan 2022, Published online: 06 May 2022

References

  • Bank A. The thalassemia syndromes. Blood. 1978;51(3):369–384.
  • Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704–712.
  • Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010;5:11.
  • Giardine BM, Joly P, Pissard S, et al. Clinically relevant updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2021;49(D1):D1192–D1196.
  • Cao A, Galanello R. Beta-thalassemia. Genet Med. 2010;12(2):61–76.
  • Aydinok Y. Thalassemia. Hematology. 2012;17(Suppl 1):S28–S31.
  • Taher AT, Weatherall DJ, Cappellini MD. Thalassaemia. Lancet. 2018;391(10116):155–167.
  • Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann NY Acad Sci. 1998;850:251–269.
  • Lai K, Huang G, Su L, et al. The prevalence of thalassemia in mainland China: evidence from epidemiological surveys. Sci Rep. 2017;7(1):920.
  • Xiong F, Sun M, Zhang X, et al. Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang Autonomous Region of southern China. Clin Genet. 2010;78(2):139–148.
  • Zheng C-G, Liu M, Du J, et al. Molecular spectrum of α- and β-globin gene mutations detected in the population of Guangxi Zhuang Autonomous Region, People's Republic of China. Hemoglobin. 2011;35(1):28–39.
  • Tang W, Zhang C, Lu F, et al. Spectrum of α-thalassemia and β-thalassemia mutations in the Guilin Region of southern China. Clin Biochem. 2015;48(16–17):1068–1072.
  • Pan HF, Long GF, Li Q, et al. Current status of thalassemia in minority populations in Guangxi, China. Clin Genet. 2007;71(5):419–426.
  • Cai R, Li L, Liang X, et al. [Prevalence survey and molecular characterization of alpha and beta thalassemia in Liuzhou city of Guangxi.] [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23(4):281–285.
  • Li B, Han X, Ma J, et al. Mutation spectrum and erythrocyte indices characterisation of α-thalassaemia and β-thalassaemia in Sichuan women in China: a thalassaemia screening survey of 42,155 women. J Clin Pathol. 2021;74(3):182–186.
  • Zhao Y, Jiang F, Li D-Z. Hematological characteristics of β-globin gene Mutation -50 (G>A) (HBB: c.-100G>A) Carriers in Mainland China. Hemoglobin. 2020;44(4):240–243.
  • Xu L-L, Yang Y, Zhen L, et al. The trend in timing of prenatal diagnosis for thalassemia at a Chinese Tertiary obstetric center. Hemoglobin. 2020;44(5):325–328.
  • Tan J-R, Li W-J, Ma J-Y, et al. [Molecular epidemiological study of alpha- and beta- thalassemia in Sihui city.] [in Chinese]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23(7):716–719.
  • Miri-Moghaddam E, Bahrami S, Naderi M, et al. Molecular characterization of β-thalassemia intermedia in Southeast Iran. Hemoglobin. 2016;40(3):173–178.
  • Alibakhshi R, Moradi K, Aznab M, et al. The spectrum of β-thalassemia mutations in Hamadan Province, West Iran. Hemoglobin. 2019;43(1):18–22.
  • Yılmaz S. The spectrum of β-thalassemia mutations in Siirt Province, Southeastern Turkey. Hemoglobin. 2019;43(3):174–181.
  • Sirdah MM, Sievertsen J, Al-Yazji MS, et al. The spectrum of β-thalassemia mutations in Gaza Strip. Palestine. Blood Cells Mol Dis. 2013;50(4):247–251.
  • Shrivastava M, Bathri R, Chatterjee N. Mutational analysis of thalassemia in transfusion-dependent beta-thalassemia patients from central India. Asian J Transfus Sci. 2019;13(2):105–109.
  • Yang Z, Cui Q, Zhou W, et al. Comparison of gene mutation spectrum of thalassemia in different regions of China and Southeast Asia. Mol Genet Genomic Med. 2019;7(6):e680.
  • Lin Y-H, Lin W, Wang X-X. [Genotyping of patients with α and β thalassemia in Fujian Province area in China]. [in Chinese]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(3):899–903.
  • Li M, Xiang S-H, Ding Y, et al. [Genotype Analysis of Patients with Thalassemia in Sanya Area of Hainan Province in China]. [in Chinese] Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26(4):1146–1150.
  • Yu X, Yang L-Y, Yang H-T, et al. Molecular epidemiological investigation of thalassemia in the Chengdu region, Sichuan Province, Southwest China. Hemoglobin. 2015;39(6):393–397.
  • Yao X-Y, Zhang Y-M, Qin Z-Z, et al. [Prevalence and molecular analysis of β-thalassemia in children of Han ethnicity in Chongqing city.] [in Chinese]. Zhonghua Er Ke Za Zhi. 2013;51(7):518–522.
  • Huang S-W, Liu X-M, Li G-F, et al. Spectrum of β-thalassemia mutations in Guizhou Province, PR China, including first observation of codon 121 (GAA>TAA) in Chinese population. Clin Biochem. 2013;46(18):1865–1868.
  • Liu Q, Jia Z-J, Xi H, et al. [Analysis on the genotype of 5018 cases of thalassemia in Hunan area.] [in Chinese]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(6):1938–1942.
  • Qiu X-Q, Chen P, Zhang N, et al. [Study on the incidence of β-thalassemia and genotypes among children under 7 year-olds in Nanning, Liuzhou and Baise areas, Guangxi province.] [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30(10):1021–1024.
  • He S, Qin Q, Yi S, et al. Prevalence and genetic analysis of α- and β-thalassemia in Baise region, a multi-ethnic region in southern China. Gene. 2017;619:71–75.
  • He S, Li J, Li DM, et al. Molecular characterization of α- and β-thalassemia in the Yulin region of Southern China. Gene. 2018;655:61–64.
  • Ye L-H, Pan H-J, Hu J-Y, et al. [Analysis of gene mutation types in 920 cases of thalassemia.] [in Chinese]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(2):545–548.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.