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Research Article

Formulating a Sulfonated Antiviral Dendrimer in a Vaginal Microbicidal Gel Having Dual Mechanisms of Action

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Pages 515-524 | Published online: 01 May 2009

REFERENCES

  • S. R. Abner, P. C. Guenthner, J. Guarner, K. A. Hancock, J. E. CumminsJr., A. Fink, G. T. Gilmore, C. Staley, A. Ward, O. Ali, S. Binderow, S. Cohen, L. A. Grohskopf, L. Paxton, C. E. Hart, and C. S. Dezzutti. (2005). A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J. Infect. Dis. 192:1545–1556.
  • E. Adriaens, and J. P. Remon. (2008). Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex. Transm. Dis. 35:512–516.
  • S. A. Ballagh, V. Brache, C. Mauck, M. M. Callahan, L. Cochon, A. Wheeless, and T. R. Moench. (2008). A phase I study of the functional performance, safety and acceptability of the BufferGel Duet. Contraception 77:130–137.
  • D. I. Bernstein, L. R. Stanberry, S. Sacks, N. K. Ayisi, Y. H. Gong, J. Ireland, R. J. Mumper, G. Holan, B. Matthews, T. McCarthy, and N. Bourne. (2003). Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes. Antimicrob. Agents Chemother. 47:3784–3788.
  • R. A. Cone, T. Hoen, X. Wong, R. Abusuwwa, D. J. Anderson, and T. R. Moench. (2006). Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect. Dis. 6:90.
  • J. E. CumminsJr., J. Guarner, L. Flowers, P. C. Guenthner, J. Bartlett, T. Morken, L. A. Grohskopf, L. Paxton, and C. S. Dezzutti. (2007). Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrob. Agents Chemother. 51:1770–1779.
  • S. P. Dimitonova, S. T. Danova, J. P. Serkedjieva, and B. V. Bakalov. (2007). Antimicrobial activity and protective properties of vaginal lactobacilli from healthy Bulgarian women. Anaerobe 13:178–184.
  • G. Flemstrom, A. Hallgren, O. Nylander, L. Engstrand, E. Wilander, and A. Allen. (1999). Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo. Am. J. Physiol. 277:G375–G382.
  • E. Gong, B. Matthews, T. McCarthy, J. Chu, G. Holan, J. Raff, and S. Sacks. (2005). Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses. Antiviral Res. 68:139–146.
  • G. J. Howlett, A. P. Minton, and G. Rivas. (2006). Analytical ultracentrifugation for the study of protein association and assembly. Curr. Opin. Chem. Biol. 10:430–436.
  • Y. H. Jiang, P. Emau, J. S. Cairns, L. Flanary, W. R. Morton, T. D. McCarthy, and C. C. Tsai. (2005). SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6p in macaques. AIDS Res. Hum. Retroviruses 21:207–213.
  • M. J. Joralemon, R. K. O'reilly, C. J. Hawker, and K. L. Wooley. (2005). Shell click-crosslinked (SCC) nanoparticles: A new methodology for synthesis and orthogonal functionalization. J. Am. Chem. Soc. 127:16892–16899.
  • C. Lackman-Smith, C. Osterling, K. Luckenbaugh, M. Mankowski, B. Snyder, G. Lewis, J. Paull, A. Profy, R. G. Ptak, R. W. BuckheitJr., K. M. Watson, J. E. CumminsJr., and B. E. Sanders-Beer. (2008). Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides. Antimicrob. Agents Chemother. 52:1768–1781.
  • C. Lacey. (2008). Unacceptable side effects of a hyperosmolar vaginal microbicide in a Phase I trial. Microbicides 2008 B08–B527. Abstract
  • L. Liu, P. Li, and S. A. Asher. (1999). Entropic trapping of macromolecules by mesoscopic periodic voids in a polymer hydrogel. Nature 397:141–144.
  • D. S. MacLean-McDavitt, J. D. Robertson, and M. Jay. (2003). Monitoring the in vivo delivery of proteins from carbomer hydrogels by X-ray fluorescence. Pharm. Res. 20:435–441.
  • R. A. Maguire, N. Bergman, and D. M. Phillips. (2001). Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization. Sex. Transm. Dis. 28:259–265.
  • K. H. Mayer, J. Peipert, T. Fleming, A. Fullem, T. Moench, S. Cu-Uvin, M. Bentley, M. Chesney, and Z. Rosenberg. (2001). Safety and tolerability of BufferGel, a novel vaginal microbicide, in women in the United States. Clin. Infect. Dis. 32:476–482.
  • T. D. McCarthy, P. Karellas, S. A. Henderson, M. Giannis, D. F. O'Keefe, G. Heery, J. R. Paull, B. R. Matthews, and G. Holan. (2005). Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention. Mol. Pharm. 2:312–318.
  • V. M. Ndesendo, V. Pillay, Y. E. Choonara, E. Buchmann, D. N. Bayever, and L. C. Meyer. (2008). A review of current intravaginal drug delivery approaches employed for the prophylaxis of HIV/AIDS and prevention of sexually transmitted infections. AAPS PharmSciTech. 9:505–520.
  • A. R. Neurath, N. Strick, and Y. Y. Li. (2002). Anti-HIV-1 activity of anionic polymers: A comparative study of candidate microbicides. BMC Infect. Dis. 2:27.
  • S. S. Olmsted, N. H. Dubin, R. A. Cone, and T. R. Moench. (2000). The rate at which human sperm are immobilized and killed by mild acidity. Fertil Steril 73:687–693.
  • S. S. Olmsted, K. V. Khanna, E. M. Ng, S. T. Whitten, O. N. JohnsonIII, R. B. Markham, R. A. Cone, and T. R. Moench. (2005). Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model. BMC Infect. Dis. 5:79.
  • S. S. Olmsted, J. L. Padgett, A. I. Yudin, K. J. Whaley, T. R. Moench, and R. A. Cone. (2001). Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys. J. 81:1930–1937.
  • D. L. Patton, Y. C. Sweeney, P. K. Cummings, L. Meyn, L. K. Rabe, and S. L. Hillier. (2004). Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model. Sex. Transm. Dis. 31:290–296.
  • S. Roth, M. Monsour, A. Dowland, P. C. Guenthner, K. Hancock, C. Y. Ou, and C. S. Dezzutti. (2007). Effect of topical microbicides on infectious human immunodeficiency virus type 1 binding to epithelial cells. Antimicrob. Agents Chemother. 51:1972–1978.
  • R. Rupp, S. L. Rosenthal, and L. R. Stanberry. (2007). VivaGel (SPL7013 Gel): A candidate dendrimer–microbicide for the prevention of HIV and HSV infection. Int. J. Nanomedicine 2:561–566.
  • D. Tien, R. L. Schnaare, F. Kang, G. Cohl, T. J. McCormick, T. M. Moench, G. Doncel, K. Watson, R. W. BuckheitJr., M. G. Lewis, J. Schwartz, K. Douville, and J. W. Romano. (2005). In vitro and in vivo characterisation of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS Res. Human Retroviruses 21 (10):845–853.
  • J. A. Turpin. (2002). Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. Expert Opin. Investig. Drugs 11:1077–1097.
  • J. Van De Wijgert, A. Fullem, C. Kelly, S. Mehendale, S. Rugpao, N. Kumwenda, Z. Chirenje, S. Joshi, T. Taha, N. Padian, R. Bollinger, and K. Nelson. (2001). Phase 1 trial of the topical microbicide BufferGel: Safety results from four international sites. J. Acquir. Immune Defic. Syndr. 26:21–27.
  • D. L. Williams, D. R. Newman, S. A. Ballagh, M. D. Creinin, K. Barnhart, D. H. Weiner, A. J. Bell, and D. J. Jamieson. (2007). Phase I safety trial of two vaginal microbicide gels (Acidform or BufferGel) used with a diaphragm compared to KY jelly used with a diaphragm. Sex. Transm. Dis. 34:977–984.
  • L. Zeitlin, T. E. Hoen, S. L. Achilles, T. A. Hegarty, A. E. Jerse, J. W. Kreider, S. S. Olmsted, K. J. Whaley, R. A. Cone, and T. R. Moench. (2001). Tests of buffergel for contraception and prevention of sexually transmitted diseases in animal models. Sex. Transm. Dis. 28:417–423.

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