363
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats

, , , , , , & show all
Pages 1082-1091 | Received 11 Nov 2008, Accepted 24 Jan 2009, Published online: 05 Oct 2009

References

  • Hurst S, Loi CM, Brodfuehrer J, El-Kattan A. (2007). Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans. Expert Opin Drug Metab Toxicol, 3:469–89.
  • Thomas VH, Bhattachar S, Hitchingham L, Zocharski P, Naath M, Surendran N, . (2006). The road map to oral bioavailability: An industrial perspective. Expert Opin Drug Metab Toxicol, 2:591–608.
  • Avdeef A. (2001). Physicochemical profiling (solubility, permeability and charge state). Curr Top Med Chem, 1:277–351.
  • Avdeef A, Testa B. (2002). Physicochemical profiling in drug research: A brief survey of the state-of-the-art of experimental techniques. Cell Mol Life Sci, 59:1681–9.
  • He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, . (1998). Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J Pharm Sci, 87:626–33.
  • Aungst BJ. (2000). Intestinal permeation enhancers. J Pharm Sci, 89:429–42.
  • Junginger HE, Verhoef JC. (1998). Macromolecules as safe penetration enhancers for hydrophilic drugs—a fiction?. Pharm Sci Technol Today, 1:370–6.
  • Sogias IA, Williams AC, Khutoryanskiy VV. (2008). Why is chitosan mucoadhesive?. Biomacromolecules, 9:1837–42.
  • Borchard G, Luessen HL, de Boer AG, Verhoef JC, Lehr C-M, Junginger HE. (1996). The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J Control Release, 39:131–8.
  • Kotze AF, Luessen HL, de Leeuw BJ, de Boer AG, Verhoef JC, Junginger HE. (1998). Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release, 51:35–46.
  • Arai K, Kinumaki T, Fujita T. (1968). Toxicity of chitosan. Bull Tokai Reg Fish Res Lab, 43:89–94.
  • Grabovac V, Guggi D, Bernkop-Schnurch A. (2005). Comparison of the mucoadhesive properties of various polymers. Adv Drug Deliv Rev, 57:1713–23.
  • Lehr CM, Bouwstra JA, Kok W, De Boer AG, Tukker JJ, Verhoef JC, . (1992). Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. J Pharm Pharmacol, 44:402–7.
  • Lu Z, Chen W, Hamman JH, Ni J, Zhai X. (2008). Chitosan-polycarbophil interpolyelectrolyte complex as an excipient for bioadhesive matrix systems to control macromolecular drug delivery. Pharm Dev Technol, 13:37–47.
  • Bernkop-Schnurch A. (1998). The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J Control Release, 52:1–16.
  • Bernkop-Schnurch A, Pasta M. (1998). Intestinal peptide and protein delivery: Novel bioadhesive drug-carrier matrix shielding from enzymatic attack. J Pharm Sci, 87:430–4.
  • Chiou WL, Ma C, Chung SM, Wu TC, Jeong HY. (2000). Similarity in the linear and non-linear oral absorption of drugs between human and rat. Int J Clin Pharmacol Ther, 38:532–9.
  • Ganapathy ME, Huang W, Wang H, Ganapathy V, Leibach FH. (1998). Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun, 246:470–5.
  • Burnette TC, de Miranda P. (1994). Metabolic disposition of the acyclovir prodrug valaciclovir in the rat. Drug Metab Dispos, 22:60–4.
  • Kim SH, Choi YM, Lee MG. (1993). Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J Pharmacokinet Biopharm, 21:1–17.
  • Gibaldi M, Perrier D. (1992). Pharmacokinetics. New York: Marcel Dekker, Inc.; 1982.
  • Miller JC, Miller JN. (1992). Statics for analytical chemistry. West Sussex, England: Ellis Hardwood Limited.
  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res, 10:1093–5.
  • de Miranda P, Krasny HC, Page DA, Elion GB. (1981). The disposition of acyclovir in different species. J Pharmacol Exp Ther, 219:309–15.
  • Meadows KC, Dressman JB. (1990). Mechanism of acyclovir uptake in rat jejunum. Pharm Res, 7:299–303.
  • Shao Z, Park GB, Krishnamoorthy R, Mitra AK. (1994). The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2′-ester prodrugs. Pharm Res, 11:237–42.
  • Zornoza T, Cano-Cebrian MJ, Nalda-Molina R, Guerri C, Granero L, Polache A. (2004). Assessment and modulation of acamprosate intestinal absorption: Comparative studies using in situ, in vitro (CACO-2 cell monolayers) and in vivo models. Eur J Pharm Sci, 22:347–56.
  • Luessen HL, Rentel CO, Kotze AF, Lehr C-M, de Boer AG, Verhoef JC, . (1997). Mucoadhesive polymers in peroral peptide delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal membrane in vitro. J Control Release, 45:15–23.
  • . (2005). Sheskey PJ, Rowe RC, Owen SC, eds. Handbook of pharmaceutical excipients. Washington, DC: American Association of Pharmaceutical Sciences.
  • Kofoid CA, McNeil E, Cailleau R. (1932). Electrometric pH determinations of the walls and contents of the gastrointestinal tracts of normal albino rats. Univ Calif Publ Zool, 36:347–55.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.