795
Views
81
CrossRef citations to date
0
Altmetric
Research Article

Current Therapies and Technological Advances in Aqueous Aerosol Drug Delivery

, &
Pages 913-922 | Published online: 20 Oct 2008

REFERENCES

  • P. J. Anderson. (2001). Delivery options and devices for aerosolized therapeutics. Chest 120 (S3):89S–93S.
  • P. Bartram. (2005). Use of a micropump nebulizer for aerosolized medication delivery in a ventilated infant. Neonatal Intensive Care 18 (1):14.
  • P. K. P. Burnell, L. Asking, L. Borgstrom, S. C. Nichols, B. Olsson, D. Prime, and et al. (2007). Studies of the human oropharyngeal airspaces using magnetic resonance imaging IV – the oropharyngeal retention effect for four inhalation delivery systems. J. Aerosol. Med. 20 (3):269–281.
  • D. Cipolla, B. Boyd, R. Evans, S. Warren, G. Taylor, and S. Farr. (2000). Bolus administration of INS365: Studying the feasibility of delivering high dose drugs using the AERX pulmonary delivery system. Respir. Drug Deliv. 7:231–239.
  • M. Cloupeau, and B. Prunet-Foch. (1989). Electrostatic spraying of liquids in cone-jet mode. J. Electron. 22:135–159.
  • T. E. Corcoran, J. H. Dauber, N. Chigier, and A. T. Iacono. (2002). Improving drug delivery from medical nebulizers: The effects of increased nebulizer flow rates and reservoirs. J. Aerosol Med. 15 (3):271–282.
  • R. N. Dalby, M. Spallek, and T. Voshaar. (2004). A review of the development of respimat soft mist inhaler. Int. J. Pharm. 283:1–9.
  • W. H. DeHaan, and W. H. Finlay. (2001). In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices. J. Aerosol Med. 14 (3):361–367.
  • J. Denyer, K. Nikander, and N. J. Smith. (2004). Adaptive aerosol delviery (AAD) technology. Expert Opinion Drug Deliv. 1 (1):165–176.
  • D. S. Deshpande, J. D. Blanchard, J. Schuster, D. Fairbanks, C. Hobbs, R. Beihn, and et al. (2005). Gamma scintigraphic evaluation of a miniaturized AERx pulmonary delivery system for aerosol delivery to anesthetized animals using a positive pressure ventilation system. J. Aerosol Med. 18 (1):34–44.
  • D. Deshpande, J. Blanchard, S. Srinivasan, D. Fairbanks, J. Fujimoto, T. Sawa, and et al. (2002). Aerosolization of lipoplexes using AERx pulmonary delivery system. AAPS PharmSci 4 (3):1–10.
  • J. F. Dessanges. (2001). A history of nebulization. J. Aerosol Med. 14:65–71.
  • R. Dhand. (2005). Aerosol plumes: Slow and steady wins the race. J. Aerosol Med. 18 (3):261–263.
  • A. M. A. Elhissi, M. Faizi, W. F. Naji, H. S. Gill, and K. M. G. Taylor. (2007). Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures. Int. J. Pharm. 334:62–70.
  • A. M. A. Elhissi, and K. M. G. Taylor. (2005). Delivery of liposomes generated from proliposomes using air-jet, ultrasonic, and vibrating-mesh nebulisers. J. Drug Deliv. Sci. Technol. 15 (4):261–265.
  • S. Farr, S. Warren, P. Lloyd, J. Okikawa, J. Schuster, A. Rowe, and et al. (2000). Comparison of in vitro and in vivo efficiencies of a novel unit-dose liquid aerosol generator and a pressurized metered dose inhaler. Int. J. Pharm. 198:63–70.
  • S. J. Farr, A. McElduff, L. E. Mather, J. Okikawa, M. E. Ward, I. Gonda, and et al. (2000). Pulmonary insulin administration using the AERx® system: Physicological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects. Diabetes Technol. Ther. 2:185–197.
  • W. H. Finlay, C. F. Lange, M. King, and D. P. Speert. (2000). Lung delivery of aerosolized dextran. Am. J. Respir. Crit. Care Med 161:91–97.
  • W. H. Finlay, and A. R. Martin. (2007). Modeling of aerosol deposition with interface devices. J. Aerosol Med. 20 (S1):S19–S28.
  • D. Geller, J. Thipphawong, B. Otulana, D. Caplan, D. Ericson, L. Milgram, and et al. (2003). Bolus inhalation of rhDNase with the AERx system in subjects with cystic fibrosis. J. Aerosol Med. 16 (2):175–182.
  • T. Ghazanfari, A. M. A. Elhissi, Z. Ding, and K. M. G. Taylor. (2007). The influence of fluid physicochemical properties on vibrating-mesh nebulization. Int. J. Pharm. 339:103–111.
  • B. K. Gurses, and G. C. Smaldone. (2003). Effect of tubing depostion, breathing pattern, and temperature on aerosol mass distribution measured by cascade impactor. J. Aerosol Med. 16 (4):387–394.
  • R. R. Henry, S. R. D. Mudaliar, W. C. Howland, N. Chu, D. Kim, B. An, and et al. (2003). Inhaled insulin using the AERx insulin diabetes management system in healthy and asthmatic subjects. Diabetes Care 26:764–769.
  • K. Hermansen, T. Ronnemaa, A. H. Petersen, S. Bellaire, and U. Adamson. (2004). Intensive therapy with inhaled insulin via the AERx insulin diabetes management system. Diabetes Care 27 (1):162–167.
  • D. R. Hess, D. Fisher, P. Williams, S. Pooler, and R. M. Kacmarek. (1996). Medication nebulizer performance. Effects of diluant volume. Chest 110 (2):498–505.
  • M. Hindle. Soft mist inhalers: A review of current technology The Drug Delivery Companies Report(Autumn/Winter). (2004), 31–34.
  • S. L. Ho, W. T. J. Kwong, L. O'Drowsky, and A. L. Coates. (2001). Evaluation of four breath-enhanced nebulizers for home use. J. Aerosol Med. 14 (4):467–475.
  • D. Hochrainer, H. Holz, C. Kreher, L. Scaffidi, M. Spallek, and H. Wachtel. (2005). Comparison of the aerosol velocity and spray duration of Respimat Soft Mist Inhaler and pressurized metered dose inhalers. J. Aerosol Med. 18 (3):273–282.
  • C. Kapitza, M. Hompesch, B. Scharling, and T. Heise. (2004). Intrasubject variability of inhaled insulin in type 1 diabetes: a comparison with subcutaneous insulin. Diabetes Technol. Ther. 6 (4):466–472.
  • F. Kassner, R. Hodder, and E. D. Bateman. (2004). A review of ipratropium bromide/fenoterol hydrobromide (Berodual) delivered Via Respimat Soft Mist Inhaler in patients with asthma and chronic obstructive pulmonary disease. Drugs 64 (15):1671–1682.
  • S. A. Kilfeather, H. H. Pointz, E. Beck, P. Schmidt, A. Lee, I. Bowen, and et al. (2004). Improved delivery of ipratropium bromide/fenoterol from respimat soft mist inhaler in patients with COPD. Respir. Med. 98 (5):387–397.
  • E. Kohler, V. Sollich, R. Schuster-Wonka, and J. Huhnerbein. (2003). Lung deposition in cystic fibrosis patients using an ultrasonic or a jet nebulizer. J. Aerosol Med. 16 (1):37–46.
  • N. V. Koshkina, E. Golunski, L. E. Roberts, B. E. Gilbert, and V. Knight. (2004). Cyclosporin a aerosol improves the anticancer effect of paclitaxel aerosol in mice. J. Aerosol Med. 17 (1):7–14.
  • C. F. Lange, and W. H. Finlay. (2006). Liquid atomizing: Nebulizing and other methods of producing aerosols. J. Aerosol Med. 19 (1):28–35.
  • B. L. Laube. (2001). Treating diabetes with aerosolized insulin. Chest 120 (3):S99–S106.
  • Y. K. Lentz, T. J. Anchordoquy, and C. S. Lengsfeld. (2006). Rationale for the selection of an aerosol delivery system for gene delivery. J. Aerosol Med. 19 (3):372–384.
  • Y. K. Lentz, L. R. Worden, T. J. Anchordoquy, and C. S. Lengsfeld. (2005). Effect of jet nebulization on DNA: Identifying the dominant degradation mechanism and mitigation methods. Aerosol Sci. 36:973–990.
  • K. Leung, E. Louca, and A. L. Coates. (2004). Comparison of breath-enhanced to breath-actuated nebulizers for rate, consistency, and efficiency. Chest 126 (5):1619–1627.
  • J. Lynch, N. Behan, and C. Birkinshaw. (2007). Factors controlling particle size during nebulization of DNA-polycation complexes. J. Aerosol Med. 20 (3):257–268.
  • L. E. Mather, A. Woodhouse, M. E. Ward, S. J. Farr, R. Rubsamen, and L. G. Eltherington. (1998). Pulmonary administration of aerosolised fentanyl: Pharmacokinetic analysis of systemic delivery. Br. J. Clin. Pharmacol. 46:37–43.
  • O. N. M. McCallion, K. M. G. Taylor, P. A. Bridges, M. Thomas, and A. J. Taylor. (1996). Jet nebulisers for pulmonary drug delivery. Int. J. Pharm. 130:1–11.
  • S. McGuire. (2006). The I-neb adaptive aerosol delivery (AAD) system – a holistic approach to inhaled drug delivery including regulatory approval. Drug Deliv. Rep., (Spring/Summer) 6:8–71.
  • T. T. Mercer. (1981). Production of therapeutic aerosols: Principles and techniques. Chest 80 (6 suppl):813–818.
  • C. Mitsakou, C. Helmis, and C. Housiadas. (2005). Eulerian modeling of lung deposition with sectional representation of aerosol dynamics. Aerosol Sci. 36:75–94.
  • S. P. Newman, J. Brown, K. P. Steed, S. J. Reader, and H. Kladders. (1998). Lung deposition of fenoterol and flunisolide delivered using a novel device for inhaled medicines: Comparison of Respimat with conventional metered-dose inhalers with and without spacer devices. Chest 113:957–963.
  • S. Newman, and A. Gee-Turner. (2005). The omron MicroAir vibrating mesh technology nebulizer, a 21st century approach to inhalation therapy. J. Appl. Ther. Res 5 (4):29–33.
  • S. P. Newman, D. Pavia, F. Moren, N. F. Sheahan, and S. W. Clarke. (1981). Deposition of pressurised aerosols in the human respiratory tract. Thorax 36:52–55.
  • S. P. Newman, K. P. Steed, M. Phil, S. J. Reader, D. Pavia, and A. K. Sohal. (2007). An in vitro study to assess facial and ocular deposition from Respimat Soft Mist Inhaler. J. Aerosol Med. 20 (1):7–12.
  • K. Nikander, L. Arheden, J. Denyer, and N. Cobos. (2003). Parents’ adherence with nebulizer treatment of their children when using an adaptive aerosol delivery (AAD) system. J. Aerosol Med. 16 (3):2003.
  • K. Nikander, J. Denyer, M. Everard, and G. C. Smaldone. (2000). Validation of a new breathing simulator generating and measuring inhaled aerosol with adult breathing patterns. J. Aerosol Med. 13 (2):139–146.
  • K. Nikander, J. Denyer, N. Smith, and P. Wollmer. (2001). Breathing patterns and aerosol delivery: Impact of regular human patterns, and sine and square waveforms on rate of delivery. J. Aerosol Med. 14 (3):327–333.
  • L. V. None, D. Grimbert, J. Bordenave, G. Benoit, Y. Furet, B. Fauroux, and et al. (2004). Residual gravimetric method to measure nebulizer output. J. Aerosol Med. 17 (1):63–71.
  • F. W. Okumu, R. Y. Lee, J. D. Blanchard, A. Queirolo, C. M. Woods, P. M. Lloyd, and et al. (2002). Evaluation of the AERx pulmonary delivery system for the systemic delivery of a poorly soluble selective D-1 agonist ABT-431. Pharm. Res. 19 (7):1009–1012.
  • C. O'Callaghan, and P. W. Barry. (1997). The science of nebulised drug delivery. Thorax 52:31–44.
  • C. O'Callaghan, and P. Wright. The metered dose inhaler. Drug delivery to the lungC. Bisgaard, C. O'Callaghan, and G. C. Smaldone. Marcel Dekker, New York, (2002), 337–370.
  • K. M. Pedersen, V. N. Handlos, L. Heslet, and G. Kristensen. (2006). Factors influencing the in vitro deposition of tobramycin aerosol: A comparison of an ultrasonic nebulizer and a high-frequency vibrating mesh nebulizer. J. Aerosol Med. 19 (2):175–183.
  • G. R. Pitcairn, S. J. Reader, D. Pavia, and S. P. Newman. (2005). Deposition of corticosteroid aerosol in the human lung by Respimat Soft Mist Inhaler compared to deposition by metered dose inhaler or Turbuhaler Dry Powder Inhaler. J. Aerosol Med. 18 (3):264–272.
  • R. Potter, I. Prince, T. Dyche, R. H. M. Hatley, and N. J. Smith. (2005). Abstracts from the international society for aerosols in medicine. J. Aerosol Med. 18 (1):112–113.
  • A. P. Roth, C. F. Lange, and W. H. Finlay. (2003). The effect of breathing pattern on nebulizer drug delivery. J. Aerosol Med. 16 (3):325–329.
  • S. Sanjar, and J. Matthews. (2001). Treating systemic diseases via the lung. J. Aerosol Med. 14 (S1):S51–S58.
  • K. G. Schuepp, J. Jauernig, H. M. Janssens, H. A. W. M. Tiddens, D. A. Straub, R. Stangl, and et al. (2005). In vitro determination of the optimal particle size for nebulized aerosol delivery to infants. J. Aerosol Med. 18 (2):225–235.
  • J. Schuster, S. Farr, D. Cipolla, T. Wilbanks, J. Rosell, P. Lloyd, and et al. (1998). Design performance validation of a highly efficient and reproducible compact aerosol delivery system: AERx®. Respir.Drug Deliv. 6:83–90.
  • J. Schuster, R. Rubsamen, P. Lloyd, and J. Lloyd. (1997). The AERx® aerosol delivery system. Pharm. Res. 14 (3):354–357.
  • J. Shaw. (2004). Aerogen impacts pulmonary drug delivery in the acute care setting. Drug Deliv. Technol. 4 (6):1–3.
  • V. L. Silkstone, J. H. Dennis, C. A. Pieron, and H. Chrystyn. (2002). An investigation of in vitro/in vivo correlations for salbutamol nebulized by eight systems. J. Aerosol Med. 15 (3):251–259.
  • G. C. Smaldone. (2006). Advances in aerosols: Adult respiratory disease. J. Aerosol Med. 19 (1):36–46.
  • K. Smith. (2004). The advantages of nebulization in the treatment of mechanically ventilated neonates. Neonatal Intensive Care 17 (3):12–16.
  • E. C. Smith, J. Denyer, and A. H. Kendrick. (1995). Comparison of twenty-three nebulizer/compressor combinations in domiciliary use. Eur. Respir. J. 8:1214–1221.
  • M. Spallek, D. Hochrainer, and H. Wachtel. (2002). Optimizing nozzles for soft mist inhalers. Respir. Drug Deliv. 8 (2):375–378.
  • K. M. G. Taylor, and O. N. M. McCallion. (1997). Ultrasonic nebulisers for pulmonary drug delivery. Int. J. Pharm. 153:93–104.
  • J. B. Thipphawong, N. Babul, R. J. Morishige, H. K. Findlay, K. R. Reber, G. J. Millward, and et al. (2003). Analgesic efficacy of inhaled morphine in patients after bunionectomy surgery. Anesthesiology 99 (3):693–700.
  • R. E. Van Dyke, and K. Nikander. (2007). Delivery of Iloprost inhalation solution with the HaloLite, Prodose, and I-neb adaptive aerosol delivery systems: An in vitro study. Respir. Care 52 (2):184–190.
  • T. Voshaar, R. Lapidus, R. Maleki-Yazdi, W. Timmer, E. Rubin, L. Lowe, and et al. (2006). A randomised study of tiotropium Respimat Soft Mist Inhaler versus ipratropium pMDI in chronic obstructive pulmonary disease. Thorax 61 (S2):ii40.
  • A. Wagner, K. Vorauer-Uhl, and H. Katinger. (2006). Nebulization of liposomal rh-cu/zn-SOD with a novel vibrating membrane nebulizer. J. Liposome Res. 16:113–125.
  • J. C. Waldrep. (1998). New aerosol drug delivery systems for the treatment of immune-mediated pulmonary diseases. Drugs Today 34 (6):549–561.
  • J. C. Waldrep, A. Berlinski, and R. Dhand. (2007). Comparative analysis of methods to measure aerosols generated by a vibrating mesh nebulizer. J. Aerosol Med. 20 (3):310–319.
  • M. E. Ward, A. Woodhouse, L. E. Mather, S. J. Farr, J. Okikawa, P. Lloyd, and et al. (1997). Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system. Clinical Pharmacol. Ther. 62 (6):596–609.
  • L. Williams. Novel pulmonary delivery technology [electronic version]. Pharma-Mag.. (2007), 4–5.
  • L. Wilson, R. Simmons, and P. S. Uster. Aerosol characteristics of adeno-associated viral vectors produced by an electronic micropump inhaler, Poster presented at the Cystic Fibrosis Foundation Meeting, (2003)
  • Pieber Wollmer, T. R. M. Gall, and S. Brunton. (2007). Delivering needle-free insulin using AERx iDMS technology. Diabetes Technol. Ther. 9 (Suppl 1):S57–S63.
  • B. M. Z. Zainudin, M. Biddiscombe, S. E. J. Tolfree, M. Short, and S. G. Spiro. (1990). Comparison of bronchodilator responses and deposition patterns of salbutamol inhaled from a pressurised metered dose inhaler, as a dry powder, and as a nebulised solution. Thorax 45:469–473.
  • W. C. Zimlich, J. Y. Ding, D. R. Busick, R. R. Moutvic, M. E. Placke, P. H. Hirst, and et al. (2000). The development of a novel electrohydrodynamic pulmonary drug delivery device. Respir. Drug Deliv. 7:241–246.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.