Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies

References

• Knutsen-Larson S, Dawson AL, Dunnick CA, Dellavale RP. Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatol Clin 2012;30:99–106.
   PubMed Web of Science ®Google Scholar
• Collier CN, Harper JC, Cantrell WC, et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol 2008;58:56–9.
   PubMed Web of Science ®Google Scholar
• Munavalli GS, Weiss RA. Evidence for laser- and light-based treatment of acne vulgaris. Semin Cutan Med Surg 2008;27:207–11.
   PubMed Web of Science ®Google Scholar
• Williams HC, Dellavalle RP, Garner S. Acne Vulgaris. Lancet 2012;379:361–70.
   PubMed Web of Science ®Google Scholar
• Date AA, Naik B, Nagarsenker MS. Novel drug delivery systems: potential in improving topical delivery of antiacne agents. Skin Pharmacol Physiol 2006;19:2–16.
   PubMed Web of Science ®Google Scholar
• Guterres SS, Alves MP, Pohlmann AP. Polymeric nanoparticles, nanospheres and nanocapsules for cutaneous applications. Drug Target Insights 2007;2:147–57.
   PubMedGoogle Scholar
• Bettoli V, Sarno O, Zauli S, et al. What’s new in acne? New therapeutic. Ann Dermatol 2010;137:34–8.
   Google Scholar
• Mora-Huertas CE, Fessi H, Elaissari A. Polymer based nanocapsules for drug delivery. Int J Pharm 2010;385:113–42.
   PubMed Web of Science ®Google Scholar
• Poletto FS, Beck RC, Guterres SS, Pohlmann AR. Polymeric nanocapsules: concepts and applications. In: Beck R, Guterres S, Pohlmann AR, eds. Nanocosmetics and nanomedicines. new approaches for the skin care. Berlin, Germany: Springer; 2011:49–68.
   Google Scholar
• Durán N, Teixeira Z, Marcatto PD. Topical application of nanostructures: solid lipid, polymeric and metallic nanoparticles. In: Beck RR, Guterres SS, Pohlmann AR, eds. Nanocosmetics and nanomedicines. new approaches for the skin care. Berlin, Germany: Springer; 2011:37–45.
   Google Scholar
• Ourique AF, Melero A, Silva CB, et al. Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomedicine. Eur J Pharm Biopharm 2011;79:95–101.
   PubMed Web of Science ®Google Scholar
• Oliveira C, Venturini CG, Donida B, et al. An algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations. Soft Matter 2013;9:1141–51.
   Web of Science ®Google Scholar
• Venturini CG, Jager E, Oliveira CP, et al. Formulation of lipid core nanocapsules. Colloids Surf A 2011;375:200–8.
   Web of Science ®Google Scholar
• Brum T, Fiel LA, Contri RV, et al. Polymeric nanocapsules and lipid-core nanocapsules have diverse skin penetration. J Nanosci Nanotechnol 2014;14:1–8.
   PubMed Web of Science ®Google Scholar
• Irby CE, Yentzer BA, Feldman SR. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health 2008;43:421–4.
   PubMed Web of Science ®Google Scholar
• Wozel VEG. Innovative use of dapsone. Dermatol Clin 2010;28:599–610.
   PubMed Web of Science ®Google Scholar
• Fessi H, Puisieux F, Devissaguet J-P, et al. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989;55:R1–4.
   Web of Science ®Google Scholar
• Calvo P, Vila-Jato JL, Alonso MJ. Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules and nanoemulsions, as ocular drug carrier. J Pharm Sci 1996;85:530–6.
   PubMed Web of Science ®Google Scholar
• International Conference on Harmonization of technical requirements for registration of pharmaceuticals for human use. Validation of analytical methods text and methodology Q2(R1). Switzerland: ICH Steering Committee; 2005.
   Google Scholar
• United States Pharmacopeia 37. Rockville: US Pharmacopeial Convention; 2014.
   Google Scholar
• Luepke NP. Hen's egg chorioallantoic membrane test for irritation potential. Food Chem Toxicol 1985;23:287–91.
   PubMed Web of Science ®Google Scholar
• Spielmann H, Liebsch M. HET-CAM Test. INVITTOX Protocol 47. 2004. Available from: http://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/ocubrd/hetcam/hetcamappa1.pdf [last accessed Mar 2015].
   Google Scholar
• Katzer T, Chaves P, Bernardo A, et al. Prednisolone-loaded nanocapsules as ocular drug delivery system: development, in vitro drug release and eye toxicity. J Microencapsul 2013;31:519–28.
   Web of Science ®Google Scholar
• Jain AK, Jaina A, Garga NK, et al. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf B Biointerfaces 2014;121:222–9.
   PubMed Web of Science ®Google Scholar
• Schaffazick SR, Guterres SS, Freitas LL, Pohlmann AR. Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos. Quim Nova 2003;26:726–37.
   Web of Science ®Google Scholar
• Schaffazick SR, Siqueira IR, Badejo AS, et al. Incorporation in polymeric nanocapsules improves the antioxidant effect of melatonin against lipid peroxidation in mice brain and liver. Eur J Pharm Biopharm 2008;69:64–71.
   PubMed Web of Science ®Google Scholar
• Jager E, Venturini CG, Poletto FS, et al. Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area. J Biomed Nanotechnol 2009;5:130–40.
   PubMed Web of Science ®Google Scholar
• Paese K, Jager A, Poletto FS, et al. Semisolid formulation containing a nanoencapsulated sunscreen: effectiveness, in vitro photostability and immune response. J Biomed Nanotechnol 2009;5:1–7.
   PubMed Web of Science ®Google Scholar
• Raber AS, Mittal A, Schäfer J, et al. Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm. J Control Release 2014;179:25–32.
   PubMed Web of Science ®Google Scholar
• Terroso T, Kulkamp IC, Jornada DS, et al. Development of semi-solid cosmetic formulations containing coenzyme Q-10 loaded nanocapsules. Latin Am J Pharm 2009;28:819–26.
   Web of Science ®Google Scholar
• Alves MP, Pohlmann AR, Guterres SS. Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development and rheological characterization. Pharmazie 2005;60:900–4.
   PubMed Web of Science ®Google Scholar
• Liu W, Hu M, Liu M, et al. Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. Int J Pharm 2008;364:135–41.
   PubMed Web of Science ®Google Scholar
• Barry B. Liberação Transdérmica de Fármacos. In: Aulton ME, ed. Delineamento de Formas Farmacêuticas. Porto Alegre: Artmed; 2005:504–36.
   Google Scholar
• Paese K. Desenvolvimento tecnológico, estudo de fotoestabilidade e avaliação da permeação cutânea in vitro da benzofenona-3 a partir de nanocápsulas poliméricas incorporadas em diferentes veículos semissólidos. Porto Alegre: Programa de Pós-Graduação em Ciências Farmacêuticas, UFRGS; 2008.
   Google Scholar
• Michalowski CB, Guterres SS, Dalla Costa T. Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles. J Pharm Biomed Anal 2004;35:1093–100.
   PubMed Web of Science ®Google Scholar
• Borges VRA, Simons A, Sena ARC, et al. Nano emulsion containing dapsone for topical administration: a study of in vitro release and epidermal permeation. Int J Nanomedicine 2013;8:535–44.
   PubMed Web of Science ®Google Scholar
• Alavarez-Román R, Naik A, Kalia YN, et al. Skin penetration and distribution of polymeric nanoparticles. J Control Release 2004;99:53–62.
   PubMed Web of Science ®Google Scholar
• Alves MP, Scarrone AL, Santos M, et al. Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int J Pharm 2007;341:215–20.
   PubMed Web of Science ®Google Scholar