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Drug Development and Industrial Pharmacy Volume 35, 2009 - Issue 9
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Original Article

Optimization of fluid bed formulations of metoprolol granules and tablets using an experimental design

I. Tomuţă Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, ‘Iuliu Hatieganu’ University, Cluj-Napoca, RomaniaCorrespondence[email protected]
,
C. Alecu S.C. Polipharma Industries SRL, Sibiu, Romania
,
L.L. Rus S.C. Polipharma Industries SRL, Sibiu, Romania
&
S.E. Leuçuta Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, ‘Iuliu Hatieganu’ University, Cluj-Napoca, Romania
Pages 1072-1081 | Received 05 Oct 2008, Accepted 23 Jan 2009, Published online: 05 Oct 2009

References

  • Sweetman SC. (2002). Martindale: The complete drug reference. 35th ed. London: Pharmaceutical Press, 931–2.
  • Niazi SK. (2004). Handbook of pharmaceutical manufacturing formulations compressed solid products, Vol. 1. London: CRC PRESS, 139–40.
  • Aulton ME. (2001). Pharmaceutics: The science of dosage form design. 2nd ed. Churchill Livingstone Publisher: London, 365–6.
  • Rambali B, Baert L, Thone D, Massart DL. (2001). Using experimental design to optimize the process parameters in fluidized bed granulation. Drug Dev Ind Pharm, 27(1):47–55.
  • Hu X, Cunningham J, Winstead D. (2008). Understanding and predicting bed humidity in fluidized bed granulation. J Pharm Sci, 97(4):1564–77.
  • Hlinak AJ, Saleki-Gerhardt A. (2000). An evaluation of fluid bed drying of aqueous granulations. Pharm Dev Technol, 5(1):11–17.
  • Dacanal GC, Menegalli FC. (2008). Experimental study of fluidized bed agglomeration of acerola powder. Braz J Chem Eng, 25(1):51–8.
  • Rambali B, Baert L, Massart DL. (2001). Using experimental design to optimize the process parameters in fluidized bed granulation on a semi-full scale. Int J Pharm, 220(1–2):149–60.
  • Rambali B, Van Aelst S, Baert L, Massart DL. (2003). Using deepest regression method for optimization of fluidized bed granulation on semi-full scale. Int J Pharm, 258(1–2):85–94.
  • Faure A, York P, Rowe RC. (2001). Process control and scale-up of pharmaceutical wet granulation processes: A review. Eur J Pharm Biopharm, 52(3):269–77.
  • Cryer SA, Scherer PN. (2003). Observations and process parameter sensitivities in fluidbed granulation. AIChE J, 49(11):2802–9.
  • Gao JZ H, Jain A, Motheram R, Gray DB, Hussain MA. (2002). Fluid bed granulation of a poorly water soluble, low density, micronized drug: Comparison with high shear granulation. Int J Pharm, 237(1–2):1–14.
  • Eriksson L, Johansson E, Kettaneh-Wold N, Wikstrom C, Wold S. (2000). Design of experiments: Principles and applications, Umeå: Umetrics Academy Inc., 85–93.
  • MODDE 6. (2001). Software for design of experiments and optimization: User2s guide and tutorial. Umeå: Umetrics Academy Inc, 129–56.
  • Parikh DM. (2005). Handbook of pharmaceutical granulation technology. New York, London: Taylor & Francis Group, 513–34.
  • European Pharmacopoeia. (2007). 6th ed, CD version.
  • Rudnic EM, Schwartz JB. (2005). Oral solid dosage forms. In Remington: The science and practice of pharmacy. Philadelphia: Lippincott Williams & Wilkins Press, 916–7.
  • Dilip PM. (2005). Handbook of pharmaceutical granulation technology. 2nd ed. New York: Taylor & Francis Group, LLC, 513–34.
  • Capes CE. (1980). Particle size enlargement. New York: Elservier, Inc.
  • Merkku P, Lindqvist AS, Leiviska K, Ylirussi J. (1994). Influence of granulation and compresion process variable on flow rate of granules and tablet properties with special reference to weight variation. Int J Pharm, 102:117–25.
  • USP 31. The United States Pharmacopeia. 31th ed; 2008, CD version
  • Armstrong NA. (2006). Pharmaceutical experimental design and interpretation. 2nd ed. London: Taylor & Francis Group, LLC, 118–29.
  • Behzadi SS, Klocker J, Hüttlin H, Wolschann P, Viernstein H. (2005). Validation of fluid bed granulation utilizing artificial neural network. Int J Pharm, 291(1–2):139–48.
  • Chaplin G, Pugsley T, Winters C. (2005). Monitoring the fluidized bed granulation process based on S-statistic analysis of a pressure time series. AAPS PharmSciTech, 6(2):198–201.

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