Flurbiprofen-loaded niosomes-in-gel system improves the ocular bioavailability of flurbiprofen in the aqueous humor

References

• Ahuja M, Dhake AS, Sharma SK, Majumdar DK. Topical ocular delivery of NSAIDs. AAPS J 2008;10:229–41.
   PubMed Web of Science ®Google Scholar
• Van Sorge AA, Wijnen PH, Van Delft JL, et al. Flurbiprofen, S(+), eyedrops: formulation, enantiomeric assay, shelf life and pharmacology. Pharm World Sci 1999;21:91–5.
   PubMedGoogle Scholar
• Brown RM, Roberts CW. Preoperative and postoperative use of nonsteroidal antiinflammatory drugs in cataract surgery. Insight J 1996;21:13–16.
   Google Scholar
• Bandara BM, Sankaridurg PR, Willcox MD. Non-steroidal anti-inflammatory agents decrease bacterial colonisation of contact lenses and prevent adhesion to human corneal epithelial cells. Curr Eye Res 2004;29:245–51.
   PubMed Web of Science ®Google Scholar
• Lang JC. Ocular drug delivery conventional ocular formulations. Adv Drug Delivery Rev 1995;16:39–43.
   Web of Science ®Google Scholar
• Zhang W, Prausnitz MR, Edwards A. Model of transient drug diffusion across cornea. J Control Release 2004;99:241–58.
   PubMed Web of Science ®Google Scholar
• Ramos Yacasi GR, García López ML, Espina García M, et al. Influence of freeze-drying and γ-irradiation in preclinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using d-(+)-trehalose and polyethylene glycol. Int J Nanomedicine 2016; 11:4093–106.
   PubMed Web of Science ®Google Scholar
• Quinteros DA, Tártara LI, Palma SD, et al. Ocular delivery of flurbiprofen based on Eudragit(®) E-flurbiprofen complex dispersed in aqueous solution: preparation, characterization, in vitro corneal penetration, and ocular irritation. J Pharm Sci 2014;103:3859–68.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Mira E, Nikolić S, Calpena AC, et al. Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC-based hydrogels. J Pharm Sci 2012;101:707–25.
   PubMed Web of Science ®Google Scholar
• Han S, Shen JQ, Gan Y, et al. Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability. Acta Pharmacol Sin 2010;31:990–8.
   PubMed Web of Science ®Google Scholar
• Araújo J, Gonzalez E, Egea MA, et al. Nanomedicines for ocular NSAIDS: safety on drug delivery. Nanomedicine 2009;5:394–401.
   PubMed Web of Science ®Google Scholar
• Gannu PK, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery an-overview. Acta Pharm Sin B 2011;1:208–19.
   Google Scholar
• Uchegbu IF, Vyas SP. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm 1998;172:33–70.
   Web of Science ®Google Scholar
• Kaur IP, Garg A, Singla AK, Aggarwal D. Vesicular systems in ocular drug delivery: an overview. Int J Pharm 2004;269:1–14.
   PubMed Web of Science ®Google Scholar
• Abu Hashim II, El-Dahan MS, Yusif RM, et al. Potential use of niosomal hydrogel as an ocular delivery system for atenolol. Biol Pharm Bull 2014;37:541–51.
   PubMed Web of Science ®Google Scholar
• Abdelkader H, Ismail S, Kamal A, Alany RG. Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization. Pharmazie 2010;65:811–17.
   PubMed Web of Science ®Google Scholar
• Aggarwal D, Garg A, Kaur IP. Development of a topical niosomal preparation of acetazolamide: preparation and evaluation. J Pharm Pharmacol 2004;56:1509–17.
   PubMed Web of Science ®Google Scholar
• Abdelbary G, El-Gendy N. Niosome-encapsulated gentamicin for ophthalmic controlled delivery. AAPS PharmSciTech 2008;9:740–7.
   PubMed Web of Science ®Google Scholar
• Khalil RM, Abdelbary GA, Basha M, et al. Enhancement of lomefloxacin Hcl ocular efficacy via niosomal encapsulation: in vitro characterization and in vivo evaluation. J Liposome Res 2016;30:1–12.
   Google Scholar
• Li Q, Li Z, Zeng W, et al. Proniosome-derived niosomes for tacrolimus topical ocular delivery: in vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection. Eur J Pharm Sci 2014;62:115–23.
   PubMed Web of Science ®Google Scholar
• Azmin MN, Florence AT, Handjani-Vila RM, et al. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm. Pharmacol 1985;37:237–42.
   PubMed Web of Science ®Google Scholar
• Mokhtar M, Sammour OA, Hammad MA, Megrab NA. Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes. Int J Pharm 2008;361:104–11.
   PubMed Web of Science ®Google Scholar
• Aggarwal D, Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. Int J Pharm 2005;290:155–9.
   PubMed Web of Science ®Google Scholar
• Chandran S, Saha RN. Simple rapid validated RP-LC method for the estimation of flurbiprofen in rabbit serum and aqueous humor. Anal Lett 2008;41:1318–34.
   Web of Science ®Google Scholar
• Kumbhat S, Mathur N. Determination of flurbiprofen in aqueous humor of human by high performance liquid chromatography. Anal Lett 1990;23:627–34.
   Web of Science ®Google Scholar
• Muzzalupo R, Tavano L, Cassano R, et al. A new approach for the evaluation of niosomes as effective transdermal drug delivery systems. Eur J Pharm Biopharm 2011;79:28–35.
   PubMed Web of Science ®Google Scholar
• Diestelhorst M, Aspacher F, Konen W, Krieglstein GK. The effect of flurbiprofen 0.03% eye drops on the blood aqueous barrier in extracapsular cataract extraction with IOL implantation. Int Ophthalmol 1991;15:69–73.
   PubMed Web of Science ®Google Scholar
• Makeshwar KB, Wasankar SR. Niosome: a novel drug delivery system. AJPS 2013;3:16–20.
   Google Scholar
• Talsma H, Van Steenbergen MJ, Borchert JC, Crommelin DJ. A novel technique for the one‐step preparation of liposomes and nonionic surfactant vesicles without the use of organic solvents. Liposome formation in a continuous gas stream: the ‘bubble’method. J Pharm Sci 1994;83:276–80.
   PubMed Web of Science ®Google Scholar
• Mohawed O, El-Ashmoony M. Niosome-encapsulated clomipramine for transdermal controlled delivery. Int J Pharm Pharm Sci 2014;6:567–75.
   Google Scholar
• Kumbhar D, Wavikar P, Vavia P. Niosomal gel of lornoxicam for topical delivery: in vitro assessment and pharmacodynamic activity. AAPS PharmSciTech 2013;14:1072–82.
   PubMed Web of Science ®Google Scholar
• Abdelkader H, Mansour HF. Comparative studies for ciprofloxacin hydrochloride pre-formed gels and thermally triggered (in situ) gels: in vitro and in vivo appraisal using a bacterial keratitis model in rabbits. Pharm Dev Technol 2015;20:410–16.
   PubMed Web of Science ®Google Scholar
• Abou El Ela A. e S, Khatib MM. Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels. Saudi Pharm J 2014;22:555–63.
   PubMed Web of Science ®Google Scholar