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Research Article

Conjugates of Unsaturated Fatty Acids with Propylene Glycol as Potentially Less-Irritant Skin Penetration Enhancers

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Pages 1169-1175 | Published online: 25 Sep 2008

REFERENCES

  • Arellano A., Santoyo S., Martín C., Ygartua P. Influence of propylene glycol and isopropyl myristate on the in vitro percutaneous penetration of diclofenac sodium from carbopol gels. Eur. J. Pharm. Sci. 1999; 7: 129–135
  • Aungst B. J. Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants. Pharm. Res. 1989; 6: 244–247
  • Aungst B. J., Rogers N. J., Shefter E. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides, and amides. Int. J. Pharm. 1986; 33: 225–234
  • Bendas B., Schmalfuss U., Neubert R. Influence of propylene glycol as cosolvent on mechanisms of drug transport from hydrogels. Int. J. Pharm. 1995; 116: 19–30
  • Ben-Shabat S., Benisty R., Wormser U., Sintov A. C. Vitamin D3-based conjugates for topical treatment of psoriasis: Synthesis, antiproliferative activity, and cutaneous penetration studies. Pharm. Res. 2005; 22: 50–57
  • Buyuktimkin N., Buyuktimkin S., Rytting J. H. Chemical means of transdermal drug permeation enhancement. Transdermal and topical drug delivery systems, T. K. Ghosh, W.R. Pfister, S.I. Yum. Interpharm Press, Inc., Buffalo Grove, , IL 1997; 357–475
  • Finnin B. C., Morgan T. M. Transdermal penetration enhancers: Application, limitation, and potential. J. Pharm. Sci. 1999; 88: 955–958
  • Kanicky J. R., Shah D. O. Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids. J. Colloid Interface. Sci. 2002; 256: 201–207
  • Kanikkannan N., Kandimalla K., Lamba S. S., Singh M. Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery. Curr. Med. Chem. 2000; 7: 593–608
  • Loftsson T., Gudmundsdóttir T. K., Fridriksdóttir H., Sigurdaróttir A. M., Thorkelsson J., Gudmundsson G., Hjaltason B. Fatty acids from cod-liver oil as skin penetration enhancers. Pharmazie 1995; 50: 188–190
  • Loftsson T., Thormar H., Ólafsson J. H., Gunnarsdóttir T. M., Hjaltason B., Gudmundsson G. Fatty acid extract from cod-liver oil: Activity against herpes simplex virus and enhancement of transdermal delivery of acyclovir in-vitro. Pharm. Pharmacol. Commun. 1998; 4: 287–291
  • Naik A., Pechtold L. A. R. M., Potts R. O., Guy R. H. Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans. J. Control. Release 1995; 37: 299–306
  • Oh S. Y., Jeong S. Y., Park T. G., Lee J. H. Enhanced transdermal delivery of AZT (zidovudine) using iontophoresis and penetration enhancer. J. Control. Release 1998; 51: 161–168
  • Okamoto H., Muta K., Hashida M., Sezaki H. Percutaneous penetration of acyclovir through excised hairless mouse and rat skin; Effect of vehicle and percutaneous penetration enhancer. Pharm. Res. 1990; 7: 64–68
  • Ongpipattanakul B., Burnette R. R., Potts R. O., Francoeur M. L. Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm. Res. 1991; 8: 350–354
  • Santoyo S., Ygartua P. Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application. Eur. J. Pharm. Biopharm. 2000; 50: 245–250
  • Sasaki H., Kojima M., Nakamura J., Shibasaki J. Acute toxicity and skin irritation of pyrrolidone derivatives as transdermal penetration enhancer. Chem. Pharm. Bull. 1990; 38: 2308–2310
  • Sintov A., Ze'evi A., Uzan R., Nyska A. Influence of pharmaceutical gel vehicles containing oleic/sodium oleate combinations on hairless mouse skin, a histological evaluation. Eur. J. Pharm. Biopharm. 1999; 47: 299–303
  • Sintov A. C., Behar-Canetti C., Friedman Y., Tamarkin D. Percutaneous penetration and skin metabolism of ethylsalicylate-containing agent, TU-2100: in vitro and in vivo evaluation in guinea pigs. J. Control. Rel. 2002; 79: 113–122
  • Sintov A. C., Botner S. Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. Int. J. Pharm. 2006a; 311: 55–62
  • Sintov A. C., Brandys-Sitton R. Facilitated skin penetration of lidocaine by using a combination of iontophoresis and microemulsion-based formulation. Int. J. Pharm. 2006b; 19: 58–67
  • Sintov A. C., Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J. Control. Rel. 2004; 95: 173–183
  • Smith E. W., Maibach H. I. Percutaneous penetration enhancers. CRC Press, Boca Raton, , FL 1995
  • Squillante E., Needham T., Maniar A., Kislalioglu S., Zia H. Codiffusion of propylene glycol and dimethyl isosorbide in hairless mouse skin. Eur. J. Pharm. Biopharm. 1998; 46: 265–271
  • Touitou E., Godin B., Karl Y., Bujanover S., Becker Y. Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes. J. Control. Release 2002; 80: 1–7
  • Walters K. A. Penetration enhancers and their use in transdermal therapeutic systems. Transdermal drug delivery, developmental issues and research initiatives, J. Hadgraft, R. H. Guy. Marcel Dekker, Inc, New York 1989; 197–246
  • Williams A. C., Barry B. W. Penetration enhancers. Adv. Drug Del. Rev. 2004; 56: 603–618

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